CA2569310A1 - Pharmaceutical compositions - Google Patents
Pharmaceutical compositions Download PDFInfo
- Publication number
- CA2569310A1 CA2569310A1 CA002569310A CA2569310A CA2569310A1 CA 2569310 A1 CA2569310 A1 CA 2569310A1 CA 002569310 A CA002569310 A CA 002569310A CA 2569310 A CA2569310 A CA 2569310A CA 2569310 A1 CA2569310 A1 CA 2569310A1
- Authority
- CA
- Canada
- Prior art keywords
- polymer
- solid dispersion
- pharmaceutical composition
- amorphous
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 81
- BBAWEDCPNXPBQM-GDEBMMAJSA-N telaprevir Chemical compound N([C@H](C(=O)N[C@H](C(=O)N1C[C@@H]2CCC[C@@H]2[C@H]1C(=O)N[C@@H](CCC)C(=O)C(=O)NC1CC1)C(C)(C)C)C1CCCCC1)C(=O)C1=CN=CC=N1 BBAWEDCPNXPBQM-GDEBMMAJSA-N 0.000 claims abstract description 324
- 229960002935 telaprevir Drugs 0.000 claims abstract description 323
- 239000000203 mixture Substances 0.000 claims abstract description 132
- 229920000642 polymer Polymers 0.000 claims description 181
- 239000007962 solid dispersion Substances 0.000 claims description 179
- 238000000034 method Methods 0.000 claims description 89
- 239000004094 surface-active agent Substances 0.000 claims description 69
- 239000002904 solvent Substances 0.000 claims description 67
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 66
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 66
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 54
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 53
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 47
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 47
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 46
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 46
- 239000003112 inhibitor Substances 0.000 claims description 44
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims description 38
- 239000006185 dispersion Substances 0.000 claims description 36
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims description 35
- 238000001694 spray drying Methods 0.000 claims description 32
- 239000007788 liquid Substances 0.000 claims description 28
- 239000003795 chemical substances by application Substances 0.000 claims description 27
- 239000007787 solid Substances 0.000 claims description 27
- 230000008569 process Effects 0.000 claims description 25
- 239000000126 substance Substances 0.000 claims description 25
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims description 23
- 230000009477 glass transition Effects 0.000 claims description 23
- 239000002245 particle Substances 0.000 claims description 19
- 229920003169 water-soluble polymer Polymers 0.000 claims description 14
- 239000007900 aqueous suspension Substances 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 12
- 239000003443 antiviral agent Substances 0.000 claims description 11
- 210000004369 blood Anatomy 0.000 claims description 11
- 239000008280 blood Substances 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 239000011734 sodium Substances 0.000 claims description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
- 229910052708 sodium Inorganic materials 0.000 claims description 10
- 241000124008 Mammalia Species 0.000 claims description 9
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 9
- 235000017858 Laurus nobilis Nutrition 0.000 claims description 8
- 235000005212 Terminalia tomentosa Nutrition 0.000 claims description 8
- 208000003311 Cytochrome P-450 Enzyme Inhibitors Diseases 0.000 claims description 7
- 239000003937 drug carrier Substances 0.000 claims description 6
- 108091005804 Peptidases Proteins 0.000 claims description 5
- 239000004365 Protease Substances 0.000 claims description 5
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims description 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 4
- 230000002519 immonomodulatory effect Effects 0.000 claims description 4
- 229940122280 Cytochrome P450 inhibitor Drugs 0.000 claims description 3
- 244000125380 Terminalia tomentosa Species 0.000 claims 4
- 238000009472 formulation Methods 0.000 abstract description 27
- 229910052799 carbon Inorganic materials 0.000 description 40
- 239000000725 suspension Substances 0.000 description 35
- 239000000306 component Substances 0.000 description 30
- 229940079593 drug Drugs 0.000 description 29
- 239000003814 drug Substances 0.000 description 29
- 239000003981 vehicle Substances 0.000 description 27
- 239000002552 dosage form Substances 0.000 description 22
- 150000001875 compounds Chemical class 0.000 description 20
- 239000000243 solution Substances 0.000 description 20
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 17
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 17
- 238000002360 preparation method Methods 0.000 description 17
- 238000001035 drying Methods 0.000 description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
- -1 less than about 35% Chemical compound 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 238000002425 crystallisation Methods 0.000 description 13
- 230000008025 crystallization Effects 0.000 description 13
- 238000003860 storage Methods 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 11
- 229920003081 Povidone K 30 Polymers 0.000 description 10
- 239000006194 liquid suspension Substances 0.000 description 10
- 239000000546 pharmaceutical excipient Substances 0.000 description 10
- 101100424627 Caenorhabditis elegans mec-12 gene Proteins 0.000 description 9
- 239000003826 tablet Substances 0.000 description 9
- 208000005176 Hepatitis C Diseases 0.000 description 8
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 8
- 239000012736 aqueous medium Substances 0.000 description 8
- 238000004090 dissolution Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 8
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 8
- 239000013557 residual solvent Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 7
- 241000700159 Rattus Species 0.000 description 7
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 7
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- 235000002639 sodium chloride Nutrition 0.000 description 7
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000036765 blood level Effects 0.000 description 6
- 230000001419 dependent effect Effects 0.000 description 6
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 239000011877 solvent mixture Substances 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- 230000000087 stabilizing effect Effects 0.000 description 6
- 108010044467 Isoenzymes Proteins 0.000 description 5
- 229920003083 Kollidon® VA64 Polymers 0.000 description 5
- 238000001704 evaporation Methods 0.000 description 5
- 230000008020 evaporation Effects 0.000 description 5
- 208000010710 hepatitis C virus infection Diseases 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000000634 powder X-ray diffraction Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 238000001291 vacuum drying Methods 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 244000147568 Laurus nobilis Species 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- JBPUGFODGPKTDW-SFHVURJKSA-N [(3s)-oxolan-3-yl] n-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate Chemical compound C=1C=C(C=2OC=NC=2)C(OC)=CC=1NC(=O)NC(C=1)=CC=CC=1CNC(=O)O[C@H]1CCOC1 JBPUGFODGPKTDW-SFHVURJKSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical group O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 208000006454 hepatitis Diseases 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000006186 oral dosage form Substances 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- 229940083037 simethicone Drugs 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 241000711549 Hepacivirus C Species 0.000 description 3
- 102000014150 Interferons Human genes 0.000 description 3
- 108010050904 Interferons Proteins 0.000 description 3
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 3
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 description 3
- GYCPCOJTCINIFZ-JXFKEZNVSA-N [(2s)-1-cyanobutan-2-yl] n-[(1s)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate Chemical compound N#CC[C@H](CC)OC(=O)N[C@@H](C)C1=CC=CC(NC(=O)NC=2C=C(OC)C(C=3OC=NC=3)=CC=2)=C1 GYCPCOJTCINIFZ-JXFKEZNVSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
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- 206010073071 hepatocellular carcinoma Diseases 0.000 description 3
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- 229960000329 ribavirin Drugs 0.000 description 3
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 3
- 229960000311 ritonavir Drugs 0.000 description 3
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 3
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- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
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- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 2
- PCLITLDOTJTVDJ-UHFFFAOYSA-N Chlormethiazole Chemical compound CC=1N=CSC=1CCCl PCLITLDOTJTVDJ-UHFFFAOYSA-N 0.000 description 2
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- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
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- WHBIGIKBNXZKFE-UHFFFAOYSA-N delavirdine Chemical compound CC(C)NC1=CC=CN=C1N1CCN(C(=O)C=2NC3=CC=C(NS(C)(=O)=O)C=C3C=2)CC1 WHBIGIKBNXZKFE-UHFFFAOYSA-N 0.000 description 2
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 2
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- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 2
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- RIKMMFOAQPJVMX-UHFFFAOYSA-N fomepizole Chemical compound CC=1C=NNC=1 RIKMMFOAQPJVMX-UHFFFAOYSA-N 0.000 description 2
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Landscapes
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| MY169670A (en) | 2003-09-03 | 2019-05-08 | Tibotec Pharm Ltd | Combinations of a pyrimidine containing nnrti with rt inhibitors |
| MY148123A (en) * | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
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| US8119602B2 (en) | 2005-06-02 | 2012-02-21 | Schering Corporation | Administration of HCV protease inhibitors in combination with food to improve bioavailability |
| EP2402331A1 (en) * | 2005-08-02 | 2012-01-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| US8039475B2 (en) * | 2006-02-27 | 2011-10-18 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| JP5646814B2 (ja) * | 2006-03-06 | 2014-12-24 | アッヴィ・インコーポレイテッド | Ｈｃｖを治療するためのリトナビルの組成物及び使用方法 |
| KR20080112303A (ko) | 2006-03-16 | 2008-12-24 | 버텍스 파마슈티칼스 인코포레이티드 | 중수소화 ｃ형 간염 프로테아제 억제제 |
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| PT2114924E (pt) * | 2007-02-27 | 2012-04-03 | Vertex Pharma | Co-cristais e composições farmacêuticas que compreendem os mesmos |
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-
2005
- 2005-06-08 EP EP05757623A patent/EP1765283A4/en not_active Withdrawn
- 2005-06-08 WO PCT/US2005/019929 patent/WO2005123076A2/en not_active Ceased
- 2005-06-08 KR KR1020127008036A patent/KR20120039763A/ko not_active Ceased
- 2005-06-08 BR BRPI0511900-6A patent/BRPI0511900A/pt not_active IP Right Cessation
- 2005-06-08 CN CNA200580024232XA patent/CN1988885A/zh active Pending
- 2005-06-08 US US11/147,524 patent/US20060089385A1/en not_active Abandoned
- 2005-06-08 RU RU2006147247/15A patent/RU2373923C2/ru not_active IP Right Cessation
- 2005-06-08 TW TW094118847A patent/TWI389688B/zh not_active IP Right Cessation
- 2005-06-08 NZ NZ588471A patent/NZ588471A/en not_active IP Right Cessation
- 2005-06-08 AU AU2005253957A patent/AU2005253957B2/en not_active Ceased
- 2005-06-08 JP JP2007527639A patent/JP2008501802A/ja active Pending
- 2005-06-08 AR ARP050102345A patent/AR049297A1/es unknown
- 2005-06-08 CN CN2011103013245A patent/CN102512372A/zh active Pending
- 2005-06-08 ZA ZA200700030A patent/ZA200700030B/xx unknown
- 2005-06-08 CA CA002569310A patent/CA2569310A1/en not_active Abandoned
- 2005-06-08 KR KR1020077000437A patent/KR101370580B1/ko not_active Expired - Fee Related
- 2005-06-08 MX MXPA06014253A patent/MXPA06014253A/es not_active Application Discontinuation
- 2005-06-08 SG SG200903859-7A patent/SG153800A1/en unknown
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2006
- 2006-12-04 IL IL179809A patent/IL179809A/en not_active IP Right Cessation
-
2007
- 2007-01-08 NO NO20070130A patent/NO20070130L/no not_active Application Discontinuation
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2008
- 2008-03-26 ZA ZA200802676A patent/ZA200802676B/en unknown
-
2012
- 2012-01-05 JP JP2012000814A patent/JP5337262B2/ja not_active Expired - Fee Related
- 2012-09-20 IL IL222003A patent/IL222003A0/en unknown
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2013
- 2013-04-12 US US13/861,791 patent/US20130274180A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005253957B2 (en) | 2011-08-25 |
| WO2005123076A3 (en) | 2006-06-15 |
| WO2005123076A2 (en) | 2005-12-29 |
| KR20120039763A (ko) | 2012-04-25 |
| MXPA06014253A (es) | 2007-07-13 |
| TWI389688B (zh) | 2013-03-21 |
| US20060089385A1 (en) | 2006-04-27 |
| IL179809A (en) | 2012-10-31 |
| EP1765283A2 (en) | 2007-03-28 |
| RU2006147247A (ru) | 2008-07-20 |
| ZA200700030B (en) | 2009-06-24 |
| JP2012067138A (ja) | 2012-04-05 |
| IL222003A0 (en) | 2012-12-02 |
| CN102512372A (zh) | 2012-06-27 |
| KR20070030270A (ko) | 2007-03-15 |
| ZA200802676B (en) | 2009-12-30 |
| AR049297A1 (es) | 2006-07-12 |
| JP5337262B2 (ja) | 2013-11-06 |
| EP1765283A4 (en) | 2012-11-28 |
| KR101370580B1 (ko) | 2014-03-06 |
| RU2373923C2 (ru) | 2009-11-27 |
| TW200608975A (en) | 2006-03-16 |
| AU2005253957A1 (en) | 2005-12-29 |
| US20130274180A1 (en) | 2013-10-17 |
| IL179809A0 (en) | 2007-05-15 |
| BRPI0511900A (pt) | 2008-01-22 |
| JP2008501802A (ja) | 2008-01-24 |
| CN1988885A (zh) | 2007-06-27 |
| SG153800A1 (en) | 2009-07-29 |
| NO20070130L (no) | 2007-01-25 |
| NZ588471A (en) | 2012-02-24 |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20160126 |