CA2456988A1 - Gas microsphere liposome composites - Google Patents
Gas microsphere liposome composites Download PDFInfo
- Publication number
- CA2456988A1 CA2456988A1 CA002456988A CA2456988A CA2456988A1 CA 2456988 A1 CA2456988 A1 CA 2456988A1 CA 002456988 A CA002456988 A CA 002456988A CA 2456988 A CA2456988 A CA 2456988A CA 2456988 A1 CA2456988 A1 CA 2456988A1
- Authority
- CA
- Canada
- Prior art keywords
- gas
- formulation
- microsphere
- filled
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
- 235000019743 Choline chloride Nutrition 0.000 description 1
- 108010069514 Cyclic Peptides Proteins 0.000 description 1
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- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
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- 229910052770 Uranium Inorganic materials 0.000 description 1
- SORGEQQSQGNZFI-UHFFFAOYSA-N [azido(phenoxy)phosphoryl]oxybenzene Chemical compound C=1C=CC=CC=1OP(=O)(N=[N+]=[N-])OC1=CC=CC=C1 SORGEQQSQGNZFI-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 208000035269 cancer or benign tumor Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229960003178 choline chloride Drugs 0.000 description 1
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- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 150000002634 lipophilic molecules Chemical class 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 description 1
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- YFZBPSXRYCOKCW-UHFFFAOYSA-N n-(3-aminopropyl)acetamide Chemical compound CC(=O)NCCCN YFZBPSXRYCOKCW-UHFFFAOYSA-N 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
- 150000002835 noble gases Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 125000005497 tetraalkylphosphonium group Chemical group 0.000 description 1
- DAUOXRUBCACRRL-UHFFFAOYSA-N tetradecylphosphane Chemical compound CCCCCCCCCCCCCCP DAUOXRUBCACRRL-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acoustics & Sound (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Radiology & Medical Imaging (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2001/025685 WO2003015831A1 (en) | 2001-08-16 | 2001-08-16 | Gas microsphere liposome composites |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2456988A1 true CA2456988A1 (en) | 2003-02-27 |
Family
ID=21742778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002456988A Abandoned CA2456988A1 (en) | 2001-08-16 | 2001-08-16 | Gas microsphere liposome composites |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1416974A1 (ko) |
| JP (1) | JP2005505532A (ko) |
| KR (1) | KR20040030121A (ko) |
| CN (1) | CN1620314A (ko) |
| BR (1) | BR0117106A (ko) |
| CA (1) | CA2456988A1 (ko) |
| IL (1) | IL160228A0 (ko) |
| MX (1) | MXPA04001468A (ko) |
| NO (1) | NO20040654L (ko) |
| PL (1) | PL368072A1 (ko) |
| WO (1) | WO2003015831A1 (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8257338B2 (en) | 2006-10-27 | 2012-09-04 | Artenga, Inc. | Medical microbubble generation |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9364569B2 (en) | 2003-02-04 | 2016-06-14 | Bracco Suisse S.A. | Ultrasound contrast agents and process for the preparation thereof |
| AU2004255160A1 (en) * | 2003-06-13 | 2005-01-20 | Imarx Therapeutics, Inc. | Non-invasive intravascular thrombolyisis using modified ultrasound techniques |
| JP2005154282A (ja) * | 2003-11-20 | 2005-06-16 | Mebiopharm Co Ltd | ガス封入リポソームの製造法 |
| WO2005063305A1 (en) * | 2003-12-22 | 2005-07-14 | Bracco Research Sa | Gas-filled microvesicle assembly for contrast imaging |
| AU2004308757B2 (en) * | 2003-12-22 | 2010-06-17 | Bracco Suisse S.A. | Assembly of gas-filled microvesicle with active component for contrast imaging |
| WO2007008220A2 (en) * | 2004-08-05 | 2007-01-18 | Baylor Research Institute | Gene or drug delivery system |
| EP1784228B1 (en) | 2004-08-18 | 2016-10-05 | Bracco Suisse SA | Gas-filled microvesicles composition for contrast imaging |
| KR20070052747A (ko) * | 2004-09-10 | 2007-05-22 | 도레이 가부시끼가이샤 | 의약품제제 |
| EP1853916A4 (en) * | 2005-02-16 | 2008-03-26 | Univ California | BUBBLE ARCHITECTURES AND METHODS OF OBTAINING AND USING SAME |
| EP1884232A1 (en) * | 2005-05-23 | 2008-02-06 | Mebiopharm Co., Ltd. | Method of producing liposomes containing gas enclosed therein |
| US20090155345A1 (en) * | 2005-12-08 | 2009-06-18 | Ben Gurion University Of The Negev Research And Development Authority | Methods for affecting liposome composition ultrasound irradiation |
| WO2008079834A2 (en) * | 2006-12-21 | 2008-07-03 | Lantheus Medical Imaging, Inc. | Preparation of paramagnetic nanoparticles conjugated to leukotriene b4 (ltb4) receptor antagonists, and their use as mri contrast agents for the detection of infection and inflammation |
| DE102007008484A1 (de) * | 2007-02-19 | 2008-08-21 | Epo Experimentelle Pharmakologie & Onkologie Berlin-Buch Gmbh | Pharmazeutische Zubereitung zur Bekämpfung von Metastasen |
| US9446150B2 (en) | 2007-10-09 | 2016-09-20 | Washington University | Particles for imaging |
| WO2009049089A1 (en) | 2007-10-09 | 2009-04-16 | Washington University In St. Louis | Ligand directed toroidal nanoparticles for therapy and diagnostic imaging |
| KR101006347B1 (ko) * | 2008-08-05 | 2011-01-10 | 주식회사 이엠따블유 | 스피커 일체형 안테나 |
| US9808500B2 (en) | 2009-12-17 | 2017-11-07 | Washington University | Antithrombotic nanoparticle |
| US9764043B2 (en) * | 2009-12-17 | 2017-09-19 | Washington University | Antithrombotic nanoparticle |
| AU2011239414A1 (en) | 2010-04-15 | 2012-11-08 | The Washington University | Prodrug compositions, prodrug nanoparticles, and methods of use thereof |
| WO2012098937A1 (ja) * | 2011-01-21 | 2012-07-26 | 国立大学法人 神戸大学 | リポソームの製造方法 |
| US20130123781A1 (en) * | 2011-08-24 | 2013-05-16 | California Institute Of Technology | Targeting microbubbles |
| CN102764456B (zh) * | 2012-07-24 | 2014-10-15 | 上海交通大学 | 血管栓塞剂及其用途、制备方法 |
| WO2015133828A1 (ko) * | 2014-03-07 | 2015-09-11 | 주식회사 퍼시픽시스템 | 약물 전달을 위해 기포를 포함하는 미셀 및 이를 제작하는 방법 |
| WO2016205359A2 (en) | 2015-06-17 | 2016-12-22 | Smith & Nephew, Inc. | Surgical instrument with phase change cooling |
| CN105169420B (zh) * | 2015-09-02 | 2018-01-05 | 上海市第十人民医院 | 一种新型射频诊疗剂及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620689A (en) * | 1989-10-20 | 1997-04-15 | Sequus Pharmaceuuticals, Inc. | Liposomes for treatment of B-cell and T-cell disorders |
| US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| EP0717617B1 (de) * | 1993-09-09 | 2000-10-25 | Schering Aktiengesellschaft | Wirkstoffe und gas enthaltende mikropartikel |
| US6090800A (en) * | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| ES2244169T3 (es) * | 1998-02-09 | 2005-12-01 | Bracco International B.V. | Suministro direccionado de medios biologicamente activos. |
-
2001
- 2001-08-16 BR BR0117106-2A patent/BR0117106A/pt not_active IP Right Cessation
- 2001-08-16 JP JP2003520788A patent/JP2005505532A/ja active Pending
- 2001-08-16 MX MXPA04001468A patent/MXPA04001468A/es not_active Application Discontinuation
- 2001-08-16 IL IL16022801A patent/IL160228A0/xx unknown
- 2001-08-16 PL PL01368072A patent/PL368072A1/xx not_active Application Discontinuation
- 2001-08-16 CN CNA018237088A patent/CN1620314A/zh active Pending
- 2001-08-16 EP EP01967995A patent/EP1416974A1/en not_active Withdrawn
- 2001-08-16 CA CA002456988A patent/CA2456988A1/en not_active Abandoned
- 2001-08-16 WO PCT/US2001/025685 patent/WO2003015831A1/en not_active Application Discontinuation
- 2001-08-16 KR KR10-2004-7002278A patent/KR20040030121A/ko not_active Application Discontinuation
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2004
- 2004-02-13 NO NO20040654A patent/NO20040654L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8257338B2 (en) | 2006-10-27 | 2012-09-04 | Artenga, Inc. | Medical microbubble generation |
Also Published As
| Publication number | Publication date |
|---|---|
| IL160228A0 (en) | 2004-07-25 |
| WO2003015831A1 (en) | 2003-02-27 |
| EP1416974A1 (en) | 2004-05-12 |
| JP2005505532A (ja) | 2005-02-24 |
| CN1620314A (zh) | 2005-05-25 |
| KR20040030121A (ko) | 2004-04-08 |
| BR0117106A (pt) | 2004-08-17 |
| MXPA04001468A (es) | 2004-05-20 |
| PL368072A1 (en) | 2005-03-21 |
| NO20040654L (no) | 2004-05-14 |
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