CA2587387C - Method of contact coating a microneedle array - Google Patents

Method of contact coating a microneedle array Download PDF

Info

Publication number
CA2587387C
CA2587387C CA2587387A CA2587387A CA2587387C CA 2587387 C CA2587387 C CA 2587387C CA 2587387 A CA2587387 A CA 2587387A CA 2587387 A CA2587387 A CA 2587387A CA 2587387 C CA2587387 C CA 2587387C
Authority
CA
Canada
Prior art keywords
coating
microneedles
microneedle array
substrate
flexible film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2587387A
Other languages
English (en)
French (fr)
Other versions
CA2587387A1 (en
Inventor
Hye-Ok Choi
Gordon P. Knutson
Moses M. David
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kindeva Drug Delivery LP
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of CA2587387A1 publication Critical patent/CA2587387A1/en
Application granted granted Critical
Publication of CA2587387C publication Critical patent/CA2587387C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/28—Processes for applying liquids or other fluent materials performed by transfer from the surfaces of elements carrying the liquid or other fluent material, e.g. brushes, pads, rollers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
CA2587387A 2004-11-18 2005-11-18 Method of contact coating a microneedle array Expired - Lifetime CA2587387C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62918704P 2004-11-18 2004-11-18
US60/629,187 2004-11-18
PCT/US2005/041993 WO2006055844A2 (en) 2004-11-18 2005-11-18 Method of contact coating a microneedle array

Publications (2)

Publication Number Publication Date
CA2587387A1 CA2587387A1 (en) 2006-05-26
CA2587387C true CA2587387C (en) 2013-06-25

Family

ID=36130000

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2587387A Expired - Lifetime CA2587387C (en) 2004-11-18 2005-11-18 Method of contact coating a microneedle array

Country Status (9)

Country Link
US (2) US8414959B2 (enExample)
EP (2) EP2388078B1 (enExample)
JP (1) JP5015787B2 (enExample)
KR (1) KR101246015B1 (enExample)
CN (1) CN101076409B (enExample)
AU (1) AU2005306372B2 (enExample)
CA (1) CA2587387C (enExample)
IL (1) IL183132A (enExample)
WO (1) WO2006055844A2 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138719A2 (en) 2005-06-17 2006-12-28 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
CA2614927A1 (en) * 2005-07-25 2007-02-01 Nanotechnology Victoria Pty Ltd Microarray device
EP1957145A4 (en) 2005-11-30 2011-03-23 3M Innovative Properties Co MICRONADEL ASSEMBLIES AND APPLICATION METHOD
NL2001718C2 (nl) 2008-06-24 2009-12-28 Needle Holding B V U Micronaald, micronaaldarray en fabricagewerkwijze daarvoor.
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US10245421B2 (en) * 2010-04-28 2019-04-02 Sorrento Therapeutics, Inc. Nanopatterned medical device with enhanced cellular interaction
WO2012075339A1 (en) * 2010-12-02 2012-06-07 Lanco Biosciences, Inc. Delivery of heparins by microinjection systems
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
HK1209658A1 (en) 2012-05-01 2016-04-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
CN103386164B (zh) * 2012-05-08 2015-11-04 中国科学院理化技术研究所 实心微针阵列器件载药的方法及装置
JP2015525794A (ja) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
JP6372353B2 (ja) * 2012-11-09 2018-08-15 凸版印刷株式会社 針状構造体及びその製造方法
CA2919773A1 (en) 2013-08-05 2015-02-12 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions
KR101724251B1 (ko) * 2014-04-30 2017-04-06 킴벌리-클라크 월드와이드, 인크. 도포식 현미침 조립체
CN106659777A (zh) 2014-06-13 2017-05-10 葛兰素史密丝克莱恩生物有限公司 免疫原性组合产品
WO2016018148A1 (en) 2014-07-30 2016-02-04 Biomarque B.V. Biosensor comprising a modified metal surface and method for the modification of a metal surface
WO2016052108A1 (ja) * 2014-09-29 2016-04-07 日本写真印刷株式会社 成形体の製造装置及び成形体の製造方法
JP2018502927A (ja) * 2015-01-27 2018-02-01 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルワクチンパッチ用ミョウバン含有コーティング製剤
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
KR101676861B1 (ko) * 2015-04-10 2016-11-17 씨앤텍 주식회사 마이크로 니들 패치 제조장치와 방법, 및 이에 의해 제조되는 마이크로 니들 패치
US10695289B2 (en) 2015-10-09 2020-06-30 3M Innovative Properties Company Zinc compositions for coated microneedle arrays
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
AU2017253674B2 (en) 2016-04-18 2021-07-29 Kindeva Drug Delivery L.P. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
EP3586905B1 (en) * 2017-02-24 2023-07-26 Hisamitsu Pharmaceutical Co., Inc. Method for producing microneedle device
EP3616744A4 (en) * 2017-04-27 2020-05-27 Think-Lands Co., Ltd. PROCESS FOR PRODUCING MICRO NEEDLES
US11460411B2 (en) 2018-06-18 2022-10-04 Kindeva Drug Delivery L.P. Process and apparatus for inspecting microneedle arrays
KR102039582B1 (ko) * 2018-12-12 2019-11-01 주식회사 라파스 인장 공정으로 제조하기에 적합한 마이크로니들 재료의 적합성 시험 방법 및 이를 포함하는 마이크로니들 제조 방법
CA3138526A1 (en) * 2019-05-02 2020-11-05 General Automation Lab Technologies Inc. Microfabricated device with hydrophilic microwells and hydrophobic interstitial space
WO2020232394A1 (en) 2019-05-16 2020-11-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
CN110270007A (zh) * 2019-07-15 2019-09-24 上海交通大学 一种担载生物分子微针及其制备方法
CN113116718B (zh) * 2021-03-26 2023-03-07 上海长征医院 一种用于防治呕吐的穴位埋针复合装置及其包装板
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
CN115674522B (zh) * 2021-07-28 2025-11-28 上海悦肤达生物科技有限公司 制备微针的设备和方法
CN116920260A (zh) * 2023-07-19 2023-10-24 北京化工大学 一种可准确控制涂层高度并易于批量化制备涂层微针的方法

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US2619962A (en) 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US3072122A (en) 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3136314A (en) 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3221740A (en) 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3470011A (en) * 1967-02-07 1969-09-30 American Cyanamid Co Process for applying liquid biologicals to applicators for intracutaneous injection
US3466131A (en) 1967-09-07 1969-09-09 Becton Dickinson Co Dispensing applicator package
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3688764A (en) 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
US4473083A (en) 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5402798A (en) 1991-07-18 1995-04-04 Swierczek; Remi Disposable skin perforator and blood testing device
US5340572A (en) 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
US5440446A (en) 1993-10-04 1995-08-08 Catalina Coatings, Inc. Acrylate coating material
FR2720003B1 (fr) 1994-05-23 1998-06-26 Samsung Electro Mech Dispositif servant à inciser la peau pour une médication transcutanée.
EP0782614A1 (en) 1994-09-30 1997-07-09 Rutgers, The State University Of New Jersey Direct introduction of foreign materials into cells
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
DE69719761T2 (de) 1996-06-18 2003-12-18 Alza Corp., Palo Alto Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
ATE231015T1 (de) 1996-09-17 2003-02-15 Deka Products Lp System zur medikamentenabgabe durch transport
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
DE69806963T2 (de) 1997-12-11 2002-11-21 Alza Corp., Mountain View Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
DE69839969D1 (de) 1997-12-11 2008-10-16 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
CA2229522A1 (en) 1998-04-15 1999-10-15 Thomas Randall Inkpen Needle aid
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
CA2341446C (en) 1998-08-31 2008-10-07 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
US6713291B2 (en) 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
WO2000044438A1 (en) 1999-01-28 2000-08-03 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
TW480759B (en) 1999-03-18 2002-03-21 Seiko Epson Corp Electronic machine, charged electronic machine and control method of electronic machine
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US20040039342A1 (en) 2000-06-08 2004-02-26 Jonathan Eppstein Transdermal integrated actuator device, methods of making and using same
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
CN1390148A (zh) 1999-11-15 2003-01-08 维尔克鲁工业公司 皮肤附着件
US6881538B1 (en) 2000-03-05 2005-04-19 3M Innovative Properties Company Array comprising diamond-like glass film
US6696157B1 (en) * 2000-03-05 2004-02-24 3M Innovative Properties Company Diamond-like glass thin films
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US7473244B2 (en) 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
NZ524646A (en) 2000-09-08 2004-10-29 Alza Corp Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
US6855131B2 (en) 2000-10-13 2005-02-15 Alza Corporation Microprotrusion member retainer for impact applicator
EP1341442B1 (en) 2000-10-13 2005-06-29 Alza Corporation Microblade array impact applicator
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
BR0114909A (pt) * 2000-10-26 2004-02-03 Alza Corp Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas
ES2705729T3 (es) 2000-11-30 2019-03-26 Valeritas Inc Sistemas de suministro y medición de fluidos
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
ES2333849T3 (es) 2001-04-20 2010-03-02 Alza Corporation Disposicion de microsalientes que presenta un revestimiento que contiene un agente beneficioso.
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
CA2451816A1 (en) 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
JP2003105583A (ja) 2001-09-28 2003-04-09 Seiko Epson Corp 微細構造パターンを備えた構造体製造用母型及びそれを用いた前記構造体の製造方法、並びにこの製造方法によって製造された前記構造体
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
WO2003092785A1 (en) 2002-04-30 2003-11-13 Morteza Shirkhanzadeh Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents
MXPA05000205A (es) * 2002-06-28 2005-09-30 Johnson & Johnson Dispositivos transdermicos para suministro de farmaco que tienen microprotrusiones revestidas.
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
WO2004032990A2 (en) 2002-07-22 2004-04-22 Becton, Dickinson And Company Patch-like infusion device
CA2497128C (en) 2002-08-29 2011-10-18 Becton, Dickinson And Company Microprotrusion arrays and methods for using same to deliver substances into tissue
EP1590034B1 (en) 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
BRPI0412021A (pt) * 2003-06-30 2006-08-15 Alza Corp método para revestir microprojeções de perfuração de pele
CA2530954A1 (en) 2003-07-02 2005-01-13 Alza Corporation Microprojection array immunization patch and method
CA2534823A1 (en) 2003-08-04 2005-02-24 Alza Corporation Method and device for enhancing transdermal agent flux
BRPI0413538B8 (pt) 2003-08-12 2021-06-22 Becton Dickison And Company dispositivo para fornecer um medicamento para o corpo de um paciente por injeção
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
CN1897898A (zh) 2003-10-24 2007-01-17 阿尔扎公司 用于增强透皮药物传递的预处理方法和系统
AU2004285481A1 (en) 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
AU2004287059A1 (en) 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
JP2007518468A (ja) 2003-11-21 2007-07-12 アルザ・コーポレーシヨン 超音波支援経皮ワクチン送達方法およびシステム
MXPA06006041A (es) 2003-11-28 2007-01-31 Acrux Dds Pty Ltd Metodo y sistema para administracion transdermica rapida.
ZA200604661B (en) 2003-12-18 2008-05-28 Novo Nordisk As Nozzle device with skin stretching means
AU2004311977A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Medical devices and kits including same
US20070191761A1 (en) 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US7627938B2 (en) * 2004-10-15 2009-12-08 Board Of Regents, The Univeristy Of Texas System Tapered hollow metallic microneedle array assembly and method of making and using the same

Also Published As

Publication number Publication date
US20120114857A1 (en) 2012-05-10
KR20070086222A (ko) 2007-08-27
EP2388078A1 (en) 2011-11-23
IL183132A0 (en) 2007-09-20
EP2388078B1 (en) 2013-03-20
CA2587387A1 (en) 2006-05-26
WO2006055844A2 (en) 2006-05-26
AU2005306372A1 (en) 2006-05-26
AU2005306372B2 (en) 2011-01-06
JP2008520433A (ja) 2008-06-19
JP5015787B2 (ja) 2012-08-29
US8414959B2 (en) 2013-04-09
CN101076409A (zh) 2007-11-21
EP1827715A2 (en) 2007-09-05
KR101246015B1 (ko) 2013-03-20
IL183132A (en) 2011-06-30
US20130216694A1 (en) 2013-08-22
WO2006055844A3 (en) 2006-09-21
EP1827715B1 (en) 2013-07-17
US8741377B2 (en) 2014-06-03
CN101076409B (zh) 2011-11-23

Similar Documents

Publication Publication Date Title
CA2587387C (en) Method of contact coating a microneedle array
US8057842B2 (en) Method of contact coating a microneedle array
CA2588080C (en) Masking method for coating a microneedle array
US6855372B2 (en) Method and apparatus for coating skin piercing microprojections
WO2007061964A1 (en) Methods for coating microneedles
US20080262416A1 (en) Microneedle Arrays and Methods of Preparing Same
EP2906284A1 (en) Force-controlled applicator for applying a microneedle device to skin
WO2007059289A1 (en) Microneedle arrays and methods of preparing same
JP5870551B2 (ja) マイクロニードルデバイスの製造方法
CN115445072A (zh) 可溶气泡微针阵列层、可溶气泡滚轮微针及其制备方法

Legal Events

Date Code Title Description
EEER Examination request