CA2418189A1 - Optimization of an electrostatically dosed dry powder inhaler - Google Patents
Optimization of an electrostatically dosed dry powder inhaler Download PDFInfo
- Publication number
- CA2418189A1 CA2418189A1 CA002418189A CA2418189A CA2418189A1 CA 2418189 A1 CA2418189 A1 CA 2418189A1 CA 002418189 A CA002418189 A CA 002418189A CA 2418189 A CA2418189 A CA 2418189A CA 2418189 A1 CA2418189 A1 CA 2418189A1
- Authority
- CA
- Canada
- Prior art keywords
- dose
- dpi
- agglomeration
- electro
- delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0083—Timers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0003364A SE517225C2 (sv) | 2000-09-21 | 2000-09-21 | Optimering av en elektrostatiskt doserad inhalator för torrt pulver |
SE0003364-7 | 2000-09-21 | ||
PCT/SE2001/001942 WO2002024264A1 (en) | 2000-09-21 | 2001-09-12 | Optimization of an electrostatically dosed dry powder inhaler |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2418189A1 true CA2418189A1 (en) | 2002-03-28 |
Family
ID=20281098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002418189A Abandoned CA2418189A1 (en) | 2000-09-21 | 2001-09-12 | Optimization of an electrostatically dosed dry powder inhaler |
Country Status (12)
Country | Link |
---|---|
US (1) | US6571793B1 ( ) |
EP (1) | EP1322361A1 ( ) |
JP (1) | JP2004508899A ( ) |
KR (1) | KR20030033072A ( ) |
CN (1) | CN1462196A ( ) |
AU (1) | AU2001290410A1 ( ) |
BR (1) | BR0113994A ( ) |
CA (1) | CA2418189A1 ( ) |
PL (1) | PL360125A1 ( ) |
RU (1) | RU2003105888A ( ) |
SE (1) | SE517225C2 ( ) |
WO (1) | WO2002024264A1 ( ) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US20030072717A1 (en) * | 2001-02-23 | 2003-04-17 | Vapotronics, Inc. | Inhalation device having an optimized air flow path |
DE60318938T2 (de) | 2002-03-20 | 2009-01-22 | Mannkind Corp., Valencia | Inhalationsgerät |
SE524957C2 (sv) * | 2002-04-12 | 2004-11-02 | Microdrug Ag | Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament |
SE525027C2 (sv) | 2002-04-12 | 2004-11-16 | Microdrug Ag | Anordning utgörande en pulverlufthyvel |
GB0308771D0 (en) * | 2003-04-16 | 2003-05-21 | Univ Loughborough | Pulmonary drug delivery |
SE527200C2 (sv) * | 2003-06-19 | 2006-01-17 | Microdrug Ag | Inhalatoranordning samt kombinerade doser av formaterol och fluticason |
SE527069C2 (sv) | 2003-06-19 | 2005-12-13 | Mederio Ag | Förfarande och anordning för administrering av läkemedelspulver |
SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
EP1691782A1 (en) * | 2003-12-03 | 2006-08-23 | Microdrug AG | Medical product containing tiotropium |
SE0303270L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Metod för administration av tiotropium |
GB0328959D0 (en) * | 2003-12-12 | 2004-01-14 | Okpala Joseph | Crystalline and aerodynamic particles for patients with low inspiratory flow rates |
EP1696875A2 (en) * | 2003-12-12 | 2006-09-06 | Joseph Okpala | A method of engineering particles for use in the delivery of drugs via inhalation |
DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
JP4990142B2 (ja) | 2004-08-23 | 2012-08-01 | マンカインド コーポレイション | 薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩 |
TWI274641B (en) * | 2005-08-30 | 2007-03-01 | Rexon Ind Corp Ltd | Cutting machine |
HUE028691T2 (en) | 2005-09-14 | 2016-12-28 | Mannkind Corp | A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients |
AU2007216966C1 (en) | 2006-02-22 | 2014-03-20 | Mannkind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
EP1998832B1 (en) * | 2006-03-24 | 2014-10-22 | 3M Innovative Properties Company | Method for assessing the suitability of metered dose inhaler actuators |
US8261738B2 (en) * | 2007-07-24 | 2012-09-11 | Respironics Respiratory Drug Delivery (Uk) Ltd. | Apparatus and method for maintaining consistency for aerosol drug delivery treatments |
PT2230934E (pt) | 2007-12-14 | 2012-11-20 | Aerodesigns Inc | Distribuir produtos alimentares aerossolizáveis |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
ES2655921T3 (es) | 2008-06-13 | 2018-02-22 | Mannkind Corporation | Un inhalador de polvo seco y sistema para administración de fármacos |
ES2904623T3 (es) | 2008-06-20 | 2022-04-05 | Mannkind Corp | Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación |
TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
EP2405963B1 (en) | 2009-03-11 | 2013-11-06 | MannKind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
WO2010144789A2 (en) | 2009-06-12 | 2010-12-16 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
KR20130117755A (ko) | 2010-06-21 | 2013-10-28 | 맨카인드 코포레이션 | 건조 분말 약물 운반 시스템 및 방법 |
CN105667994B (zh) | 2011-04-01 | 2018-04-06 | 曼金德公司 | 用于药物药盒的泡罩包装 |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
WO2013063160A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
CN108057154B (zh) | 2012-07-12 | 2021-04-16 | 曼金德公司 | 干粉药物输送系统和方法 |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
JP6523247B2 (ja) | 2013-03-15 | 2019-05-29 | マンカインド コーポレイション | 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法 |
EP3021834A1 (en) | 2013-07-18 | 2016-05-25 | MannKind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
GB2521148B (en) * | 2013-12-10 | 2016-06-08 | Kind Consumer Ltd | Airflow testing apparatus |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10987048B2 (en) | 2014-08-13 | 2021-04-27 | Elwha Llc | Systems, methods, and devices to incentivize inhaler use |
US10765817B2 (en) | 2014-08-13 | 2020-09-08 | Elwha, Llc | Methods, systems, and devices related to delivery of alcohol with an inhaler |
CA2958891A1 (en) | 2014-08-28 | 2016-03-03 | Microdose Therapeutx, Inc. | Tidal dry powder inhaler with miniature pressure sensor activation |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
EP3552649B1 (en) | 2015-04-02 | 2023-08-23 | Hill-Rom Services PTE. LTD. | Pressure control of respiratory device |
CA3024721A1 (en) | 2016-05-19 | 2017-11-23 | Mannkind Corporation | Apparatus, system and method for detecting and monitoring inhalations |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3023648A1 (de) * | 1980-06-24 | 1982-01-21 | Jaeger, Erich, 8700 Würzburg | Einrichtung zur untersuchung der atemwege auf reizstoff-ueberempfindlichkeit |
FI76929C (fi) * | 1984-09-25 | 1989-01-10 | Etelae Haemeen Keuhkovammayhdi | Inhalationsdoseringsanordning, som aer avsedd foer nogrann dosering av disponerande laekemedel som ges aot andningssjuka i undersoekningsskedet och/eller laekemedel som ges som spray under behandlingen. |
ATE138814T1 (de) * | 1989-04-28 | 1996-06-15 | Riker Laboratories Inc | Inhalationsvorrichtung für trockenpulver |
US6024090A (en) * | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US5819726A (en) * | 1993-01-29 | 1998-10-13 | Aradigm Corporation | Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease |
US6012450A (en) * | 1993-01-29 | 2000-01-11 | Aradigm Corporation | Intrapulmonary delivery of hematopoietic drug |
US5522385A (en) * | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
US6309671B1 (en) * | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
SE504458C2 (sv) * | 1995-06-21 | 1997-02-17 | Lars Gunnar Nilsson | Inhalator för elektrisk dosering av substanser |
US5848587A (en) * | 1995-09-21 | 1998-12-15 | Medi-Nuclear Corporation, Inc. | Aerosol medication delivery system |
US6041777A (en) * | 1995-12-01 | 2000-03-28 | Alliance Pharmaceutical Corp. | Methods and apparatus for closed-circuit ventilation therapy |
US6026809A (en) * | 1996-01-25 | 2000-02-22 | Microdose Technologies, Inc. | Inhalation device |
US5694920A (en) * | 1996-01-25 | 1997-12-09 | Abrams; Andrew L. | Inhalation device |
DE19613185A1 (de) * | 1996-04-02 | 1997-10-09 | Pfeiffer Erich Gmbh & Co Kg | Dosiereinrichtung für strömungsfähige Medien wie Pulver/Luft-Dispersionen |
US5839430A (en) * | 1996-04-26 | 1998-11-24 | Cama; Joseph | Combination inhaler and peak flow rate meter |
GB9610821D0 (en) * | 1996-05-23 | 1996-07-31 | Glaxo Wellcome Inc | Metering apparatus |
US6131570A (en) * | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
US6003512A (en) * | 1997-11-13 | 1999-12-21 | Lovelace Respiratory Research Institute | Dust gun-aerosol generator and generation |
US6142146A (en) * | 1998-06-12 | 2000-11-07 | Microdose Technologies, Inc. | Inhalation device |
-
2000
- 2000-09-21 SE SE0003364A patent/SE517225C2/sv not_active IP Right Cessation
- 2000-10-17 US US09/688,697 patent/US6571793B1/en not_active Expired - Fee Related
-
2001
- 2001-09-12 AU AU2001290410A patent/AU2001290410A1/en not_active Abandoned
- 2001-09-12 CN CN01816118A patent/CN1462196A/zh active Pending
- 2001-09-12 BR BR0113994-0A patent/BR0113994A/pt not_active Application Discontinuation
- 2001-09-12 WO PCT/SE2001/001942 patent/WO2002024264A1/en not_active Application Discontinuation
- 2001-09-12 KR KR10-2003-7003961A patent/KR20030033072A/ko not_active Application Discontinuation
- 2001-09-12 CA CA002418189A patent/CA2418189A1/en not_active Abandoned
- 2001-09-12 JP JP2002528333A patent/JP2004508899A/ja active Pending
- 2001-09-12 EP EP01970409A patent/EP1322361A1/en not_active Withdrawn
- 2001-09-12 RU RU2003105888/14A patent/RU2003105888A/ru not_active Application Discontinuation
- 2001-09-12 PL PL36012501A patent/PL360125A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1322361A1 (en) | 2003-07-02 |
KR20030033072A (ko) | 2003-04-26 |
AU2001290410A1 (en) | 2002-04-02 |
CN1462196A (zh) | 2003-12-17 |
PL360125A1 (en) | 2004-09-06 |
SE0003364L (sv) | 2002-03-22 |
SE0003364D0 (sv) | 2000-09-21 |
JP2004508899A (ja) | 2004-03-25 |
WO2002024264A1 (en) | 2002-03-28 |
BR0113994A (pt) | 2003-08-12 |
SE517225C2 (sv) | 2002-05-14 |
US6571793B1 (en) | 2003-06-03 |
RU2003105888A (ru) | 2004-09-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |