DE60227507D1 - Niedrigdosierte lhrh antagonisten zur behandlung von neurodegenerativen krankheiten, insbesondere alzheimer krankheit - Google Patents

Niedrigdosierte lhrh antagonisten zur behandlung von neurodegenerativen krankheiten, insbesondere alzheimer krankheit

Info

Publication number
DE60227507D1
DE60227507D1 DE60227507T DE60227507T DE60227507D1 DE 60227507 D1 DE60227507 D1 DE 60227507D1 DE 60227507 T DE60227507 T DE 60227507T DE 60227507 T DE60227507 T DE 60227507T DE 60227507 D1 DE60227507 D1 DE 60227507D1
Authority
DE
Germany
Prior art keywords
treatment
dosed
low
alzheimer disease
lhrh antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60227507T
Other languages
English (en)
Inventor
Juergen Engel
Rainer Voegeli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Aeterna Zentaris GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris GmbH filed Critical Aeterna Zentaris GmbH
Application granted granted Critical
Publication of DE60227507D1 publication Critical patent/DE60227507D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DE60227507T 2001-04-30 2002-04-27 Niedrigdosierte lhrh antagonisten zur behandlung von neurodegenerativen krankheiten, insbesondere alzheimer krankheit Expired - Fee Related DE60227507D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28743401P 2001-04-30 2001-04-30
PCT/EP2002/004677 WO2002102401A1 (en) 2001-04-30 2002-04-27 Treatment of dementia and neurodegenerative diseases with intermediate doses of lhrh antagonists

Publications (1)

Publication Number Publication Date
DE60227507D1 true DE60227507D1 (de) 2008-08-21

Family

ID=23102886

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60227507T Expired - Fee Related DE60227507D1 (de) 2001-04-30 2002-04-27 Niedrigdosierte lhrh antagonisten zur behandlung von neurodegenerativen krankheiten, insbesondere alzheimer krankheit

Country Status (28)

Country Link
US (1) US7288517B2 (de)
EP (1) EP1392348B1 (de)
JP (1) JP2004529207A (de)
KR (1) KR20040000446A (de)
CN (1) CN1317030C (de)
AT (1) ATE400287T1 (de)
AU (1) AU2002310788B2 (de)
BG (1) BG108339A (de)
BR (1) BR0209290A (de)
CA (1) CA2444876A1 (de)
CZ (1) CZ20033167A3 (de)
DE (1) DE60227507D1 (de)
DK (1) DK1392348T3 (de)
ES (1) ES2307760T3 (de)
HK (1) HK1072000A1 (de)
HU (1) HUP0400067A2 (de)
IL (1) IL156777A0 (de)
MX (1) MXPA03008666A (de)
NO (1) NO20034322D0 (de)
NZ (1) NZ544417A (de)
PL (1) PL362319A1 (de)
PT (1) PT1392348E (de)
RU (1) RU2319501C2 (de)
SI (1) SI1392348T1 (de)
SK (1) SK14512003A3 (de)
UA (1) UA80679C2 (de)
WO (1) WO2002102401A1 (de)
ZA (1) ZA200305326B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
US20020077327A1 (en) * 1999-09-23 2002-06-20 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
AU2001271022B2 (en) * 2000-07-05 2006-08-17 Astellas Pharma Inc. Propane-1,3-dione derivatives
DE10137174A1 (de) * 2001-07-31 2003-02-13 Zentaris Ag Verwendung von LHRH-Antagonisten in nichtkastrierenden Dosen zur Verbesserung der T-Zellen-vermittelten Immunität
CA2568590C (en) 2004-06-04 2011-01-18 Astellas Pharma Inc. Propane-1,3-dione derivative or salt thereof useful as gnrh receptor antagonist
US20080171736A1 (en) * 2004-12-23 2008-07-17 Gregory Christopher W Treatment of Alzheimer's Disease and Mild Cognitive impairment using GnRH-I analogs and one or more of acetylcholinesterase inhibitors and NMDA receptor antagonists
JP2008525439A (ja) * 2004-12-23 2008-07-17 ボイジャー・ファーマシューティカル・コーポレーション アルツハイマー病の治療のための酢酸ロイプロリド及びアセチルコリンエステラーゼインヒビターまたはｎｍｄａレセプターアゴニスト
AU2006232469B2 (en) * 2005-03-31 2011-03-31 Astellas Pharma Inc. Propane-1,3-dion derivative or salt thereof
JP5406030B2 (ja) * 2006-10-21 2014-02-05 アボット ゲーエムベーハー ウント カンパニー カーゲー 複素環化合物およびそれらのグリコーゲンシンターゼキナーゼ３阻害薬としての使用
RU2010113981A (ru) * 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) Применение гексапептидного антагониста рецептора тромбоцитарного фибриногена и альфа-эндорфина в качестве терапевтических средств
EP2187943A2 (de) * 2007-09-11 2010-05-26 Mondobiotech Laboratories AG Gamma 1 msh allein oder in kombination mit pentagastrin als therapeutisches mittel
EP2095818A1 (de) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Verwendung von LHRH-Antagonisten in nicht-kastrierenden Dosen
CA2726247C (en) * 2008-05-29 2018-06-26 Isr Immune System Regulation Ab Method and means for treating viral disease, in particular hiv/aids
EP2621914B1 (de) 2010-09-27 2016-12-28 Abbott GmbH & Co. KG Heterocyclische verbindungen und ihre verwendung als glycogensynthasekinase-3-inhibitoren
US9090592B2 (en) 2010-12-30 2015-07-28 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
EP3560555A1 (de) * 2018-04-26 2019-10-30 LifeArc Zusammensetzung zur behandlung einer oder mehrerer östrogenvermittelter krankheiten

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3135743A (en) * 1960-06-29 1964-06-02 Sterling Drug Inc Steroido[2. 3-d]isoxazoles and preparation thereof
EP0901489A1 (de) 1996-05-20 1999-03-17 Merck & Co., Inc. Gonadotropin releasing hormone-antagoniste
DE19911771B4 (de) 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
EP1185530A1 (de) 1999-05-14 2002-03-13 Neurocrine Biosciences, Inc. Imidazo- und pyrrolo[1,2-a]pyrimid-4-one als antagonisten des rezeptors für das gonadotropin freisetzende hormon
CA2309395A1 (en) 1999-06-04 2000-12-04 Richard Lloyd Bowen Methods for preventing and treating alzheimer's disease
WO2001029044A1 (en) * 1999-10-15 2001-04-26 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
EP1393747A1 (de) 2000-04-13 2004-03-03 Takeda Chemical Industries, Ltd. Mittel zur prävention/behandlung von alzheimer-krankheit
AU2001271022B2 (en) 2000-07-05 2006-08-17 Astellas Pharma Inc. Propane-1,3-dione derivatives

Also Published As

Publication number Publication date
EP1392348A1 (de) 2004-03-03
KR20040000446A (ko) 2004-01-03
NO20034322L (no) 2003-09-26
US7288517B2 (en) 2007-10-30
IL156777A0 (en) 2004-02-08
HUP0400067A2 (hu) 2004-04-28
DK1392348T3 (da) 2008-09-29
RU2319501C2 (ru) 2008-03-20
ZA200305326B (en) 2003-07-30
CZ20033167A3 (cs) 2004-08-18
SI1392348T1 (sl) 2008-12-31
MXPA03008666A (es) 2004-10-15
ATE400287T1 (de) 2008-07-15
BR0209290A (pt) 2004-07-13
PL362319A1 (en) 2004-10-18
NZ544417A (en) 2008-03-28
JP2004529207A (ja) 2004-09-24
CA2444876A1 (en) 2002-12-27
PT1392348E (pt) 2008-09-09
RU2003134949A (ru) 2005-02-10
HK1072000A1 (en) 2005-08-12
UA80679C2 (en) 2007-10-25
EP1392348B1 (de) 2008-07-09
CN1317030C (zh) 2007-05-23
AU2002310788B2 (en) 2007-04-05
NO20034322D0 (no) 2003-09-26
SK14512003A3 (sk) 2004-08-03
BG108339A (bg) 2004-11-30
CN1575185A (zh) 2005-02-02
WO2002102401A1 (en) 2002-12-27
US20020177556A1 (en) 2002-11-28
ES2307760T3 (es) 2008-12-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee