CA2516319C - Method for preparing 17.alpha.-acetoxy-11.beta.-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates - Google Patents

Method for preparing 17.alpha.-acetoxy-11.beta.-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates Download PDF

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Publication number
CA2516319C
CA2516319C CA2516319A CA2516319A CA2516319C CA 2516319 C CA2516319 C CA 2516319C CA 2516319 A CA2516319 A CA 2516319A CA 2516319 A CA2516319 A CA 2516319A CA 2516319 C CA2516319 C CA 2516319C
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CA
Canada
Prior art keywords
compound
formula
alpha
epoxide
beta
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2516319A
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English (en)
French (fr)
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CA2516319A1 (en
Inventor
Hyun K. Kim
Pemmaraju N. Rao
Anne-Marie Simmons
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Texas Biomedical Research Institute
United States Department of Health and Human Services
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Texas Biomedical Research Institute
United States Department of Health and Human Services
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Application granted granted Critical
Publication of CA2516319C publication Critical patent/CA2516319C/en
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Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2516319A 2003-02-28 2004-02-13 Method for preparing 17.alpha.-acetoxy-11.beta.-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates Expired - Fee Related CA2516319C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45109603P 2003-02-28 2003-02-28
US60/451,096 2003-02-28
PCT/US2004/004246 WO2004078709A2 (en) 2003-02-28 2004-02-13 METHOD FOR PREPARING 17 α-ACETOXY-11β-(4-N,N-DIMETHYLAMINOPHENYL)-19-NORPREGNA-4,9-DIENE-3,20-DIONE, INTERMEDIATES THEREOF, AND METHODS FOR THE PREPARATION OF SUCH INTERMEDIATES

Publications (2)

Publication Number Publication Date
CA2516319A1 CA2516319A1 (en) 2004-09-16
CA2516319C true CA2516319C (en) 2012-09-18

Family

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CA2516319A Expired - Fee Related CA2516319C (en) 2003-02-28 2004-02-13 Method for preparing 17.alpha.-acetoxy-11.beta.-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates

Country Status (6)

Country Link
US (1) US20060111577A1 (enExample)
EP (1) EP1613640A4 (enExample)
JP (1) JP2006519255A (enExample)
AU (1) AU2004217988C1 (enExample)
CA (1) CA2516319C (enExample)
WO (1) WO2004078709A2 (enExample)

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CN102344478B (zh) * 2011-07-22 2013-08-07 上海希迈医药科技有限公司 一种17α-乙酰氧基-11β-(4-N,N-二甲氨基苯基)-19-去甲孕甾-4,9-二烯-3,20-二酮的结晶物及其制备方法
CN102321141B (zh) * 2011-07-22 2013-05-15 上海希迈医药科技有限公司 一种17α-乙酰氧基-11β-（4-N,N-二甲氨基苯基）-19-去甲孕甾-4，9-二烯-3,20-二酮的无定形物及其制备方法
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EP2641602A1 (en) 2012-03-23 2013-09-25 PregLem S.A. Method for treating gynecological diseases
CN103755765B (zh) * 2012-04-17 2018-01-02 常州市第四制药厂有限公司 醋酸乌利司他的多晶型及其制备方法
CN102675395B (zh) * 2012-04-17 2014-04-30 常州市第四制药厂有限公司 醋酸乌利司他的多晶型及其制备方法
HUE037889T2 (hu) 2012-05-25 2018-09-28 Hra Pharma Lab Ulipristal acetát melltumorok megelõzésére és kezelésére
CN102702296B (zh) * 2012-06-19 2014-09-03 山东诚创医药技术开发有限公司 环-3,20-双(1,2-亚乙基缩醛)-17α-羟基-17β-乙酰基-雌甾-5(10),9(11)-二烯-3-酮的制备方法
WO2014050107A1 (en) 2012-09-28 2014-04-03 Aska Pharmaceutical Co., Ltd. Crystalline polymorphic form of ulipristal acetate
JP6474722B2 (ja) 2012-09-28 2019-02-27 あすか製薬株式会社 ウリプリスタール酢酸エステルの結晶多形
JP6200493B2 (ja) * 2012-09-28 2017-09-20 あすか製薬株式会社 無定形ウリプリスタール酢酸エステル
WO2014060888A1 (en) 2012-10-18 2014-04-24 Lupin Limited Novel process and intermediate for preparation of ulipristal
CN102942612A (zh) * 2012-10-30 2013-02-27 四川大学 一种合成醋酸乌利司他的新方法
CN103804456B (zh) * 2012-11-15 2017-08-04 上海创诺医药集团有限公司 醋酸乌利司他中间体及其制备方法
KR20150139919A (ko) 2013-04-10 2015-12-14 쁘레글렘 에스아 자궁 섬유종의 치료에서 사용하기 위한 프로게스테론 수용체 조절제
HU230319B1 (hu) * 2013-10-01 2016-01-28 Richter Gedeon Nyrt. Ipari eljárás szteroid hatóanyagok előállítására
RU2017112748A (ru) 2014-11-17 2018-12-19 Арно Терапьютикс, Инк. Композиции онапристона пролонгированного действия и способы
AU2016326657B2 (en) 2015-09-25 2019-10-24 Context Biopharma, Inc. Methods of making onapristone intermediates
HK1255104A1 (zh) 2015-12-15 2019-08-02 Context Biopharma Inc. 无定形的奥那司酮组合物及其制备方法
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
CN110028543B (zh) * 2018-01-11 2024-04-12 上海汇伦医药股份有限公司 一种醋酸优力司特的制备方法

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Also Published As

Publication number Publication date
AU2004217988C1 (en) 2010-06-03
EP1613640A4 (en) 2010-05-19
AU2004217988A1 (en) 2004-09-16
CA2516319A1 (en) 2004-09-16
WO2004078709A2 (en) 2004-09-16
US20060111577A1 (en) 2006-05-25
AU2004217988B2 (en) 2009-12-10
JP2006519255A (ja) 2006-08-24
WO2004078709A3 (en) 2005-02-24
EP1613640A2 (en) 2006-01-11

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