CA2502437A1 - Procede et composition contenant du latanoprost destines au traitement de l'hypertension oculaire et d'un glaucome - Google Patents
Procede et composition contenant du latanoprost destines au traitement de l'hypertension oculaire et d'un glaucome Download PDFInfo
- Publication number
- CA2502437A1 CA2502437A1 CA002502437A CA2502437A CA2502437A1 CA 2502437 A1 CA2502437 A1 CA 2502437A1 CA 002502437 A CA002502437 A CA 002502437A CA 2502437 A CA2502437 A CA 2502437A CA 2502437 A1 CA2502437 A1 CA 2502437A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- ophthalmic composition
- ophthalmic
- benzalkonium chloride
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract 53
- 208000010412 Glaucoma Diseases 0.000 title claims abstract 9
- 206010030043 Ocular hypertension Diseases 0.000 title claims abstract 9
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 title claims abstract 8
- 229960001160 latanoprost Drugs 0.000 title claims abstract 8
- 238000000034 method Methods 0.000 title claims 17
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract 16
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract 16
- 208000001344 Macular Edema Diseases 0.000 claims abstract 5
- 206010025415 Macular oedema Diseases 0.000 claims abstract 5
- 239000004480 active ingredient Substances 0.000 claims abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 5
- 208000035475 disorder Diseases 0.000 claims abstract 5
- 201000010230 macular retinal edema Diseases 0.000 claims abstract 5
- 239000003795 chemical substances by application Substances 0.000 claims 12
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 6
- 229940054534 ophthalmic solution Drugs 0.000 claims 6
- 239000002997 ophthalmic solution Substances 0.000 claims 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 6
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 6
- 229920000053 polysorbate 80 Polymers 0.000 claims 6
- 229940068968 polysorbate 80 Drugs 0.000 claims 6
- 229960004605 timolol Drugs 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Abstract
L'invention concerne une composition ophthalmique permettant de traiter l'hypertension oculaire et un glaucome avec des effets secondaires réduits, tels qu'une kératoconjonctivité et un oedème maculaire. Cette composition contient du latanoprost comme substance active et est sensiblement exempte de chlorure de benzalkonium. La composition selon l'invention est particulièrement utile pour le traitement d'un patient souffrant ou susceptible de souffrir d'une kératoconjonctivité et/ou d'un oedème maculaire.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42077602P | 2002-10-24 | 2002-10-24 | |
US60/420,776 | 2002-10-24 | ||
US42104402P | 2002-10-25 | 2002-10-25 | |
US60/421,044 | 2002-10-25 | ||
US10/429,677 US7074827B2 (en) | 2002-10-24 | 2003-05-06 | Method for treating ocular hypertension and glaucoma |
US10/429,677 | 2003-05-06 | ||
PCT/JP2003/013452 WO2004037267A1 (fr) | 2002-10-24 | 2003-10-22 | Procede et composition contenant du latanoprost destines au traitement de l'hypertension oculaire et d'un glaucome |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2502437A1 true CA2502437A1 (fr) | 2004-05-06 |
CA2502437C CA2502437C (fr) | 2012-07-17 |
Family
ID=32110845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2502437A Expired - Fee Related CA2502437C (fr) | 2002-10-24 | 2003-10-22 | Procede et composition contenant du latanoprost destines au traitement de l'hypertension oculaire et d'un glaucome |
Country Status (9)
Country | Link |
---|---|
US (2) | US7074827B2 (fr) |
EP (2) | EP2253322A1 (fr) |
JP (2) | JP2006503913A (fr) |
AT (1) | ATE480240T1 (fr) |
AU (1) | AU2003274734A1 (fr) |
CA (1) | CA2502437C (fr) |
DE (1) | DE60334134D1 (fr) |
DK (1) | DK1553953T3 (fr) |
WO (1) | WO2004037267A1 (fr) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004283091A1 (en) * | 2003-10-03 | 2005-05-06 | Allergan, Inc. | Compositions and methods comprising prostaglandin-related compounds and trefoil factor family peptides for the treatment of glaucoma with reduced hyperemia |
ATE412400T1 (de) * | 2004-11-09 | 2008-11-15 | Novagali Pharma Sa | Öl-in-wasser-emulsion mit niedriger konzentration des kationischen mittels und positivem zetapotential |
GB0501192D0 (en) * | 2005-01-20 | 2005-03-02 | Resolution Chemicals Ltd | Stable prostaglandin-containing compositions |
DE102005035986B4 (de) * | 2005-07-28 | 2009-10-15 | Bausch & Lomb Incorporated | Steriles tropfbares mehrphasiges emulgatorfreies ophthalmisches Präparat |
CN101282714B (zh) * | 2005-10-10 | 2012-12-12 | 诺瓦加利制药公司 | 包含前列腺素的眼用乳剂 |
CA2681668C (fr) | 2006-03-23 | 2014-04-01 | Michael S. Singer | Compositions comprenant des analogues de la prostaglandine f2-alpha et procedes pour reduire la graisse corporelle |
TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
EP2066300B2 (fr) * | 2006-09-28 | 2019-01-23 | Novartis Ag | Compositions pharmaceutiques aqueuses à conservation spontanée |
FR2912207B1 (fr) * | 2007-02-01 | 2012-10-26 | Air Liquide | Procede et appareil de production de monoxyde de carbone par distillation cryogenique |
WO2008096804A1 (fr) * | 2007-02-07 | 2008-08-14 | Teika Pharmaceutical Co., Ltd. | Préparation de gouttes ophtalmiques comprenant du latanoprost |
JP2008247828A (ja) * | 2007-03-30 | 2008-10-16 | Wakamoto Pharmaceut Co Ltd | ラタノプロストを含有する水性医薬組成物。 |
FR2918891B1 (fr) * | 2007-07-20 | 2009-09-25 | Thea Sa Lab | Solution ophtalmique a base de prostaglandines sans conservateur |
JP2009040727A (ja) * | 2007-08-09 | 2009-02-26 | Towa Yakuhin Kk | ラタノプロストを有効成分とする安定な点眼液剤 |
JP5327809B2 (ja) * | 2007-08-29 | 2013-10-30 | わかもと製薬株式会社 | ラタノプロスト含有水性医薬組成物 |
MX2007011165A (es) * | 2007-09-12 | 2009-03-11 | Arturo Jimenez Bayardo | Composición farmacéutica estable de timolol, dorzolamida y brimonidina. |
JP5583111B2 (ja) * | 2008-03-17 | 2014-09-03 | アルコン リサーチ, リミテッド | ボレート−ポリオール錯体を含有する水性薬学的組成物 |
TWI544927B (zh) * | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
EP2127638A1 (fr) | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Procédé et composition pour traiter l'hypertension oculaire et le glaucome |
EP2228058A1 (fr) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Émulsion anionique d'huile dans l'eau contenant des prostaglandines et leurs utilisations |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
US20100298335A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and Methods for Ameliorating or Reducing Presbyopia |
JP2010275259A (ja) * | 2009-05-29 | 2010-12-09 | Toa Yakuhin Kk | 均一、かつ安定なラタノプロスト点眼液剤組成物 |
TWI489997B (zh) * | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸-多元醇錯合物之水性藥學組成物 |
EP2269575A1 (fr) | 2009-06-30 | 2011-01-05 | Santen Pharmaceutical Co., Ltd | Procédé pour améliorer le biodisponibilité du latanoprost |
EP2389939A1 (fr) | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Utilisation de prostaglandines F2alpha et analogues pour la cicatrisation des lésions de la cornée et du conjonctif |
KR101656121B1 (ko) | 2010-03-17 | 2016-09-08 | 노바리크 게엠베하 | 안압 증가를 치료하기 위한 약학 조성물 |
FR2961694B1 (fr) * | 2010-06-29 | 2013-01-25 | Thea Lab | Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur |
WO2012015996A2 (fr) * | 2010-07-29 | 2012-02-02 | Allergan, Inc. | Solutions de bimatoprost sans conservateur |
CA2807081C (fr) * | 2010-07-29 | 2018-09-18 | Allergan, Inc. | Solutions de bimatoprost et de timolol sans conservateur |
US9061034B2 (en) | 2010-07-29 | 2015-06-23 | Allergan, Inc. | Preservative free bimatoprost and timolol solutions |
EP2452669A1 (fr) | 2010-10-29 | 2012-05-16 | Omnivision GmbH | Composition ophtalmique |
EP2462921A1 (fr) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Compositions pharmaceutiques liquides pour le traitement d'une maladie de la chambre postérieure de l'oeil |
EP3378480A1 (fr) | 2011-01-19 | 2018-09-26 | Topokine Therapeutics, Inc. | Procédés et compositions de traitement du syndrome métabolique |
US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
CN107970506B (zh) * | 2012-04-10 | 2020-06-16 | 艾诺维亚股份有限公司 | 具有可控制的微滴电荷的定向微滴流在制备药物中的用途 |
EA201491906A1 (ru) | 2012-04-20 | 2015-03-31 | Айновиа, Инк. | Распылительное эжекторное устройство и способы его использования |
KR102168906B1 (ko) | 2012-05-14 | 2020-10-22 | 아이노비아 인코포레이티드 | 층류 액적 생성기 디바이스 및 이용 방법들 |
EP2849949A4 (fr) | 2012-05-15 | 2017-07-26 | Eyenovia, Inc. | Dispositifs éjecteurs, procédés, pilotes, et circuits correspondants |
JP6039152B2 (ja) | 2012-09-12 | 2016-12-07 | ノバリック ゲーエムベーハー | 半フッ素化アルカン組成物 |
CA2869676C (fr) | 2012-11-21 | 2015-06-23 | Topokine Therapeutics, Inc. | Utilisations et compositions comprenant de la thiazolidinedione et de l'acide oleique pour augmenter localement la graisse sous-cutanee |
WO2014159679A1 (fr) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Procédés pour utiliser la lubiprostone pour absorber un fluide depuis l'espace sous-rétinien |
NO2753788T3 (fr) | 2013-05-10 | 2018-06-16 | ||
US9820993B2 (en) | 2013-05-15 | 2017-11-21 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
TW201542196A (zh) * | 2013-08-26 | 2015-11-16 | Rohto Pharma | 眼科用製劑 |
GR1008483B (el) * | 2013-12-23 | 2015-05-12 | Rafarm Α.Ε.Β.Ε., | Οφθαλμικη φαρμακευτικη συνθεση και μεθοδος για την παρασκευη αυτης |
US10188661B2 (en) | 2014-06-27 | 2019-01-29 | Topokine Therapeutics, Inc. | Topical dosage regimen |
US10326270B2 (en) | 2014-08-05 | 2019-06-18 | Sony Corporation | DC power transmission device, DC power reception device, and DC power transmission system |
DE202016008738U1 (de) | 2015-09-30 | 2019-04-09 | Novaliq Gmbh | Semifluorierte Verbindungen und ihre Zusammensetzungen |
CN108349855B (zh) | 2015-09-30 | 2021-07-20 | 诺瓦利克有限责任公司 | 用于眼部给药的半氟化化合物 |
GR1009040B (el) * | 2016-04-19 | 2017-05-19 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου |
ES2763121T3 (es) | 2016-06-23 | 2020-05-27 | Novaliq Gmbh | Método de administración tópica |
CN116172987A (zh) | 2016-09-22 | 2023-05-30 | 诺瓦利克有限责任公司 | 用于治疗睑缘炎的药物组合物 |
US10813976B2 (en) | 2016-09-23 | 2020-10-27 | Novaliq Gmbh | Ophthalmic compositions comprising ciclosporin |
US11278503B2 (en) | 2017-05-12 | 2022-03-22 | Novaliq Gmbh | Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of contact lense-related conditions |
CN111372566A (zh) | 2017-09-27 | 2020-07-03 | 诺瓦利克有限责任公司 | 用于治疗眼部疾病的包含拉坦前列素的眼科用组合物 |
CN111182893A (zh) | 2017-10-04 | 2020-05-19 | 诺瓦利克有限责任公司 | 包含f6h8的眼用组合物 |
SG11202007858VA (en) | 2018-03-02 | 2020-09-29 | Novaliq Gmbh | Pharmaceutical compositions comprising nebivolol |
SG11202102820VA (en) | 2018-10-12 | 2021-04-29 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
PL3886799T3 (pl) | 2019-08-07 | 2024-03-18 | Aneira Pharma, Inc. | Kompozycje do leczenia utraty włosów |
JP2022120120A (ja) * | 2022-06-13 | 2022-08-17 | 東亜薬品株式会社 | 眼科用水性組成物及びプロスタグランジンF2α誘導体の含量の低下を抑制する方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990002553A1 (fr) * | 1988-09-06 | 1990-03-22 | Pharmacia Ab | Derives de prostaglandine servant au traitement des glaucomes ou de l'hypertension oculaire |
US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
AU665287B2 (en) | 1992-12-21 | 1995-12-21 | Alcon Laboratories, Inc. | Prostaglandin combinations in glaucoma therapy |
WO1997023225A1 (fr) | 1995-12-22 | 1997-07-03 | Alcon Laboratories, Inc. | Combinaisons de prostaglandines de type dp et fp destinees a abaisser la pression intraoculaire |
JPH10259179A (ja) * | 1996-09-19 | 1998-09-29 | Santen Pharmaceut Co Ltd | 多置換アリールオキシ基を有するプロスタグランジン類およびその用途 |
AR002194A1 (es) | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
US6646001B2 (en) * | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
JP4000505B2 (ja) * | 1999-12-01 | 2007-10-31 | 第一三共株式会社 | 緑内障を治療するための併用剤 |
SE0002211D0 (sv) | 2000-06-13 | 2000-06-13 | Synphora Ab | Methods and compositions for prevention of myopia |
US20020035148A1 (en) * | 2000-07-20 | 2002-03-21 | Ryuji Ueno | Treatment of ocular hypertension |
PT1321144E (pt) | 2000-09-13 | 2011-03-10 | Santen Pharmaceutical Co Ltd | Colírio |
JP3876355B2 (ja) * | 2000-09-13 | 2007-01-31 | 参天製薬株式会社 | 点眼液 |
AR035541A1 (es) | 2000-11-13 | 2004-06-16 | Pharmacia Ab | Un metodo de tratamiento para pacientes que sufren de glaucoma severo o necesitan una reduccion de la presion intraocular (pio) y el uso de una combinacion de agentes reductores de la pio |
US8549114B2 (en) * | 2002-06-12 | 2013-10-01 | Bladelogic, Inc. | Method and system for model-based heterogeneous server configuration management |
KR20100132557A (ko) * | 2002-08-23 | 2010-12-17 | 산텐 세이야꾸 가부시키가이샤 | 라타노프로스트를 유효 성분으로 하는 점안액의 안정화 방법 |
KR20050057251A (ko) | 2002-09-09 | 2005-06-16 | 산텐 세이야꾸 가부시키가이샤 | 라타노프로스트를 유효 성분으로 하는 투명한 점안액 |
-
2003
- 2003-05-06 US US10/429,677 patent/US7074827B2/en not_active Expired - Fee Related
- 2003-10-22 WO PCT/JP2003/013452 patent/WO2004037267A1/fr active Application Filing
- 2003-10-22 JP JP2005501572A patent/JP2006503913A/ja active Pending
- 2003-10-22 EP EP10171708A patent/EP2253322A1/fr not_active Withdrawn
- 2003-10-22 AU AU2003274734A patent/AU2003274734A1/en not_active Abandoned
- 2003-10-22 DK DK03758746.6T patent/DK1553953T3/da active
- 2003-10-22 EP EP03758746A patent/EP1553953B1/fr not_active Expired - Lifetime
- 2003-10-22 AT AT03758746T patent/ATE480240T1/de active
- 2003-10-22 DE DE60334134T patent/DE60334134D1/de not_active Expired - Lifetime
- 2003-10-22 CA CA2502437A patent/CA2502437C/fr not_active Expired - Fee Related
-
2006
- 2006-05-23 US US11/438,290 patent/US8673973B2/en not_active Expired - Fee Related
-
2012
- 2012-05-31 JP JP2012125019A patent/JP2012162570A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US8673973B2 (en) | 2014-03-18 |
US20040082660A1 (en) | 2004-04-29 |
WO2004037267A1 (fr) | 2004-05-06 |
CA2502437C (fr) | 2012-07-17 |
US7074827B2 (en) | 2006-07-11 |
DE60334134D1 (de) | 2010-10-21 |
JP2006503913A (ja) | 2006-02-02 |
AU2003274734A1 (en) | 2004-05-13 |
ATE480240T1 (de) | 2010-09-15 |
EP2253322A1 (fr) | 2010-11-24 |
JP2012162570A (ja) | 2012-08-30 |
EP1553953B1 (fr) | 2010-09-08 |
DK1553953T3 (da) | 2010-10-25 |
EP1553953A1 (fr) | 2005-07-20 |
US20060205725A1 (en) | 2006-09-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2502437A1 (fr) | Procede et composition contenant du latanoprost destines au traitement de l'hypertension oculaire et d'un glaucome | |
JP2006503913A5 (fr) | ||
US10792288B2 (en) | Preservative free brimonidine and timolol solutions | |
PL396553A1 (pl) | Zastosowanie czynnika do wytwarzania leku do leczenia jaskry | |
AU772406B2 (en) | Use of H1 antagonist and a safe steroid to treat eye conditions | |
KR101820184B1 (ko) | 방부제가 없는 비마토프로스트 및 티몰롤 용액 | |
JP2011093923A (ja) | 点眼剤 | |
US20150099807A1 (en) | Preservative free bimatoprost solutions | |
JP2002316926A (ja) | コンタクトレンズ用眼科用組成物及び眼刺激性の緩和方法 | |
JP5041761B2 (ja) | 眼粘膜適用製剤 | |
JP2003073303A (ja) | 眼局所用液剤の清涼化作用の持続方法 | |
EP3369422A1 (fr) | Préparation externe | |
MXPA04000980A (es) | Tratamiento de hipertension ocular y glaucoma. | |
JPH06211665A (ja) | ジラゼプを必須成分とする眼圧降下剤 | |
EP1415666A4 (fr) | Compositions de medicaments pour usage ophtalmologique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20151022 |