CA2468575A1 - Oral immunostimulation of mammals, birds, fish and reptiles from (1-4) linked .beta.-d-mannuronic acid - Google Patents
Oral immunostimulation of mammals, birds, fish and reptiles from (1-4) linked .beta.-d-mannuronic acid Download PDFInfo
- Publication number
- CA2468575A1 CA2468575A1 CA002468575A CA2468575A CA2468575A1 CA 2468575 A1 CA2468575 A1 CA 2468575A1 CA 002468575 A CA002468575 A CA 002468575A CA 2468575 A CA2468575 A CA 2468575A CA 2468575 A1 CA2468575 A1 CA 2468575A1
- Authority
- CA
- Canada
- Prior art keywords
- content
- alginate
- fish
- immunostimulating
- solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000003308 immunostimulating effect Effects 0.000 title claims abstract description 42
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 37
- 241000124008 Mammalia Species 0.000 title claims abstract description 16
- 241000271566 Aves Species 0.000 title claims abstract description 9
- 241000938605 Crocodylia Species 0.000 title abstract description 7
- 229920000615 alginic acid Polymers 0.000 claims abstract description 114
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 114
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 88
- 229940072056 alginate Drugs 0.000 claims abstract description 88
- 239000000463 material Substances 0.000 claims abstract description 65
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 76
- 239000000284 extract Substances 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 34
- 239000007787 solid Substances 0.000 claims description 23
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 claims description 13
- 241001474374 Blennius Species 0.000 claims description 11
- 241001512709 Lessonia <stramenopiles> Species 0.000 claims description 11
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 230000004936 stimulating effect Effects 0.000 claims description 8
- 241000270322 Lepidosauria Species 0.000 claims description 7
- 235000015872 dietary supplement Nutrition 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002417 nutraceutical Substances 0.000 claims description 7
- 235000021436 nutraceutical agent Nutrition 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 239000007909 solid dosage form Substances 0.000 claims description 7
- 210000000987 immune system Anatomy 0.000 claims description 6
- 235000021056 liquid food Nutrition 0.000 claims description 6
- 239000012669 liquid formulation Substances 0.000 claims description 6
- 235000021055 solid food Nutrition 0.000 claims description 6
- 230000008961 swelling Effects 0.000 claims description 5
- 241001466453 Laminaria Species 0.000 claims description 4
- 230000004584 weight gain Effects 0.000 claims description 4
- 235000019786 weight gain Nutrition 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000000969 carrier Substances 0.000 abstract description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 36
- 239000000243 solution Substances 0.000 description 36
- 241000282887 Suidae Species 0.000 description 27
- 239000002245 particle Substances 0.000 description 14
- 239000000523 sample Substances 0.000 description 12
- 241000195493 Cryptophyta Species 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 239000000835 fiber Substances 0.000 description 11
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 239000004744 fabric Substances 0.000 description 7
- 238000001914 filtration Methods 0.000 description 7
- 210000004698 lymphocyte Anatomy 0.000 description 7
- 241000922583 Anarhichas minor Species 0.000 description 6
- AEMOLEFTQBMNLQ-BZINKQHNSA-N D-Guluronic Acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@H]1O AEMOLEFTQBMNLQ-BZINKQHNSA-N 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 102000008100 Human Serum Albumin Human genes 0.000 description 6
- 108091006905 Human Serum Albumin Proteins 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 210000000265 leukocyte Anatomy 0.000 description 6
- 239000013535 sea water Substances 0.000 description 6
- 238000005481 NMR spectroscopy Methods 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 5
- 230000028993 immune response Effects 0.000 description 5
- 210000001616 monocyte Anatomy 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 230000019254 respiratory burst Effects 0.000 description 5
