TWI362381B - Caspase inhibitors and uses thereof - Google Patents
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- TWI362381B TWI362381B TW094106099A TW94106099A TWI362381B TW I362381 B TWI362381 B TW I362381B TW 094106099 A TW094106099 A TW 094106099A TW 94106099 A TW94106099 A TW 94106099A TW I362381 B TWI362381 B TW I362381B
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Classifications
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| US62966104P | 2004-11-19 | 2004-11-19 | |
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| BR (1) | BRPI0508102A (enExample) |
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| NO (2) | NO20064351L (enExample) |
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Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI9909660B8 (pt) * | 1998-03-19 | 2021-05-25 | Vertex Pharma | compostos inibidores de caspases, composição farmacêutica e uso de ditos compostos |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| WO2005117846A2 (en) * | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| CA2768700C (en) * | 2004-03-12 | 2014-04-29 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
| US20060128696A1 (en) * | 2004-05-15 | 2006-06-15 | Annamaria Vezzani | Treating seizures using ice inhibitors |
| WO2011094426A1 (en) * | 2010-01-29 | 2011-08-04 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Caspase inhibitors |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| SG11201609256SA (en) | 2014-05-12 | 2016-12-29 | Conatus Pharmaceuticals Inc | Treatment of the complications of chronic liver disease with caspase inhibitors |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| US20190022043A1 (en) | 2015-12-31 | 2019-01-24 | Conatus Pharmaceuticals Inc. | Methods of using caspase inhibitors in treatment of liver disease |
| CN105853408B (zh) * | 2016-04-15 | 2018-12-04 | 浙江大学 | 苯酰胺衍生物在制备Caspase-1抑制剂中的应用 |
| WO2018065902A1 (en) | 2016-10-05 | 2018-04-12 | Novartis Ag | Combination compositions comprising fxr agonists for treating or preventing a fibrotic,cirrhotic disease or disorder |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| WO2024044098A2 (en) * | 2022-08-23 | 2024-02-29 | Alexion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| CZ291758B6 (cs) * | 1994-07-22 | 2003-05-14 | Altana Pharma Ag | Dihydrobenzofurany, způsob jejich výroby, jejich použití a farmaceutický prostředek |
| AP9600817A0 (en) * | 1995-06-06 | 1996-07-31 | Pfizer | Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt. |
| WO1998010778A1 (en) * | 1996-09-12 | 1998-03-19 | Idun Pharmaceuticals, Inc. | INHIBITION OF APOPTOSIS USING INTERLEUKIN-1β-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS |
| IL128940A0 (en) * | 1996-09-12 | 2000-02-17 | Idun Pharmaceuticals Inc | C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ice/ced-3 family of cysteine proteases and pharmaceutical compositions containing them |
| FR2766188B1 (fr) | 1997-07-15 | 2000-02-11 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes |
| BRPI9909660B8 (pt) * | 1998-03-19 | 2021-05-25 | Vertex Pharma | compostos inibidores de caspases, composição farmacêutica e uso de ditos compostos |
| US7053056B2 (en) | 1998-07-02 | 2006-05-30 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6630473B1 (en) | 1999-01-29 | 2003-10-07 | Senju Pharmaceutical Co., Ltd. | Anti-inflammatory agents and inhibitors against increase in ocular tension caused by irradiation with lasers, containing 1,4-dihydropyridine derivatives |
| DE60142470D1 (de) | 2000-04-24 | 2010-08-12 | Vertex Pharma | Verfahren und zwischenprodukte zur herstellung von substituierten asparaginsäure-acetalen |
| PE20011350A1 (es) * | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| CA2380935A1 (en) | 2000-05-23 | 2001-11-29 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| AU2001275279B2 (en) | 2000-06-07 | 2007-01-04 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| PE20020500A1 (es) | 2000-09-13 | 2002-06-25 | Vertex Pharma | Derivados de piperidina, tetrahidroquinolina, tetrahidroisoquinolina como inhibidores de caspasas |
| MXPA03009647A (es) | 2001-04-19 | 2004-01-29 | Vertex Pharma | Heterociclildicarbamidas como inhibidores de caspasa. |
| US6645994B1 (en) | 2001-06-01 | 2003-11-11 | Alcon, Inc. | Method of treating dry eye disorders |
| WO2003068242A1 (en) | 2002-02-11 | 2003-08-21 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
| CA2768700C (en) * | 2004-03-12 | 2014-04-29 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
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2005
- 2005-02-28 EP EP05724143A patent/EP1718639A2/en not_active Withdrawn
- 2005-02-28 CA CA2557645A patent/CA2557645C/en not_active Expired - Fee Related
- 2005-02-28 JP JP2007500824A patent/JP2007525503A/ja active Pending
- 2005-02-28 CN CN2010106215884A patent/CN102161656B/zh not_active Expired - Fee Related
- 2005-02-28 EP EP10013186A patent/EP2270004A1/en not_active Withdrawn
- 2005-02-28 AR ARP050100737A patent/AR047981A1/es unknown
- 2005-02-28 AU AU2005219861A patent/AU2005219861B2/en not_active Ceased
- 2005-02-28 NZ NZ549665A patent/NZ549665A/en not_active IP Right Cessation
- 2005-02-28 WO PCT/US2005/006540 patent/WO2005085236A2/en not_active Ceased
- 2005-02-28 BR BRPI0508102-5A patent/BRPI0508102A/pt not_active IP Right Cessation
- 2005-02-28 KR KR1020067019903A patent/KR20060129069A/ko not_active Ceased
- 2005-02-28 US US11/069,895 patent/US7652153B2/en not_active Expired - Fee Related
- 2005-02-28 RU RU2006134258/04A patent/RU2382780C2/ru not_active IP Right Cessation
- 2005-03-01 TW TW094106099A patent/TWI362381B/zh not_active IP Right Cessation
- 2005-03-01 TW TW101100244A patent/TW201217332A/zh unknown
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2006
- 2006-08-27 IL IL177709A patent/IL177709A0/en not_active IP Right Cessation
- 2006-09-12 ZA ZA2006/07634A patent/ZA200607634B/en unknown
- 2006-09-26 NO NO20064351A patent/NO20064351L/no not_active Application Discontinuation
- 2006-09-26 NO NO20064344A patent/NO20064344L/no unknown
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2009
- 2009-12-03 US US12/630,350 patent/US20100105914A1/en not_active Abandoned
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2011
- 2011-04-21 JP JP2011095553A patent/JP2011144203A/ja not_active Withdrawn
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2014
- 2014-05-09 JP JP2014097786A patent/JP2014140385A/ja active Pending
Also Published As
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| AU2005219861B2 (en) | 2011-08-11 |
| WO2005085236A3 (en) | 2005-10-20 |
| WO2005085236A2 (en) | 2005-09-15 |
| JP2014140385A (ja) | 2014-08-07 |
| BRPI0508102A (pt) | 2007-07-17 |
| US20050233979A1 (en) | 2005-10-20 |
| TW201217332A (en) | 2012-05-01 |
| RU2382780C2 (ru) | 2010-02-27 |
| US7652153B2 (en) | 2010-01-26 |
| NO20064344L (no) | 2006-10-19 |
| EP1718639A2 (en) | 2006-11-08 |
| RU2006134258A (ru) | 2008-04-10 |
| JP2011144203A (ja) | 2011-07-28 |
| HK1159614A1 (en) | 2012-08-03 |
| EP2270004A1 (en) | 2011-01-05 |
| AR047981A1 (es) | 2006-03-15 |
| HK1099757A1 (en) | 2007-08-24 |
| KR20060129069A (ko) | 2006-12-14 |
| CN102161656A (zh) | 2011-08-24 |
| AU2005219861A1 (en) | 2005-09-15 |
| CA2557645A1 (en) | 2005-09-15 |
| NZ549665A (en) | 2010-09-30 |
| JP2007525503A (ja) | 2007-09-06 |
| NO20064351L (no) | 2006-11-20 |
| ZA200607634B (en) | 2008-01-08 |
| US20100105914A1 (en) | 2010-04-29 |
| IL177709A0 (en) | 2006-12-31 |
| TW200540152A (en) | 2005-12-16 |
| CN102161656B (zh) | 2013-02-20 |
| CA2557645C (en) | 2013-09-24 |
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