CA2477785A1 - Isolation, purification and structural identification of a bioactive component of a water soluble extract of a botanical species for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals - Google Patents
Isolation, purification and structural identification of a bioactive component of a water soluble extract of a botanical species for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals Download PDFInfo
- Publication number
- CA2477785A1 CA2477785A1 CA002477785A CA2477785A CA2477785A1 CA 2477785 A1 CA2477785 A1 CA 2477785A1 CA 002477785 A CA002477785 A CA 002477785A CA 2477785 A CA2477785 A CA 2477785A CA 2477785 A1 CA2477785 A1 CA 2477785A1
- Authority
- CA
- Canada
- Prior art keywords
- mammal
- extract
- bioactive component
- quinic acid
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/093,794 US6964784B2 (en) | 2002-03-07 | 2002-03-07 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals |
| US10/093,794 | 2002-03-07 | ||
| PCT/IB2003/000824 WO2003074062A2 (en) | 2002-03-07 | 2003-03-07 | Isolation, purification and structural identification of a bioactive component of a water soluble extract of a botanical species for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2477785A1 true CA2477785A1 (en) | 2003-09-12 |
Family
ID=27788020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002477785A Abandoned CA2477785A1 (en) | 2002-03-07 | 2003-03-07 | Isolation, purification and structural identification of a bioactive component of a water soluble extract of a botanical species for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US6964784B2 (https=) |
| EP (1) | EP1485114A2 (https=) |
| JP (1) | JP2005526053A (https=) |
| KR (1) | KR20040099300A (https=) |
| CN (1) | CN1649610A (https=) |
| AU (1) | AU2003207894A1 (https=) |
| BR (1) | BRPI0308253A2 (https=) |
| CA (1) | CA2477785A1 (https=) |
| IL (1) | IL163886A0 (https=) |
| MX (1) | MXPA04008567A (https=) |
| WO (1) | WO2003074062A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002042429A2 (en) * | 2000-11-03 | 2002-05-30 | Proteotech, Inc. | Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants |
| US6964784B2 (en) * | 2002-03-07 | 2005-11-15 | Optigenex, Inc. | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals |
| BRPI0409179A (pt) | 2003-04-04 | 2006-05-02 | Unigen Pharmaceuticals Inc | formulação de inibidores duplos de ciclooxigenase (cox) e lipoxigenase (lox) para cuidados com a pele de mamìferos |
| ES2402996T5 (es) † | 2004-04-01 | 2017-06-28 | Industrial Farmacéutica Cantabria, S.A. | Composiciones fotoprotectoras y/o fotoinmunoprotectoras de la piel y sus usos |
| US20050226825A1 (en) * | 2004-04-13 | 2005-10-13 | Giampapa Vincent C | Topical composition for preventing and treating skin damage caused by UV light exposure |
| US20050287227A1 (en) * | 2004-04-16 | 2005-12-29 | Ronald Pero | Supplement containing carotenoid, nicotinamide, zinc, water soluble extract of uncaria species and method of the same |
| KR100545304B1 (ko) * | 2004-09-01 | 2006-05-08 | 주식회사 유니젠 | 아선약을 포함하는 운카리아 속 식물, 또는 이의 황금및/또는 녹차의 배합물을 포함하는 사이클로옥시게나제및/또는 5-리폭시게나제 억제용 조성물 |
| US20090275656A1 (en) * | 2005-03-16 | 2009-11-05 | Pero Ronald W | Medicinal Compositions of Salts, Chelates and/or Free Acids of Alpha Hydroxyl Organic Acids and Related Processes and Methods |
| US20090035395A1 (en) * | 2007-08-01 | 2009-02-05 | Peter Koepke | Spondias mombin l. extract and methods of extracting and using such extract |
| US7879369B2 (en) | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
| JP5660898B2 (ja) * | 2007-11-09 | 2015-01-28 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 経口投与用の抗炎症性キナ酸誘導体 |
| AU2009322474A1 (en) * | 2008-12-01 | 2011-07-21 | Lifespan Extension Llc | Methods and compositions for altering health, wellbeing, and lifespan |
| US8911774B2 (en) * | 2009-05-18 | 2014-12-16 | Cellhealth Technologies Ltd. | Topical composition for anti-aging skin treatment using dual DNA repair mechanism and method of use |
| US9457009B2 (en) | 2012-05-31 | 2016-10-04 | The United States Of America As Represented By The Department Of Veterans Affairs | Methods and compositions for preventing and treating auditory dysfunctions |
| ES2821528T3 (es) | 2012-11-14 | 2021-04-26 | Grace W R & Co | Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado |
| AU2016227767A1 (en) * | 2015-03-03 | 2017-07-27 | Société des Produits Nestlé S.A. | Compound use in promoting energy expenditure |
| US10098922B1 (en) * | 2017-11-30 | 2018-10-16 | Optigenex, Inc. | Increasing telomere length in a cell |
| CN113759067A (zh) * | 2021-08-06 | 2021-12-07 | 北京康仁堂药业有限公司 | 一种薄层色谱的构建方法和鉴定方法及其应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE538512A (https=) * | 1954-05-28 | |||
| DE1905875A1 (de) * | 1969-02-06 | 1970-08-20 | Stark Dr Hans C | Mittel,hergestellt durch die Kombination verschiedener chemischer Koerper,das die Regulierung und vorzeitige Hervorrufung der Periodenblutung bewirkt sowie im Klimakterium die Menstruation nach dem Stillstand wieder hervorruft und fuer mehrere Jahre verlaengert |
| US4363815A (en) * | 1975-07-23 | 1982-12-14 | Yu Ruey J | Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions |
| US5385938B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
| US5389677B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of treating wrinkles using glycalic acid |
| US4940803A (en) * | 1988-05-23 | 1990-07-10 | Merck & Co., Inc. | Process for synthesis of 1R,2R,5R-2-hydroxy-6-oxo-7-oxabicyclo[3.2.1]-octane |
| EP0581980B1 (fr) * | 1992-08-03 | 1999-03-03 | Societe Des Produits Nestle S.A. | Dérivés de l'acide quinique 3- et/ou 4-substitués et procédé de préparation de dérivés de l'acide quinique 3- et/ou 4-substitués |
| BR9607098B8 (pt) * | 1995-02-27 | 2014-11-18 | Gilead Sciences Inc | Composto e composição farmacêutica. |
| US6039949A (en) * | 1997-02-27 | 2000-03-21 | Campamed, Inc. | Method of preparation and composition of a water soluble extract of the plant species uncaria |
| US6238675B1 (en) * | 1997-02-27 | 2001-05-29 | Campamed Corp. | Method of preparation and composition of a water soluble extract of the plant species Uncaria for enhancing immune, anti-inflammatory and anti-tumor processes of warm blooded animals |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| TW477783B (en) * | 1997-12-12 | 2002-03-01 | Gilead Sciences Inc | Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same |
| JPH11245503A (ja) * | 1998-03-02 | 1999-09-14 | Bando Chem Ind Ltd | 水性インク吸収材及び該吸収材の層を有する積層フィルム |
| EP1176195B1 (en) * | 1999-04-09 | 2013-05-22 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| US6723368B1 (en) * | 1999-12-21 | 2004-04-20 | Loretta M. Zapp | Method for enhancing post-processing content of beneficial compounds in beverages naturally containing same |
| US20010047032A1 (en) * | 1999-12-30 | 2001-11-29 | Castillo Gerardo M. | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases |
| US6410246B1 (en) * | 2000-06-23 | 2002-06-25 | Genetastix Corporation | Highly diverse library of yeast expression vectors |
| EP2322644A1 (en) * | 2000-06-28 | 2011-05-18 | GlycoFi, Inc. | Methods for producing modified glycoproteins |
| US7795002B2 (en) * | 2000-06-28 | 2010-09-14 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
| US7449308B2 (en) * | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
| US20060029604A1 (en) * | 2000-06-28 | 2006-02-09 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform |
| US20060034830A1 (en) * | 2000-06-28 | 2006-02-16 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GalGlcNAcMan5GLcNAc2 glycoform |
| US7863020B2 (en) * | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
| US20060034828A1 (en) * | 2000-06-28 | 2006-02-16 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform |
| US7598055B2 (en) * | 2000-06-28 | 2009-10-06 | Glycofi, Inc. | N-acetylglucosaminyltransferase III expression in lower eukaryotes |
| US20060024304A1 (en) * | 2000-06-28 | 2006-02-02 | Gerngross Tillman U | Immunoglobulins comprising predominantly a Man5GlcNAc2 glycoform |
| US7625756B2 (en) * | 2000-06-28 | 2009-12-01 | GycoFi, Inc. | Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells |
| GB0108903D0 (en) * | 2000-10-05 | 2001-05-30 | Aventis Pharm Prod Inc | Novel crystalline forms of a factor Xa inhibitor |
| US7064191B2 (en) * | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| US6632459B2 (en) * | 2000-12-11 | 2003-10-14 | Nutricia N.V. | Chlorogenic acid and an analog thereof for immune system stimulation |
| CA2347879A1 (en) * | 2001-05-11 | 2002-11-11 | Vanderbilt University | Substituted dicinnamoylquinides and their use in augmentation of adenosine function |
| US20060034829A1 (en) * | 2001-12-27 | 2006-02-16 | Gerngross Tillman U | Immunoglobulins comprising predominantly a MAN3GLCNAC2 glycoform |
| US20060024292A1 (en) * | 2001-12-27 | 2006-02-02 | Gerngross Tillman U | Immunoglobulins comprising predominantly a Gal2GlcNAc2Man3GlcNAc2 glycoform |
| JP4820055B2 (ja) * | 2001-12-27 | 2011-11-24 | グライコフィ, インコーポレイテッド | 哺乳動物型糖質構造を操作するための方法 |
| US6964784B2 (en) * | 2002-03-07 | 2005-11-15 | Optigenex, Inc. | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals |
| US7332299B2 (en) * | 2003-02-20 | 2008-02-19 | Glycofi, Inc. | Endomannosidases in the modification of glycoproteins in eukaryotes |
| EP2341128A1 (en) * | 2003-12-24 | 2011-07-06 | GlycoFi, Inc. | Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins |
| EP1730293A2 (en) * | 2004-03-17 | 2006-12-13 | Glycofi, Inc. | Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in fungi and yeast |
| US7465577B2 (en) * | 2004-04-29 | 2008-12-16 | Glycofi, Inc. | Methods for reducing or eliminating α-mannosidase resistant glycans for the production of glycoproteins |
-
2002
- 2002-03-07 US US10/093,794 patent/US6964784B2/en not_active Expired - Lifetime
-
2003
- 2003-03-07 CN CNA038101599A patent/CN1649610A/zh active Pending
- 2003-03-07 WO PCT/IB2003/000824 patent/WO2003074062A2/en not_active Ceased
- 2003-03-07 KR KR10-2004-7013931A patent/KR20040099300A/ko not_active Withdrawn
- 2003-03-07 CA CA002477785A patent/CA2477785A1/en not_active Abandoned
- 2003-03-07 EP EP03704896A patent/EP1485114A2/en not_active Withdrawn
- 2003-03-07 BR BRPI0308253A patent/BRPI0308253A2/pt not_active Application Discontinuation
- 2003-03-07 AU AU2003207894A patent/AU2003207894A1/en not_active Abandoned
- 2003-03-07 MX MXPA04008567A patent/MXPA04008567A/es unknown
- 2003-03-07 JP JP2003572579A patent/JP2005526053A/ja active Pending
- 2003-03-07 IL IL16388603A patent/IL163886A0/xx unknown
-
2004
- 2004-10-21 US US10/970,144 patent/US7595064B2/en not_active Expired - Lifetime
-
2005
- 2005-11-09 US US11/270,235 patent/US7579023B2/en not_active Expired - Lifetime
-
2009
- 2009-05-28 US US12/473,396 patent/US7947312B2/en not_active Expired - Fee Related
- 2009-07-17 US US12/504,845 patent/US7955626B2/en not_active Expired - Fee Related
-
2011
- 2011-05-18 US US13/110,603 patent/US8372449B2/en not_active Expired - Fee Related
- 2011-05-18 US US13/110,557 patent/US8372448B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7947312B2 (en) | 2011-05-24 |
| IL163886A0 (en) | 2005-12-18 |
| US20110245337A1 (en) | 2011-10-06 |
| US7955626B2 (en) | 2011-06-07 |
| US20050176825A1 (en) | 2005-08-11 |
| WO2003074062A3 (en) | 2004-02-05 |
| US6964784B2 (en) | 2005-11-15 |
| MXPA04008567A (es) | 2004-12-06 |
| US20110263706A1 (en) | 2011-10-27 |
| CN1649610A (zh) | 2005-08-03 |
| BRPI0308253A2 (pt) | 2016-07-12 |
| US20060068035A1 (en) | 2006-03-30 |
| US8372448B2 (en) | 2013-02-12 |
| US20090298939A1 (en) | 2009-12-03 |
| US20090281180A1 (en) | 2009-11-12 |
| KR20040099300A (ko) | 2004-11-26 |
| US7595064B2 (en) | 2009-09-29 |
| JP2005526053A (ja) | 2005-09-02 |
| AU2003207894A1 (en) | 2003-09-16 |
| US20030170320A1 (en) | 2003-09-11 |
| WO2003074062A2 (en) | 2003-09-12 |
| US7579023B2 (en) | 2009-08-25 |
| US8372449B2 (en) | 2013-02-12 |
| EP1485114A2 (en) | 2004-12-15 |
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| JP2599160C (https=) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |