CA2444876A1 - Treatment of dementia and neurodegenerative diseases with intermediate doses of lhrh antagonists - Google Patents

Treatment of dementia and neurodegenerative diseases with intermediate doses of lhrh antagonists Download PDF

Info

Publication number
CA2444876A1
CA2444876A1 CA002444876A CA2444876A CA2444876A1 CA 2444876 A1 CA2444876 A1 CA 2444876A1 CA 002444876 A CA002444876 A CA 002444876A CA 2444876 A CA2444876 A CA 2444876A CA 2444876 A1 CA2444876 A1 CA 2444876A1
Authority
CA
Canada
Prior art keywords
use according
lhrh antagonist
methyl
treatment
monthly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002444876A
Other languages
English (en)
French (fr)
Inventor
Jurgen Engel
Rainer Voegeli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Zentaris AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris AG filed Critical Zentaris AG
Publication of CA2444876A1 publication Critical patent/CA2444876A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
CA002444876A 2001-04-30 2002-04-27 Treatment of dementia and neurodegenerative diseases with intermediate doses of lhrh antagonists Abandoned CA2444876A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28743401P 2001-04-30 2001-04-30
US60/287,434 2001-04-30
PCT/EP2002/004677 WO2002102401A1 (en) 2001-04-30 2002-04-27 Treatment of dementia and neurodegenerative diseases with intermediate doses of lhrh antagonists

Publications (1)

Publication Number Publication Date
CA2444876A1 true CA2444876A1 (en) 2002-12-27

Family

ID=23102886

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002444876A Abandoned CA2444876A1 (en) 2001-04-30 2002-04-27 Treatment of dementia and neurodegenerative diseases with intermediate doses of lhrh antagonists

Country Status (27)

