CA2511806A1 - Indole-derivative modulators of steroid hormone nuclear receptors - Google Patents
Indole-derivative modulators of steroid hormone nuclear receptors Download PDFInfo
- Publication number
- CA2511806A1 CA2511806A1 CA002511806A CA2511806A CA2511806A1 CA 2511806 A1 CA2511806 A1 CA 2511806A1 CA 002511806 A CA002511806 A CA 002511806A CA 2511806 A CA2511806 A CA 2511806A CA 2511806 A1 CA2511806 A1 CA 2511806A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- phenyl
- methyl
- compound according
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 0 CC(*)(*)C(/C1=C/*/C=C2)=C(*)N(*)/C1=C/*2=* Chemical compound CC(*)(*)C(/C1=C/*/C=C2)=C(*)N(*)/C1=C/*2=* 0.000 description 1
Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- Obesity (AREA)
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- Urology & Nephrology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44194703P | 2003-01-22 | 2003-01-22 | |
| US60/441,947 | 2003-01-22 | ||
| PCT/US2004/000017 WO2004067529A1 (en) | 2003-01-22 | 2004-01-20 | Indole-derivative modulators of steroid hormone nuclear receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2511806A1 true CA2511806A1 (en) | 2004-08-12 |
Family
ID=32825176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002511806A Abandoned CA2511806A1 (en) | 2003-01-22 | 2004-01-20 | Indole-derivative modulators of steroid hormone nuclear receptors |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060235222A1 (enExample) |
| EP (1) | EP1597254A1 (enExample) |
| JP (1) | JP2007500253A (enExample) |
| CN (1) | CN1742007A (enExample) |
| AU (1) | AU2004207740A1 (enExample) |
| BR (1) | BRPI0406883A (enExample) |
| CA (1) | CA2511806A1 (enExample) |
| MX (1) | MXPA05007857A (enExample) |
| WO (1) | WO2004067529A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| DE102004021637A1 (de) * | 2004-05-03 | 2005-12-01 | Merck Patent Gmbh | Dihydrobenzothiophene |
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| GEP20115239B (en) | 2006-10-31 | 2011-06-10 | Pfizer Prod Inc | Pyrazoline compounds as mineralocorticoid receptor antagonists |
| JP2010138072A (ja) * | 2007-03-29 | 2010-06-24 | Dainippon Sumitomo Pharma Co Ltd | 新規な縮合ピロール誘導体 |
| KR20090018593A (ko) | 2007-08-17 | 2009-02-20 | 주식회사 엘지생명과학 | 세포괴사 저해제로서의 인돌 및 인다졸 화합물 |
| DE102008030207A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung |
| DE102008030206A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung |
| CN102711729B (zh) | 2009-08-21 | 2015-04-01 | 诺万公司 | 局部用凝胶 |
| WO2011137220A1 (en) * | 2010-04-28 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Small molecule neuropeptide s antagonists for the treatment of addictive disorders, mood, anxiety and sleep disorders |
| ES2641144T3 (es) | 2010-05-10 | 2017-11-07 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Métodos y composiciones para el tratamiento de la acumulación de líquido en y/o bajo la retina |
| US10414760B2 (en) | 2016-11-29 | 2019-09-17 | Angion Biomedica Corp. | Cytochrome P450 inhibitors and uses thereof |
| EP2576544A4 (en) * | 2010-06-01 | 2013-09-11 | Angion Biomedica Corp | INHIBITORS OF CYTOCHROMES P450 AND USES THEREOF |
| US9241944B2 (en) | 2010-06-16 | 2016-01-26 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Methods and compositions for stimulating reepithelialisation during wound healing |
| EP2665707B1 (en) * | 2011-01-20 | 2017-01-18 | Merck Sharp & Dohme Corp. | Mineralocorticoid receptor antagonists |
| EP2697203B1 (en) * | 2011-04-13 | 2017-05-24 | Merck Sharp & Dohme Corporation | Mineralocorticoid receptor antagonists |
| AR091731A1 (es) * | 2012-07-19 | 2015-02-25 | Merck Sharp & Dohme | Antagonistas del receptor de mineralocorticoides |
| WO2014094357A1 (en) * | 2012-12-21 | 2014-06-26 | Abbvie Inc. | Heterocyclic nuclear hormone receptor modulators |
| AU2015301891B2 (en) | 2014-08-11 | 2019-12-05 | Angion Biomedica Corporation | Cytochrome P450 inhibitors and uses thereof |
| US10189819B2 (en) | 2014-12-10 | 2019-01-29 | Merck Sharp & Dohme, Corp. | Factor IXa inhibitors |
| EP3240778A4 (en) | 2014-12-31 | 2018-07-11 | Angion Biomedica Corp. | Methods and agents for treating disease |
| ES2906778T3 (es) * | 2015-03-30 | 2022-04-20 | Corcept Therapeutics Inc | Uso de antagonistas del receptor de glucocorticoides en combinación con glucocorticoides para tratar la insuficiencia suprarrenal |
| TN2018000020A1 (en) * | 2015-07-20 | 2019-07-08 | Genzyme Corp | Colony stimulating factor-1 receptor (csf-1r) inhibitors. |
| CN109053736A (zh) * | 2018-08-08 | 2018-12-21 | 青岛科技大学 | 一种吡咯并[1,2-α]吲哚-3-醇衍生物的制备方法 |
| CN109293550B (zh) * | 2018-11-23 | 2020-09-25 | 南京林业大学 | 一种含三氟甲基3,6’-非对称双吲哚化合物及其合成方法 |
| JP2024500919A (ja) | 2020-12-23 | 2024-01-10 | ジェンザイム・コーポレーション | 重水素化コロニー刺激因子-1受容体(csf-1r)阻害剤 |
| CN115894330B (zh) * | 2022-09-06 | 2024-12-10 | 吉林医药学院 | 一种1-乙酰基-1h-吲哚-3-基乙酸酯衍生物的合成方法和应用 |
| WO2024229040A1 (en) * | 2023-05-01 | 2024-11-07 | Seed Therapeutics, Inc | Heteroaromatic indolesulfonamides |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2750283C2 (de) * | 1977-11-10 | 1985-08-22 | Bayer Ag, 5090 Leverkusen | Druck- und wärmeempfindliches Aufzeichnungsmaterial |
| JPS62503194A (ja) * | 1985-07-03 | 1987-12-17 | ポラロイド コ−ポレ−シヨン | カラー拡散転写写真フィルム単位 |
| US5041547A (en) * | 1986-08-28 | 1991-08-20 | Appleton Papers Inc. | Chromogenic substituted 4,7-diazaphthalides |
| GB9609641D0 (en) * | 1996-05-09 | 1996-07-10 | Pfizer Ltd | Compounds useful in therapy |
| CN1492863A (zh) * | 2000-12-22 | 2004-04-28 | 作为5-羟色胺-6配基的杂环基烷基-吲哚或氮杂吲哚化合物 |
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2004
- 2004-01-20 CN CNA2004800026858A patent/CN1742007A/zh active Pending
- 2004-01-20 JP JP2006536489A patent/JP2007500253A/ja active Pending
- 2004-01-20 US US10/542,621 patent/US20060235222A1/en not_active Abandoned
- 2004-01-20 MX MXPA05007857A patent/MXPA05007857A/es unknown
- 2004-01-20 WO PCT/US2004/000017 patent/WO2004067529A1/en not_active Ceased
- 2004-01-20 AU AU2004207740A patent/AU2004207740A1/en not_active Abandoned
- 2004-01-20 CA CA002511806A patent/CA2511806A1/en not_active Abandoned
- 2004-01-20 EP EP04703558A patent/EP1597254A1/en not_active Withdrawn
- 2004-01-20 BR BR0406883-1A patent/BRPI0406883A/pt not_active IP Right Cessation
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| AU2004207740A1 (en) | 2004-08-12 |
| US20060235222A1 (en) | 2006-10-19 |
| JP2007500253A (ja) | 2007-01-11 |
| WO2004067529A1 (en) | 2004-08-12 |
| BRPI0406883A (pt) | 2006-01-03 |
| MXPA05007857A (es) | 2005-10-18 |
| EP1597254A1 (en) | 2005-11-23 |
| CN1742007A (zh) | 2006-03-01 |
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