EP1633851A4 - Methods and compositions for amino acid production - Google Patents

Methods and compositions for amino acid production

Info

Publication number
EP1633851A4
EP1633851A4 EP04754180A EP04754180A EP1633851A4 EP 1633851 A4 EP1633851 A4 EP 1633851A4 EP 04754180 A EP04754180 A EP 04754180A EP 04754180 A EP04754180 A EP 04754180A EP 1633851 A4 EP1633851 A4 EP 1633851A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
amino acid
acid production
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04754180A
Other languages
German (de)
French (fr)
Other versions
EP1633851A2 (en
Inventor
Richard B Bailey
Paul Blomquist
Reed Doten
Edward M Driggers
Kevin T Madden
Jessica O'leary
George A O'toole
Joshua Trueheart
Michael J Walbridge
Peter Yorgey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbia Inc
Original Assignee
Microbia Precision Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbia Precision Engineering Inc filed Critical Microbia Precision Engineering Inc
Publication of EP1633851A2 publication Critical patent/EP1633851A2/en
Publication of EP1633851A4 publication Critical patent/EP1633851A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
EP04754180A 2003-05-30 2004-06-01 Methods and compositions for amino acid production Withdrawn EP1633851A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47500003P 2003-05-30 2003-05-30
US55186004P 2004-03-10 2004-03-10
PCT/US2004/017513 WO2004108894A2 (en) 2003-05-30 2004-06-01 Methods and compositions for amino acid production

Publications (2)

Publication Number Publication Date
EP1633851A2 EP1633851A2 (en) 2006-03-15
EP1633851A4 true EP1633851A4 (en) 2009-04-08

Family

ID=33514039

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04754180A Withdrawn EP1633851A4 (en) 2003-05-30 2004-06-01 Methods and compositions for amino acid production

Country Status (7)

Country Link
EP (1) EP1633851A4 (en)
JP (1) JP2007525951A (en)
KR (1) KR20060018868A (en)
AU (1) AU2004245988A1 (en)
BR (1) BRPI0410861A (en)
CA (1) CA2526365A1 (en)
WO (1) WO2004108894A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101117513B1 (en) * 2003-12-05 2012-03-15 아지노모토 가부시키가이샤 L-Threonine producing bacterium belonging to the genus Escherichia and method for producing L-threonine
RU2275424C2 (en) 2003-12-05 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Method for preparing l-threonine by using bacterium belonging to genus escherichia
US7723097B2 (en) * 2005-03-11 2010-05-25 Archer-Daniels-Midland Company Escherichia coli strains that over-produce L-threonine and processes for their production
ATE489471T1 (en) * 2005-07-18 2010-12-15 Evonik Degussa Gmbh USE OF DIMETHYL DISULFIDE FOR METHIONINE PRODUCTION IN MICROORGANISMS
KR20080031504A (en) * 2005-08-05 2008-04-08 미시간 스테이트 유니버시티 Genes from actinobacillus succinogenes 13oz (atcc 55618) for production of chemicals from the a. succinogenes c4-pathway
JP2007068437A (en) * 2005-09-05 2007-03-22 Chisso Corp Variant aspartokinase and method for utilizing the same
CN101351558B (en) * 2006-01-04 2013-08-14 代谢探索者公司 Method preparing methilanin and prosome homoserine or succinyl homoserine thereof using sulphate permease expression-enhanced tiny organism
WO2008033001A1 (en) * 2006-09-15 2008-03-20 Cj Cheiljedang Corporation A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same
KR20080061801A (en) * 2006-12-28 2008-07-03 씨제이제일제당 (주) Novel l-methionine exporter
US20090215133A1 (en) * 2007-02-02 2009-08-27 Evonik Degussa Gmbh Production of l-lysine and l-lysine-containing feed additives
PL2808382T3 (en) * 2007-04-11 2016-09-30 Compositions and methods of producing methionine
US8283152B2 (en) * 2009-08-28 2012-10-09 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
KR101250651B1 (en) 2010-12-21 2013-04-03 씨제이제일제당 (주) New O-acetylhomoserine sulfhydrylase or mutants, and L-methionine conversion method uging the enzyme
ES2650451T3 (en) * 2010-12-21 2018-01-18 Cj Cheiljedang Corporation Polypeptide variant that has homoserine acetyltransferase activity and microorganism that expresses the same
KR101485222B1 (en) * 2012-10-05 2015-01-22 상지대학교산학협력단 Corynebacterium sp. microorganism having enhanced L-threonine productivity by regulation of dapA activity and a method of producing L-threonine using the same
KR101947959B1 (en) * 2018-05-28 2019-02-13 씨제이제일제당 (주) A modified homoserine dehydrogenase and a method for producing homoserine or L- amino acid derived from homoserine using the same
KR101996769B1 (en) * 2018-12-21 2019-10-01 씨제이제일제당 (주) A homoserine dehydrogenase variant and a method for producing homoserine or L-amino acid derived from homoserine using the same
MX2021015557A (en) * 2019-06-14 2022-05-30 Cj Cheiljedang Corp Composition for preventing, treating, or improving gastrointestinal diseases comprising strain of genus corynebacterium and culture thereof.
KR102472559B1 (en) * 2019-06-28 2022-12-01 씨제이제일제당 주식회사 A method of producing sulfur-containing amino acids and derivatives thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4601983A (en) * 1983-06-15 1986-07-22 Ajinomoto Co., Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine
US5766925A (en) * 1994-03-04 1998-06-16 Ajinomoto Co., Inc. Method of producing L-lysine
WO1999053035A1 (en) * 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6451564B1 (en) * 1999-07-02 2002-09-17 Massachusetts Institute Of Technology Methods for producing L-isoleucine
WO2004024933A2 (en) * 2002-08-26 2004-03-25 Basf Aktiengesellschaft Method for zymotic production of fine chemicals (mety) containing sulphur

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4601983A (en) * 1983-06-15 1986-07-22 Ajinomoto Co., Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine
US5766925A (en) * 1994-03-04 1998-06-16 Ajinomoto Co., Inc. Method of producing L-lysine
WO1999053035A1 (en) * 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6451564B1 (en) * 1999-07-02 2002-09-17 Massachusetts Institute Of Technology Methods for producing L-isoleucine
WO2004024933A2 (en) * 2002-08-26 2004-03-25 Basf Aktiengesellschaft Method for zymotic production of fine chemicals (mety) containing sulphur

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARCHER J A C ET AL: "A C-terminal deletion in Corynebacterium glutamicum homoserine dehydrogenase abolishes allosteric inhibition by l-threonine", GENE, ELSEVIER, AMSTERDAM, NL, vol. 107, no. 1, 30 October 1991 (1991-10-30), pages 53 - 59, XP023539886, ISSN: 0378-1119, [retrieved on 19911030] *
FERNÁNDEZ MÓNICA ET AL: "Characterization of the hom-thrC-thrB cluster in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.", MICROBIOLOGY (READING, ENGLAND) MAY 2002 LNKD- PUBMED:11988515, vol. 148, no. Pt 5, May 2002 (2002-05-01), pages 1413 - 1420, ISSN: 1350-0872 *
SRITHARAN V. ET AL: "METABOLISM OF ASPARTATE IN MYCOBACTERIUM-SMEGMATIS", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 180, no. 3, 1989, pages 587 - 594, ISSN: 0014-2956 *

Also Published As

Publication number Publication date
AU2004245988A1 (en) 2004-12-16
CA2526365A1 (en) 2004-12-16
JP2007525951A (en) 2007-09-13
WO2004108894A2 (en) 2004-12-16
WO2004108894A3 (en) 2007-11-22
BRPI0410861A (en) 2006-05-23
KR20060018868A (en) 2006-03-02
EP1633851A2 (en) 2006-03-15

Similar Documents

Publication Publication Date Title
EP1578447A4 (en) Methods and compositions for increasing antibody production
IL173382A0 (en) Amino acid prodrugs
EP1633851A4 (en) Methods and compositions for amino acid production
EP1569943A4 (en) Method for preparation of amino acid chelate
IL173726A (en) Pharmaceutical compositions comprising n-n-dihaloamino acid and uses thereof
EP1701725A4 (en) Methods and compositions
EP1680535A4 (en) Electroplating compositions and methods for electroplating
HK1156311A1 (en) Preparation of pyridonecarboxylic acid antibacterials
EP1648416A4 (en) Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EG24152A (en) Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
EP1845979A4 (en) Methods and compositions for decreasing saliva production
AU2003291443A8 (en) Compositions and processes for nanoimprinting
GB0303609D0 (en) Novel therapeutic method and compositions
HK1116417A1 (en) Amino acid derivatives
EP1552826A4 (en) Amino acid compositions for improving central functions
EP1569973A4 (en) Microgel composition and process for preparation thereof
EP1630207A4 (en) White powder and method for production thereof
PL366653A1 (en) Method for manufacture of polyorganooxosilane compositions
ZA200508655B (en) Compositions and methods relating to stop-1
EP1482937A4 (en) Novel tyloindicines and related processes, pharmaceutical compositions and methods
ZA200510463B (en) Methods and compositions for amino acid production
HK1100424A1 (en) Oral preparations and process for production thereof
IL176019A0 (en) Process for preparation of substituted amino alcohols
PT1768988E (en) Novel phenyl-boronic acid derivatives and methods for the preparation thereof
EP1738755A4 (en) Tablet containing branched chain amino acid and process for producing the same

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20051215

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL HR LT LV MK

DAX Request for extension of the european patent (deleted)
RIN1 Information on inventor provided before grant (corrected)

Inventor name: YORGEY, PETER

Inventor name: WALBRIDGE, MICHAEL, J.

Inventor name: TRUEHEART, JOSHUA

Inventor name: O'TOOLE, GEORGE, A.

Inventor name: O'LEARY, JESSICA

Inventor name: MADDEN, KEVIN, T.

Inventor name: DRIGGERS, EDWARD, M.

Inventor name: DOTEN, REED

Inventor name: BLOMQUIST, PAUL

Inventor name: BAILEY, RICHARD, B.

PUAK Availability of information related to the publication of the international search report

Free format text: ORIGINAL CODE: 0009015

RIC1 Information provided on ipc code assigned before grant

Ipc: C07H 21/02 20060101ALI20080104BHEP

Ipc: C07K 1/00 20060101ALI20080104BHEP

Ipc: C12N 9/14 20060101ALI20080104BHEP

Ipc: C12N 9/02 20060101ALI20080104BHEP

Ipc: C07H 21/04 20060101ALI20080104BHEP

Ipc: C12N 15/00 20060101ALI20080104BHEP

Ipc: C12N 1/20 20060101ALI20080104BHEP

Ipc: C12N 9/12 20060101ALI20080104BHEP

Ipc: C12N 9/00 20060101AFI20080104BHEP

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MICROBIA PRECISION ENGINEERING, INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20090309

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MICROBIA, INC.

17Q First examination report despatched

Effective date: 20100610

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20101221