CA2476448A1 - Antibiotic conjugates - Google Patents
Antibiotic conjugates Download PDFInfo
- Publication number
- CA2476448A1 CA2476448A1 CA002476448A CA2476448A CA2476448A1 CA 2476448 A1 CA2476448 A1 CA 2476448A1 CA 002476448 A CA002476448 A CA 002476448A CA 2476448 A CA2476448 A CA 2476448A CA 2476448 A1 CA2476448 A1 CA 2476448A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- independently
- alkenyl
- aryl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/552—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being an antibiotic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35758402P | 2002-02-15 | 2002-02-15 | |
US60/357,584 | 2002-02-15 | ||
PCT/US2003/004714 WO2003070254A1 (en) | 2002-02-15 | 2003-02-14 | Antibiotic conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2476448A1 true CA2476448A1 (en) | 2003-08-28 |
Family
ID=27757642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002476448A Abandoned CA2476448A1 (en) | 2002-02-15 | 2003-02-14 | Antibiotic conjugates |
Country Status (6)
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL151012A0 (en) * | 2001-08-03 | 2003-02-12 | Ribosomes Structure And Protei | Ribosomes structure and protein synthesis inhibitors |
US7579324B2 (en) | 2002-02-15 | 2009-08-25 | C-A-I-R Biosciences Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
WO2003070173A2 (en) * | 2002-02-15 | 2003-08-28 | Sympore Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
WO2004005310A2 (en) | 2002-07-08 | 2004-01-15 | Pliva-Istrazivacki Institut D.O.O. | New compounds, compositions and methods for treatment of inflammatory diseases and conditions |
NZ537716A (en) | 2002-07-08 | 2007-05-31 | Glaxosmithkline Zagreb | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use |
ES2325495T3 (es) * | 2002-07-08 | 2009-09-07 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas. |
AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
WO2005042554A1 (en) * | 2003-10-30 | 2005-05-12 | Rib-X Pharmaceuticals, Inc. | Bifunctional macrolide heterocyclic compounds and methods of making and using the same |
WO2005085266A2 (en) | 2004-02-27 | 2005-09-15 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
US7468428B2 (en) * | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
JP2008509899A (ja) * | 2004-08-12 | 2008-04-03 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 胃腸管の炎症性疾患治療用の細胞特異的コンジュゲートの使用 |
US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
EP1907392A1 (en) * | 2005-07-26 | 2008-04-09 | Merckle Gmbh | Macrolide conjugates of pyrrolizine and indolizine compounds as inhibitors of 5-lipooxygenase and cyclooxygenase |
WO2012051126A2 (en) * | 2010-10-10 | 2012-04-19 | Synovo Gmbh | Anti-inflammatory macrolides |
CN103857440B (zh) | 2011-06-22 | 2018-09-25 | 维奥姆生物科学有限公司 | 基于缀合物的抗真菌和抗细菌前药 |
WO2013085152A1 (en) * | 2011-12-07 | 2013-06-13 | Union Korea Pharm Co., Ltd. | Combined antibiotics comprising cephalosporins and beta-lactamase inhibitors |
AU2014252462A1 (en) * | 2013-04-10 | 2015-10-01 | Probiotic Pharmaceuticals Aps | Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect |
US20210369675A1 (en) * | 2016-08-20 | 2021-12-02 | John Malcolm Hall Gregg | Antimicrobial drug methods of use & therapeutic compositions |
US11744859B2 (en) | 2017-07-07 | 2023-09-05 | Epicentrx, Inc. | Compositions and methods for parenteral administration of therapeutic agents |
CN112552240A (zh) * | 2019-09-10 | 2021-03-26 | 天津大学 | 一种含甲硝唑的药物单体及其制备方法 |
EP4051687A4 (en) * | 2020-01-08 | 2022-12-21 | Beijing Continent Pharmaceuticals Co., Ltd. | MACROLIDE COMPOUND AND USE THEREOF FOR THE TREATMENT OF CHRONIC RESPIRATORY DISEASE |
CN117222433A (zh) * | 2020-10-01 | 2023-12-12 | 密西西比州立大学 | 与磷酸己糖缀合的药物及其制备和使用方法 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3417077A (en) * | 1966-05-16 | 1968-12-17 | Lilly Co Eli | Erythromycin derivative and process for the preparation thereof |
US4375414A (en) * | 1971-05-20 | 1983-03-01 | Meir Strahilevitz | Immunological methods for removing species from the blood circulatory system and devices therefor |
US3884903A (en) * | 1973-06-21 | 1975-05-20 | Abbott Lab | 4{41 -Deoxy-4{41 -oxoerythromycin B derivatives |
ATE3367T1 (de) | 1978-10-02 | 1983-06-15 | Merck & Co. Inc. | Lysosomotropische therapeutische fluorierte aminverbindungen und sie enthaltende zusammensetzungen. |
YU43116B (en) * | 1979-04-02 | 1989-04-30 | Pliva Pharm & Chem Works | Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox |
YU43006B (en) * | 1981-03-06 | 1989-02-28 | Pliva Pharm & Chem Works | Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof |
US4382086A (en) * | 1982-03-01 | 1983-05-03 | Pfizer Inc. | 9-Dihydro-11,12-ketal derivatives of erythromycin A and epi-erythromycin A |
US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
US4518590A (en) | 1984-04-13 | 1985-05-21 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method |
US4585759A (en) | 1985-01-22 | 1986-04-29 | Pfizer Inc. | Antibacterial derivatives of a neutral macrolide |
JPH0720857B2 (ja) * | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
US5466681A (en) * | 1990-02-23 | 1995-11-14 | Microcarb, Inc. | Receptor conjugates for targeting penicillin antibiotics to bacteria |
US5405975A (en) * | 1993-03-29 | 1995-04-11 | Molecular Probes, Inc. | Fluorescent ion-selective diaryldiaza crown ether conjugates |
SI9011409A (en) | 1990-07-18 | 1995-10-31 | Pliva Pharm & Chem Works | O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them |
JPH07103148B2 (ja) | 1991-12-16 | 1995-11-08 | 株式会社ディ・ディ・エス研究所 | アントラサイクリン−マクロライド複合体 |
US20030068362A1 (en) * | 1993-02-22 | 2003-04-10 | American Bioscience, Inc. | Methods and formulations for the delivery of pharmacologically active agents |
US5486536A (en) * | 1994-08-15 | 1996-01-23 | The Regents Of The University Of Michigan | Sulfatides as anti-inflammatory compounds |
US5750493A (en) * | 1995-08-30 | 1998-05-12 | Raymond F. Schinazi | Method to improve the biological and antiviral activity of protease inhibitors |
DE69715621T2 (de) * | 1996-04-26 | 2003-05-22 | Massachusetts Inst Technology | Drei hybriden screening test |
US5827533A (en) * | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
EP0895999A1 (en) * | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
WO1999020639A2 (en) | 1997-10-16 | 1999-04-29 | Pliva, Farmaceutska Industrija ,Dionicko, Drustvo | NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES |
HRP980189B1 (en) | 1998-04-06 | 2004-04-30 | Pliva Pharm & Chem Works | Novel 15-membered lactams ketolides |
AU4549999A (en) | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Novel polyene macrolide compounds and uses |
EP1085846A2 (en) | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
JP2002517458A (ja) | 1998-06-08 | 2002-06-18 | アドバンスド メディスン インコーポレーテッド | 多結合ライブラリーのコンビナトリアル合成 |
US6043227A (en) | 1998-08-19 | 2000-03-28 | Pfizer Inc. | C11 carbamates of macrolide antibacterials |
US6100240A (en) | 1998-10-09 | 2000-08-08 | Pfizer Inc | Macrolide derivatives |
ID27331A (id) | 1999-09-29 | 2001-03-29 | Pfizer Prod Inc | Pembuatan antibiotik-antibiotik ketolida karbamat |
AU780724B2 (en) * | 2000-01-14 | 2005-04-14 | Migenix Inc. | Derivatives of polyene macrolides and preparation and use thereof |
EP1122261A3 (en) | 2000-01-31 | 2001-09-26 | Pfizer Products Inc. | 13 and 14-membered antibacterial macrolides |
DK1167376T3 (da) | 2000-06-30 | 2004-10-25 | Pfizer Prod Inc | Makrolidantibiotika |
HRP20010018A2 (en) | 2001-01-09 | 2002-12-31 | Pliva D D | Novel anti-inflammatory compounds |
US7122525B2 (en) * | 2001-11-21 | 2006-10-17 | Activbiotics, Inc. | Targeted therapeutics and uses thereof |
US7579324B2 (en) * | 2002-02-15 | 2009-08-25 | C-A-I-R Biosciences Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
WO2003070173A2 (en) * | 2002-02-15 | 2003-08-28 | Sympore Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
-
2003
- 2003-02-14 US US10/367,104 patent/US7271154B2/en not_active Expired - Fee Related
- 2003-02-14 CA CA002476448A patent/CA2476448A1/en not_active Abandoned
- 2003-02-14 EP EP03742793A patent/EP1482957A4/en not_active Withdrawn
- 2003-02-14 US US10/504,792 patent/US20060069047A1/en not_active Abandoned
- 2003-02-14 AU AU2003211113A patent/AU2003211113B2/en not_active Ceased
- 2003-02-14 WO PCT/US2003/004714 patent/WO2003070254A1/en active IP Right Grant
- 2003-02-14 NZ NZ535355A patent/NZ535355A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1482957A1 (en) | 2004-12-08 |
EP1482957A4 (en) | 2006-07-19 |
AU2003211113B2 (en) | 2007-08-09 |
US20040033969A1 (en) | 2004-02-19 |
US7271154B2 (en) | 2007-09-18 |
NZ535355A (en) | 2007-09-28 |
AU2003211113A1 (en) | 2003-09-09 |
WO2003070254A1 (en) | 2003-08-28 |
US20060069047A1 (en) | 2006-03-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |