BRPI0308253A2 - isolamento, purificação e identificação estrutural de um componente bioativo de um extrato solúvel em água de uma espécie botânica para realçar processos imunes, antiinflamatórios, antitumor e de reparo de dna de animais de sangue quente - Google Patents

isolamento, purificação e identificação estrutural de um componente bioativo de um extrato solúvel em água de uma espécie botânica para realçar processos imunes, antiinflamatórios, antitumor e de reparo de dna de animais de sangue quente

Info

Publication number
BRPI0308253A2
BRPI0308253A2 BRPI0308253A BR0308253A BRPI0308253A2 BR PI0308253 A2 BRPI0308253 A2 BR PI0308253A2 BR PI0308253 A BRPI0308253 A BR PI0308253A BR 0308253 A BR0308253 A BR 0308253A BR PI0308253 A2 BRPI0308253 A2 BR PI0308253A2
Authority
BR
Brazil
Prior art keywords
antitumor
inflammatory
warm
isolation
purification
Prior art date
Application number
BRPI0308253A
Other languages
English (en)
Portuguese (pt)
Inventor
Ronald W Pero
Original Assignee
Ronald W Pero
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27788020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0308253(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ronald W Pero filed Critical Ronald W Pero
Publication of BRPI0308253A2 publication Critical patent/BRPI0308253A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
BRPI0308253A 2002-03-07 2003-03-07 isolamento, purificação e identificação estrutural de um componente bioativo de um extrato solúvel em água de uma espécie botânica para realçar processos imunes, antiinflamatórios, antitumor e de reparo de dna de animais de sangue quente BRPI0308253A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/093,794 US6964784B2 (en) 2002-03-07 2002-03-07 Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals
PCT/IB2003/000824 WO2003074062A2 (en) 2002-03-07 2003-03-07 Isolation, purification and structural identification of a bioactive component of a water soluble extract of a botanical species for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals

Publications (1)

Publication Number Publication Date
BRPI0308253A2 true BRPI0308253A2 (pt) 2016-07-12

Family

ID=27788020

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0308253A BRPI0308253A2 (pt) 2002-03-07 2003-03-07 isolamento, purificação e identificação estrutural de um componente bioativo de um extrato solúvel em água de uma espécie botânica para realçar processos imunes, antiinflamatórios, antitumor e de reparo de dna de animais de sangue quente

Country Status (11)

Country Link
US (7) US6964784B2 (https=)
EP (1) EP1485114A2 (https=)
JP (1) JP2005526053A (https=)
KR (1) KR20040099300A (https=)
CN (1) CN1649610A (https=)
AU (1) AU2003207894A1 (https=)
BR (1) BRPI0308253A2 (https=)
CA (1) CA2477785A1 (https=)
IL (1) IL163886A0 (https=)
MX (1) MXPA04008567A (https=)
WO (1) WO2003074062A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042429A2 (en) * 2000-11-03 2002-05-30 Proteotech, Inc. Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants
US6964784B2 (en) * 2002-03-07 2005-11-15 Optigenex, Inc. Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals
BRPI0409179A (pt) 2003-04-04 2006-05-02 Unigen Pharmaceuticals Inc formulação de inibidores duplos de ciclooxigenase (cox) e lipoxigenase (lox) para cuidados com a pele de mamìferos
ES2402996T5 (es) † 2004-04-01 2017-06-28 Industrial Farmacéutica Cantabria, S.A. Composiciones fotoprotectoras y/o fotoinmunoprotectoras de la piel y sus usos
US20050226825A1 (en) * 2004-04-13 2005-10-13 Giampapa Vincent C Topical composition for preventing and treating skin damage caused by UV light exposure
US20050287227A1 (en) * 2004-04-16 2005-12-29 Ronald Pero Supplement containing carotenoid, nicotinamide, zinc, water soluble extract of uncaria species and method of the same
KR100545304B1 (ko) * 2004-09-01 2006-05-08 주식회사 유니젠 아선약을 포함하는 운카리아 속 식물, 또는 이의 황금및/또는 녹차의 배합물을 포함하는 사이클로옥시게나제및/또는 5-리폭시게나제 억제용 조성물
US20090275656A1 (en) * 2005-03-16 2009-11-05 Pero Ronald W Medicinal Compositions of Salts, Chelates and/or Free Acids of Alpha Hydroxyl Organic Acids and Related Processes and Methods
US20090035395A1 (en) * 2007-08-01 2009-02-05 Peter Koepke Spondias mombin l. extract and methods of extracting and using such extract
US7879369B2 (en) 2007-09-18 2011-02-01 Selvamedica, Llc Combretum laurifolium Mart. extract and methods of extracting and using such extract
JP5660898B2 (ja) * 2007-11-09 2015-01-28 ユニバーシティ オブ テネシー リサーチ ファウンデーション 経口投与用の抗炎症性キナ酸誘導体
AU2009322474A1 (en) * 2008-12-01 2011-07-21 Lifespan Extension Llc Methods and compositions for altering health, wellbeing, and lifespan
US8911774B2 (en) * 2009-05-18 2014-12-16 Cellhealth Technologies Ltd. Topical composition for anti-aging skin treatment using dual DNA repair mechanism and method of use
US9457009B2 (en) 2012-05-31 2016-10-04 The United States Of America As Represented By The Department Of Veterans Affairs Methods and compositions for preventing and treating auditory dysfunctions
ES2821528T3 (es) 2012-11-14 2021-04-26 Grace W R & Co Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado
AU2016227767A1 (en) * 2015-03-03 2017-07-27 Société des Produits Nestlé S.A. Compound use in promoting energy expenditure
US10098922B1 (en) * 2017-11-30 2018-10-16 Optigenex, Inc. Increasing telomere length in a cell
CN113759067A (zh) * 2021-08-06 2021-12-07 北京康仁堂药业有限公司 一种薄层色谱的构建方法和鉴定方法及其应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE538512A (https=) * 1954-05-28
DE1905875A1 (de) * 1969-02-06 1970-08-20 Stark Dr Hans C Mittel,hergestellt durch die Kombination verschiedener chemischer Koerper,das die Regulierung und vorzeitige Hervorrufung der Periodenblutung bewirkt sowie im Klimakterium die Menstruation nach dem Stillstand wieder hervorruft und fuer mehrere Jahre verlaengert
US4363815A (en) * 1975-07-23 1982-12-14 Yu Ruey J Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions
US5385938B1 (en) * 1986-12-23 1997-07-15 Tristrata Inc Method of using glycolic acid for treating wrinkles
US5389677B1 (en) * 1986-12-23 1997-07-15 Tristrata Inc Method of treating wrinkles using glycalic acid
US4940803A (en) * 1988-05-23 1990-07-10 Merck & Co., Inc. Process for synthesis of 1R,2R,5R-2-hydroxy-6-oxo-7-oxabicyclo[3.2.1]-octane
EP0581980B1 (fr) * 1992-08-03 1999-03-03 Societe Des Produits Nestle S.A. Dérivés de l'acide quinique 3- et/ou 4-substitués et procédé de préparation de dérivés de l'acide quinique 3- et/ou 4-substitués
BR9607098B8 (pt) * 1995-02-27 2014-11-18 Gilead Sciences Inc Composto e composição farmacêutica.
US6039949A (en) * 1997-02-27 2000-03-21 Campamed, Inc. Method of preparation and composition of a water soluble extract of the plant species uncaria
US6238675B1 (en) * 1997-02-27 2001-05-29 Campamed Corp. Method of preparation and composition of a water soluble extract of the plant species Uncaria for enhancing immune, anti-inflammatory and anti-tumor processes of warm blooded animals
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
TW477783B (en) * 1997-12-12 2002-03-01 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
JPH11245503A (ja) * 1998-03-02 1999-09-14 Bando Chem Ind Ltd 水性インク吸収材及び該吸収材の層を有する積層フィルム
EP1176195B1 (en) * 1999-04-09 2013-05-22 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
US6723368B1 (en) * 1999-12-21 2004-04-20 Loretta M. Zapp Method for enhancing post-processing content of beneficial compounds in beverages naturally containing same
US20010047032A1 (en) * 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
US6410246B1 (en) * 2000-06-23 2002-06-25 Genetastix Corporation Highly diverse library of yeast expression vectors
EP2322644A1 (en) * 2000-06-28 2011-05-18 GlycoFi, Inc. Methods for producing modified glycoproteins
US7795002B2 (en) * 2000-06-28 2010-09-14 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
US7449308B2 (en) * 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US20060029604A1 (en) * 2000-06-28 2006-02-09 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform
US20060034830A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GalGlcNAcMan5GLcNAc2 glycoform
US7863020B2 (en) * 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
US20060034828A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US20060024304A1 (en) * 2000-06-28 2006-02-02 Gerngross Tillman U Immunoglobulins comprising predominantly a Man5GlcNAc2 glycoform
US7625756B2 (en) * 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
GB0108903D0 (en) * 2000-10-05 2001-05-30 Aventis Pharm Prod Inc Novel crystalline forms of a factor Xa inhibitor
US7064191B2 (en) * 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
US6632459B2 (en) * 2000-12-11 2003-10-14 Nutricia N.V. Chlorogenic acid and an analog thereof for immune system stimulation
CA2347879A1 (en) * 2001-05-11 2002-11-11 Vanderbilt University Substituted dicinnamoylquinides and their use in augmentation of adenosine function
US20060034829A1 (en) * 2001-12-27 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a MAN3GLCNAC2 glycoform
US20060024292A1 (en) * 2001-12-27 2006-02-02 Gerngross Tillman U Immunoglobulins comprising predominantly a Gal2GlcNAc2Man3GlcNAc2 glycoform
JP4820055B2 (ja) * 2001-12-27 2011-11-24 グライコフィ， インコーポレイテッド 哺乳動物型糖質構造を操作するための方法
US6964784B2 (en) * 2002-03-07 2005-11-15 Optigenex, Inc. Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals
US7332299B2 (en) * 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
EP2341128A1 (en) * 2003-12-24 2011-07-06 GlycoFi, Inc. Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
EP1730293A2 (en) * 2004-03-17 2006-12-13 Glycofi, Inc. Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in fungi and yeast
US7465577B2 (en) * 2004-04-29 2008-12-16 Glycofi, Inc. Methods for reducing or eliminating α-mannosidase resistant glycans for the production of glycoproteins

Also Published As

Publication number Publication date
US7947312B2 (en) 2011-05-24
IL163886A0 (en) 2005-12-18
CA2477785A1 (en) 2003-09-12
US20110245337A1 (en) 2011-10-06
US7955626B2 (en) 2011-06-07
US20050176825A1 (en) 2005-08-11
WO2003074062A3 (en) 2004-02-05
US6964784B2 (en) 2005-11-15
MXPA04008567A (es) 2004-12-06
US20110263706A1 (en) 2011-10-27
CN1649610A (zh) 2005-08-03
US20060068035A1 (en) 2006-03-30
US8372448B2 (en) 2013-02-12
US20090298939A1 (en) 2009-12-03
US20090281180A1 (en) 2009-11-12
KR20040099300A (ko) 2004-11-26
US7595064B2 (en) 2009-09-29
JP2005526053A (ja) 2005-09-02
AU2003207894A1 (en) 2003-09-16
US20030170320A1 (en) 2003-09-11
WO2003074062A2 (en) 2003-09-12
US7579023B2 (en) 2009-08-25
US8372449B2 (en) 2013-02-12
EP1485114A2 (en) 2004-12-15

Similar Documents

Publication Publication Date Title
BRPI0308253A2 (pt) isolamento, purificação e identificação estrutural de um componente bioativo de um extrato solúvel em água de uma espécie botânica para realçar processos imunes, antiinflamatórios, antitumor e de reparo de dna de animais de sangue quente
BRPI0313269A2 (pt) processo para produzir proteína de soja
BRPI0516497A (pt) oligonucleotìdeos imunoestimuladores semi-macios de classe c
CL2006003348A1 (es) Virus de influenza aviar quimericos; metodo de produccion de una composicion inmunogena; y metodo para inducir una respuesta inmunitaria a dos agentes infecciosos en un ave o humano.
ITMO20050067A1 (it) Mezzi di illuminazione e metodo per ottenere mezzi di illuminazione.
DK1523489T3 (da) Modificerede 2'- og 3'-nukleosidprodrugs til behandling af flaviridae-infektioner
PT2397486E (pt) Fitases, ácidos nucleicos que as codificam e métodos para as preparar e utilizar
BRPI0820162A2 (pt) composto, composição farmacêutica, método para a profilazia ou tratamento de infecção pela hiv ou para a profilaxia, tratamento ou retardo no início da aids
BRPI1011581A2 (pt) Preparação de proteína de soja isolada usando extração de cloreto de cálcio ("s703")
DK1668025T3 (da) Seneca Valley-virusbaserede præparater og fremgangsmåder til behandling af sygdom
BRPI0918876A2 (pt) composições para a profilaxia e tratamento de doença dermatológica/mucosa, e suas utilizações
BRPI0706871A2 (pt) uso de um extrato de sambucus nigra l., método de tratamento de uma infecção viral de influenza e método de inibição da infecção viral de influenza
BRPI0915471A2 (pt) composto, composição farmacêutica, métodos de inibir dna girase bacteriana e/ou topoisomerase bacteriana iv, para produzir um efeito antibacteriano em um animal de sangue quente e para tratar uma infecção bacteriana em um animal de sangue quente, e, uso de um composto
WO2004089289A3 (en) Treating or preventing hot flashes using prodrugs of gaba analogs
BRPI0820258A2 (pt) composto, composições de vacina e farmacêutica, e , métodos para estimular uma resposta imune em um indivíduo e para tratar um indivíduo
PT2310379E (pt) Método para o fraccionamento de extracto de madeira nodosa e utilização de uma extracção líquido-líquido para purificação do extracto de madeira nodosa
EP1853290A4 (en) ANTI-HYPERTENSIVE DIETETIC COMPOUND DERIVED FROM SALMON OR ONCORHYNCHUS PROTEIN HYDROLYSATES
EP1510217A4 (en) An anti-rheumatism medicament and method to prepare thereof
DK1835907T3 (da) Lægemidler til behandling eller forebyggelse af fibrotiske sygdomme
SG131822A1 (en) Treating avian influenza infections
ZA201201690B (en) Picrorhiza kurroa extract for prevention,elimination and treatment of rna viruses and infection or diseases caused by the same in humans,animals and in biotech industry
DK1658879T3 (da) Radix Salviae Miltiorrhizae, ekstrakt og sammensætning deraf til behandling af aspirinresistente sygdomme
TWI317635B (en) Herbal extract having anti- influenza virus activity and preparation of same
DE60315858D1 (de) Ihnv g fusionsprotein für die immunstimulation
DE602004012104D1 (de) Pflanzenextraktionsverfahren und extrakt

Legal Events

Date Code Title Description
B25C Requirement related to requested transfer of rights

Owner name: RONALD W. PERO (US)

Free format text: A FIM DE ATENDER A(S) TRANSFERENCIA(S), REQUERIDA(S) ATRAVES DA PETICAO NO 20050019523, DE 22/03/2005, E NECESSARIO APRESENTAR A TRADUCAO JURAMENTADA DO DOCUMENTO DE CESSAO, CONFORME ART. 18, DO DEC.13.609/43.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: OPTIGENEX, INC. (US)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15W Others matters related to applications: legal action concerning application

Free format text: INPI NO 52400.205786/18 ORIGEM: JUIZO DA 09A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO: 5009520-94.2018.4.02.5101 ACAO COMINATORIA COM OBRIGACAO DE FAZER COM PEDIDO DE ANTECIPACAO DE TUTELA AUTOR: OPTIGENEX INC. REU(S): INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL