CA2479647A1 - Human deubiquitinating protease gene on chromosome 7 and its murine ortholog - Google Patents

Human deubiquitinating protease gene on chromosome 7 and its murine ortholog Download PDF

Info

Publication number
CA2479647A1
CA2479647A1 CA002479647A CA2479647A CA2479647A1 CA 2479647 A1 CA2479647 A1 CA 2479647A1 CA 002479647 A CA002479647 A CA 002479647A CA 2479647 A CA2479647 A CA 2479647A CA 2479647 A1 CA2479647 A1 CA 2479647A1
Authority
CA
Canada
Prior art keywords
ser
pro
lys
ala
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002479647A
Other languages
English (en)
French (fr)
Inventor
Chang Hahn
Hong Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0218518.9A external-priority patent/GB0218518D0/en
Application filed by Individual filed Critical Individual
Publication of CA2479647A1 publication Critical patent/CA2479647A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Plant Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Analytical Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002479647A 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog Abandoned CA2479647A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US36660102P 2002-03-22 2002-03-22
US60/366,601 2002-03-22
GB0218518.9 2002-08-09
GBGB0218518.9A GB0218518D0 (en) 2002-03-22 2002-08-09 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
PCT/US2003/008590 WO2003083050A2 (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog

Publications (1)

Publication Number Publication Date
CA2479647A1 true CA2479647A1 (en) 2003-10-09

Family

ID=28676509

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002479647A Abandoned CA2479647A1 (en) 2002-03-22 2003-03-21 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog

Country Status (8)

Country Link
EP (1) EP1495117A4 (es)
JP (1) JP2005520567A (es)
AU (1) AU2003230701C1 (es)
BR (1) BR0307759A (es)
CA (1) CA2479647A1 (es)
IL (1) IL164088A0 (es)
MX (1) MXPA04006975A (es)
WO (1) WO2003083050A2 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006247A2 (en) * 1995-08-09 1997-02-20 Dana Farber Cancer Institute Deubiquitinating enzymes that regulate cell growth
JP2003510024A (ja) * 1999-08-09 2003-03-18 インサイト・ゲノミックス・インコーポレイテッド プロテアーゼ及びプロテアーゼインヒビター
AU1071901A (en) * 1999-09-29 2001-04-30 Millennium Pharmaceuticals, Inc. 23431, a novel human ubiquitin protease

Also Published As

Publication number Publication date
JP2005520567A (ja) 2005-07-14
WO2003083050A2 (en) 2003-10-09
AU2003230701B2 (en) 2008-06-05
AU2003230701A1 (en) 2003-10-13
WO2003083050A3 (en) 2004-02-26
MXPA04006975A (es) 2004-11-10
EP1495117A4 (en) 2005-06-08
BR0307759A (pt) 2004-12-21
IL164088A0 (en) 2005-12-18
EP1495117A2 (en) 2005-01-12
AU2003230701C1 (en) 2009-08-27

Similar Documents

Publication Publication Date Title
D'Andrea et al. Deubiquitinating enzymes: a new class of biological regulators
Ciechanover The ubiquitin-proteasome proteolytic pathway
Vincenz et al. Fas-associated death domain protein interleukin-1β-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95-and p55-mediated death signaling
Baker et al. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases
Baek et al. DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes
Fujiwara et al. Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease
US6287858B1 (en) DeUBiquitinating enzymes that regulate cell growth
US7179631B2 (en) Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
Chen et al. Proteasome-dependent down-regulation of activated Stat5A in the nucleus
AU2003230701C1 (en) Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
AU2003215370B2 (en) Human analogs of murine deubiquitinating protease genes
US7202073B2 (en) Human analogs of murine deubiquitinating proteases
Tanaka et al. NUB1‐mediated targeting of the ubiquitin precursor UbC1 for its C‐terminal hydrolysis
Baker et al. Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S
Baek et al. Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution
AU2008203478A1 (en) Human analogs of murine deubiquitinating protease genes
KR100532234B1 (ko) 닭 근육에 있는 새로운 유비퀴틴-프로테아제 및 그 유전자
Baek et al. Essential regions of deubiquitinating enzyme activity and enhancer function for DUB-2A expressed in T-lymphocytes
US20050158802A1 (en) UbcH8 Ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an interferon alpha/beta induced Ubiquitin-like protein
JP2002300880A (ja) 新規ユビキチン特異プロテアーゼ
WO1998048020A2 (en) Mammalian ubiquitin-isopeptidases that control cell proliferation
Lin Structure-function relationships of enzymes involved in ubiquitination
JP2001292800A (ja) アポトーシス調節物質のスクリーニング方法
WO2004011636A2 (en) Method of enzymatic deubiquitination
KR20050077663A (ko) 탈유비퀴틴 효소로 작용하는 마우스의 ｍＨＡＵＳＰ, 이를코딩하는 ｃＤＮＡ 및 이를 구성하는 아미노산 서열

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued