CA2534570A1 - Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use - Google Patents

Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use Download PDF

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Publication number
CA2534570A1
CA2534570A1 CA002534570A CA2534570A CA2534570A1 CA 2534570 A1 CA2534570 A1 CA 2534570A1 CA 002534570 A CA002534570 A CA 002534570A CA 2534570 A CA2534570 A CA 2534570A CA 2534570 A1 CA2534570 A1 CA 2534570A1
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Canada
Prior art keywords
methods
diseases
isoindol
dihydro
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA002534570A
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English (en)
French (fr)
Inventor
Christopher Tegley
Jeffrey A. Adams
Benny C. Askew, Jr.
Michael Croghan
Daniel Elbaum
Julie Germain
Gregory J. Habgood
Scott Harried
Aiwen Li
Nobuko Nishimura
Rana Nomak
Andrew Tasker
Kevin Yang
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Amgen Inc
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Individual
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Publication of CA2534570A1 publication Critical patent/CA2534570A1/en
Abandoned legal-status Critical Current

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    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
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  • Pulmonology (AREA)
  • Manufacturing & Machinery (AREA)
  • Ceramic Engineering (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Structural Engineering (AREA)
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  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
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CA002534570A 2003-08-25 2004-08-25 Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use Abandoned CA2534570A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US49787803P 2003-08-25 2003-08-25
US60/497,878 2003-08-25
US10/926,238 US7320992B2 (en) 2003-08-25 2004-08-24 Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US10/926,238 2004-08-24
PCT/US2004/027595 WO2005021532A1 (en) 2003-08-25 2004-08-25 Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use

Publications (1)

Publication Number Publication Date
CA2534570A1 true CA2534570A1 (en) 2005-03-10

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ID=34228620

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CA002534570A Abandoned CA2534570A1 (en) 2003-08-25 2004-08-25 Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use

Country Status (10)

Country Link
US (1) US7320992B2 (OSRAM)
EP (1) EP1664027B1 (OSRAM)
JP (1) JP2007503450A (OSRAM)
AT (1) ATE453636T1 (OSRAM)
AU (1) AU2004269000A1 (OSRAM)
CA (1) CA2534570A1 (OSRAM)
DE (1) DE602004024900D1 (OSRAM)
ES (1) ES2337062T3 (OSRAM)
MX (1) MXPA06001923A (OSRAM)
WO (1) WO2005021532A1 (OSRAM)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006237920A1 (en) * 2005-04-19 2006-10-26 Kyowa Hakko Kirin Co., Ltd. Nitrogen-containing heterocyclic compound
WO2006134989A1 (ja) * 2005-06-15 2006-12-21 Kyowa Hakko Kogyo Co., Ltd. 含窒素複素環化合物
ES2434946T3 (es) * 2005-08-31 2013-12-18 Celgene Corporation Compuestos de isoindol imida y composiciones que los comprenden y métodos para usarlo
US7989461B2 (en) 2005-12-23 2011-08-02 Amgen Inc. Substituted quinazolinamine compounds for the treatment of cancer
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
PE20080695A1 (es) * 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
WO2008005910A2 (en) * 2006-07-06 2008-01-10 Bristol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
NZ578096A (en) * 2007-01-10 2011-11-25 Albany Molecular Res Inc 5-pyridinone substituted indazoles
US20110053953A1 (en) * 2007-02-09 2011-03-03 Abdelmalik Slassi AZA-Isoindolones and Their Use as Metabotropic Glutamate Receptor Potentiators - 613
AU2008229383B2 (en) 2007-03-20 2013-09-05 Celgene Corporation 4'-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
ES2382982T3 (es) * 2007-07-21 2012-06-15 Albany Molecular Research, Inc. Indazoles sustituidos con 5-piridinona y composiciones farmacéuticas de los mismos
TW200918062A (en) * 2007-09-12 2009-05-01 Wyeth Corp Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists
EP2573080A1 (en) * 2007-09-27 2013-03-27 The United States of America, as Represented by the Secretary, Department of Health and Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
US8329711B2 (en) * 2007-10-23 2012-12-11 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
KR101068835B1 (ko) * 2007-10-26 2011-09-30 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를가지는 이소인돌론 화합물 및 이의 제조 방법
WO2009072581A1 (ja) * 2007-12-05 2009-06-11 Aska Pharmaceutical Co., Ltd. ラクタム化合物又はその塩及びｐｐａｒ活性化剤
US20110092452A1 (en) * 2008-03-05 2011-04-21 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating pancreatic cancer
AU2009245791B2 (en) 2008-05-08 2013-05-16 Basf Se Method for manufacturing aryl carboxamides
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
CN102369199A (zh) 2009-04-01 2012-03-07 巴斯夫欧洲公司 用于防治无脊椎动物害虫的异*唑啉化合物
WO2011006803A1 (en) * 2009-07-14 2011-01-20 Nerviano Medical Sciences S.R.L. 3-0x0-2, 3, -dihydro-lh-isoindole-4-carboxamides with selective parp-1 inhibition
AU2010294209A1 (en) * 2009-09-10 2012-03-29 Irm Llc Ether derivatives of bicyclic heteroaryls
AU2010303567B2 (en) * 2009-10-06 2016-06-09 Millennium Pharmaceuticals, Inc Heterocyclic compounds useful as PDK1 inhibitors
US8440710B2 (en) 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
DK2516434T3 (en) 2009-12-23 2015-08-31 Takeda Pharmaceutical FUSED HETEROAROMATIC PYRROLIDINONS AS SICK INHIBITORS
WO2012177714A1 (en) 2011-06-22 2012-12-27 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
AR088320A1 (es) 2011-10-14 2014-05-28 Incyte Corp Derivados de isoindolinona y pirrolopiridinona como inhibidores de akt
EP2821401B1 (en) 2012-03-02 2020-09-09 Takeda Pharmaceutical Company Limited Dihydroquinolinone compounds as modulators of the muscarininc m1 receptor
EP2921480B1 (en) * 2012-11-19 2017-10-11 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound
JP2016521259A (ja) * 2013-03-20 2016-07-21 バイエル・ファルマ・アクティエンゲゼルシャフト 置換Ｎ−ビフェニル−３−アセチルアミノ−ベンズアミドおよびＮ−［３−（アセチルアミノ）フェニル］−ビフェニル−カルボキサミドならびにＷｎｔシグナル伝達経路の阻害剤としてのそれらの使用
EP4019518A1 (en) * 2014-02-28 2022-06-29 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
EP3119757B1 (en) 2014-03-17 2018-05-16 Pfizer Inc Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders
EP3144308B1 (en) * 2014-05-16 2020-06-24 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound
US11071793B2 (en) * 2014-08-29 2021-07-27 Chdi Foundation, Inc. Probes for imaging huntingtin protein
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
KR101789430B1 (ko) * 2016-06-28 2017-10-25 동국대학교 산학협력단 Smo 저해 활성을 갖는 신규 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 조성물
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
EP3743063A4 (en) * 2018-01-26 2021-10-20 Nurix Therapeutics, Inc. CBL-B INHIBITORS AND THEIR METHODS OF USE
CA3106239A1 (en) 2018-07-27 2020-01-30 Biotheryx, Inc. Bifunctional compounds as cdk modulators
AU2020272937B2 (en) 2019-04-09 2024-09-26 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for Cbl-b inhibition, and use of a Cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
JP7587528B2 (ja) 2019-05-17 2024-11-20 ニューリックス セラピューティクス，インコーポレイテッド Ｃｂｌ－ｂ阻害のためのシアノシクロブチル化合物及びその使用
CA3144450A1 (en) 2019-06-26 2020-12-30 Nurix Therapeutics, Inc. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof
WO2021032935A1 (en) * 2019-08-21 2021-02-25 Kalvista Pharmaceuticals Limited Enzyme inhibitors
US12121540B2 (en) 2019-09-24 2024-10-22 Nurix Therapeutics, Inc. CBL inhibitors and compositions for use in adoptive cell therapy
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications
MX2023011883A (es) 2021-04-08 2023-11-09 Nurix Therapeutics Inc Terapias combinadas con compuestos inhibidores de cbl-b.
CN118201918A (zh) * 2021-11-04 2024-06-14 莱德克斯制药公共有限公司 用于治疗癌症和纤维化疾病的ddr1和ddr2抑制剂

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005722A1 (en) 1988-11-21 1990-05-31 Eastman Kodak Company Phthalimide compounds for forming amorphous layers by vacuum deposition
US5032598A (en) 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
JPH04445A (ja) 1990-04-17 1992-01-06 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の処理方法
US5231099A (en) 1991-04-15 1993-07-27 Du Pont Merck Pharmaceutical Company Use of sigma receptor antagonists to enhance the effects of antipsychotic drugs
US5324743A (en) 1992-12-10 1994-06-28 Eli Lilly And Company Leukotriene B4 antagonists
NZ277556A (en) 1993-12-27 1997-06-24 Eisai Co Ltd N-phenyl(alkyl)- and n-pyridyl(alkyl)anthranilic acid derivatives; intermediates
FR2717812B1 (fr) 1994-03-28 1996-05-10 Rhone Poulenc Rorer Sa Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
JPH10500402A (ja) 1994-04-29 1998-01-13 武田薬品工業株式会社 縮合複素環化合物またはその塩、その製造法および用途
US5789434A (en) 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
HUT76640A (en) 1995-08-17 1997-10-28 Chinoin Gyogyszer Es Vegyeszet Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use
AU1618697A (en) 1996-02-06 1997-08-28 Japan Tobacco Inc. Novel compounds and pharmaceutical use thereof
US5932582A (en) 1996-06-28 1999-08-03 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5798368A (en) * 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
DE19650975A1 (de) 1996-12-09 1998-06-10 Basf Ag Neue heterocyclisch substituierte Benzamide und deren Anwendung
KR19980074060A (ko) 1997-03-21 1998-11-05 김윤배 신규한 치환된 3,4-디알콕시페닐 유도체
JP2001511448A (ja) 1997-07-31 2001-08-14 セルジーン コーポレイション 置換アルカノヒドロキサム酸およびＴＮＦαレベルの減少方法
AU1556299A (en) 1997-12-17 1999-07-05 Novo Nordisk A/S Novel pyridine and pyrimidine derivatives
US20010006973A1 (en) 1998-03-16 2001-07-05 Hon-Wah Man 1-oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels
US6020358A (en) 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
US6667316B1 (en) 1999-11-12 2003-12-23 Celgene Corporation Pharmaceutically active isoindoline derivatives
US6482951B2 (en) * 2000-12-13 2002-11-19 Hoffmann-La Roche Inc. Isoindolin-1-one glucokinase activators
US20030045552A1 (en) * 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof

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ATE453636T1 (de) 2010-01-15
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US20050054670A1 (en) 2005-03-10
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