CA2580208A1 - Virus-like particles comprising a fusion protein of the coat protein of ap205 and an antigenic polypeptide - Google Patents

Virus-like particles comprising a fusion protein of the coat protein of ap205 and an antigenic polypeptide Download PDF

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Publication number
CA2580208A1
CA2580208A1 CA002580208A CA2580208A CA2580208A1 CA 2580208 A1 CA2580208 A1 CA 2580208A1 CA 002580208 A CA002580208 A CA 002580208A CA 2580208 A CA2580208 A CA 2580208A CA 2580208 A1 CA2580208 A1 CA 2580208A1
Authority
CA
Canada
Prior art keywords
polypeptide
seq
antigen
vlp
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002580208A
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English (en)
French (fr)
Inventor
Martin Bachmann
Alain Tissot
Gary Jennings
Regina Renhofa
Paul Pumpens
Indulis Cielens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytos Biotechnology AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2580208A1 publication Critical patent/CA2580208A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6075Viral proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/18011Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111Leviviridae
    • C12N2795/18123Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002580208A 2004-09-21 2005-09-21 Virus-like particles comprising a fusion protein of the coat protein of ap205 and an antigenic polypeptide Abandoned CA2580208A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US61130804P 2004-09-21 2004-09-21
US60/611,308 2004-09-21
EP05105229 2005-06-14
EP05105229.8 2005-06-14
PCT/EP2005/054721 WO2006032674A1 (en) 2004-09-21 2005-09-21 Virus-like particles comprising a fusion protein of the coat protein of ap205 and an antigenic polypeptide

Publications (1)

Publication Number Publication Date
CA2580208A1 true CA2580208A1 (en) 2006-03-30

Family

ID=46307785

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002580208A Abandoned CA2580208A1 (en) 2004-09-21 2005-09-21 Virus-like particles comprising a fusion protein of the coat protein of ap205 and an antigenic polypeptide

Country Status (10)

Country Link
US (1) US20080292652A1 (enExample)
EP (1) EP1791870A1 (enExample)
JP (1) JP2008513035A (enExample)
AU (1) AU2005286475A1 (enExample)
BR (1) BRPI0516953A (enExample)
CA (1) CA2580208A1 (enExample)
MX (1) MX2007003171A (enExample)
NZ (1) NZ554387A (enExample)
RU (1) RU2409667C2 (enExample)
WO (1) WO2006032674A1 (enExample)

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EP2196217A1 (en) 2001-09-14 2010-06-16 Cytos Biotechnology AG Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
DK1524994T3 (da) * 2002-07-19 2011-08-15 Cytos Biotechnology Ag Vaccinesammensætninger indeholdende amyloid beta 1-6-antigen-arrays
CN101948835A (zh) 2002-10-29 2011-01-19 科勒制药集团股份有限公司 Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用
CN100560719C (zh) * 2003-03-26 2009-11-18 赛托斯生物技术公司 Melan-a肽类似物-病毒样颗粒偶联物
KR20070059207A (ko) 2004-10-05 2007-06-11 사이토스 바이오테크놀로지 아게 Vlp-항원 컨쥬게이트 및 백신으로서 그의 용도
EP1809335A2 (en) 2004-10-25 2007-07-25 Cytos Biotechnology AG Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof
EP1896068A1 (en) * 2005-06-14 2008-03-12 Cytos Biotechnology AG Antigen conjugates and uses thereof
ES2310062B1 (es) 2005-07-15 2009-11-13 Bionostra, S.L. Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones.
JP5312028B2 (ja) 2005-09-28 2013-10-09 サイトス バイオテクノロジー アーゲー インターロイキン−1コンジュゲート及びその使用
JP5484732B2 (ja) * 2005-12-14 2014-05-07 サイトス バイオテクノロジー アーゲー 過敏症の治療のための免疫賦活性核酸パッケージ粒子
AT503690A1 (de) * 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
KR101552227B1 (ko) 2006-06-12 2015-09-10 사이토스 바이오테크놀로지 아게 올리고뉴클레오티드를 rna 박테리오파지의 바이러스-유사 입자로 패키징하는 방법
AU2013204383B2 (en) * 2006-06-12 2016-09-22 Kuros Us Llc Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages
WO2008057529A2 (en) * 2006-11-06 2008-05-15 Coley Pharmaceutical Group, Inc. Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (cetp)
AU2007333147B2 (en) 2006-12-12 2013-12-19 Kuros Us Llc Oligonucleotides containing high concentrations of guanine monomers
CA2672826A1 (en) * 2006-12-21 2008-06-26 Cytos Biotechnology Ag Circular ccr5 peptide conjugates and uses thereof
CN101245110B (zh) * 2007-02-16 2010-09-15 鲁南制药集团股份有限公司 重组中性粒细胞抑制因子和水蛭原嵌合蛋白及其药物组合物
US20110262472A1 (en) * 2008-04-22 2011-10-27 Cytos Biotechnology Ag Vaccine compositions for the treatment of dengue fever and uses thereof
WO2010122164A1 (en) 2009-04-23 2010-10-28 Cytos Biotechnology Ag VIRUS-LIKE PARTICLES OF BACTERIOPHAGE φCB5
JP2012525134A (ja) * 2009-04-30 2012-10-22 サイトス バイオテクノロジー アーゲー インフルエンザ赤血球凝集素の組成物とその使用
BR112012024708A2 (pt) * 2010-03-29 2016-06-07 Novartis Ag composição de compostos orgânicos
GB201121571D0 (en) * 2011-12-15 2012-01-25 Astrimmune Ltd Compounds and uses thereof
BR112014013035A2 (pt) 2011-12-22 2018-10-09 Hoffmann La Roche métodos de seleção de células, conjuntos de expressão bicistrônica, células eucarióticas, vetores lentivirais, uso de vetor lentiviral, bibliotecas de ventores lentivirais e de células eucarióticas, métodos de seleção de células, fluxos de trabalho e uso de célula
WO2013122262A1 (en) * 2012-02-16 2013-08-22 Vlp Therapeutics, Llc Virus like particle composition
WO2015193143A1 (en) * 2014-06-18 2015-12-23 Morphosys Ag Fusion proteins and uses thereof
CN104255335B (zh) * 2014-08-24 2016-08-31 苗建军 一种吊放蔓用钳
RU2568872C1 (ru) * 2014-10-15 2015-11-20 Игорь Геннадьевич Сивов Лекарственное средство для лечения вирусного гепатита с
MA40824A (fr) 2014-10-22 2017-08-29 Saiba Gmbh Particules de cmv de type virus modifié
AU2016207099C1 (en) 2015-01-15 2021-02-04 University Of Copenhagen Virus-like particle with efficient epitope display
DK3368068T3 (da) 2015-10-30 2021-02-22 Univ Copenhagen Viruslignende partikler med effektiv epitopdisplay
US10588953B2 (en) 2015-12-18 2020-03-17 Agilvax, Inc. Compositions and methods related to xCT peptides
KR102469478B1 (ko) * 2016-04-27 2022-11-23 벤치마크 애니멀 헬스 엘티디. 개 아토피성 피부염의 치료
CN112500456B (zh) * 2020-12-02 2022-10-28 深圳赫兹生命科学技术有限公司 一种去势ap205病毒样颗粒亚单位疫苗
CN117202926A (zh) * 2021-02-02 2023-12-08 普罗瓦克萨斯股份有限公司 新型免疫调节平台及其使用方法
BR112023020640A2 (pt) 2021-04-12 2023-12-05 Saiba AG Partículas similares a vírus de bacteriófago ap205 modificadas
US20240156937A1 (en) * 2021-04-23 2024-05-16 Unm Rainforest Innovations Baceriophage virus-like particles vaccines for chlamydia trachomatis infections
CN114933639B (zh) * 2022-05-05 2023-12-29 中国农业科学院兰州兽医研究所 非洲猪瘟病毒p72N抗原表位蛋白及其制备方法和用途
CN115819623A (zh) * 2022-12-12 2023-03-21 长春百克生物科技股份公司 一种重组病毒样颗粒疫苗组合物的制备及应用
CN118684781A (zh) * 2023-03-21 2024-09-24 深圳赫兹生命科学技术有限公司 GnRH-VLP重组去势疫苗及其制备方法
WO2025000310A1 (zh) * 2023-06-29 2025-01-02 深圳赫兹生命科学技术有限公司 去势ap205病毒样颗粒亚单位疫苗的制备方法

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US20020193565A1 (en) * 1998-03-27 2002-12-19 Stanley Margaret Anne Antigen preparation and use
WO2003031466A2 (en) * 2001-10-05 2003-04-17 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
US7128911B2 (en) * 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
EP2196217A1 (en) * 2001-09-14 2010-06-16 Cytos Biotechnology AG Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
CA2492823A1 (en) * 2001-09-14 2003-03-27 Martin F. Bachmann In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
ES2316628T3 (es) * 2001-11-07 2009-04-16 Cytos Biotechnology Ag Disposicion ordenada de antigenos que comprende rankl para el tratamiento de enfermedades oseas.
PL369863A1 (en) * 2001-11-07 2005-05-02 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
ATE489969T1 (de) * 2002-06-20 2010-12-15 Cytos Biotechnology Ag Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung
CN1665528B (zh) * 2002-07-05 2013-05-15 弗利亚生物技术公司 佐剂病毒颗粒
WO2004007538A2 (en) * 2002-07-17 2004-01-22 Cytos Biotechnology Ag Molecular antigen arrays using a virus like particle derived from the ap205 coat protein

Also Published As

Publication number Publication date
MX2007003171A (es) 2007-05-23
EP1791870A1 (en) 2007-06-06
NZ554387A (en) 2009-09-25
WO2006032674A1 (en) 2006-03-30
BRPI0516953A (pt) 2008-09-30
RU2409667C2 (ru) 2011-01-20
JP2008513035A (ja) 2008-05-01
US20080292652A1 (en) 2008-11-27
RU2007114956A (ru) 2008-10-27
AU2005286475A1 (en) 2006-03-30

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130923