CA2568571C - Combinations comprising antimuscarinic agents and corticosteroids - Google Patents

Combinations comprising antimuscarinic agents and corticosteroids Download PDF

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Publication number
CA2568571C
CA2568571C CA2568571A CA2568571A CA2568571C CA 2568571 C CA2568571 C CA 2568571C CA 2568571 A CA2568571 A CA 2568571A CA 2568571 A CA2568571 A CA 2568571A CA 2568571 C CA2568571 C CA 2568571C
Authority
CA
Canada
Prior art keywords
antagonist
corticosteroid
muscarinic receptors
simultaneous
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2568571A
Other languages
English (en)
French (fr)
Other versions
CA2568571A1 (en
Inventor
Jordi Gras Escardo
Jesus Llenas Calvo
Hamish Ryder
Pio Orviz Diaz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES200401312A external-priority patent/ES2257152B1/es
Application filed by Almirall SA filed Critical Almirall SA
Publication of CA2568571A1 publication Critical patent/CA2568571A1/en
Application granted granted Critical
Publication of CA2568571C publication Critical patent/CA2568571C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2568571A 2004-05-31 2005-05-31 Combinations comprising antimuscarinic agents and corticosteroids Expired - Fee Related CA2568571C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
ES200401312A ES2257152B1 (es) 2004-05-31 2004-05-31 Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
ESP200401312 2004-05-31
EP2005001969 2005-02-24
EPPCT/EP2005/001969 2005-02-24
GB2005000722 2005-02-25
GB2005000740 2005-02-25
GBPCT/GB2005/000740 2005-02-25
GBPCT/GB2005/000722 2005-02-25
PCT/EP2005/005838 WO2005115464A1 (en) 2004-05-31 2005-05-31 Combinations comprising antimuscarinic agents and corticosteroids

Publications (2)

Publication Number Publication Date
CA2568571A1 CA2568571A1 (en) 2005-12-08
CA2568571C true CA2568571C (en) 2012-12-18

Family

ID=34968792

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2568571A Expired - Fee Related CA2568571C (en) 2004-05-31 2005-05-31 Combinations comprising antimuscarinic agents and corticosteroids
CA2568568A Expired - Fee Related CA2568568C (en) 2004-05-31 2005-05-31 Combinations comprising antimuscarinic agents and beta-adrenergic agonists
CA2569074A Expired - Fee Related CA2569074C (en) 2004-05-31 2005-05-31 Combinations comprising antimuscarinic agents and pde4 inhibitors

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2568568A Expired - Fee Related CA2568568C (en) 2004-05-31 2005-05-31 Combinations comprising antimuscarinic agents and beta-adrenergic agonists
CA2569074A Expired - Fee Related CA2569074C (en) 2004-05-31 2005-05-31 Combinations comprising antimuscarinic agents and pde4 inhibitors

Country Status (21)

Country Link
US (2) US20110224177A1 (instruction)
EP (5) EP1905451B1 (instruction)
JP (1) JP2012211183A (instruction)
AT (3) ATE474601T1 (instruction)
AU (3) AU2005247104B2 (instruction)
BE (1) BE2015C012I2 (instruction)
CA (3) CA2568571C (instruction)
CY (1) CY1110829T1 (instruction)
DE (3) DE602005012102D1 (instruction)
DK (2) DK1891974T3 (instruction)
ES (2) ES2336144T3 (instruction)
HR (3) HRP20090106T3 (instruction)
IL (3) IL179686A0 (instruction)
MX (3) MXPA06013849A (instruction)
NZ (3) NZ551669A (instruction)
PL (2) PL1891974T3 (instruction)
PT (3) PT1905451E (instruction)
RS (3) RS51206B (instruction)
RU (3) RU2385156C2 (instruction)
SI (3) SI1905451T1 (instruction)
WO (3) WO2005115464A1 (instruction)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US20100150884A1 (en) * 2005-02-10 2010-06-17 Oncolys Biopharma Inc. Anticancer Agent to Be Combined with Telomelysin
KR20090121338A (ko) * 2007-02-19 2009-11-25 씨아이피엘에이 엘티디. 두 개 이상의 기관지확장제 또는 기관지확장제와 코르티코스테로이드의 약제학적 조합
EP2080508A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Dry powder formulation comprising an anticholinergic drug
EP2080523A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Compositions comprising an antimuscarinic and a long-acting beta-agonist
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) * 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
GB0811100D0 (en) * 2008-06-17 2008-07-23 Astrazeneca Ab New combination
GB0814728D0 (en) * 2008-08-12 2008-09-17 Argenta Discovery Ltd New combination
PL3578169T3 (pl) 2009-02-26 2024-09-02 Glaxo Group Limited Preparaty farmaceutyczne zawierające 4-{(1r)-2-[(6-{2-[(2,6-dichlorobenzylo)oksy]etoksy}heksylo)amino]-1-hydroksyetylo}-2-(hydroksymetylo)fenol
WO2010097114A1 (en) * 2009-02-26 2010-09-02 Glaxo Group Limited Novel combination of therapeutic agents
JP5752114B2 (ja) 2009-05-14 2015-07-22 天津和美生物技術有限公司 チオフェン誘導体
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
KR20140147891A (ko) 2012-04-13 2014-12-30 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 응집체 입자
GB201222679D0 (en) 2012-12-17 2013-01-30 Glaxo Group Ltd Pharmaceutical combination products
RU2666624C2 (ru) * 2013-03-15 2018-09-11 ВЕРОНА ФАРМА ПиэЛСи Комбинация лекарственных средств
GB201308933D0 (en) * 2013-05-17 2013-07-03 Diurnal Ltd Paediatric composition
US20160122764A1 (en) * 2013-07-05 2016-05-05 Bioneer Corporation Respiratory disease-related gene specific sirna, double-helical oligo rna structure containing sirna, compositon containing same for preventing or treating respiratory disease
TW201542207A (zh) * 2013-10-03 2015-11-16 Otsuka Pharma Co Ltd 嚴重氣喘治療劑

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT7920688U1 (it) 1979-02-05 1980-08-05 Chiesi Paolo Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore
EP0069715B1 (en) 1981-07-08 1986-11-05 Aktiebolaget Draco Powder inhalator
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
FI69963C (fi) 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
DE3927170A1 (de) 1989-08-17 1991-02-21 Boehringer Ingelheim Kg Inhalator
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5201308A (en) 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
WO1992003175A1 (en) 1990-08-11 1992-03-05 Fisons Plc Inhalation device
DE4027391A1 (de) 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
ES2113889T3 (es) 1990-09-26 1998-05-16 Pharmachemie Bv Dispositivos inhaladores provistos de un deposito para varias dosis de producto de inhalacion, dispositivo de transporte y camaras de turbulencia.
GB9026025D0 (en) 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
DE4239402A1 (de) 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
NZ259241A (en) 1992-12-18 1996-12-20 Schering Corp Inhaler including a counter ring, a nozzle to break powder agglomerates and spring-biased, bi-directionally rotatable metering plate and powder house
US5837699A (en) * 1994-01-27 1998-11-17 Schering Corporation Use of mometasone furoate for treating upper airway passage diseases
RO119116B1 (ro) 1995-04-14 2004-04-30 Glaxo Wellcome Inc. Inhalator pentru dozarea salmeterolului
CZ294782B6 (cs) 1995-06-21 2005-03-16 Sofotec Gmbh & Co. Kg Inhalátor pro prášková léčiva
DE19528145A1 (de) * 1995-08-01 1997-02-06 Boehringer Ingelheim Kg Neue Arzneimittel und ihre Verwendung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
GB0009583D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
GB0009592D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009606D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
GB0009605D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Medicaments
EP1318973A2 (en) * 2000-09-22 2003-06-18 Glaxo Group Limited Novel alkanoic acid derivatives
WO2002036106A2 (de) 2000-10-31 2002-05-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue arzneimittelkompositionen auf der basis von anticholingergika und corticosteroiden
DE10062712A1 (de) 2000-12-15 2002-06-20 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
DE60121813T2 (de) * 2000-12-28 2007-09-20 Almirall Ag Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthalten
JP2004530705A (ja) * 2001-05-25 2004-10-07 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 閉塞性気道疾患及びその他の炎症性疾患を治療するためのpde4インヒビター及びチオトロピウム又はその誘導体の組み合わせ
DE10130371A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika
ES2206021B1 (es) * 2002-04-16 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de pirrolidinio.
ES2195785B1 (es) 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
US20050182042A1 (en) * 2002-05-17 2005-08-18 Feldman David L. Pharmaceutical composition comprising a renin inhibitor, a calcium channel blocker and a diuretic
BR0311747A (pt) * 2002-06-12 2005-06-07 Epigenesis Pharmaceuticals Inc Composição farmacêutica, forma de dose simples ou de múltiplas doses da composição, kit, e, método para tratar doença
ES2211315B1 (es) 2002-11-12 2005-10-16 Almirall Prodesfarma, S.A. Nuevos compuestos triciclicos.
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
US20060189642A1 (en) * 2003-03-28 2006-08-24 Altana Pharma Ag Synergistic combination comprising roflumilast and an anticholinergic agent selected from ipratropium, oxitropium and tiotropium salts for the treatment of respiratory diseases
US20060147382A1 (en) * 2003-03-28 2006-07-06 Altana Pharma Ag Synergistic combination comprising roflumilast and an anticholinergic agent selected from ipratropium, oxitropium and tiotropium salts for the treatment of respiratory diseases
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.

Also Published As

Publication number Publication date
PT1891974E (pt) 2010-09-27
CA2568568C (en) 2012-12-18
AU2005247106B2 (en) 2010-11-11
HRP20100490T1 (hr) 2010-10-31
WO2005115464A1 (en) 2005-12-08
AU2005247104B2 (en) 2010-11-11
WO2005115465A1 (en) 2005-12-08
EP1761279A1 (en) 2007-03-14
EP1765405A1 (en) 2007-03-28
SI1891974T1 (sl) 2010-11-30
ATE454904T1 (de) 2010-01-15
ES2317245T3 (es) 2009-04-16
ATE419011T1 (de) 2009-01-15
US20110224177A1 (en) 2011-09-15
SI1765404T1 (sl) 2009-04-30
DE602005012102D1 (de) 2009-02-12
NZ551669A (en) 2010-07-30
RU2385156C2 (ru) 2010-03-27
HK1096605A1 (en) 2007-06-08
JP2012211183A (ja) 2012-11-01
IL179690A (en) 2012-10-31
PL1891974T3 (pl) 2010-12-31
IL179685A (en) 2012-01-31
RU2006147269A (ru) 2008-07-20
SI1905451T1 (sl) 2010-05-31
CA2569074A1 (en) 2005-12-08
HRP20090106T3 (en) 2009-03-31
RS51206B (sr) 2010-12-31
MXPA06013850A (es) 2007-03-02
HRP20100104T1 (hr) 2010-04-30
ES2336144T3 (es) 2010-04-08
RU2006146673A (ru) 2008-07-20
AU2005247104A1 (en) 2005-12-08
EP1891974A1 (en) 2008-02-27
AU2005247106A1 (en) 2005-12-08
DK1891974T3 (da) 2010-11-08
NZ551670A (en) 2010-07-30
IL179690A0 (en) 2007-05-15
EP1905451B1 (en) 2010-01-13
CA2568568A1 (en) 2005-12-08
PL1905451T3 (pl) 2010-05-31
AU2005247105A1 (en) 2005-12-08
EP2210614A1 (en) 2010-07-28
RS50786B (sr) 2010-08-31
US20130196961A1 (en) 2013-08-01
ATE474601T1 (de) 2010-08-15
RU2379033C2 (ru) 2010-01-20
MXPA06013846A (es) 2007-03-01
BE2015C012I2 (instruction) 2024-10-08
CA2568571A1 (en) 2005-12-08
DK1905451T3 (da) 2010-05-10
RS51422B (en) 2011-02-28
DE602005022499D1 (de) 2010-09-02
MXPA06013849A (es) 2007-03-01
RU2006146813A (ru) 2008-07-20
IL179686A0 (en) 2007-05-15
DE602005018969D1 (de) 2010-03-04
WO2005115463A1 (en) 2005-12-08
RU2404772C2 (ru) 2010-11-27
CA2569074C (en) 2012-12-18
AU2005247105B2 (en) 2010-11-11
PT1905451E (pt) 2010-03-31
IL179685A0 (en) 2007-05-15
EP1891974B1 (en) 2010-07-21
PT1765404E (pt) 2009-03-31
EP1905451A1 (en) 2008-04-02
CY1110829T1 (el) 2015-06-10
NZ551666A (en) 2010-07-30

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