CA2479647A1 - Gene humain de la protease de desubiquitination positionnee sur le chromosome 7 et son orthologue murin - Google Patents

Gene humain de la protease de desubiquitination positionnee sur le chromosome 7 et son orthologue murin Download PDF

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Publication number
CA2479647A1
CA2479647A1 CA002479647A CA2479647A CA2479647A1 CA 2479647 A1 CA2479647 A1 CA 2479647A1 CA 002479647 A CA002479647 A CA 002479647A CA 2479647 A CA2479647 A CA 2479647A CA 2479647 A1 CA2479647 A1 CA 2479647A1
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Canada
Prior art keywords
ser
pro
lys
ala
arg
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Abandoned
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CA002479647A
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English (en)
Inventor
Chang Hahn
Hong Liu
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Aventis Pharmaceuticals Inc
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Individual
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Filing date
Publication date
Priority claimed from GBGB0218518.9A external-priority patent/GB0218518D0/en
Application filed by Individual filed Critical Individual
Publication of CA2479647A1 publication Critical patent/CA2479647A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Plant Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Analytical Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Selon l'invention, on a identifié des analogues humains et murins d'enzymes de désubiquitination, des protéases de désubiquitination à spécificité hématopoïétique, inductibles par cytokine, groupées sur le chromosome 7 et leurs régions régulatrices respectives. Le nucléotide ou les protéines codées par celui-ci peuvent être utilisés dans des analyses afin d'identifier les inhibiteurs de hDUB7 ou de mDUB7. L'invention concerne également des peptides de transduction comprenant NLS ou une séquence de transduction de hDUB7 ou mDUB7 liés à une molécule cargo ainsi que des méthodes permettant d'administrer une protéine bioactive, un composé efficace sur le plan thérapeutique, un nucléotide antisens ou un composé de test à une cellule en ajoutant, par voie exogène, un peptide de transduction à une cellule.
CA002479647A 2002-03-22 2003-03-21 Gene humain de la protease de desubiquitination positionnee sur le chromosome 7 et son orthologue murin Abandoned CA2479647A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US36660102P 2002-03-22 2002-03-22
US60/366,601 2002-03-22
GBGB0218518.9A GB0218518D0 (en) 2002-03-22 2002-08-09 Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
GB0218518.9 2002-08-09
PCT/US2003/008590 WO2003083050A2 (fr) 2002-03-22 2003-03-21 Gene humain de la protease de desubiquitination positionnee sur le chromosome 7 et son orthologue murin

Publications (1)

Publication Number Publication Date
CA2479647A1 true CA2479647A1 (fr) 2003-10-09

Family

ID=28676509

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002479647A Abandoned CA2479647A1 (fr) 2002-03-22 2003-03-21 Gene humain de la protease de desubiquitination positionnee sur le chromosome 7 et son orthologue murin

Country Status (8)

Country Link
EP (1) EP1495117A4 (fr)
JP (1) JP2005520567A (fr)
AU (1) AU2003230701C1 (fr)
BR (1) BR0307759A (fr)
CA (1) CA2479647A1 (fr)
IL (1) IL164088A0 (fr)
MX (1) MXPA04006975A (fr)
WO (1) WO2003083050A2 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2229204C (fr) * 1995-08-09 2012-10-09 Alan D. D'andrea Enzymes de desubiquitination regulant la croissance des cellules
CA2374745A1 (fr) * 1999-08-09 2001-02-15 Incyte Genomics, Inc. Proteases et inhibiteurs de proteases
WO2001023589A2 (fr) * 1999-09-29 2001-04-05 Millennium Pharmaceuticals, Inc. Nouvelle ubiquitine protease humaine nommee 23431

Also Published As

Publication number Publication date
WO2003083050A3 (fr) 2004-02-26
EP1495117A4 (fr) 2005-06-08
JP2005520567A (ja) 2005-07-14
EP1495117A2 (fr) 2005-01-12
AU2003230701C1 (en) 2009-08-27
WO2003083050A2 (fr) 2003-10-09
BR0307759A (pt) 2004-12-21
MXPA04006975A (es) 2004-11-10
AU2003230701A1 (en) 2003-10-13
IL164088A0 (en) 2005-12-18
AU2003230701B2 (en) 2008-06-05

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FZDE Discontinued