CA2565944C - Stabilized hyaluronan preparations and related methods - Google Patents

Stabilized hyaluronan preparations and related methods Download PDF

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Publication number
CA2565944C
CA2565944C CA2565944A CA2565944A CA2565944C CA 2565944 C CA2565944 C CA 2565944C CA 2565944 A CA2565944 A CA 2565944A CA 2565944 A CA2565944 A CA 2565944A CA 2565944 C CA2565944 C CA 2565944C
Authority
CA
Canada
Prior art keywords
hyaluronan
polyglycol
range
chloride
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2565944A
Other languages
English (en)
French (fr)
Other versions
CA2565944A1 (en
Inventor
Hampar L. Karageozian
John Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SK Pharmaceuticals Inc
Original Assignee
SK Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SK Pharmaceuticals Inc filed Critical SK Pharmaceuticals Inc
Publication of CA2565944A1 publication Critical patent/CA2565944A1/en
Application granted granted Critical
Publication of CA2565944C publication Critical patent/CA2565944C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
CA2565944A 2004-05-07 2005-05-09 Stabilized hyaluronan preparations and related methods Expired - Lifetime CA2565944C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56940704P 2004-05-07 2004-05-07
US60/569,407 2004-05-07
PCT/US2005/016271 WO2005110439A2 (en) 2004-05-07 2005-05-09 Stabilized hyaluronan preparations and related methods

Publications (2)

Publication Number Publication Date
CA2565944A1 CA2565944A1 (en) 2005-11-24
CA2565944C true CA2565944C (en) 2011-07-19

Family

ID=35394663

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2565944A Expired - Lifetime CA2565944C (en) 2004-05-07 2005-05-09 Stabilized hyaluronan preparations and related methods

Country Status (7)

Country Link
US (1) US7544671B2 (https=)
EP (1) EP1746884A4 (https=)
JP (1) JP2007536277A (https=)
AU (1) AU2005244059A1 (https=)
CA (1) CA2565944C (https=)
MX (1) MXPA06013056A (https=)
WO (1) WO2005110439A2 (https=)

Families Citing this family (27)

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US20070104798A1 (en) 1999-10-04 2007-05-10 S.K. Pharmaceuticals, Inc. Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
US20070031468A1 (en) * 2005-08-04 2007-02-08 Endomedix, Inc. Modified chitosan for vascular embolization
US20070031467A1 (en) * 2005-08-04 2007-02-08 Abrahams John M Composition and method for vascular embolization
TW200733993A (en) * 2005-11-03 2007-09-16 Reseal Internat Ltd Partnership Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein
US20080075657A1 (en) * 2006-04-18 2008-03-27 Abrahams John M Biopolymer system for tissue sealing
US20070243130A1 (en) * 2006-04-18 2007-10-18 Weiliam Chen Biopolymer system for tissue sealing
US7854923B2 (en) * 2006-04-18 2010-12-21 Endomedix, Inc. Biopolymer system for tissue sealing
US20080124395A1 (en) * 2006-06-22 2008-05-29 Weiliam Chen Formulations and devices for treatment or prevention of neural ischemic damage
KR20090053892A (ko) * 2006-07-25 2009-05-28 오스모티카 코프. 점안액
DE102006049580A1 (de) * 2006-10-20 2008-04-24 Rochel, Michael, Dr. med. Topische Zusammensetzung zur Behandlung von Ekzemen
WO2009006130A2 (en) * 2007-06-28 2009-01-08 Bausch & Lomb Incorporated Salt free hyaluronate ophthalmic solution
WO2010030725A1 (en) * 2008-09-15 2010-03-18 Bausch & Lomb Incorporated Compositions comprising polymers having amino sugar units and methods of making and using same
WO2010125069A1 (en) * 2009-04-28 2010-11-04 Pharmasurgics In Sweden Ab Hyaluronic acid for preventing post surgical adhesions
IT1394223B1 (it) 2009-05-15 2012-06-01 Thea Sas Lab Kit per la valutazione e la selezione personalizzata di lacrime artificiali
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
DE102011077393A1 (de) * 2011-06-10 2012-12-13 Johannes Reinmüller Antiinfektives Mittel
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
KR101383941B1 (ko) * 2012-03-09 2014-04-10 동아에스티 주식회사 피록시캄 또는 약제학적으로 허용되는 그의 염과 히알루론산 또는 약제학적으로 허용되는 그의 염의 안정한 액상 조성물 및 그 제조방법
EP4137139A1 (en) 2013-07-10 2023-02-22 Matrix Biology Institute Compositions of hyaluronan with high elasticity and uses thereof
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
PL3352766T3 (pl) 2015-09-24 2021-08-02 Matrix Biology Institute Kompozycie z hialuronanem o dużej elastyczności i sposoby ich użycia
EP3231417B1 (de) * 2016-04-15 2018-12-05 Dr. Gerhard Mann Chem.-Pharm. Fabrik GmbH Lagerungsstabile, ophthalmische zusammensetzung
DE102018124022A1 (de) 2018-09-28 2020-04-02 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Hyaluronsäurestabilisator
US10517988B1 (en) 2018-11-19 2019-12-31 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629623A (en) * 1984-06-11 1986-12-16 Biomatrix, Inc. Hyaluronate-poly (ethylene oxide) compositions and cosmetic formulations thereof
JPS6479103A (en) * 1987-06-09 1989-03-24 Lion Corp External preparation
US5141741A (en) * 1988-12-09 1992-08-25 Lion Corporation Anti-sunburn skin-care preparation
JPH05170641A (ja) * 1991-12-25 1993-07-09 Shiseido Co Ltd 化粧料
JPH09227385A (ja) * 1996-02-29 1997-09-02 Ofutekusu:Kk 眼手術用補助剤
JPH1072376A (ja) * 1996-09-02 1998-03-17 Ofutekusu:Kk ヒアルロン酸含有点眼水溶液
JPH10290830A (ja) * 1997-04-18 1998-11-04 Ofutekusu:Kk 眼手術用補助剤
KR100514963B1 (ko) * 1997-07-11 2005-09-15 도레이 가부시끼가이샤 4,5-에폭시모르피난 유도체를 함유하는 안정한 의약품 조성물
JP2003530136A (ja) * 1999-04-02 2003-10-14 フジオメッド インコーポレイテッド ポリ酸及びポリエーテルの組成物及び接着の低減におけるその使用方法
JP2001019611A (ja) * 1999-07-08 2001-01-23 Pola Chem Ind Inc 皮膚外用組成物
US7074424B2 (en) * 2000-11-28 2006-07-11 Genzyme Corporation Polyalkylene glycol viscosity-enhancing polymeric formulations
JP2002193815A (ja) * 2000-12-25 2002-07-10 Ophtecs Corp 眼手術用角膜乾燥防止点眼剤
FR2825273B1 (fr) * 2001-05-29 2006-11-24 Oreal Composition pour le traitement des signes cutanes du vieillissement
CA2472188C (en) * 2002-01-18 2011-06-21 Control Delivery Systems, Inc. Polymeric gel system for the controlled delivery of codrugs
JP4263456B2 (ja) * 2002-03-18 2009-05-13 わかもと製薬株式会社 ヒアルロン酸含有熱ゲル化製剤
US20040137079A1 (en) * 2003-01-08 2004-07-15 Cook James N. Contact lens and eye drop rewetter compositions and methods
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation

Also Published As

Publication number Publication date
EP1746884A2 (en) 2007-01-31
US7544671B2 (en) 2009-06-09
EP1746884A4 (en) 2010-01-13
CA2565944A1 (en) 2005-11-24
MXPA06013056A (es) 2007-04-17
JP2007536277A (ja) 2007-12-13
AU2005244059A1 (en) 2005-11-24
WO2005110439A2 (en) 2005-11-24
US20060029571A1 (en) 2006-02-09
WO2005110439A3 (en) 2006-05-11

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Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE

Effective date: 20251106