CA2593156C - Heterocyclic carboxamide compounds as steroid nuclear receptors ligands - Google Patents
Heterocyclic carboxamide compounds as steroid nuclear receptors ligands Download PDFInfo
- Publication number
- CA2593156C CA2593156C CA2593156A CA2593156A CA2593156C CA 2593156 C CA2593156 C CA 2593156C CA 2593156 A CA2593156 A CA 2593156A CA 2593156 A CA2593156 A CA 2593156A CA 2593156 C CA2593156 C CA 2593156C
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- CA
- Canada
- Prior art keywords
- optionally substituted
- pheny1
- pyrrole
- carboxylic acid
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 Heterocyclic carboxamide compounds Chemical class 0.000 title claims abstract description 189
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- 108020004017 nuclear receptors Proteins 0.000 title abstract description 98
- 150000003431 steroids Chemical class 0.000 title abstract description 66
- 239000003446 ligand Substances 0.000 title description 12
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 77
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 53
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 51
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- 125000003118 aryl group Chemical group 0.000 claims description 47
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 43
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 34
- 239000001257 hydrogen Substances 0.000 claims description 33
- 238000011282 treatment Methods 0.000 claims description 33
- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 32
- 125000004426 substituted alkynyl group Chemical group 0.000 claims description 32
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 32
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- FQCQGOZEWWPOKI-UHFFFAOYSA-K trisalicylate-choline Chemical compound [Mg+2].C[N+](C)(C)CCO.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O FQCQGOZEWWPOKI-UHFFFAOYSA-K 0.000 description 1
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- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Engineering & Computer Science (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
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- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
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- Rheumatology (AREA)
- Psychiatry (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64283905P | 2005-01-10 | 2005-01-10 | |
| US60/642,839 | 2005-01-10 | ||
| PCT/US2006/000319 WO2006076202A1 (en) | 2005-01-10 | 2006-01-06 | Heterocyclic carboxamide compounds as steroid nuclear receptors ligands |
Publications (2)
| Publication Number | Publication Date |
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| CA2593156A1 CA2593156A1 (en) | 2006-07-20 |
| CA2593156C true CA2593156C (en) | 2015-05-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2593156A Active CA2593156C (en) | 2005-01-10 | 2006-01-06 | Heterocyclic carboxamide compounds as steroid nuclear receptors ligands |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110144128A1 (enExample) |
| EP (1) | EP1844020B1 (enExample) |
| JP (1) | JP5123668B2 (enExample) |
| AU (1) | AU2006205220B2 (enExample) |
| CA (1) | CA2593156C (enExample) |
| WO (1) | WO2006076202A1 (enExample) |
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| US8937184B2 (en) * | 2005-02-16 | 2015-01-20 | Abbvie B.V. | 1H-imidazole derivatives as cannabinoid CB2 receptor modulators |
| RU2410377C2 (ru) * | 2005-02-16 | 2011-01-27 | Солвей Фармасьютикалс Б.В. | Производные 1н-имидазола как модуляторы рецептора каннабиноидов св2 |
| MX2008000141A (es) | 2005-06-27 | 2008-04-07 | Exelixis Inc | Moduladores de lxr basados en imidazol. |
| WO2007024744A2 (en) * | 2005-08-21 | 2007-03-01 | Exelixis, Inc. | Heterocyclic carboxamide compounds as steroid nuclear receptor ligands |
| CA2661647C (en) * | 2006-08-24 | 2013-02-05 | Hiroshima University | Method for highly amplifying target gene in mammalian cell and vector therefor |
| HRP20120078T1 (hr) | 2006-10-31 | 2012-02-29 | Pfizer Products Inc. | Pirazolinski spojevi kao antagonisti mineralokortikoidnih receptora |
| EP2121621B1 (en) * | 2006-12-08 | 2014-05-07 | Exelixis Patent Company LLC | Lxr and fxr modulators |
| PT2133330E (pt) | 2007-04-09 | 2014-03-31 | Daiichi Sankyo Co Ltd | Atropisómero de derivado de pirrole |
| CA2720164A1 (en) * | 2008-03-31 | 2009-10-08 | Teva Pharmaceutical Industries Ltd. | Processes for preparing sunitinib and salts thereof |
| US8410279B2 (en) * | 2008-06-11 | 2013-04-02 | Genentech, Inc. | Substituted pyrroles and methods of use |
| WO2010098286A1 (ja) * | 2009-02-25 | 2010-09-02 | 第一三共株式会社 | ミネラルコルチコイド受容体拮抗薬を含有する医薬 |
| AR079967A1 (es) | 2010-01-26 | 2012-02-29 | Sanofi Aventis | Derivados de acido 3-heteroaroilamino-propionico sustituidos con oxigeno y su uso como productos farmaceuticos |
| EP2977084B1 (en) | 2010-05-10 | 2017-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
| WO2011157798A1 (en) | 2010-06-16 | 2011-12-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for stimulating reepithelialisation during wound healing |
| WO2012071573A2 (en) * | 2010-11-24 | 2012-05-31 | Mount Sinai School Of Medicine | Materials and methods for the prevention and treatment of cancer |
| TWI523844B (zh) | 2011-01-26 | 2016-03-01 | 賽諾菲公司 | 經胺基取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途 |
| US8669370B2 (en) | 2011-01-26 | 2014-03-11 | Sanofi | Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals |
| US20140221319A1 (en) * | 2011-06-29 | 2014-08-07 | Mayo Foundation For Medical Education And Research | Small Molecule CD38 Inhibitors and Methods of Using Same |
| CN103827098B (zh) | 2011-07-26 | 2016-06-15 | 赛诺菲 | 取代的3-(噻唑-4-羰基)-或者3-(噻唑-2-羰基)-氨基丙酸衍生物及其作为药物的用途 |
| WO2013014204A2 (en) | 2011-07-26 | 2013-01-31 | Sanofi | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals |
| WO2013055606A1 (en) | 2011-10-13 | 2013-04-18 | Merck Sharp & Dohme Corp. | Mineralocorticoid receptor antagonists |
| US20130123325A1 (en) | 2011-11-14 | 2013-05-16 | Sven Ruf | Use of boceprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases |
| US20130123276A1 (en) | 2011-11-14 | 2013-05-16 | Sven Ruf | Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases |
| DK2880025T3 (en) * | 2012-08-02 | 2019-03-18 | Nerviano Medical Sciences Srl | SUBSTITUTED PYROLES ACTIVE AS KINase INHIBITORS |
| WO2014108337A1 (en) | 2013-01-10 | 2014-07-17 | Grünenthal GmbH | Pyrazolyl-based carboxamides i as crac channel inhibitors |
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| CN112707854B (zh) * | 2019-10-25 | 2022-03-15 | 年衍药业(珠海)有限公司 | 吡咯酰胺类化合物及其用途 |
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| FR2104931B1 (enExample) * | 1970-09-08 | 1975-01-10 | Ferlux | |
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| AU780572B2 (en) * | 1999-10-18 | 2005-04-07 | University Of Connecticut, The | Pyrazole derivatives as cannabinoid receptor antagonists |
| US7119108B1 (en) * | 1999-10-18 | 2006-10-10 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
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| RU2266285C2 (ru) * | 2001-05-31 | 2005-12-20 | Нихон Нохияку Ко.,Лтд. | Замещенное анилидное производное, его промежуточное соединение, химикаты для борьбы с вредителями сельскохозяйственных и плодовых культур и их использование |
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| WO2003063781A2 (en) * | 2002-01-29 | 2003-08-07 | Merck & Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
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| JP2006521316A (ja) * | 2003-03-24 | 2006-09-21 | ビーエーエスエフ アクチェンゲゼルシャフト | トリフルオロメチルチオフェンカルボキシアニリドおよび殺菌剤としてのその使用 |
| AU2004265299B2 (en) * | 2003-08-07 | 2008-05-01 | Merck & Co., Inc. | Pyrazole carboxamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 |
| WO2006012642A2 (en) * | 2004-07-30 | 2006-02-02 | Exelixis, Inc. | Pyrrole derivatives as pharmaceutical agents |
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- 2006-01-06 EP EP06717506.7A patent/EP1844020B1/en active Active
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| JP2008526869A (ja) | 2008-07-24 |
| JP5123668B2 (ja) | 2013-01-23 |
| AU2006205220A1 (en) | 2006-07-20 |
| CA2593156A1 (en) | 2006-07-20 |
| AU2006205220B2 (en) | 2012-09-13 |
| EP1844020A1 (en) | 2007-10-17 |
| US20110144128A1 (en) | 2011-06-16 |
| WO2006076202A1 (en) | 2006-07-20 |
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