AR047981A1 - Inhibidores de caspasa y sus usos correspondientes - Google Patents

Inhibidores de caspasa y sus usos correspondientes

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Publication number
AR047981A1
AR047981A1 ARP050100737A ARP050100737A AR047981A1 AR 047981 A1 AR047981 A1 AR 047981A1 AR P050100737 A ARP050100737 A AR P050100737A AR P050100737 A ARP050100737 A AR P050100737A AR 047981 A1 AR047981 A1 AR 047981A1
Authority
AR
Argentina
Prior art keywords
aliphatic
group
optionally
ring
cor9
Prior art date
Application number
ARP050100737A
Other languages
English (en)
Spanish (es)
Inventor
Jean-Damien Charrier
Steven Durrant
Michael Mortimore
Donnell Michael O
Alistair Rutherford
Sharn Ramaya
John R Studley
Martin Trudeau
Adam Looker
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34923260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR047981(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR047981A1 publication Critical patent/AR047981A1/es

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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ARP050100737A 2004-02-27 2005-02-28 Inhibidores de caspasa y sus usos correspondientes AR047981A1 (es)

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200103406T2 (tr) * 1998-03-19 2002-06-21 Vertex Pharmaceuticals Incorporated Kaspaz inhibitörleri.
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
CA2559303C (en) * 2004-03-12 2013-09-10 Vertex Pharmaceuticals Incorporated Processes and intermediates for the preparation of aspartic acetal caspase inhibitors
CN102362867A (zh) * 2004-05-15 2012-02-29 沃泰克斯药物股份有限公司 使用ice抑制剂治疗癫痫发作
EP1778221A2 (en) * 2004-05-27 2007-05-02 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
WO2011094426A1 (en) * 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Caspase inhibitors
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
WO2015175381A1 (en) 2014-05-12 2015-11-19 Conatus Pharmaceuticals, Inc. Treatment of the complications of chronic liver disease with caspase inhibitors
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
JP2019500397A (ja) 2015-12-31 2019-01-10 クオナトウス ファーマシューティカルズ，インコーポレイテッド カスパーゼ阻害剤を肝疾患の治療に使用する方法
CN105853408B (zh) * 2016-04-15 2018-12-04 浙江大学 苯酰胺衍生物在制备Caspase-1抑制剂中的应用
RU2019113150A (ru) 2016-10-05 2020-11-06 Новартис Аг Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients
WO2024044098A2 (en) * 2022-08-23 2024-02-29 Alexion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
DE59508773D1 (de) * 1994-07-22 2000-11-09 Byk Gulden Lomberg Chem Fab Dihydrobenzofurane
EP0832066B1 (en) * 1995-06-06 2001-09-12 Pfizer Inc. Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors
AU738048B2 (en) * 1996-09-12 2001-09-06 Idun Pharmaceuticals, Inc. Inhibition of apoptosis using interleukin-1beta-converting enzyme (ICE)/CED-3 family inhibitors
AU739321B2 (en) * 1996-09-12 2001-10-11 Idun Pharmaceuticals, Incorporated C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
FR2766188B1 (fr) 1997-07-15 2000-02-11 Hoechst Marion Roussel Inc Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
TR200103406T2 (tr) * 1998-03-19 2002-06-21 Vertex Pharmaceuticals Incorporated Kaspaz inhibitörleri.
US7053056B2 (en) 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
CA2360689A1 (en) 1999-01-29 2000-08-03 Senju Pharmaceutical Co., Ltd. Anti-inflammatory agents and inhibitors against increase in ocular tension caused by irradiation with lasers, containing 1,4-dihydropyridine derivatives
ES2347133T3 (es) 2000-04-24 2010-10-26 Vertex Pharmaceuticals Incorporated Procedimiento e intermedios para preparar acetales de acido aspartico sustituidos.
PE20011350A1 (es) * 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
AR028619A1 (es) 2000-05-23 2003-05-14 Vertex Pharma Un compuesto inhibidor de caspasas
EP1289993B9 (en) 2000-06-07 2008-08-20 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
EP1317454B1 (en) 2000-09-13 2011-05-25 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
EP1381602A1 (en) 2001-04-19 2004-01-21 Vertex Pharmaceuticals Incorporated Heterocyclyldicarbamides as caspase inhibitors
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
AU2003211052A1 (en) 2002-02-11 2003-09-04 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
CA2559303C (en) * 2004-03-12 2013-09-10 Vertex Pharmaceuticals Incorporated Processes and intermediates for the preparation of aspartic acetal caspase inhibitors

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IL177709A0 (en) 2006-12-31
NO20064344L (no) 2006-10-19
AU2005219861B2 (en) 2011-08-11
TW200540152A (en) 2005-12-16
WO2005085236A2 (en) 2005-09-15
RU2006134258A (ru) 2008-04-10
TW201217332A (en) 2012-05-01
TWI362381B (en) 2012-04-21
EP2270004A1 (en) 2011-01-05
ZA200607634B (en) 2008-01-08
BRPI0508102A (pt) 2007-07-17
RU2382780C2 (ru) 2010-02-27
JP2014140385A (ja) 2014-08-07
US7652153B2 (en) 2010-01-26
KR20060129069A (ko) 2006-12-14
JP2007525503A (ja) 2007-09-06
HK1099757A1 (en) 2007-08-24
AU2005219861A1 (en) 2005-09-15
NZ549665A (en) 2010-09-30
CN102161656A (zh) 2011-08-24
CN102161656B (zh) 2013-02-20
CA2557645C (en) 2013-09-24
CA2557645A1 (en) 2005-09-15
US20050233979A1 (en) 2005-10-20
WO2005085236A3 (en) 2005-10-20
NO20064351L (no) 2006-11-20
JP2011144203A (ja) 2011-07-28
HK1159614A1 (en) 2012-08-03
US20100105914A1 (en) 2010-04-29

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