RU2409667C2 - Вирусоподобные частицы, включающие гибридный белок белка оболочки бактериофага ар205 и антигенного полипептида - Google Patents
Вирусоподобные частицы, включающие гибридный белок белка оболочки бактериофага ар205 и антигенного полипептида Download PDFInfo
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- RU2409667C2 RU2409667C2 RU2007114956/10A RU2007114956A RU2409667C2 RU 2409667 C2 RU2409667 C2 RU 2409667C2 RU 2007114956/10 A RU2007114956/10 A RU 2007114956/10A RU 2007114956 A RU2007114956 A RU 2007114956A RU 2409667 C2 RU2409667 C2 RU 2409667C2
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61130804P | 2004-09-21 | 2004-09-21 | |
| US60/611,308 | 2004-09-21 | ||
| EP05105229.8 | 2005-06-14 | ||
| EP05105229 | 2005-06-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007114956A RU2007114956A (ru) | 2008-10-27 |
| RU2409667C2 true RU2409667C2 (ru) | 2011-01-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2007114956/10A RU2409667C2 (ru) | 2004-09-21 | 2005-09-21 | Вирусоподобные частицы, включающие гибридный белок белка оболочки бактериофага ар205 и антигенного полипептида |
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| Country | Link |
|---|---|
| US (1) | US20080292652A1 (enExample) |
| EP (1) | EP1791870A1 (enExample) |
| JP (1) | JP2008513035A (enExample) |
| AU (1) | AU2005286475A1 (enExample) |
| BR (1) | BRPI0516953A (enExample) |
| CA (1) | CA2580208A1 (enExample) |
| MX (1) | MX2007003171A (enExample) |
| NZ (1) | NZ554387A (enExample) |
| RU (1) | RU2409667C2 (enExample) |
| WO (1) | WO2006032674A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2568872C1 (ru) * | 2014-10-15 | 2015-11-20 | Игорь Геннадьевич Сивов | Лекарственное средство для лечения вирусного гепатита с |
| RU2705301C2 (ru) * | 2012-02-16 | 2019-11-06 | Влп Терапьютикс, Ллк | Композиция вирусоподобных частиц |
| RU2852174C1 (ru) * | 2025-01-31 | 2025-12-04 | Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук" | Рекомбинантная вакцина против вируса гриппа а человека и способ ее получения |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| ATE447967T1 (de) * | 2001-09-14 | 2009-11-15 | Cytos Biotechnology Ag | Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung |
| RU2450827C2 (ru) * | 2002-07-19 | 2012-05-20 | Цитос Биотехнологи Аг | Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6 |
| MXPA05004588A (es) | 2002-10-29 | 2005-12-14 | Coley Pharmaceutical Group Ltd | Metodos y productos relacionados con el tratamiento y prevencion de infeccion de virus de hepatitis c. |
| JP5022028B2 (ja) * | 2003-03-26 | 2012-09-12 | サイトス・バイオテクノロジー・アクチェンゲゼルシャフト | メラン−ａペプチドアナログ−ウイルス様粒子コンジュゲート |
| AU2005291231B2 (en) | 2004-10-05 | 2010-12-23 | Cytos Biotechnology Ag | VLP-antigen conjugates and their uses as vaccines |
| CA2580919A1 (en) | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof |
| CN101193654A (zh) * | 2005-06-14 | 2008-06-04 | 赛托斯生物技术公司 | 抗原偶联物及其用途 |
| ES2310062B1 (es) | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| KR20080047564A (ko) | 2005-09-28 | 2008-05-29 | 사이토스 바이오테크놀로지 아게 | 인터루킨-1 컨쥬게이트 및 그의 용도 |
| EP1973608A1 (en) * | 2005-12-14 | 2008-10-01 | Cytos Biotechnology AG | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| AT503690A1 (de) * | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| AU2013204383B2 (en) * | 2006-06-12 | 2016-09-22 | Kuros Us Llc | Processes for packaging oligonucleotides into virus-like particles of RNA bacteriophages |
| NZ573622A (en) | 2006-06-12 | 2011-12-22 | Cytos Biotechnology Ag | Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages |
| US20090142362A1 (en) * | 2006-11-06 | 2009-06-04 | Avant Immunotherapeutics, Inc. | Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (CETP) |
| CA2671873C (en) | 2006-12-12 | 2018-10-09 | Brian Stephen Sproat | Oligonucleotides containing high concentrations of guanine monomers |
| AU2007336132A1 (en) * | 2006-12-21 | 2008-06-26 | Cytos Biotechnology Ag | Circular CCR5 peptide conjugates and uses thereof |
| CN101245110B (zh) * | 2007-02-16 | 2010-09-15 | 鲁南制药集团股份有限公司 | 重组中性粒细胞抑制因子和水蛭原嵌合蛋白及其药物组合物 |
| CA2721657A1 (en) * | 2008-04-22 | 2009-10-29 | Cytos Biotechnology Ag | Vaccine compositions for the treatment of dengue fever and uses thereof |
| WO2010122164A1 (en) | 2009-04-23 | 2010-10-28 | Cytos Biotechnology Ag | VIRUS-LIKE PARTICLES OF BACTERIOPHAGE φCB5 |
| US20120263743A1 (en) * | 2009-04-30 | 2012-10-18 | Cytos Biotechnology Ag | Influenza hemagglutinin compositions and uses thereof |
| CN104436212A (zh) * | 2010-03-29 | 2015-03-25 | 诺华股份有限公司 | 包含与病毒样颗粒偶联的淀粉样β1-6肽及佐剂的组合物 |
| GB201121571D0 (en) * | 2011-12-15 | 2012-01-25 | Astrimmune Ltd | Compounds and uses thereof |
| EP2794662A1 (en) | 2011-12-22 | 2014-10-29 | F.Hoffmann-La Roche Ag | Full length antibody display system for eukaryotic cells and its use |
| EP3158058B1 (en) | 2014-06-18 | 2019-04-17 | MorphoSys AG | Fusion proteins and uses thereof |
| CN104255335B (zh) * | 2014-08-24 | 2016-08-31 | 苗建军 | 一种吊放蔓用钳 |
| MA40824A (fr) | 2014-10-22 | 2017-08-29 | Saiba Gmbh | Particules de cmv de type virus modifié |
| WO2016112921A1 (en) | 2015-01-15 | 2016-07-21 | University Of Copenhagen | Virus-like particle with efficient epitope display |
| WO2017071713A1 (en) | 2015-10-30 | 2017-05-04 | University Of Copenhagen | Virus like particle with efficient epitope display |
| EP3389693A4 (en) | 2015-12-18 | 2019-08-21 | Agilvax, Inc. | COMPOSITIONS AND METHODS RELATED TO XCT PEPTIDES |
| MX394254B (es) * | 2016-04-27 | 2025-03-24 | Benchmark Animal Health Ltd | Composiciones para el tratamiento de dermatitis atópica canina y sus usos. |
| CN112500456B (zh) * | 2020-12-02 | 2022-10-28 | 深圳赫兹生命科学技术有限公司 | 一种去势ap205病毒样颗粒亚单位疫苗 |
| CN117202926A (zh) * | 2021-02-02 | 2023-12-08 | 普罗瓦克萨斯股份有限公司 | 新型免疫调节平台及其使用方法 |
| US20240189407A1 (en) | 2021-04-12 | 2024-06-13 | Saiba AG | Modified virus-like particles of bacteriophage ap205 |
| US20240156937A1 (en) * | 2021-04-23 | 2024-05-16 | Unm Rainforest Innovations | Baceriophage virus-like particles vaccines for chlamydia trachomatis infections |
| CN114933639B (zh) * | 2022-05-05 | 2023-12-29 | 中国农业科学院兰州兽医研究所 | 非洲猪瘟病毒p72N抗原表位蛋白及其制备方法和用途 |
| CN115819623A (zh) * | 2022-12-12 | 2023-03-21 | 长春百克生物科技股份公司 | 一种重组病毒样颗粒疫苗组合物的制备及应用 |
| CN118684781A (zh) * | 2023-03-21 | 2024-09-24 | 深圳赫兹生命科学技术有限公司 | GnRH-VLP重组去势疫苗及其制备方法 |
| WO2025000310A1 (zh) * | 2023-06-29 | 2025-01-02 | 深圳赫兹生命科学技术有限公司 | 去势ap205病毒样颗粒亚单位疫苗的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020193565A1 (en) * | 1998-03-27 | 2002-12-19 | Stanley Margaret Anne | Antigen preparation and use |
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| ATE447967T1 (de) * | 2001-09-14 | 2009-11-15 | Cytos Biotechnology Ag | Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung |
| EP1425040A2 (en) * | 2001-09-14 | 2004-06-09 | Cytos Biotechnology AG | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| AU2002362696B2 (en) * | 2001-10-05 | 2008-05-29 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| PL369863A1 (en) * | 2001-11-07 | 2005-05-02 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| KR20050044316A (ko) * | 2001-11-07 | 2005-05-12 | 사이토스 바이오테크놀로지 아게 | 호산구성 알레르기 질환 치료용의 ｉｌ-5, ｉｌ-13 또는에오탁신을 제시하는 항원 어레이 |
| ATE489969T1 (de) * | 2002-06-20 | 2010-12-15 | Cytos Biotechnology Ag | Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung |
| MXPA05000287A (es) * | 2002-07-05 | 2005-09-08 | Leclerc Denis | Particula viral adyuvante. |
| RU2324704C2 (ru) * | 2002-07-17 | 2008-05-20 | Цитос Байотекнолоджи Аг | Молекулярные массивы антигенов |
-
2005
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- 2005-09-21 JP JP2007532893A patent/JP2008513035A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| VORONKOVA T. et al., "Chimeric bacteriophage fr virus-like particles harboring the immunodominant C-terminal region of hamster polyomavirus VP1 induce a strong VP1-specific antibody response in rabbits and mice". Viral Immunol. 2002; 15(4):627-43. * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2705301C2 (ru) * | 2012-02-16 | 2019-11-06 | Влп Терапьютикс, Ллк | Композиция вирусоподобных частиц |
| RU2568872C1 (ru) * | 2014-10-15 | 2015-11-20 | Игорь Геннадьевич Сивов | Лекарственное средство для лечения вирусного гепатита с |
| RU2852174C1 (ru) * | 2025-01-31 | 2025-12-04 | Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук" | Рекомбинантная вакцина против вируса гриппа а человека и способ ее получения |
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|---|---|
| JP2008513035A (ja) | 2008-05-01 |
| US20080292652A1 (en) | 2008-11-27 |
| EP1791870A1 (en) | 2007-06-06 |
| BRPI0516953A (pt) | 2008-09-30 |
| WO2006032674A1 (en) | 2006-03-30 |
| RU2007114956A (ru) | 2008-10-27 |
| MX2007003171A (es) | 2007-05-23 |
| CA2580208A1 (en) | 2006-03-30 |
| AU2005286475A1 (en) | 2006-03-30 |
| NZ554387A (en) | 2009-09-25 |
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