Country Link
US (1) US7288517B2 (https=)
EP (1) EP1392348B1 (https=)
JP (1) JP2004529207A (https=)
KR (1) KR20040000446A (https=)
CN (1) CN1317030C (https=)
AT (1) ATE400287T1 (https=)
AU (1) AU2002310788B2 (https=)
BG (1) BG108339A (https=)
BR (1) BR0209290A (https=)
CA (1) CA2444876A1 (https=)
CZ (1) CZ20033167A3 (https=)
DE (1) DE60227507D1 (https=)
DK (1) DK1392348T3 (https=)
ES (1) ES2307760T3 (https=)
HU (1) HUP0400067A2 (https=)
IL (1) IL156777A0 (https=)
MX (1) MXPA03008666A (https=)
NO (1) NO20034322D0 (https=)
NZ (1) NZ544417A (https=)
PL (1) PL362319A1 (https=)
PT (1) PT1392348E (https=)
RU (1) RU2319501C2 (https=)
SI (1) SI1392348T1 (https=)
SK (1) SK14512003A3 (https=)
UA (1) UA80679C2 (https=)
WO (1) WO2002102401A1 (https=)
ZA (1) ZA200305326B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
US20020077327A1 (en) * 1999-09-23 2002-06-20 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
CN1186326C (zh) 2000-07-05 2005-01-26 山之内制药株式会社 丙－1,3－二酮衍生物
DE10137174A1 (de) * 2001-07-31 2003-02-13 Zentaris Ag Verwendung von LHRH-Antagonisten in nichtkastrierenden Dosen zur Verbesserung der T-Zellen-vermittelten Immunität
NZ552372A (en) 2004-06-04 2009-11-27 Astellas Pharma Inc Propane-1,3-dione derivative or its salt
US20080171736A1 (en) * 2004-12-23 2008-07-17 Gregory Christopher W Treatment of Alzheimer's Disease and Mild Cognitive impairment using GnRH-I analogs and one or more of acetylcholinesterase inhibitors and NMDA receptor antagonists
EP1827468B1 (en) * 2004-12-23 2012-08-22 Curaxis Pharmaceutical Corporation Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
SI1864976T1 (sl) * 2005-03-31 2012-12-31 Astellas Pharma Inc. Propan-1,3-dionski derivat ali njegova sol
AU2007312165A1 (en) * 2006-10-21 2008-04-24 Abbott Gmbh & Co. Kg Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors
EP2197469A2 (en) * 2007-09-11 2010-06-23 Mondobiotech Laboratories AG Use of nf-kappab inhibitor sn50 and optionally angiotensin iii as therapeutic agents in the treatment of eg hbv infection
RU2010114025A (ru) * 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) ПРИМЕНЕНИЕ ПЕПТИДА Gly-Arg-Gly-Asp-Asn-Pro В КАЧЕСТВЕ ТЕРАПЕВТИЧЕСКОГО СРЕДСТВА
EP2095818A1 (en) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
WO2009145690A1 (en) * 2008-05-29 2009-12-03 Isr Immune System Regulation Ab Method and means for treating viral disease, in particular hiv/aids
CA2810954A1 (en) 2010-09-27 2012-04-05 Abbott Gmbh & Co. Kg Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
US9090592B2 (en) 2010-12-30 2015-07-28 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
EP3560555A1 (en) * 2018-04-26 2019-10-30 LifeArc A composition for treating one or more estrogen related diseases
WO2025155903A1 (en) * 2024-01-19 2025-07-24 Temple University-Of The Commonwealth System Of Higher Education Compositions of antioxidant translation modulators for treating neurodegenerative disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3135743A (en) 1960-06-29 1964-06-02 Sterling Drug Inc Steroido[2. 3-d]isoxazoles and preparation thereof
US6150352A (en) * 1996-05-20 2000-11-21 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
DE19911771B4 (de) * 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
CA2372044A1 (en) 1999-05-14 2000-11-23 Neurocrine Biosciences, Inc. Imidazo- and pyrrolo[1,2-a]pyrimid-4-ones as gonadotropin-releasing hormone receptor antagonists
CA2309395A1 (en) * 1999-06-04 2000-12-04 Richard Lloyd Bowen Methods for preventing and treating alzheimer's disease
DE60022769T2 (de) 1999-10-15 2006-07-06 Neurocrine Biosciences, Inc., San Diego Gonadotropin freisetzenden hormon rezeptor antagonisten und ihre verwandten verwendungen
WO2001078780A1 (en) 2000-04-13 2001-10-25 Takeda Chemical Industries, Ltd. Preventives/remedies for alzheimer's disease
CN1186326C (zh) * 2000-07-05 2005-01-26 山之内制药株式会社 丙－1,3－二酮衍生物

Also Published As

Publication number Publication date
CN1317030C (zh) 2007-05-23
DK1392348T3 (da) 2008-09-29
CZ20033167A3 (cs) 2004-08-18
ATE400287T1 (de) 2008-07-15
NZ544417A (en) 2008-03-28
MXPA03008666A (es) 2004-10-15
EP1392348B1 (en) 2008-07-09
RU2003134949A (ru) 2005-02-10
IL156777A0 (en) 2004-02-08
NO20034322L (no) 2003-09-26
EP1392348A1 (en) 2004-03-03
SI1392348T1 (sl) 2008-12-31
PL362319A1 (en) 2004-10-18
BG108339A (bg) 2004-11-30
CN1575185A (zh) 2005-02-02
SK14512003A3 (sk) 2004-08-03
ES2307760T3 (es) 2008-12-01
UA80679C2 (en) 2007-10-25
HUP0400067A2 (hu) 2004-04-28
US7288517B2 (en) 2007-10-30
BR0209290A (pt) 2004-07-13
AU2002310788B2 (en) 2007-04-05
US20020177556A1 (en) 2002-11-28
NO20034322D0 (no) 2003-09-26
WO2002102401A1 (en) 2002-12-27
JP2004529207A (ja) 2004-09-24
PT1392348E (pt) 2008-09-09
ZA200305326B (en) 2003-07-30
HK1072000A1 (en) 2005-08-12
KR20040000446A (ko) 2004-01-03
DE60227507D1 (de) 2008-08-21
RU2319501C2 (ru) 2008-03-20

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued