WO2004108894A3 - Methods and compositions for amino acid production - Google Patents

Methods and compositions for amino acid production Download PDF

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Publication number
WO2004108894A3
WO2004108894A3 PCT/US2004/017513 US2004017513W WO2004108894A3 WO 2004108894 A3 WO2004108894 A3 WO 2004108894A3 US 2004017513 W US2004017513 W US 2004017513W WO 2004108894 A3 WO2004108894 A3 WO 2004108894A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
amino acid
acid production
disclosed
Prior art date
Application number
PCT/US2004/017513
Other languages
French (fr)
Other versions
WO2004108894A2 (en
Inventor
Richard B Bailey
Paul Blomquist
Reed Doten
Edward M Driggers
Kevin T Madden
Jessica O'leary
George A O'toole
Joshua Trueheart
Michael J Walbridge
Peter Yorgey
Original Assignee
Microbia Inc
Richard B Bailey
Paul Blomquist
Reed Doten
Edward M Driggers
Kevin T Madden
Jessica O'leary
George A O'toole
Joshua Trueheart
Michael J Walbridge
Peter Yorgey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbia Inc, Richard B Bailey, Paul Blomquist, Reed Doten, Edward M Driggers, Kevin T Madden, Jessica O'leary, George A O'toole, Joshua Trueheart, Michael J Walbridge, Peter Yorgey filed Critical Microbia Inc
Priority to BRPI0410861-2A priority Critical patent/BRPI0410861A/en
Priority to JP2006515133A priority patent/JP2007525951A/en
Priority to AU2004245988A priority patent/AU2004245988A1/en
Priority to CA002526365A priority patent/CA2526365A1/en
Priority to EP04754180A priority patent/EP1633851A4/en
Publication of WO2004108894A2 publication Critical patent/WO2004108894A2/en
Publication of WO2004108894A3 publication Critical patent/WO2004108894A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Methods and compositions for amino acid production using genetically modified bacteria are disclosed.
PCT/US2004/017513 2003-05-30 2004-06-01 Methods and compositions for amino acid production WO2004108894A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BRPI0410861-2A BRPI0410861A (en) 2003-05-30 2004-06-01 methods and compositions for the production of amino acids
JP2006515133A JP2007525951A (en) 2003-05-30 2004-06-01 Methods and compositions for amino acid production
AU2004245988A AU2004245988A1 (en) 2003-05-30 2004-06-01 Methods and compositions for amino acid production
CA002526365A CA2526365A1 (en) 2003-05-30 2004-06-01 Methods and compositions for amino acid production
EP04754180A EP1633851A4 (en) 2003-05-30 2004-06-01 Methods and compositions for amino acid production

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47500003P 2003-05-30 2003-05-30
US60/475,000 2003-05-30
US55186004P 2004-03-10 2004-03-10
US60/551,860 2004-03-10

Publications (2)

Publication Number Publication Date
WO2004108894A2 WO2004108894A2 (en) 2004-12-16
WO2004108894A3 true WO2004108894A3 (en) 2007-11-22

Family

ID=33514039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/017513 WO2004108894A2 (en) 2003-05-30 2004-06-01 Methods and compositions for amino acid production

Country Status (7)

Country Link
EP (1) EP1633851A4 (en)
JP (1) JP2007525951A (en)
KR (1) KR20060018868A (en)
AU (1) AU2004245988A1 (en)
BR (1) BRPI0410861A (en)
CA (1) CA2526365A1 (en)
WO (1) WO2004108894A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2275424C2 (en) 2003-12-05 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Method for preparing l-threonine by using bacterium belonging to genus escherichia
WO2005054490A1 (en) * 2003-12-05 2005-06-16 Ajinomoto Co., Inc. L-threonine producing bacterium belonging to the genus escherichia and method for producing l-threonine
US7723097B2 (en) * 2005-03-11 2010-05-25 Archer-Daniels-Midland Company Escherichia coli strains that over-produce L-threonine and processes for their production
BRPI0612900A8 (en) * 2005-07-18 2022-07-19 Basf Ag METHODS TO PRODUCE METHIONINE, TO IMPROVE THE USE OF DMDS FOR METHIONINE PRODUCTION, AND TO IDENTIFY A MUTANT ALLELE, COMPOSITION, METHIONINE CONTAINING PRODUCT, MICROORGANISM, ISOLATED GENE, MUTANT O-ACETYL-HOMOSERINE SULPHYDRYLASE OR O-SUCCINYL-HOMOSERINE ENZYMES SULPHYDRYLASE, AND ORGANISM
CA2618694A1 (en) * 2005-08-05 2007-02-15 Michigan State University Genes from actinobacillus succinogenes 13oz (atcc 55618) for production of chemicals from the a. succinogenes c4-pathway
JP2007068437A (en) * 2005-09-05 2007-03-22 Chisso Corp Variant aspartokinase and method for utilizing the same
ES2459617T3 (en) 2006-01-04 2014-05-12 Metabolic Explorer Procedure for the preparation of methionine and its homoserine or succinylhomoserine precursors using a microorganism
AU2007295159B2 (en) * 2006-09-15 2012-09-13 Cj Cheiljedang Corporation A Corynebacteria having enhanced L-lysine productivity and a method of producing L-lysine using the same
KR20080061801A (en) * 2006-12-28 2008-07-03 씨제이제일제당 (주) Novel l-methionine exporter
WO2008092956A1 (en) * 2007-02-02 2008-08-07 Evonik Degussa Gmbh Production of l-lysine and l-lysine-containing feed additives
PL2520645T3 (en) 2007-04-11 2015-05-29 Cj Cheiljedang Corp Compositions and methods of producing methionine
US8283152B2 (en) * 2009-08-28 2012-10-09 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
KR101250651B1 (en) * 2010-12-21 2013-04-03 씨제이제일제당 (주) New O-acetylhomoserine sulfhydrylase or mutants, and L-methionine conversion method uging the enzyme
CN103797027B (en) * 2010-12-21 2017-05-17 Cj 第一制糖株式会社 Variant polypeptide having homoserine acetyltransferase activity and microorganism expressing same
KR101485222B1 (en) * 2012-10-05 2015-01-22 상지대학교산학협력단 Corynebacterium sp. microorganism having enhanced L-threonine productivity by regulation of dapA activity and a method of producing L-threonine using the same
KR101947959B1 (en) 2018-05-28 2019-02-13 씨제이제일제당 (주) A modified homoserine dehydrogenase and a method for producing homoserine or L- amino acid derived from homoserine using the same
KR101996769B1 (en) * 2018-12-21 2019-10-01 씨제이제일제당 (주) A homoserine dehydrogenase variant and a method for producing homoserine or L-amino acid derived from homoserine using the same
JP7293406B2 (en) * 2019-06-14 2023-06-19 シージェイ チェルジェダン コーポレイション Composition for prevention, treatment or improvement of gastrointestinal disease containing Corynebacterium strain and its culture
KR102472559B1 (en) * 2019-06-28 2022-12-01 씨제이제일제당 주식회사 A method of producing sulfur-containing amino acids and derivatives thereof
WO2024084049A2 (en) 2022-10-20 2024-04-25 Cysbio Aps Genetically modified host cells producing l-serine

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US4601983A (en) * 1983-06-15 1986-07-22 Ajinomoto Co., Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine
CN1117152C (en) * 1994-03-04 2003-08-06 味之素株式会社 Process for production L-lysine
AU760575C (en) * 1998-04-13 2005-04-14 University Of Georgia Research Foundation, Inc., The Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6451564B1 (en) * 1999-07-02 2002-09-17 Massachusetts Institute Of Technology Methods for producing L-isoleucine
DE10239082A1 (en) * 2002-08-26 2004-03-04 Basf Ag Fermentative production of sulfur-containing fine chemicals, useful e.g. as feed additive, by culturing bacteria containing heterologous sequence for O-acetylhomoserine sulfhydrolase

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DEB ET AL.: "Plasmids of corynebacteria", FEMS MICROBIOL. LETT., vol. 175, no. 11/12, 1999, pages 11 - 20, XP001038258 *
KOBASHI ET AL.: "Characterization of Aspartate Kinase III of Bacillus subtilis", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 65, no. 6, 2001, pages 1391 - 1394, XP003022482 *
See also references of EP1633851A4 *

Also Published As

Publication number Publication date
BRPI0410861A (en) 2006-05-23
KR20060018868A (en) 2006-03-02
EP1633851A4 (en) 2009-04-08
JP2007525951A (en) 2007-09-13
AU2004245988A1 (en) 2004-12-16
CA2526365A1 (en) 2004-12-16
EP1633851A2 (en) 2006-03-15
WO2004108894A2 (en) 2004-12-16

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