CA2602587A1 - Multiplex fluorescence detection device having removable optical modules - Google Patents
Multiplex fluorescence detection device having removable optical modules Download PDFInfo
- Publication number
- CA2602587A1 CA2602587A1 CA002602587A CA2602587A CA2602587A1 CA 2602587 A1 CA2602587 A1 CA 2602587A1 CA 002602587 A CA002602587 A CA 002602587A CA 2602587 A CA2602587 A CA 2602587A CA 2602587 A1 CA2602587 A1 CA 2602587A1
- Authority
- CA
- Canada
- Prior art keywords
- optical
- detection device
- optical modules
- disk
- modules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 347
- 238000001917 fluorescence detection Methods 0.000 title claims description 18
- 238000001514 detection method Methods 0.000 claims abstract description 111
- 238000000034 method Methods 0.000 claims abstract description 91
- 230000008569 process Effects 0.000 claims abstract description 54
- 239000000835 fiber Substances 0.000 claims abstract description 52
- 238000003752 polymerase chain reaction Methods 0.000 claims abstract description 20
- 230000005284 excitation Effects 0.000 claims description 38
- 239000000975 dye Substances 0.000 claims description 27
- 230000015654 memory Effects 0.000 claims description 19
- 230000008878 coupling Effects 0.000 claims description 15
- 238000010168 coupling process Methods 0.000 claims description 15
- 238000005859 coupling reaction Methods 0.000 claims description 15
- 239000007850 fluorescent dye Substances 0.000 claims description 15
- 230000007246 mechanism Effects 0.000 claims description 13
- 238000003860 storage Methods 0.000 claims description 6
- 230000009977 dual effect Effects 0.000 claims 3
- 238000003753 real-time PCR Methods 0.000 abstract description 9
- 239000000523 sample Substances 0.000 description 49
- 238000006243 chemical reaction Methods 0.000 description 25
- 238000010586 diagram Methods 0.000 description 24
- 238000010438 heat treatment Methods 0.000 description 19
- 238000004891 communication Methods 0.000 description 16
- 239000013307 optical fiber Substances 0.000 description 16
- 238000012545 processing Methods 0.000 description 13
- 230000000153 supplemental effect Effects 0.000 description 13
- 108020004414 DNA Proteins 0.000 description 8
- 239000012530 fluid Substances 0.000 description 6
- 238000007403 mPCR Methods 0.000 description 6
- 230000003321 amplification Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 238000003199 nucleic acid amplification method Methods 0.000 description 5
- 238000009987 spinning Methods 0.000 description 5
- 102000053602 DNA Human genes 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000000295 emission spectrum Methods 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 239000003068 molecular probe Substances 0.000 description 3
- 150000007523 nucleic acids Chemical group 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 238000010222 PCR analysis Methods 0.000 description 2
- 238000012300 Sequence Analysis Methods 0.000 description 2
- 108020004682 Single-Stranded DNA Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000005224 forefinger Anatomy 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000003813 thumb Anatomy 0.000 description 2
- 238000009941 weaving Methods 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 230000004568 DNA-binding Effects 0.000 description 1
- 108060002716 Exonuclease Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000023077 detection of light stimulus Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- VPWFPZBFBFHIIL-UHFFFAOYSA-L disodium 4-[(4-methyl-2-sulfophenyl)diazenyl]-3-oxidonaphthalene-2-carboxylate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC(C)=CC=C1N=NC1=C(O)C(C([O-])=O)=CC2=CC=CC=C12 VPWFPZBFBFHIIL-UHFFFAOYSA-L 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 102000013165 exonuclease Human genes 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical group C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000010248 power generation Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- ABZLKHKQJHEPAX-UHFFFAOYSA-N tetramethylrhodamine Chemical compound C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C([O-])=O ABZLKHKQJHEPAX-UHFFFAOYSA-N 0.000 description 1
- 238000005382 thermal cycling Methods 0.000 description 1
- 238000013024 troubleshooting Methods 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- -1 tungsten halogen Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/173—Nucleic acid detection characterized by the use of physical, structural and functional properties staining/intercalating agent, e.g. ethidium bromide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/024—Modular construction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66746105P | 2005-04-01 | 2005-04-01 | |
| US60/667,461 | 2005-04-01 | ||
| US11/174,754 | 2005-07-05 | ||
| US11/174,754 US7507575B2 (en) | 2005-04-01 | 2005-07-05 | Multiplex fluorescence detection device having removable optical modules |
| PCT/US2006/010787 WO2006107619A1 (en) | 2005-04-01 | 2006-03-24 | Multiplex fluorescence detection device having removable optical modules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2602587A1 true CA2602587A1 (en) | 2006-10-12 |
Family
ID=36591356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002602587A Abandoned CA2602587A1 (en) | 2005-04-01 | 2006-03-24 | Multiplex fluorescence detection device having removable optical modules |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7507575B2 (enExample) |
| EP (2) | EP1872112B1 (enExample) |
| JP (1) | JP5021614B2 (enExample) |
| KR (1) | KR101265362B1 (enExample) |
| AT (1) | ATE472099T1 (enExample) |
| AU (1) | AU2006232922A1 (enExample) |
| BR (1) | BRPI0609544B8 (enExample) |
| CA (1) | CA2602587A1 (enExample) |
| DE (1) | DE602006015043D1 (enExample) |
| ES (1) | ES2347077T3 (enExample) |
| MX (1) | MX2007012159A (enExample) |
| WO (1) | WO2006107619A1 (enExample) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| JP4996248B2 (ja) | 2003-07-31 | 2012-08-08 | ハンディーラブ インコーポレイテッド | 粒子含有サンプルの処理 |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US7507575B2 (en) * | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
| US7709249B2 (en) * | 2005-04-01 | 2010-05-04 | 3M Innovative Properties Company | Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector |
| US20070009382A1 (en) * | 2005-07-05 | 2007-01-11 | William Bedingham | Heating element for a rotating multiplex fluorescence detection device |
| US7527763B2 (en) * | 2005-07-05 | 2009-05-05 | 3M Innovative Properties Company | Valve control system for a rotating multiplex fluorescence detection device |
| US7754148B2 (en) | 2006-12-27 | 2010-07-13 | Progentech Limited | Instrument for cassette for sample preparation |
| US8372340B2 (en) | 2005-10-19 | 2013-02-12 | Luminex Corporation | Apparatus and methods for integrated sample preparation, reaction and detection |
| US7727473B2 (en) | 2005-10-19 | 2010-06-01 | Progentech Limited | Cassette for sample preparation |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| ES2692380T3 (es) | 2006-03-24 | 2018-12-03 | Handylab, Inc. | Método para realizar PCR con un cartucho con varias pistas |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US8765076B2 (en) | 2006-11-14 | 2014-07-01 | Handylab, Inc. | Microfluidic valve and method of making same |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| ES2648798T3 (es) | 2007-07-13 | 2018-01-08 | Handylab, Inc. | Materiales de captura de polinucleótidos y métodos de utilización de los mismos |
| US9121055B2 (en) * | 2008-04-24 | 2015-09-01 | 3M Innovative Properties Company | Analysis of nucleic acid amplification curves using wavelet transformation |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| GB0817991D0 (en) * | 2008-10-02 | 2008-11-05 | Enigma Diagnostics Ltd | Fluorescence based detection methods and apparatus |
| JP5655232B2 (ja) * | 2008-12-05 | 2015-01-21 | ビオカルティ ナームローゼ フェノーツハップＢｉｏｃａｒｔｉｓ ＮＶ | 搬送ヒータを有する熱サイクルシステム |
| JP5279481B2 (ja) * | 2008-12-25 | 2013-09-04 | 株式会社日立ハイテクノロジーズ | 核酸分析装置 |
| JP5843614B2 (ja) | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
| AU2010237532B2 (en) * | 2009-04-15 | 2014-11-20 | Biocartis Nv | Optical detection system for monitoring rtPCR reaction |
| US20110014094A1 (en) * | 2009-07-20 | 2011-01-20 | Samsung Electronics Co., Ltd. | Disk type microfluidic device and blood testing apparatus using the same |
| DK2475788T3 (en) * | 2009-09-10 | 2018-07-30 | Diasorin S P A | COMPENSATION FOR SPECTRAL CRYSTAL SAMPLES IN MULTIPLEX NUCLEIC ACID AMPLIFICATION |
| BR112012013074B1 (pt) | 2009-12-01 | 2018-09-18 | Oxford Nanopore Technologies Limited | instrumento de análise e módulo para realizar análise bioquímica, e, método para operar um instrumento de análise para realizar análise bioquímica |
| US8729502B1 (en) | 2010-10-28 | 2014-05-20 | The Research Foundation For The State University Of New York | Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection |
| CN102175612B (zh) * | 2011-01-18 | 2012-12-26 | 河北工业大学 | 一种多路光电检测装置 |
| US9096892B1 (en) | 2011-02-04 | 2015-08-04 | K2 Biomicrosystems, LLC | Nucleic acid amplification and monitoring apparatus |
| ES2653916T3 (es) | 2011-03-08 | 2018-02-09 | Universite Laval | Dispositivo centrípeto fluídico |
| CA3082652A1 (en) * | 2011-04-15 | 2012-10-18 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
| EP2705130B1 (en) | 2011-05-04 | 2016-07-06 | Luminex Corporation | Apparatus and methods for integrated sample preparation, reaction and detection |
| BR112013027903B1 (pt) | 2011-05-18 | 2021-01-12 | Diasorin S.P.A. | estrutura de medição em um dispositivo de processamento de amostras e método para a medição volumétrica de referido dispositivo |
| CN103501908B (zh) | 2011-05-18 | 2016-03-16 | 3M创新有限公司 | 用于样品处理装置上阀调的系统和方法 |
| USD672467S1 (en) | 2011-05-18 | 2012-12-11 | 3M Innovative Properties Company | Rotatable sample processing disk |
| WO2012158997A1 (en) | 2011-05-18 | 2012-11-22 | 3M Innovative Properties Company | Systems and methods for detecting the presence of a selected volume of material in a sample processing device |
| JP6298404B2 (ja) | 2011-07-25 | 2018-03-20 | オックスフォード ナノポール テクノロジーズ リミテッド | 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法 |
| CN103959070B (zh) | 2011-09-30 | 2017-05-10 | 贝克顿·迪金森公司 | 组合试剂条 |
| US10453557B2 (en) | 2011-09-30 | 2019-10-22 | Life Technologies Corporation | Methods and systems for visualizing and evaluating data |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| EP4361607A3 (en) | 2012-02-03 | 2024-07-17 | California Institute of Technology | Signal encoding and decoding in multiplexed biochemical assays |
| ES2978107T3 (es) | 2012-02-03 | 2024-09-05 | Becton Dickinson Co | Archivos externos para distribución de pruebas de diagnóstico molecular y determinación de compatibilidad entre pruebas |
| IN2014DN07992A (enExample) * | 2012-04-03 | 2015-05-01 | Illumina Inc | |
| WO2013163129A1 (en) * | 2012-04-23 | 2013-10-31 | Siemens Healthcare Diagnostics Inc. | Biological assay sample analyzer |
| EP2875154B1 (en) | 2012-07-19 | 2017-08-23 | Oxford Nanopore Technologies Limited | SSB method for characterising a nucleic acid |
| EP2880184B1 (en) * | 2012-08-03 | 2021-03-31 | California Institute of Technology | Multiplexing and quantification in pcr with reduced hardware and requirements |
| WO2014025398A1 (en) | 2012-08-10 | 2014-02-13 | Streck, Inc. | Real-time optical system for polymerase chain reaction |
| CN103364378B (zh) * | 2013-03-05 | 2016-04-20 | 江苏天瑞仪器股份有限公司 | 一种用于原子荧光光谱仪的多功能联合进样系统 |
| AU2014224432B2 (en) | 2013-03-08 | 2019-10-24 | Oxford Nanopore Technologies Limited | Enzyme stalling method |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| US8858886B1 (en) | 2013-05-08 | 2014-10-14 | Agilent Technologies, Inc. | Scanning system with interchangeable optical cartridges for fluorescence measurements |
| EP3014251A1 (en) | 2013-06-28 | 2016-05-04 | Streck Inc. | Devices for real-time polymerase chain reaction |
| DE102013012609B4 (de) * | 2013-07-26 | 2024-06-27 | Carl Zeiss Microscopy Gmbh | Optoelektronischer Detektor, insbesondere für hochauflösende Lichtrastermikroskope und Lichtrastermikroskop |
| PT3030645T (pt) | 2013-08-08 | 2023-02-16 | Illumina Inc | Sistema de fluidos para entrega de reagente a uma célula de fluxo |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| US20180268358A1 (en) * | 2015-01-09 | 2018-09-20 | Apex Industrial Technologies Llc | Order fulfillment system and method with item sensor |
| US20160290866A1 (en) * | 2015-03-30 | 2016-10-06 | DeNovix, Inc. | Apparatus and method for measuring fluorescence of a sample |
| US10209242B2 (en) | 2015-05-21 | 2019-02-19 | Emit Imaging, Inc. | Fluorescence histo-tomography (FHT) systems and methods |
| WO2017040671A1 (en) * | 2015-08-31 | 2017-03-09 | Invicro, Llc | Fluorescence histo-tomography (fht) systems and methods |
| USD799715S1 (en) | 2015-10-23 | 2017-10-10 | Gene POC, Inc. | Fluidic centripetal device |
| US10272510B2 (en) * | 2016-01-14 | 2019-04-30 | United Technologies Corporation | Electrical discharge machining apparatus |
| JP6687834B2 (ja) * | 2016-02-03 | 2020-04-28 | 株式会社Ｊｖｃケンウッド | 分析装置及び分析方法 |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| WO2017204512A1 (ko) * | 2016-05-25 | 2017-11-30 | 옵토레인 주식회사 | 피씨알모듈 |
| KR101972579B1 (ko) * | 2016-05-25 | 2019-08-23 | (주)옵토레인 | 피씨알모듈 및 이를 이용한 검사방법 |
| CN106198480B (zh) * | 2016-08-30 | 2018-09-14 | 广州蓝勃生物科技有限公司 | 一种自动干式荧光检测仪 |
| CN106290286A (zh) * | 2016-09-20 | 2017-01-04 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | 时间分辨荧光分析系统及检测装置 |
| GB201704771D0 (en) | 2017-01-05 | 2017-05-10 | Illumina Inc | Modular optical analytic systems and methods |
| US10431441B2 (en) * | 2018-01-31 | 2019-10-01 | Palodex Group Oy | Reducing calibration of components in an imaging plate scanner |
| EP3781710A4 (en) | 2018-04-17 | 2022-01-05 | Chromacode, Inc. | METHODS AND SYSTEMS FOR MULTIPLEX ANALYSIS |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| US12203129B2 (en) | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| CN110656046A (zh) * | 2019-11-01 | 2020-01-07 | 中国人民解放军军事科学院军事医学研究院 | 一种探测装置及pcr仪 |
| CN112823890B (zh) * | 2020-07-30 | 2024-07-19 | 北京金诺美科技股份有限公司 | 一种实时荧光定量pcr仪 |
| CN112798773A (zh) * | 2020-12-27 | 2021-05-14 | 北京工业大学 | 一种基于stm32单片机的高分辨率酶标仪电控系统 |
| US12461029B2 (en) * | 2021-03-10 | 2025-11-04 | Northeastern University | Continuous flow air sampling and rapid pathogen detection system |
| CN118202229A (zh) * | 2021-10-20 | 2024-06-14 | 生物辐射实验室股份有限公司 | 荧光检测系统 |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2055944A1 (de) | 1970-11-13 | 1972-05-18 | Leitz Ernst Gmbh | Fluoreszenzauflichtilluminator |
| US3918793A (en) * | 1970-05-02 | 1975-11-11 | Leitz Ernst Gmbh | Fluorescence illuminator for incident light microscope |
| DE2420545C3 (de) | 1974-04-27 | 1979-01-25 | H. Maihak Ag, 2000 Hamburg | Infrarotstrahleranordnung |
| JPS55156840A (en) | 1979-05-25 | 1980-12-06 | Olympus Optical Co Ltd | Specimen detector |
| JPS6120839A (ja) | 1984-07-10 | 1986-01-29 | Fuji Photo Film Co Ltd | バクテリアカウンタ |
| US4726676A (en) * | 1986-02-06 | 1988-02-23 | General Signal Corporation | Optical signal power measurement method and apparatus |
| US4927766A (en) | 1986-05-27 | 1990-05-22 | The Boc Group, Inc. | Gas constituent measurement and recording |
| US4909990A (en) | 1987-09-02 | 1990-03-20 | Myron J. Block | Immunoassay apparatus |
| GB8919700D0 (en) | 1989-08-31 | 1989-10-11 | Electricity Council | Infra-red radiation emission arrangement |
| US7273749B1 (en) | 1990-06-04 | 2007-09-25 | University Of Utah Research Foundation | Container for carrying out and monitoring biological processes |
| US5296958A (en) * | 1992-05-29 | 1994-03-22 | Eastman Kodak Company | Multiple wavelength laser beam scanning system |
| JPH0634546A (ja) | 1992-07-17 | 1994-02-08 | Tosoh Corp | 蛍光検出器 |
| CA2100020C (en) | 1992-07-17 | 2001-09-11 | Walter Blumenfeld | Methods and apparatus for detecting bacterial growth by spectrophotometric sampling of a fiber-optic array |
| US5414600A (en) | 1993-07-30 | 1995-05-09 | Cogent Light Technologies, Inc. | Condensing and collecting optical system using an ellipsoidal reflector |
| AU698953B2 (en) | 1994-04-29 | 1998-11-12 | Applied Biosystems, Llc | System for real time detection of nucleic acid amplification products |
| US5766889A (en) | 1994-06-08 | 1998-06-16 | The Perkin-Elmer Corporation | Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample |
| US6327031B1 (en) | 1998-09-18 | 2001-12-04 | Burstein Technologies, Inc. | Apparatus and semi-reflective optical system for carrying out analysis of samples |
| GB9418981D0 (en) | 1994-09-21 | 1994-11-09 | Univ Glasgow | Apparatus and method for carrying out analysis of samples |
| US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| US5639668A (en) | 1995-09-14 | 1997-06-17 | Boehringer Mannheim Corporation | Optical apparatus for performing an immunoassay |
| US6342349B1 (en) | 1996-07-08 | 2002-01-29 | Burstein Technologies, Inc. | Optical disk-based assay devices and methods |
| US5751874A (en) * | 1996-09-13 | 1998-05-12 | Nuvisions International, Inc. | Coupling device for linking optical fiber connectors |
| DE19707226A1 (de) * | 1997-02-24 | 1998-08-27 | Bodenseewerk Perkin Elmer Co | Lichtabtastvorrichtung |
| EE9900377A (et) | 1997-02-28 | 2000-04-17 | Burstein Laboratories, Inc. | Labor laserkettas |
| KR100345817B1 (ko) * | 1997-03-25 | 2002-07-24 | 산요 덴키 가부시키가이샤 | 정보 재생 장치와 정보 기록 장치 및 기준 마크 검출 회로 |
| EP1010030B1 (de) * | 1997-09-05 | 2001-11-14 | Leica Microsystems AG | Mikroskop, insbesondere fluoreszenzmikroskop, insbesondere stereo-fluoreszenzmikroskop |
| US6597450B1 (en) | 1997-09-15 | 2003-07-22 | Becton, Dickinson And Company | Automated Optical Reader for Nucleic Acid Assays |
| US6561428B2 (en) * | 1997-10-17 | 2003-05-13 | Hand Held Products, Inc. | Imaging device having indicia-controlled image parsing mode |
| US5994150A (en) | 1997-11-19 | 1999-11-30 | Imation Corp. | Optical assaying method and system having rotatable sensor disk with multiple sensing regions |
| JP2002500907A (ja) * | 1998-01-26 | 2002-01-15 | マサチユセツツ・インスチチユート・オブ・テクノロジイ | 蛍光画像化用内視鏡 |
| US6210882B1 (en) | 1998-01-29 | 2001-04-03 | Mayo Foundation For Medical Education And Reseach | Rapid thermocycling for sample analysis |
| US6014618A (en) * | 1998-08-06 | 2000-01-11 | Dsp Software Engineering, Inc. | LPAS speech coder using vector quantized, multi-codebook, multi-tap pitch predictor and optimized ternary source excitation codebook derivation |
| US6161946A (en) | 1998-11-09 | 2000-12-19 | Bishop; Christopher B. | Light reflector |
| US6232075B1 (en) * | 1998-12-14 | 2001-05-15 | Li-Cor, Inc. | Heterogeneous assay for pyrophosphate detection |
| JP3597729B2 (ja) * | 1999-05-11 | 2004-12-08 | 日立ソフトウエアエンジニアリング株式会社 | 蛍光測光方法及び蛍光測光装置 |
| US7410793B2 (en) | 1999-05-17 | 2008-08-12 | Applera Corporation | Optical instrument including excitation source |
| WO2001001112A1 (en) | 1999-06-26 | 2001-01-04 | Packard Instrument Company, Inc. | Microplate reader |
| US7088650B1 (en) * | 1999-08-23 | 2006-08-08 | Worthington Mark O | Methods and apparatus for optical disc data acquisition using physical synchronization markers |
| CN1311436A (zh) * | 2000-03-01 | 2001-09-05 | 上海和泰光电科技有限公司 | 旋转平台上的生物芯片荧光图象的读取 |
| JP2001281587A (ja) * | 2000-03-31 | 2001-10-10 | Fuji Photo Optical Co Ltd | 光走査装置用光源部の保持構造 |
| US6795189B2 (en) | 2000-06-15 | 2004-09-21 | Packard Instrument Company | Universal microplate analyzer |
| US6627159B1 (en) | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
| US6734401B2 (en) * | 2000-06-28 | 2004-05-11 | 3M Innovative Properties Company | Enhanced sample processing devices, systems and methods |
| US6563581B1 (en) | 2000-07-14 | 2003-05-13 | Applera Corporation | Scanning system and method for scanning a plurality of samples |
| FR2812306B1 (fr) | 2000-07-28 | 2005-01-14 | Gabriel Festoc | Systeme d'amplification en chaine par polymerse de sequences nucleiques cibles |
| US6545758B1 (en) | 2000-08-17 | 2003-04-08 | Perry Sandstrom | Microarray detector and synthesizer |
| US6452879B1 (en) * | 2000-09-29 | 2002-09-17 | Fujitsu Limited | Optical storage apparatus |
| WO2002029850A2 (en) | 2000-10-04 | 2002-04-11 | Cogent Light Technologies, Inc. | Temperature control for arc lamps |
| SE0004296D0 (sv) | 2000-11-23 | 2000-11-23 | Gyros Ab | Device and method for the controlled heating in micro channel systems |
| US20020172980A1 (en) * | 2000-11-27 | 2002-11-21 | Phan Brigitte Chau | Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems |
| US20020076354A1 (en) | 2000-12-01 | 2002-06-20 | Cohen David Samuel | Apparatus and methods for separating components of particulate suspension |
| US20030077598A1 (en) * | 2001-01-04 | 2003-04-24 | Phan Brigitte Chau | Dual bead assays including covalent linkages for improved specificity and related optical analysis discs |
| WO2002073605A2 (en) | 2001-03-14 | 2002-09-19 | Burstein Technologies, Inc. | Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus |
| US20030054563A1 (en) | 2001-09-17 | 2003-03-20 | Gyros Ab | Detector arrangement for microfluidic devices |
| US6597832B2 (en) * | 2001-12-07 | 2003-07-22 | Yu-Feng Cheng | Optical fiber selector |
| US6889468B2 (en) | 2001-12-28 | 2005-05-10 | 3M Innovative Properties Company | Modular systems and methods for using sample processing devices |
| AU2003202951A1 (en) * | 2002-01-14 | 2003-07-30 | Burstein Technologies, Inc. | Method and apparatus for visualizing data |
| US20050023765A1 (en) | 2002-01-31 | 2005-02-03 | Coombs James Howard | Bio-safety features for optical analysis disc and disc system including same |
| US6767155B2 (en) * | 2002-04-05 | 2004-07-27 | Eastman Kodak Company | High stability latch mechanism |
| AU2003222544A1 (en) | 2002-04-08 | 2003-10-27 | Gyros Ab | Homing process |
| US6833536B2 (en) | 2002-05-22 | 2004-12-21 | Applera Corporation | Non-contact radiant heating and temperature sensing device for a chemical reaction chamber |
| AU2003243281A1 (en) | 2002-05-17 | 2003-12-02 | Applera Corporation | Optical instrument includung excitation source |
| EP3312594B1 (en) | 2002-05-17 | 2019-07-24 | Life Technologies Corporation | Apparatus for differentiating multiple fluorescence signals by excitation wavelength |
| US20030219754A1 (en) | 2002-05-23 | 2003-11-27 | Oleksy Jerome E. | Fluorescence polarization detection of nucleic acids |
| AUPS267802A0 (en) | 2002-05-30 | 2002-06-20 | Bio-Molecular Holdings Pty Limited | Improved dna amplification apparatus and method |
| JP4193421B2 (ja) | 2002-06-06 | 2008-12-10 | ソニー株式会社 | バイオアッセイ装置及びその製造方法、並びにバイオアッセイ方法 |
| US7452507B2 (en) * | 2002-08-02 | 2008-11-18 | Sandia Corporation | Portable apparatus for separating sample and detecting target analytes |
| CN100380034C (zh) | 2002-12-04 | 2008-04-09 | 斯宾克斯公司 | 流体的可程控微量控制用装置和方法 |
| US20050014249A1 (en) | 2003-02-21 | 2005-01-20 | Norbert Staimer | Chromatographic analysis on optical bio-discs and methods relating thereto |
| US20050032089A1 (en) | 2003-03-05 | 2005-02-10 | Phan Brigitte Chau | Sample preparation for colorimetric and fluorescent assays as implemented on optical analysis discs |
| WO2004087950A2 (en) | 2003-04-04 | 2004-10-14 | Roche Diagnostics Gmbh | Improved system for multi color real time pcr |
| US7148043B2 (en) | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
| US7238269B2 (en) | 2003-07-01 | 2007-07-03 | 3M Innovative Properties Company | Sample processing device with unvented channel |
| US6879032B2 (en) * | 2003-07-18 | 2005-04-12 | Agilent Technologies, Inc. | Folded flex circuit interconnect having a grid array interface |
| US7317415B2 (en) | 2003-08-08 | 2008-01-08 | Affymetrix, Inc. | System, method, and product for scanning of biological materials employing dual analog integrators |
| US20050074784A1 (en) | 2003-10-07 | 2005-04-07 | Tuan Vo-Dinh | Integrated biochip with continuous sampling and processing (CSP) system |
| US7322254B2 (en) | 2003-12-12 | 2008-01-29 | 3M Innovative Properties Company | Variable valve apparatus and methods |
| US20050130177A1 (en) | 2003-12-12 | 2005-06-16 | 3M Innovative Properties Company | Variable valve apparatus and methods |
| US7295316B2 (en) | 2004-01-14 | 2007-11-13 | Applera Corporation | Fluorescent detector with automatic changing filters |
| US7507575B2 (en) | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
| US7709249B2 (en) | 2005-04-01 | 2010-05-04 | 3M Innovative Properties Company | Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector |
| US20070009382A1 (en) | 2005-07-05 | 2007-01-11 | William Bedingham | Heating element for a rotating multiplex fluorescence detection device |
| US7754474B2 (en) | 2005-07-05 | 2010-07-13 | 3M Innovative Properties Company | Sample processing device compression systems and methods |
| US7527763B2 (en) | 2005-07-05 | 2009-05-05 | 3M Innovative Properties Company | Valve control system for a rotating multiplex fluorescence detection device |
-
2005
- 2005-07-05 US US11/174,754 patent/US7507575B2/en active Active
-
2006
- 2006-03-24 CA CA002602587A patent/CA2602587A1/en not_active Abandoned
- 2006-03-24 KR KR1020077025261A patent/KR101265362B1/ko active Active
- 2006-03-24 MX MX2007012159A patent/MX2007012159A/es active IP Right Grant
- 2006-03-24 ES ES06748651T patent/ES2347077T3/es active Active
- 2006-03-24 WO PCT/US2006/010787 patent/WO2006107619A1/en not_active Ceased
- 2006-03-24 EP EP06748651A patent/EP1872112B1/en active Active
- 2006-03-24 BR BRPI0609544A patent/BRPI0609544B8/pt active IP Right Grant
- 2006-03-24 EP EP10161462A patent/EP2207026A1/en not_active Withdrawn
- 2006-03-24 DE DE602006015043T patent/DE602006015043D1/de active Active
- 2006-03-24 AT AT06748651T patent/ATE472099T1/de not_active IP Right Cessation
- 2006-03-24 AU AU2006232922A patent/AU2006232922A1/en not_active Abandoned
- 2006-03-24 JP JP2008504192A patent/JP5021614B2/ja active Active
-
2009
- 2009-02-24 US US12/391,293 patent/US20090218517A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1872112A1 (en) | 2008-01-02 |
| US20060223169A1 (en) | 2006-10-05 |
| US7507575B2 (en) | 2009-03-24 |
| EP2207026A1 (en) | 2010-07-14 |
| JP2008537594A (ja) | 2008-09-18 |
| JP5021614B2 (ja) | 2012-09-12 |
| BRPI0609544B1 (pt) | 2018-02-06 |
| KR101265362B1 (ko) | 2013-05-20 |
| AU2006232922A1 (en) | 2006-10-12 |
| MX2007012159A (es) | 2007-12-10 |
| WO2006107619A1 (en) | 2006-10-12 |
| ATE472099T1 (de) | 2010-07-15 |
| EP1872112B1 (en) | 2010-06-23 |
| DE602006015043D1 (de) | 2010-08-05 |
| US20090218517A1 (en) | 2009-09-03 |
| ES2347077T3 (es) | 2010-10-25 |
| BRPI0609544B8 (pt) | 2021-07-27 |
| KR20080014758A (ko) | 2008-02-14 |
| BRPI0609544A2 (pt) | 2011-10-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7507575B2 (en) | Multiplex fluorescence detection device having removable optical modules | |
| US7527763B2 (en) | Valve control system for a rotating multiplex fluorescence detection device | |
| EP1866631B1 (en) | Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector | |
| US11603559B2 (en) | Compensation for spectral crosstalk in mulitplex nucleic acid amplification | |
| US20070009382A1 (en) | Heating element for a rotating multiplex fluorescence detection device | |
| CN101189505B (zh) | 具有可移除光学模块的多重荧光检测装置 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |