CA2557783A1

CA2557783A1 - Film compositions

Film compositions Download PDF

Info

Publication number: CA2557783A1
Authority: CA; Canada
Prior art keywords: water; layer; soluble; sodium; film composition
Prior art date: 2004-03-03
Legal status : Abandoned

Application number

CA002557783A

Other languages

English (en)

French (fr)

Inventor

Andre Anatoly Soshinsky

Current Assignee

Warner Lambert Co LLC

Original Assignee

Individual

Priority date

2004-03-03

Filing date

2005-02-21

Publication date

2005-10-06

2004-03-03 Priority claimed from US10/792,066 external-priority patent/US20050196354A1/en

2005-02-21 Application filed by Individual filed Critical Individual

2005-10-06 Publication of CA2557783A1 publication Critical patent/CA2557783A1/en

Status Abandoned legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 137
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 57
-1 cationic ion Chemical class 0.000 claims description 49
229920003169 water-soluble polymer Polymers 0.000 claims description 39
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 29
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 29
235000002639 sodium chloride Nutrition 0.000 claims description 26
125000000129 anionic group Chemical group 0.000 claims description 23
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 23
150000003839 salts Chemical class 0.000 claims description 23
229920001577 copolymer Polymers 0.000 claims description 22
230000007935 neutral effect Effects 0.000 claims description 18
239000003945 anionic surfactant Substances 0.000 claims description 16
125000002091 cationic group Chemical group 0.000 claims description 16
239000003093 cationic surfactant Substances 0.000 claims description 14
239000001768 carboxy methyl cellulose Substances 0.000 claims description 12
229910052708 sodium Inorganic materials 0.000 claims description 12
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 11
229920006318 anionic polymer Polymers 0.000 claims description 11
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 11
239000011734 sodium Substances 0.000 claims description 11
229920001661 Chitosan Polymers 0.000 claims description 10
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 9
229920001223 polyethylene glycol Polymers 0.000 claims description 9
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 8
239000002202 Polyethylene glycol Substances 0.000 claims description 8
229920006317 cationic polymer Polymers 0.000 claims description 8
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 8
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 8
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
229920000609 methyl cellulose Polymers 0.000 claims description 8
239000001923 methylcellulose Substances 0.000 claims description 8
235000010981 methylcellulose Nutrition 0.000 claims description 8
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 7
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 7
229920002678 cellulose Polymers 0.000 claims description 7
239000001913 cellulose Substances 0.000 claims description 7
235000010980 cellulose Nutrition 0.000 claims description 7
239000001814 pectin Substances 0.000 claims description 7
235000010987 pectin Nutrition 0.000 claims description 7
229920001277 pectin Polymers 0.000 claims description 7
235000010413 sodium alginate Nutrition 0.000 claims description 7
239000000661 sodium alginate Substances 0.000 claims description 7
229940005550 sodium alginate Drugs 0.000 claims description 7
235000019333 sodium laurylsulphate Nutrition 0.000 claims description 7
239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 6
229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 6
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 6
239000004372 Polyvinyl alcohol Substances 0.000 claims description 6
235000010418 carrageenan Nutrition 0.000 claims description 6
229920001525 carrageenan Polymers 0.000 claims description 6
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 6
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
229920002451 polyvinyl alcohol Polymers 0.000 claims description 6
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
239000000679 carrageenan Substances 0.000 claims description 5
229940113118 carrageenan Drugs 0.000 claims description 5
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 5
229960001927 cetylpyridinium chloride Drugs 0.000 claims description 5
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 5
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
229960000686 benzalkonium chloride Drugs 0.000 claims description 4
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 4
239000001110 calcium chloride Substances 0.000 claims description 4
229910001628 calcium chloride Inorganic materials 0.000 claims description 4
235000011148 calcium chloride Nutrition 0.000 claims description 4
239000001509 sodium citrate Substances 0.000 claims description 4
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 4
239000001488 sodium phosphate Substances 0.000 claims description 4
229910000162 sodium phosphate Inorganic materials 0.000 claims description 4
235000011008 sodium phosphates Nutrition 0.000 claims description 4
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 4
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 4
229920001400 block copolymer Polymers 0.000 claims description 3
MSJMDZAOKORVFC-UAIGNFCESA-L disodium maleate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C/C([O-])=O MSJMDZAOKORVFC-UAIGNFCESA-L 0.000 claims description 3
GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 3
DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 claims description 3
230000003993 interaction Effects 0.000 claims description 3
229910001629 magnesium chloride Inorganic materials 0.000 claims description 3
235000011147 magnesium chloride Nutrition 0.000 claims description 3
229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 3
229920001451 polypropylene glycol Polymers 0.000 claims description 3
235000011009 potassium phosphates Nutrition 0.000 claims description 3
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 3
NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 3
150000003751 zinc Chemical class 0.000 claims description 3
229920000688 Poly[(2-ethyldimethylammonioethyl methacrylate ethyl sulfate)-co-(1-vinylpyrrolidone)] Polymers 0.000 claims description 2
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 2
150000008043 acidic salts Chemical class 0.000 claims description 2
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 2
159000000009 barium salts Chemical class 0.000 claims description 2
159000000007 calcium salts Chemical class 0.000 claims description 2
150000001844 chromium Chemical class 0.000 claims description 2
229940079886 disodium lauryl sulfosuccinate Drugs 0.000 claims description 2
KHIQYZGEUSTKSB-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O.CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O KHIQYZGEUSTKSB-UHFFFAOYSA-L 0.000 claims description 2
159000000014 iron salts Chemical class 0.000 claims description 2
159000000003 magnesium salts Chemical class 0.000 claims description 2
150000002696 manganese Chemical class 0.000 claims description 2
229920000193 polymethacrylate Polymers 0.000 claims description 2
239000001103 potassium chloride Substances 0.000 claims description 2
235000011164 potassium chloride Nutrition 0.000 claims description 2
229910000160 potassium phosphate Inorganic materials 0.000 claims description 2
239000001632 sodium acetate Substances 0.000 claims description 2
235000017281 sodium acetate Nutrition 0.000 claims description 2
239000011780 sodium chloride Substances 0.000 claims description 2
235000011083 sodium citrates Nutrition 0.000 claims description 2
239000011775 sodium fluoride Substances 0.000 claims description 2
235000013024 sodium fluoride Nutrition 0.000 claims description 2
229940048109 sodium methyl cocoyl taurate Drugs 0.000 claims description 2
ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 claims description 2
229940039790 sodium oxalate Drugs 0.000 claims description 2
239000011592 zinc chloride Substances 0.000 claims description 2
235000005074 zinc chloride Nutrition 0.000 claims description 2
229940105329 carboxymethylcellulose Drugs 0.000 claims 2
229960000292 pectin Drugs 0.000 claims 2
229920000289 Polyquaternium Polymers 0.000 claims 1
229940080240 sodium c12-15 pareth-15 sulfonate Drugs 0.000 claims 1
230000000699 topical effect Effects 0.000 abstract description 20
230000009885 systemic effect Effects 0.000 abstract description 11
229920000642 polymer Polymers 0.000 description 33
230000002087 whitening effect Effects 0.000 description 24
239000000126 substance Substances 0.000 description 21
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 19
239000000463 material Substances 0.000 description 19
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 18
239000000047 product Substances 0.000 description 17
239000003795 chemical substances by application Substances 0.000 description 14
239000004615 ingredient Substances 0.000 description 12
238000000034 method Methods 0.000 description 12
238000004090 dissolution Methods 0.000 description 11
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 10
210000000214 mouth Anatomy 0.000 description 10
239000008213 purified water Substances 0.000 description 10
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
102000004190 Enzymes Human genes 0.000 description 8
108090000790 Enzymes Proteins 0.000 description 8
229920002125 Sokalan® Polymers 0.000 description 8
229940088598 enzyme Drugs 0.000 description 8
239000000499 gel Substances 0.000 description 8
150000002978 peroxides Chemical class 0.000 description 8
230000008901 benefit Effects 0.000 description 7
239000004365 Protease Substances 0.000 description 6
229960002163 hydrogen peroxide Drugs 0.000 description 6
229910052751 metal Inorganic materials 0.000 description 6
239000002184 metal Substances 0.000 description 6
229940069328 povidone Drugs 0.000 description 6
108091005804 Peptidases Proteins 0.000 description 5
102000035195 Peptidases Human genes 0.000 description 5
239000003054 catalyst Substances 0.000 description 5
239000003975 dentin desensitizing agent Substances 0.000 description 5
235000011187 glycerol Nutrition 0.000 description 5
239000012456 homogeneous solution Substances 0.000 description 5
229920002401 polyacrylamide Polymers 0.000 description 5
230000008569 process Effects 0.000 description 5
LTMQZVLXCLQPCT-UHFFFAOYSA-N 1,1,6-trimethyltetralin Chemical compound C1CCC(C)(C)C=2C1=CC(C)=CC=2 LTMQZVLXCLQPCT-UHFFFAOYSA-N 0.000 description 4
229910019142 PO4 Inorganic materials 0.000 description 4
229920003072 Plasdone™ povidone Polymers 0.000 description 4
208000025865 Ulcer Diseases 0.000 description 4
NJSSICCENMLTKO-HRCBOCMUSA-N [(1r,2s,4r,5r)-3-hydroxy-4-(4-methylphenyl)sulfonyloxy-6,8-dioxabicyclo[3.2.1]octan-2-yl] 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)O[C@H]1C(O)[C@@H](OS(=O)(=O)C=2C=CC(C)=CC=2)[C@@H]2OC[C@H]1O2 NJSSICCENMLTKO-HRCBOCMUSA-N 0.000 description 4
239000004480 active ingredient Substances 0.000 description 4
239000013543 active substance Substances 0.000 description 4
239000000853 adhesive Substances 0.000 description 4
230000001070 adhesive effect Effects 0.000 description 4
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 4
230000000694 effects Effects 0.000 description 4
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 4
239000003002 pH adjusting agent Substances 0.000 description 4
235000021317 phosphate Nutrition 0.000 description 4
150000003013 phosphoric acid derivatives Chemical class 0.000 description 4
239000000758 substrate Substances 0.000 description 4
231100000397 ulcer Toxicity 0.000 description 4
108010001682 Dextranase Proteins 0.000 description 3
DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 3
229920002907 Guar gum Polymers 0.000 description 3
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 3
WXOMTJVVIMOXJL-BOBFKVMVSA-A O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)OS(=O)(=O)OC[C@H]1O[C@@H](O[C@]2(COS(=O)(=O)O[Al](O)O)O[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]2OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]1OS(=O)(=O)O[Al](O)O Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)OS(=O)(=O)OC[C@H]1O[C@@H](O[C@]2(COS(=O)(=O)O[Al](O)O)O[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]2OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]1OS(=O)(=O)O[Al](O)O WXOMTJVVIMOXJL-BOBFKVMVSA-A 0.000 description 3
241000282372 Panthera onca Species 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
235000010443 alginic acid Nutrition 0.000 description 3
229920000615 alginic acid Polymers 0.000 description 3
229910052783 alkali metal Inorganic materials 0.000 description 3
230000003444 anaesthetic effect Effects 0.000 description 3
239000003963 antioxidant agent Substances 0.000 description 3
235000006708 antioxidants Nutrition 0.000 description 3
229920001222 biopolymer Polymers 0.000 description 3
229960002713 calcium chloride Drugs 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical class OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 3
239000002131 composite material Substances 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
235000011180 diphosphates Nutrition 0.000 description 3
238000001035 drying Methods 0.000 description 3
UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 3
239000003193 general anesthetic agent Substances 0.000 description 3
235000010417 guar gum Nutrition 0.000 description 3
239000000665 guar gum Substances 0.000 description 3
229960002154 guar gum Drugs 0.000 description 3
229920001983 poloxamer Polymers 0.000 description 3
229920001184 polypeptide Polymers 0.000 description 3
FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 3
102000004196 processed proteins & peptides Human genes 0.000 description 3
108090000765 processed proteins & peptides Proteins 0.000 description 3
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
238000005507 spraying Methods 0.000 description 3
239000004094 surface-active agent Substances 0.000 description 3
AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 3
229920002554 vinyl polymer Polymers 0.000 description 3
TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 2
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
YFVBASFBIJFBAI-UHFFFAOYSA-M 1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=CC=C1 YFVBASFBIJFBAI-UHFFFAOYSA-M 0.000 description 2
ANAAMBRRWOGKGU-UHFFFAOYSA-M 4-ethyl-1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=C(CC)C=C1 ANAAMBRRWOGKGU-UHFFFAOYSA-M 0.000 description 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
108010065511 Amylases Proteins 0.000 description 2
102000013142 Amylases Human genes 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
239000004322 Butylated hydroxytoluene Substances 0.000 description 2
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
229920002101 Chitin Polymers 0.000 description 2
244000060011 Cocos nucifera Species 0.000 description 2
235000013162 Cocos nucifera Nutrition 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
208000006558 Dental Calculus Diseases 0.000 description 2
229920002307 Dextran Polymers 0.000 description 2
ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
241001427367 Gardena Species 0.000 description 2
108010031186 Glycoside Hydrolases Proteins 0.000 description 2
102000005744 Glycoside Hydrolases Human genes 0.000 description 2
208000004898 Herpes Labialis Diseases 0.000 description 2
229940122957 Histamine H2 receptor antagonist Drugs 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
108090001060 Lipase Proteins 0.000 description 2
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