- 235000017550 sodium carbonate Nutrition 0.000 description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 239000007858 starting material Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 206010057249 Phagocytosis Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 210000000080 chela (arthropods) Anatomy 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 230000008782 phagocytosis Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000000684 flow cytometry Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000003760 magnetic stirring Methods 0.000 description 3
- 230000000242 pagocytic effect Effects 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- PHEDXBVPIONUQT-UHFFFAOYSA-N Cocarcinogen A1 Natural products CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C3C=C(C)C(=O)C3(O)CC(CO)=CC2C2C1(OC(C)=O)C2(C)C PHEDXBVPIONUQT-UHFFFAOYSA-N 0.000 description 2
- 241000172184 Durvillaea antarctica Species 0.000 description 2
- 241000701081 Equid alphaherpesvirus 1 Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241001260563 Lessonia nigrescens Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000199919 Phaeophyceae Species 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 239000011362 coarse particle Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003979 eosinophil Anatomy 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 235000011837 pasties Nutrition 0.000 description 2
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000012192 staining solution Substances 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 239000012224 working solution Substances 0.000 description 2
- FJQZXCPWAGYPSD-UHFFFAOYSA-N 1,3,4,6-tetrachloro-3a,6a-diphenylimidazo[4,5-d]imidazole-2,5-dione Chemical compound ClN1C(=O)N(Cl)C2(C=3C=CC=CC=3)N(Cl)C(=O)N(Cl)C12C1=CC=CC=C1 FJQZXCPWAGYPSD-UHFFFAOYSA-N 0.000 description 1
- 241000512260 Ascophyllum Species 0.000 description 1
- 241000589151 Azotobacter Species 0.000 description 1
- 241000589149 Azotobacter vinelandii Species 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 101710091342 Chemotactic peptide Proteins 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 241000304827 Durvillaea potatorum Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241001512723 Ecklonia Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000004455 Fucus spiralis Species 0.000 description 1
- 241001500351 Influenzavirus A Species 0.000 description 1
- 241000296380 Laminaria hyperborea Species 0.000 description 1
- 229920001543 Laminarin Polymers 0.000 description 1
- 241000439036 Lessonia trabeculata Species 0.000 description 1
- 241001491708 Macrocystis Species 0.000 description 1
- PRQROPMIIGLWRP-UHFFFAOYSA-N N-formyl-methionyl-leucyl-phenylalanin Chemical compound CSCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(C(O)=O)CC1=CC=CC=C1 PRQROPMIIGLWRP-UHFFFAOYSA-N 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000589774 Pseudomonas sp. Species 0.000 description 1
- 241000015177 Saccharina japonica Species 0.000 description 1
- 101100233053 Schizosaccharomyces pombe (strain 972 / ATCC 24843) cut15 gene Proteins 0.000 description 1
- 101100216234 Schizosaccharomyces pombe (strain 972 / ATCC 24843) cut20 gene Proteins 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000007894 caplet Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- PRQROPMIIGLWRP-BZSNNMDCSA-N chemotactic peptide Chemical compound CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 PRQROPMIIGLWRP-BZSNNMDCSA-N 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229960003983 diphtheria toxoid Drugs 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 125000005613 guluronic acid group Chemical group 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- -1 hetero polysaccharide Chemical class 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- DBTMGCOVALSLOR-VPNXCSTESA-N laminarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](O)C(O[C@H]2[C@@H]([C@@H](CO)OC(O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-VPNXCSTESA-N 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- SISQKQNJHCDULL-UHFFFAOYSA-N methyl benzenecarboximidate Chemical compound COC(=N)C1=CC=CC=C1 SISQKQNJHCDULL-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- MSXHSNHNTORCAW-MPGIDXPLSA-M sodium;(3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylate Chemical compound [Na+].O[C@@H]1OC(C([O-])=O)[C@@H](O)[C@H](O)[C@@H]1O MSXHSNHNTORCAW-MPGIDXPLSA-M 0.000 description 1
- 244000000000 soil microbiome Species 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 229960002766 tetanus vaccines Drugs 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Feed For Specific Animals (AREA)
- Farming Of Fish And Shellfish (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20015875 | 2001-11-30 | ||
| NO20015875A NO326145B1 (no) | 2001-11-30 | 2001-11-30 | Fremgangsmate for a stimulere vektokning hos pattedyr, fugler og krypdyr. |
| NO20022893 | 2002-06-17 | ||
| NO20022893A NO320671B1 (no) | 2001-11-30 | 2002-06-17 | Fremgangsmate for a stimulere vektokning i fisk. |
| PCT/NO2002/000432 WO2003045272A2 (en) | 2001-11-30 | 2002-11-21 | ORAL IMMUNOSTIMULATION OF MAMMALS, BIRDS, FISH AND REPTILES FROM (1-4) LINKED ß-D-MANNURONIC ACID |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2468575A1 true CA2468575A1 (en) | 2003-06-05 |
Family
ID=26649338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002468575A Abandoned CA2468575A1 (en) | 2001-11-30 | 2002-11-21 | Oral immunostimulation of mammals, birds, fish and reptiles from (1-4) linked .beta.-d-mannuronic acid |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7816340B2 (https=) |
| EP (1) | EP1460964A2 (https=) |
| JP (2) | JP2005522189A (https=) |
| CN (1) | CN1287680C (https=) |
| AU (1) | AU2002364493A1 (https=) |
| CA (1) | CA2468575A1 (https=) |
| NO (1) | NO320671B1 (https=) |
| WO (1) | WO2003045272A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011006261A1 (en) * | 2009-07-17 | 2011-01-20 | Ocean Harvest Technology (Canada) Inc. | Natural and sustainable seaweed formula that replaces synthetic additives in fish feed |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005145885A (ja) * | 2003-11-14 | 2005-06-09 | Japan Science & Technology Agency | アルギン酸オリゴマーからなる免疫機構賦活剤 |
| JP5147218B2 (ja) * | 2006-11-13 | 2013-02-20 | ハイドロックス株式会社 | 海藻由来の免疫賦活剤及び抗炎症剤 |
| JO3676B1 (ar) * | 2009-07-27 | 2020-08-27 | Arc Medical Devices Inc | مركبات صيدلانية تضم فوكانات معدلة وطرق تتعلق بها |
| DE102014200922A1 (de) * | 2014-01-20 | 2015-07-23 | Fim Biotech Gmbh | Verwendung von Tonmineral als Futterzusatzstoff und/oder als Ergänzungsfutter für aquatische Organismen |
| US20180147147A1 (en) | 2015-06-03 | 2018-05-31 | Ewos Innovation As | Oral delivery system for bioactive agents |
| PL3649869T3 (pl) | 2018-11-08 | 2025-03-10 | Biochem Zusatzstoffe Handels- und Produktionsges. mbH | Kompozycja proszkowa i kompozycja żelowa zawierająca wodne organizmy fotosyntetyzujące |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6236152A (ja) * | 1985-04-04 | 1987-02-17 | Nichiden Kagaku Kk | 養魚用餌料 |
| JPS62275656A (ja) * | 1986-05-23 | 1987-11-30 | Kimitsu Kagaku Kenkyusho:Kk | 餌料の製造法 |
| JP2840851B2 (ja) | 1989-03-23 | 1998-12-24 | 池田糖化工業株式会社 | 魚類の免疫増強剤及び養魚用餌料 |
| AU7221691A (en) * | 1990-01-23 | 1991-08-21 | Terje Espevik | Mannuronic acid containing alginate wound healing composition and method |
| US5169840A (en) * | 1991-03-27 | 1992-12-08 | Nobipols Forskningsstiftelse | Diequatorially bound β-1, 4 polyuronates and use of same for cytokine stimulation |
| DE4204012A1 (de) | 1992-02-12 | 1993-08-19 | Ulrich Prof Dr Zimmermann | Mitogenfreie substanz, deren herstellung und verwendung |
| GB9221163D0 (en) | 1992-10-08 | 1992-11-25 | Nobipol And Protan Biopolymer | Dna compounds |
| JP2824185B2 (ja) | 1993-03-22 | 1998-11-11 | 旭化成工業株式会社 | 魚類免疫賦活剤 |
| JPH08308510A (ja) * | 1995-05-11 | 1996-11-26 | Maruha Corp | アルギン酸を含有する巻貝類用人工配合飼料 |
| GB9708773D0 (en) | 1997-04-30 | 1997-06-25 | Reckitt & Colmann Prod Ltd | Organic compositions |
| NO305033B1 (no) * | 1997-05-09 | 1999-03-22 | Algipharma As | Fremgangsmate for fremstilling av uronsyreblokker fra alginat |
| US6338856B1 (en) | 1998-02-27 | 2002-01-15 | Texas Tech University | Seaweed supplement diet for enhancing immune response in mammals and poultry |
| US6706263B2 (en) | 1999-04-30 | 2004-03-16 | Kibow Biotech Inc. | Composition for alleviating symptoms of uremia in patients |
| US6706287B2 (en) | 2001-05-15 | 2004-03-16 | Kibow Biotech Inc. | Prebiotic and probiotic compositions and methods for their use in gut-based therapies |
| KR100501584B1 (ko) | 2000-02-03 | 2005-07-18 | (주)케이비피 | 저분자 폴리만유로네이트의 제조방법, 혈청지질개선제로서의 이의 신규 용도 및 이를 함유하는 기능성식품 및 건강 보조 식품 |
-
2002
- 2002-06-17 NO NO20022893A patent/NO320671B1/no not_active IP Right Cessation
- 2002-11-21 EP EP02799860A patent/EP1460964A2/en not_active Withdrawn
- 2002-11-21 AU AU2002364493A patent/AU2002364493A1/en not_active Abandoned
- 2002-11-21 CA CA002468575A patent/CA2468575A1/en not_active Abandoned
- 2002-11-21 WO PCT/NO2002/000432 patent/WO2003045272A2/en not_active Ceased
- 2002-11-21 US US10/497,212 patent/US7816340B2/en not_active Expired - Fee Related
- 2002-11-21 CN CNB028239342A patent/CN1287680C/zh not_active Expired - Fee Related
- 2002-11-21 JP JP2003546778A patent/JP2005522189A/ja active Pending
-
2010
- 2010-02-08 JP JP2010025791A patent/JP2010110332A/ja active Pending
- 2010-09-16 US US12/883,308 patent/US20110046085A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011006261A1 (en) * | 2009-07-17 | 2011-01-20 | Ocean Harvest Technology (Canada) Inc. | Natural and sustainable seaweed formula that replaces synthetic additives in fish feed |
Also Published As
| Publication number | Publication date |
|---|---|
| NO320671B1 (no) | 2006-01-16 |
| EP1460964A2 (en) | 2004-09-29 |
| CN1287680C (zh) | 2006-12-06 |
| AU2002364493A1 (en) | 2003-06-10 |
| NO20022893D0 (no) | 2002-06-17 |
| US7816340B2 (en) | 2010-10-19 |
| US20110046085A1 (en) | 2011-02-24 |
| WO2003045272A3 (en) | 2003-09-12 |
| CN1599564A (zh) | 2005-03-23 |
| JP2010110332A (ja) | 2010-05-20 |
| JP2005522189A (ja) | 2005-07-28 |
| WO2003045272A2 (en) | 2003-06-05 |
| US20050026865A1 (en) | 2005-02-03 |
| NO20022893L (no) | 2003-06-02 |
| AU2002364493A8 (en) | 2003-06-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20110046085A1 (en) | Oral Immunostimulation of Fish from (1-4) Linked Beta-D-Mannuronic Acid | |
| CN108853486B (zh) | 一种具有增强免疫力功能的配方产品 | |
| Mohan et al. | Dietary Ganoderma lucidum polysaccharides to enhance the growth, immune response and disease resistance of freshwater prawn Macrobrachium rosenbergii | |
| US7893038B2 (en) | Oral immunostimulation of mammals birds and reptiles from (1-4) linked β-D-mannuronic acid | |
| US20090227535A1 (en) | Process for producing natural immunobiotic extract and uses thereof | |
| ES2333259T3 (es) | Composiciones destinadas a mejorar la salud intestinal y el rendimiento en animales que comprenden beta-glucanos y alfa-fucanos. | |
| KR101088442B1 (ko) | 감태발효 사료첨가물, 이의 제조방법 및 이를 포함하는 사료 | |
| WO2019162425A1 (en) | New process of preparation of glycan composition & uses thereof | |
| Manayi et al. | Immunomodulation effect of aqueous extract of the artist's conk medicinal mushroom, Ganoderma applanatum (Agaricomycetes), on the rainbow trout (Oncorhynchus mykiss) | |
| KR100435981B1 (ko) | 자연 면역력 및 성장촉진 작용을 가지는 버섯 첨가 유산균발효유 함유 뱀장어 양식 사료 첨가제 및 이를 포함하는뱀장어 양식 사료 | |
| US20090092641A1 (en) | Uses of natural immunobiotic extract | |
| EP1633373B1 (en) | Pharmaceutical composition comprising glucan derived from microalgae | |
| CN104115995B (zh) | 一种提高动物精液活力的复合糖制剂及其应用 | |
| EP4342477A1 (en) | Immunostimulator and glucan composition production method | |
| JP2004215506A (ja) | 海藻抽出物 | |
| WO2026049019A1 (ja) | 多糖の製造方法 | |
| RU2502322C1 (ru) | Способ получения кормовой иммуностимулирующей добавки для профилактики и терапии заболеваний сельскохозяйственных животных | |
| KR100327966B1 (ko) | 수용성 키토산을 함유하는 양돈용 영양제 및 이의 사용방법 | |
| JP2024149402A (ja) | 経口組成物 | |
| CN111000998A (zh) | 一种鸡法氏囊病精制卵黄抗体泡腾片的制备方法 | |
| Patel et al. | Effect of fucoidan extracted from the brown seaweed, Sargassum johnstonii on growth, survival, immune response and disease resistance to vibrio parahaemolyticus in Penaeus vannamei Boone, 1931 | |
| Class et al. | Patent application title: Novel Composition to Improve Gut Health and Animal Performance and Methods of Making the Same Inventors: John O'Doherty (Belfield, IE) John O'Sullivan (Tralee, IE) Aditya Julka (Tralee, IE) Assignees: BIOATLANTIS LIMITED | |
| JP2006028070A (ja) | 抗腫瘍組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |