CA2526365A1 - Methods and compositions for amino acid production - Google Patents
Methods and compositions for amino acid production Download PDFInfo
- Publication number
- CA2526365A1 CA2526365A1 CA002526365A CA2526365A CA2526365A1 CA 2526365 A1 CA2526365 A1 CA 2526365A1 CA 002526365 A CA002526365 A CA 002526365A CA 2526365 A CA2526365 A CA 2526365A CA 2526365 A1 CA2526365 A1 CA 2526365A1
- Authority
- CA
- Canada
- Prior art keywords
- polypeptide
- variant
- bacterium
- nucleic acid
- bacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47500003P | 2003-05-30 | 2003-05-30 | |
US60/475,000 | 2003-05-30 | ||
US55186004P | 2004-03-10 | 2004-03-10 | |
US60/551,860 | 2004-03-10 | ||
PCT/US2004/017513 WO2004108894A2 (en) | 2003-05-30 | 2004-06-01 | Methods and compositions for amino acid production |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2526365A1 true CA2526365A1 (en) | 2004-12-16 |
Family
ID=33514039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002526365A Abandoned CA2526365A1 (en) | 2003-05-30 | 2004-06-01 | Methods and compositions for amino acid production |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1633851A4 (ko) |
JP (1) | JP2007525951A (ko) |
KR (1) | KR20060018868A (ko) |
AU (1) | AU2004245988A1 (ko) |
BR (1) | BRPI0410861A (ko) |
CA (1) | CA2526365A1 (ko) |
WO (1) | WO2004108894A2 (ko) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2275424C2 (ru) | 2003-12-05 | 2006-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-треонина с использованием бактерий, принадлежащих к роду escherichia |
AU2004295615A1 (en) * | 2003-12-05 | 2005-06-16 | Ajinomoto Co., Inc. | L-threonine producing bacterium belonging to the genus Escherichia and method for producing L-threonine |
US7723097B2 (en) * | 2005-03-11 | 2010-05-25 | Archer-Daniels-Midland Company | Escherichia coli strains that over-produce L-threonine and processes for their production |
DE602006018468D1 (de) * | 2005-07-18 | 2011-01-05 | Evonik Degussa Gmbh | Verwendung von dimethyldisulfid für die methioninproduktion in mikroorganismen |
BRPI0614716A2 (pt) * | 2005-08-05 | 2011-04-12 | Univ Michigan State | método para produção de um produto quìmico a partir da via c4 de a. succinogenes |
JP2007068437A (ja) * | 2005-09-05 | 2007-03-22 | Chisso Corp | 変異型アスパルトキナーゼとその利用方法 |
DK2314710T3 (en) | 2006-01-04 | 2016-06-13 | Metabolic Explorer Sa | A process for the production of methionine by culturing a microorganism modified to enhance the production of cysteine |
WO2008033001A1 (en) * | 2006-09-15 | 2008-03-20 | Cj Cheiljedang Corporation | A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same |
KR20080061801A (ko) * | 2006-12-28 | 2008-07-03 | 씨제이제일제당 (주) | L-메티오닌 생산능을 향상시키는 폴리펩타이드, 상기 폴리펩타이드를 과발현하는 미생물 및 상기 미생물을 이용한 l- 메티오닌 생산방법 |
US20090215133A1 (en) * | 2007-02-02 | 2009-08-27 | Evonik Degussa Gmbh | Production of l-lysine and l-lysine-containing feed additives |
PL2808382T3 (pl) * | 2007-04-11 | 2016-09-30 | Kompozycje i sposoby wytwarzania metioniny | |
US8283152B2 (en) * | 2009-08-28 | 2012-10-09 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
KR101250651B1 (ko) * | 2010-12-21 | 2013-04-03 | 씨제이제일제당 (주) | 신규 o-아세틸호모세린 설피드릴라제 또는 변이체 및 이를 이용한 메치오닌 전환 방법 |
MY173933A (en) * | 2010-12-21 | 2020-02-27 | Cj Cheiljedang Corp | Modified polypeptide having homoserine acetyltransferase activity and microorganism expressing the same |
KR101485222B1 (ko) * | 2012-10-05 | 2015-01-22 | 상지대학교산학협력단 | dapA 활성 조절을 통해 L-쓰레오닌 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 L-쓰레오닌 생산방법 |
KR101947959B1 (ko) | 2018-05-28 | 2019-02-13 | 씨제이제일제당 (주) | 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법 |
KR101996769B1 (ko) | 2018-12-21 | 2019-10-01 | 씨제이제일제당 (주) | 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법 |
CA3143318A1 (en) * | 2019-06-14 | 2020-12-17 | Cj Cheiljedang Corporation | Composition for preventing, treating, or improving gastrointestinal diseases comprising strain of genus corynebacterium and culture thereof |
KR102472559B1 (ko) * | 2019-06-28 | 2022-12-01 | 씨제이제일제당 주식회사 | 황 함유 아미노산 또는 그 유도체의 제조방법 |
WO2024084049A2 (en) | 2022-10-20 | 2024-04-25 | Cysbio Aps | Genetically modified host cells producing l-serine |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4601983A (en) * | 1983-06-15 | 1986-07-22 | Ajinomoto Co., Inc. | Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine |
EP0754756B1 (en) * | 1994-03-04 | 2005-11-09 | Ajinomoto Co., Inc. | Process for producing l-lysine |
DK2194122T3 (en) * | 1998-04-13 | 2016-02-15 | Univ Georgia | Overexpression of pyruvate carboxylase increased the production of biochemicals derived from oxaloacetate, in microbial cells |
US6451564B1 (en) * | 1999-07-02 | 2002-09-17 | Massachusetts Institute Of Technology | Methods for producing L-isoleucine |
DE10239082A1 (de) * | 2002-08-26 | 2004-03-04 | Basf Ag | Verfahren zur fermentativen Herstellung schwefelhaltiger Feinchemikalien |
-
2004
- 2004-06-01 AU AU2004245988A patent/AU2004245988A1/en not_active Abandoned
- 2004-06-01 EP EP04754180A patent/EP1633851A4/en not_active Withdrawn
- 2004-06-01 WO PCT/US2004/017513 patent/WO2004108894A2/en active Application Filing
- 2004-06-01 KR KR1020057022952A patent/KR20060018868A/ko not_active Application Discontinuation
- 2004-06-01 BR BRPI0410861-2A patent/BRPI0410861A/pt not_active IP Right Cessation
- 2004-06-01 CA CA002526365A patent/CA2526365A1/en not_active Abandoned
- 2004-06-01 JP JP2006515133A patent/JP2007525951A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2007525951A (ja) | 2007-09-13 |
EP1633851A4 (en) | 2009-04-08 |
BRPI0410861A (pt) | 2006-05-23 |
WO2004108894A3 (en) | 2007-11-22 |
WO2004108894A2 (en) | 2004-12-16 |
EP1633851A2 (en) | 2006-03-15 |
KR20060018868A (ko) | 2006-03-02 |
AU2004245988A1 (en) | 2004-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |