CA2466338C - New uses for anti-malarial therapeutic agents - Google Patents
New uses for anti-malarial therapeutic agents Download PDFInfo
- Publication number
- CA2466338C CA2466338C CA002466338A CA2466338A CA2466338C CA 2466338 C CA2466338 C CA 2466338C CA 002466338 A CA002466338 A CA 002466338A CA 2466338 A CA2466338 A CA 2466338A CA 2466338 C CA2466338 C CA 2466338C
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- CA
- Canada
- Prior art keywords
- use according
- hydrogen
- lower alkyl
- group
- malarial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
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- Oncology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34587201P | 2001-11-09 | 2001-11-09 | |
| US60/345,872 | 2001-11-09 | ||
| PCT/US2002/036309 WO2003039546A1 (en) | 2001-11-09 | 2002-11-12 | New uses for anti-malarial therapeutic agents |
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| CA2466338A1 CA2466338A1 (en) | 2003-05-15 |
| CA2466338C true CA2466338C (en) | 2010-01-12 |
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| US (1) | US20040167162A1 (enExample) |
| EP (1) | EP1450803A4 (enExample) |
| JP (1) | JP2005512998A (enExample) |
| CN (1) | CN1289086C (enExample) |
| AU (1) | AU2002363443B2 (enExample) |
| CA (1) | CA2466338C (enExample) |
| IL (1) | IL161821A0 (enExample) |
| MX (1) | MXPA04004393A (enExample) |
| WO (1) | WO2003039546A1 (enExample) |
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| US7084157B2 (en) * | 2002-05-17 | 2006-08-01 | Rajeev Raut | Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation |
| BR0318214A (pt) * | 2003-03-27 | 2006-03-21 | Council Scient Ind Res | análogos de 8-aminoquinolina substituìda no anel, composição anti-malárica, processo para a preparação de análogos de 8-aminoquinolina substituìda no anel, e, uso de análogos de 8-aminoquinolina substituìda no anel |
| US20070134596A1 (en) * | 2005-12-08 | 2007-06-14 | Adrian Lungu | Photosensitive printing element having nanoparticles and method for preparing the printing element |
| CN101466380A (zh) * | 2006-02-16 | 2009-06-24 | 麦克莱恩医院 | 治疗帕金森病的方法和组合物 |
| KR101067443B1 (ko) * | 2009-06-23 | 2011-09-27 | 여오영 | 하이드록시클로로퀸을 함유하는 치핵 치료를 위한 국소투여용 주사제 조성물 |
| CN103027915A (zh) * | 2011-09-29 | 2013-04-10 | 中国医学科学院基础医学研究所 | 氯喹治疗和氯丙嗪预防肺感染和损伤的用途 |
| CN103705516B (zh) * | 2013-12-11 | 2016-01-06 | 武汉威立得生物医药有限公司 | 氯喔星在制备治疗或预防流感病毒感染的药物中的应用 |
| KR101828553B1 (ko) * | 2016-04-15 | 2018-02-13 | 한국화학연구원 | 신규한 벤조싸이오펜 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물 |
| JP2019527207A (ja) * | 2016-06-28 | 2019-09-26 | アシスタンス ピュブリーク−オピト ド パリＡｓｓｉｓｔａｎｃｅ Ｐｕｂｌｉｑｕｅ−Ｈｏｐｉｔａｕｘ Ｄｅ Ｐａｒｉｓ | ガンマヘルペスウイルスに関連した障害の予防および／または処置での使用のためのヒカントン誘導体およびプリマキン誘導体 |
| CN111658648A (zh) * | 2020-02-03 | 2020-09-15 | 中国人民解放军军事科学院军事医学研究院 | 4-氨基喹啉类化合物在治疗冠状病毒感染方面的应用 |
| US20210244705A1 (en) * | 2020-02-07 | 2021-08-12 | Centre For Digestive Diseases | Therapeutic compositions, products of manufacture and methods for ameliorating or preventing coronavirus infection |
| CN114908061B (zh) * | 2020-02-16 | 2023-10-27 | 北京化工大学 | 穿山甲冠状病毒xCoV及其应用 |
| US11007187B1 (en) * | 2020-03-25 | 2021-05-18 | Therapeutica Borealis Oy | Medicine for Covid-19 and treatment |
| US11638722B2 (en) | 2020-03-25 | 2023-05-02 | Therapeutica Borealis Oy C/O Avance Attorneys Ltd. | Medicine for Covid-19 and treatment |
| WO2021191496A1 (en) * | 2020-03-25 | 2021-09-30 | Therapeutica Borealis Oy | Medicine for covid-19 and treatment |
| US11278602B2 (en) | 2020-03-25 | 2022-03-22 | Therapeutica Borealis Oy | Medicine for Covid-19 and treatment |
| WO2021204717A1 (en) * | 2020-04-06 | 2021-10-14 | Oxandia Ltd | Aminoquinolines for treating coronavirus infections |
| EP3892275A1 (en) * | 2020-04-08 | 2021-10-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Aerosolization of hcq or its metabolites for the treatment of lung infections |
| US20230123388A1 (en) * | 2020-04-14 | 2023-04-20 | Glanis Pharmaceuticals, Inc. | Transdermal and/or topical delivery system comprising hydroxychloroquine and/or chloroquine |
| CN116033903A (zh) * | 2020-04-21 | 2023-04-28 | 诺姆·科恩 | 奎宁及其产生先天免疫应答的用途 |
| AU2021261049A1 (en) * | 2020-04-24 | 2022-11-10 | Topelia Aust Limited | Products of manufacture and methods for treating, ameliorating or preventing microbial infections |
| WO2021219244A1 (en) * | 2020-04-27 | 2021-11-04 | Immunologik Gmbh | 6'-methoxycinchonan-9-ols for the treatment of coronaviral infections |
| CN115515935B (zh) * | 2020-04-30 | 2025-01-07 | 中美华世通生物医药科技(武汉)股份有限公司 | 冠状病毒感染的治疗或预防 |
| IL301183A (en) * | 2020-09-14 | 2023-05-01 | Philip Morris Products Sa | Pharmaceutical composition comprising hydroxychloroquine and uses thereof |
| DE102021000717A1 (de) * | 2021-02-12 | 2022-08-18 | Forschungszentrum Jülich GmbH | Quinacrin als lnhibitor viraler Cysteinproteasen und/oder Serinproteasen |
| US20240391876A1 (en) * | 2021-08-19 | 2024-11-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Quinacrine and derivatives thereof for treatment of viral infections |
| CN115869311A (zh) * | 2022-12-30 | 2023-03-31 | 湖北工业大学 | MefloquineHydrochloride在制备抗腺病毒ADV7药物中的应用 |
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| US4181725A (en) * | 1977-05-02 | 1980-01-01 | The Regents Of The University Of Michigan | Method for alleviating psoriasis |
| US4496549A (en) * | 1983-01-17 | 1985-01-29 | American Cyanamid Company | Treatment of malaria with antibiotics |
| US5153202A (en) * | 1988-06-30 | 1992-10-06 | Davis Michael H | Method of inhibiting the activity of human immuno deficiency virus (HIV) in vivo |
| US5376359A (en) * | 1992-07-07 | 1994-12-27 | Glaxo, Inc. | Method of stabilizing aerosol formulations |
| US5827681A (en) * | 1996-12-20 | 1998-10-27 | University Technology Corporation | Rapid detection and drug sensitivity of malaria |
| WO2000066107A2 (en) * | 1999-04-30 | 2000-11-09 | Apt Pharmaceuticals, L.L.C. | Antimalarian agents for the treatment of asthma |
-
2002
- 2002-11-12 WO PCT/US2002/036309 patent/WO2003039546A1/en not_active Ceased
- 2002-11-12 US US10/293,770 patent/US20040167162A1/en not_active Abandoned
- 2002-11-12 EP EP02802902A patent/EP1450803A4/en not_active Withdrawn
- 2002-11-12 AU AU2002363443A patent/AU2002363443B2/en not_active Ceased
- 2002-11-12 JP JP2003541837A patent/JP2005512998A/ja active Pending
- 2002-11-12 MX MXPA04004393A patent/MXPA04004393A/es not_active Application Discontinuation
- 2002-11-12 CA CA002466338A patent/CA2466338C/en not_active Expired - Fee Related
- 2002-11-12 CN CNB028267923A patent/CN1289086C/zh not_active Expired - Fee Related
- 2002-11-12 IL IL16182102A patent/IL161821A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20040167162A1 (en) | 2004-08-26 |
| IL161821A0 (en) | 2005-11-20 |
| CA2466338A1 (en) | 2003-05-15 |
| HK1075619A1 (en) | 2005-12-23 |
| EP1450803A1 (en) | 2004-09-01 |
| AU2002363443B2 (en) | 2006-02-16 |
| JP2005512998A (ja) | 2005-05-12 |
| CN1289086C (zh) | 2006-12-13 |
| CN1612735A (zh) | 2005-05-04 |
| MXPA04004393A (es) | 2005-09-12 |
| EP1450803A4 (en) | 2008-09-03 |
| WO2003039546A1 (en) | 2003-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20131113 |
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| MKLA | Lapsed |
Effective date: 20131113 |