CA2557645C - Caspase inhibitors and uses thereof - Google Patents

Caspase inhibitors and uses thereof Download PDF

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Publication number
CA2557645C
CA2557645C CA2557645A CA2557645A CA2557645C CA 2557645 C CA2557645 C CA 2557645C CA 2557645 A CA2557645 A CA 2557645A CA 2557645 A CA2557645 A CA 2557645A CA 2557645 C CA2557645 C CA 2557645C
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Prior art keywords
disease
compound
formula
compound according
carboxylic acid
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CA2557645A
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English (en)
French (fr)
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CA2557645A1 (en
Inventor
Jean-Damien Charrier
Steven Durrant
Michael Mortimore
Michael O'donnell
Alistair Rutherford
Sharn Ramaya
John R. Studley
Martin Trudeau
Adam Looker
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Priority to CA2820541A priority Critical patent/CA2820541A1/en
Publication of CA2557645A1 publication Critical patent/CA2557645A1/en
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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WO2011094426A1 (en) * 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Caspase inhibitors
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JP2019500397A (ja) 2015-12-31 2019-01-10 クオナトウス ファーマシューティカルズ，インコーポレイテッド カスパーゼ阻害剤を肝疾患の治療に使用する方法
CN105853408B (zh) * 2016-04-15 2018-12-04 浙江大学 苯酰胺衍生物在制备Caspase-1抑制剂中的应用
RU2019113150A (ru) 2016-10-05 2020-11-06 Новартис Аг Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения
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TW200540152A (en) 2005-12-16
WO2005085236A2 (en) 2005-09-15
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JP2014140385A (ja) 2014-08-07
US7652153B2 (en) 2010-01-26
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CN102161656B (zh) 2013-02-20
CA2557645A1 (en) 2005-09-15
US20050233979A1 (en) 2005-10-20
WO2005085236A3 (en) 2005-10-20
NO20064351L (no) 2006-11-20
JP2011144203A (ja) 2011-07-28
HK1159614A1 (en) 2012-08-03
US20100105914A1 (en) 2010-04-29
AR047981A1 (es) 2006-03-15

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