CA2497794A1 - Agonistes modifies du recepteur glp-1 et leurs procedes pharmacologiques d'utilisation - Google Patents

Agonistes modifies du recepteur glp-1 et leurs procedes pharmacologiques d'utilisation Download PDF

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Publication number
CA2497794A1
CA2497794A1 CA002497794A CA2497794A CA2497794A1 CA 2497794 A1 CA2497794 A1 CA 2497794A1 CA 002497794 A CA002497794 A CA 002497794A CA 2497794 A CA2497794 A CA 2497794A CA 2497794 A1 CA2497794 A1 CA 2497794A1
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CA
Canada
Prior art keywords
polypeptide
glp
diabetes
insulin
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002497794A
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English (en)
Inventor
Clark Pan
James P. Whelan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharmaceuticals Corp
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2497794A1 publication Critical patent/CA2497794A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des agonistes modifiés du récepteur GLP-1 comprenant un agoniste du récepteur GLP-1 lié à un polymère de polyéthylèneglycol de poids moléculaire supérieur à 30 kD, ainsi que des formulations associées, des doses et des procédés d'administration de ces agonistes dans des buts thérapeutiques. Ces agonistes modifiés du récepteur GLP-1, compositions et procédés sont plus particulièrement utiles en ce qu'ils constituent une option de traitement pour ceux qui sont affectés d'un trouble métabolique tel que diabète et état prédiabétique, comme l'intolérance au glucose, et l'altération de la glycémie à jeun, en induisant une sécrétion d'insuline glucodépendante sans réduction de la motilité intestinale.
CA002497794A 2002-09-06 2003-09-04 Agonistes modifies du recepteur glp-1 et leurs procedes pharmacologiques d'utilisation Abandoned CA2497794A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40869602P 2002-09-06 2002-09-06
US60/408,696 2002-09-06
US43936903P 2003-01-09 2003-01-09
US60/439,369 2003-01-09
PCT/US2003/028093 WO2004022004A2 (fr) 2002-09-06 2003-09-04 Agonistes modifies du recepteur glp-1 et leurs procedes pharmacologiques d'utilisation

Publications (1)

Publication Number Publication Date
CA2497794A1 true CA2497794A1 (fr) 2004-03-18

Family

ID=31981605

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002497794A Abandoned CA2497794A1 (fr) 2002-09-06 2003-09-04 Agonistes modifies du recepteur glp-1 et leurs procedes pharmacologiques d'utilisation

Country Status (5)

Country Link
EP (1) EP1539210A4 (fr)
JP (1) JP2006501820A (fr)
AU (1) AU2003273300A1 (fr)
CA (1) CA2497794A1 (fr)
WO (1) WO2004022004A2 (fr)

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EP1539210A4 (fr) 2006-06-07
AU2003273300A1 (en) 2004-03-29
WO2004022004A3 (fr) 2004-12-23
WO2004022004A2 (fr) 2004-03-18
JP2006501820A (ja) 2006-01-19
AU2003273300A8 (en) 2004-03-29

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