BR0113994A - Otimização em um inalador de pó seco eletrostaticamente dosificado - Google Patents

Otimização em um inalador de pó seco eletrostaticamente dosificado

Info

Publication number
BR0113994A
BR0113994A BR0113994-0A BR0113994A BR0113994A BR 0113994 A BR0113994 A BR 0113994A BR 0113994 A BR0113994 A BR 0113994A BR 0113994 A BR0113994 A BR 0113994A
Authority
BR
Brazil
Prior art keywords
ips
dose
deagglomeration
electrostatic
activation
Prior art date
Application number
BR0113994-0A
Other languages
English (en)
Inventor
Thomas Nilsson
Original Assignee
Microdrug Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microdrug Ag filed Critical Microdrug Ag
Publication of BR0113994A publication Critical patent/BR0113994A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0083—Timers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Abstract

"OTIMIZAçãO EM UM INALADOR DE Pó SECO ELETROSTATICAMENTE DOSIFICADO". São descritos um método e um processo para otimizar um inalador de pó seco eletrostaticamente dosificado (IPSE) para utilização de uma dose eletrostática pré-medida preparada consistindo de um pó eletrostático. Um sistema é configurado para determinar parâmetros que afetam a administração sistêmica ou administração pulmonar local de uma dose eletrostática pré-medida a partir de um IPS, incluindo análises da desaglomeração da dose, distribuição do tamanho de partícula, bem como a variação dose-a-dose em conjunto com tempos e fluxos de pressurização. Um inalador de pó seco, IPS, é ajustado para uma formatação para administração sistêmica ou local com relação à pressão de ativação e pressão de fechamento para um IPS com um fluxo de ar de inalação de 20 a 60 litros/minuto no caso da formatação de administração sistêmica, e 20 a 80 litros/minuto no caso da formatação de administração local. Além disto, a energia de desaglomeração é ajustada entre 0,1 e 6 watts para ser utilizada no IPS, pela otimização da queda de pressão e taxa de fluxo de inalação pela modificação do bocal e/ou do membro de dispositivo e suas relações entre si. A pressão de ativação do IPS é adicionalmente ajustada para um valor entre 0,5 e 4 kPa para eliminar a baixa energia no início da inalação. O método e o processo verificam então se o IPS atende ao conjunto de especificações relativas à energia de desaglomeração e pressões de ativação e fechamento em conjunto com a regulação do tempo dentro do tempo de ativação do IPS. Além disto, é verificado se a diferença de desaglomeração, expressa em percentagem, utilizando a expressão 100[1 - desaglomeração(Q~ 1kpa~)/desaglomeração (Q)], não é maior que 50%. Finalmente, se o IPS não é aprovado como um IPSE, o IPS testado e/ou a dose eletrostática são posteriormente ajustados para checar se o IPS pode atender às especificações para um IPSE.
BR0113994-0A 2000-09-21 2001-09-12 Otimização em um inalador de pó seco eletrostaticamente dosificado BR0113994A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0003364A SE517225C2 (sv) 2000-09-21 2000-09-21 Optimering av en elektrostatiskt doserad inhalator för torrt pulver
PCT/SE2001/001942 WO2002024264A1 (en) 2000-09-21 2001-09-12 Optimization of an electrostatically dosed dry powder inhaler

Publications (1)

Publication Number Publication Date
BR0113994A true BR0113994A (pt) 2003-08-12

Family

ID=20281098

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113994-0A BR0113994A (pt) 2000-09-21 2001-09-12 Otimização em um inalador de pó seco eletrostaticamente dosificado

Country Status (12)

Country Link
US (1) US6571793B1 (pt)
EP (1) EP1322361A1 (pt)
JP (1) JP2004508899A (pt)
KR (1) KR20030033072A (pt)
CN (1) CN1462196A (pt)
AU (1) AU2001290410A1 (pt)
BR (1) BR0113994A (pt)
CA (1) CA2418189A1 (pt)
PL (1) PL360125A1 (pt)
RU (1) RU2003105888A (pt)
SE (1) SE517225C2 (pt)
WO (1) WO2002024264A1 (pt)

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Also Published As

Publication number Publication date
WO2002024264A1 (en) 2002-03-28
EP1322361A1 (en) 2003-07-02
SE517225C2 (sv) 2002-05-14
SE0003364D0 (sv) 2000-09-21
KR20030033072A (ko) 2003-04-26
US6571793B1 (en) 2003-06-03
AU2001290410A1 (en) 2002-04-02
PL360125A1 (en) 2004-09-06
SE0003364L (sv) 2002-03-22
JP2004508899A (ja) 2004-03-25
CA2418189A1 (en) 2002-03-28
CN1462196A (zh) 2003-12-17
RU2003105888A (ru) 2004-09-20

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]