BR0113994A - Otimização em um inalador de pó seco eletrostaticamente dosificado - Google Patents

Otimização em um inalador de pó seco eletrostaticamente dosificado

Info

Publication number
BR0113994A
BR0113994A BR0113994-0A BR0113994A BR0113994A BR 0113994 A BR0113994 A BR 0113994A BR 0113994 A BR0113994 A BR 0113994A BR 0113994 A BR0113994 A BR 0113994A
Authority
BR
Brazil
Prior art keywords
ips
dose
deagglomeration
electrostatic
activation
Prior art date
Application number
BR0113994-0A
Other languages
English (en)
Inventor
Thomas Nilsson
Original Assignee
Microdrug Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microdrug Ag filed Critical Microdrug Ag
Publication of BR0113994A publication Critical patent/BR0113994A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/02Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0083Timers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Abstract

"OTIMIZAçãO EM UM INALADOR DE Pó SECO ELETROSTATICAMENTE DOSIFICADO". São descritos um método e um processo para otimizar um inalador de pó seco eletrostaticamente dosificado (IPSE) para utilização de uma dose eletrostática pré-medida preparada consistindo de um pó eletrostático. Um sistema é configurado para determinar parâmetros que afetam a administração sistêmica ou administração pulmonar local de uma dose eletrostática pré-medida a partir de um IPS, incluindo análises da desaglomeração da dose, distribuição do tamanho de partícula, bem como a variação dose-a-dose em conjunto com tempos e fluxos de pressurização. Um inalador de pó seco, IPS, é ajustado para uma formatação para administração sistêmica ou local com relação à pressão de ativação e pressão de fechamento para um IPS com um fluxo de ar de inalação de 20 a 60 litros/minuto no caso da formatação de administração sistêmica, e 20 a 80 litros/minuto no caso da formatação de administração local. Além disto, a energia de desaglomeração é ajustada entre 0,1 e 6 watts para ser utilizada no IPS, pela otimização da queda de pressão e taxa de fluxo de inalação pela modificação do bocal e/ou do membro de dispositivo e suas relações entre si. A pressão de ativação do IPS é adicionalmente ajustada para um valor entre 0,5 e 4 kPa para eliminar a baixa energia no início da inalação. O método e o processo verificam então se o IPS atende ao conjunto de especificações relativas à energia de desaglomeração e pressões de ativação e fechamento em conjunto com a regulação do tempo dentro do tempo de ativação do IPS. Além disto, é verificado se a diferença de desaglomeração, expressa em percentagem, utilizando a expressão 100[1 - desaglomeração(Q~ 1kpa~)/desaglomeração (Q)], não é maior que 50%. Finalmente, se o IPS não é aprovado como um IPSE, o IPS testado e/ou a dose eletrostática são posteriormente ajustados para checar se o IPS pode atender às especificações para um IPSE.
BR0113994-0A 2000-09-21 2001-09-12 Otimização em um inalador de pó seco eletrostaticamente dosificado BR0113994A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0003364A SE517225C2 (sv) 2000-09-21 2000-09-21 Optimering av en elektrostatiskt doserad inhalator för torrt pulver
PCT/SE2001/001942 WO2002024264A1 (en) 2000-09-21 2001-09-12 Optimization of an electrostatically dosed dry powder inhaler

Publications (1)

Publication Number Publication Date
BR0113994A true BR0113994A (pt) 2003-08-12

Family

ID=20281098

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113994-0A BR0113994A (pt) 2000-09-21 2001-09-12 Otimização em um inalador de pó seco eletrostaticamente dosificado

Country Status (12)

Country Link
US (1) US6571793B1 (pt)
EP (1) EP1322361A1 (pt)
JP (1) JP2004508899A (pt)
KR (1) KR20030033072A (pt)
CN (1) CN1462196A (pt)
AU (1) AU2001290410A1 (pt)
BR (1) BR0113994A (pt)
CA (1) CA2418189A1 (pt)
PL (1) PL360125A1 (pt)
RU (1) RU2003105888A (pt)
SE (1) SE517225C2 (pt)
WO (1) WO2002024264A1 (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US20030072717A1 (en) * 2001-02-23 2003-04-17 Vapotronics, Inc. Inhalation device having an optimized air flow path
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
SE525027C2 (sv) 2002-04-12 2004-11-16 Microdrug Ag Anordning utgörande en pulverlufthyvel
SE524957C2 (sv) * 2002-04-12 2004-11-02 Microdrug Ag Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament
GB0308771D0 (en) * 2003-04-16 2003-05-21 Univ Loughborough Pulmonary drug delivery
SE527200C2 (sv) * 2003-06-19 2006-01-17 Microdrug Ag Inhalatoranordning samt kombinerade doser av formaterol och fluticason
SE527069C2 (sv) 2003-06-19 2005-12-13 Mederio Ag Förfarande och anordning för administrering av läkemedelspulver
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
EP1691782A1 (en) * 2003-12-03 2006-08-23 Microdrug AG Medical product containing tiotropium
GB0328959D0 (en) * 2003-12-12 2004-01-14 Okpala Joseph Crystalline and aerodynamic particles for patients with low inspiratory flow rates
EP1696875A2 (en) * 2003-12-12 2006-09-06 Joseph Okpala A method of engineering particles for use in the delivery of drugs via inhalation
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR101306384B1 (ko) 2004-08-23 2013-09-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
JP5465878B2 (ja) 2005-09-14 2014-04-09 マンカインド コーポレイション 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
WO2007112271A2 (en) * 2006-03-24 2007-10-04 3M Innovative Properties Company Method for assessing the suitability of metered dose inhaler actuators
US8261738B2 (en) * 2007-07-24 2012-09-11 Respironics Respiratory Drug Delivery (Uk) Ltd. Apparatus and method for maintaining consistency for aerosol drug delivery treatments
EP2230934B8 (en) 2007-12-14 2012-10-24 AeroDesigns, Inc Delivering aerosolizable food products
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN104689432B (zh) 2008-06-13 2018-07-06 曼金德公司 干粉吸入器和用于药物输送的系统
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
EP2440184B1 (en) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazine microparticles with defined specific surface areas
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
DK2694402T3 (en) 2011-04-01 2017-07-03 Mannkind Corp BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
GB2521148B (en) * 2013-12-10 2016-06-08 Kind Consumer Ltd Airflow testing apparatus
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10765817B2 (en) 2014-08-13 2020-09-08 Elwha, Llc Methods, systems, and devices related to delivery of alcohol with an inhaler
US10987048B2 (en) 2014-08-13 2021-04-27 Elwha Llc Systems, methods, and devices to incentivize inhaler use
TW201618825A (zh) 2014-08-28 2016-06-01 微劑量醫療公司 具有小型壓力感測器啟動的浪潮式乾粉吸入器
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP6480598B2 (ja) 2015-04-02 2019-03-13 ヒル−ロム サービシーズ プライヴェート リミテッド 呼吸装置用マニホールド
CA3225148A1 (en) 2016-05-19 2017-11-23 Mannkind Corporation Apparatus, system and method for detecting and monitoring inhalations

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3023648A1 (de) * 1980-06-24 1982-01-21 Jaeger, Erich, 8700 Würzburg Einrichtung zur untersuchung der atemwege auf reizstoff-ueberempfindlichkeit
FI76929C (fi) * 1984-09-25 1989-01-10 Etelae Haemeen Keuhkovammayhdi Inhalationsdoseringsanordning, som aer avsedd foer nogrann dosering av disponerande laekemedel som ges aot andningssjuka i undersoekningsskedet och/eller laekemedel som ges som spray under behandlingen.
ES2087911T3 (es) * 1989-04-28 1996-08-01 Riker Laboratories Inc Dispositivo de inhalacion de polvo seco.
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5819726A (en) * 1993-01-29 1998-10-13 Aradigm Corporation Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease
US6012450A (en) * 1993-01-29 2000-01-11 Aradigm Corporation Intrapulmonary delivery of hematopoietic drug
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US6309671B1 (en) * 1995-04-14 2001-10-30 Inhale Therapeutic Systems Stable glassy state powder formulations
SE504458C2 (sv) * 1995-06-21 1997-02-17 Lars Gunnar Nilsson Inhalator för elektrisk dosering av substanser
US5848587A (en) * 1995-09-21 1998-12-15 Medi-Nuclear Corporation, Inc. Aerosol medication delivery system
US6041777A (en) * 1995-12-01 2000-03-28 Alliance Pharmaceutical Corp. Methods and apparatus for closed-circuit ventilation therapy
US5694920A (en) * 1996-01-25 1997-12-09 Abrams; Andrew L. Inhalation device
US6026809A (en) * 1996-01-25 2000-02-22 Microdose Technologies, Inc. Inhalation device
DE19613185A1 (de) * 1996-04-02 1997-10-09 Pfeiffer Erich Gmbh & Co Kg Dosiereinrichtung für strömungsfähige Medien wie Pulver/Luft-Dispersionen
US5839430A (en) * 1996-04-26 1998-11-24 Cama; Joseph Combination inhaler and peak flow rate meter
GB9610821D0 (en) * 1996-05-23 1996-07-31 Glaxo Wellcome Inc Metering apparatus
US6131570A (en) * 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US6003512A (en) * 1997-11-13 1999-12-21 Lovelace Respiratory Research Institute Dust gun-aerosol generator and generation
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device

Also Published As

Publication number Publication date
KR20030033072A (ko) 2003-04-26
SE0003364D0 (sv) 2000-09-21
PL360125A1 (en) 2004-09-06
US6571793B1 (en) 2003-06-03
AU2001290410A1 (en) 2002-04-02
CA2418189A1 (en) 2002-03-28
SE0003364L (sv) 2002-03-22
CN1462196A (zh) 2003-12-17
RU2003105888A (ru) 2004-09-20
SE517225C2 (sv) 2002-05-14
WO2002024264A1 (en) 2002-03-28
JP2004508899A (ja) 2004-03-25
EP1322361A1 (en) 2003-07-02

Similar Documents

Publication Publication Date Title
BR0113994A (pt) Otimização em um inalador de pó seco eletrostaticamente dosificado
Hess et al. The effect of heliox on nebulizer function using a β-agonist bronchodilator
US10369300B2 (en) Aerosol generator for generating an inhalation aerosol
Faarc Nebulizers: principles and performance
Rau et al. Performance comparison of nebulizer designs: constant-output, breath-enhanced, and dosimetric
Bhashyam et al. Aerosol delivery through nasal cannulas: an in vitro study
Scherer et al. Convective exchange in oscillatory flow through bronchial-tree models
CN101918062B (zh) 用在cpap系统中的雾化装置
Golshahi et al. The use of condensational growth methods for efficient drug delivery to the lungs during noninvasive ventilation high flow therapy
AR017196A1 (es) Aparato y metodo para asegurar el ajuste de una mascara facial sobre la cara de un paciente y para suministrar a un paciente un medicamento a ser inhalado.
US20080017198A1 (en) Aerosol delivery apparatus and method for pressure-assisted breathing systems
US20050229929A1 (en) Aerosol delivery apparatus and method for pressure-assisted breathing systems
RU2661725C2 (ru) Ингалятор
BR9709748A (pt) Método de inalação de pó seco
MX2012001118A (es) Dispositivo y metodo de presion de via aerea positiva, continua.
DE60116319D1 (de) Inhalatoren
CN106215299A (zh) 随吸供氧制氧机
WO2002009574A3 (en) Generation, delivery, measurement and control of aerosol boli for diagnostics and treatment of the respiratory tract
US20210138178A1 (en) Device And Method For Diffusing High Concentration NO With Inhalation Therapy Gas
Lin et al. Mouthpiece diameter affects deposition efficiency in cast models of the human oral airways
Longest et al. Effects of generation time on spray aerosol transport and deposition in models of the mouth–throat geometry
US6435004B1 (en) Apparatus and process for aerosol size measurement at varying gas flow rates
Gemci et al. A CFD study of the throat during aerosol drug delivery using heliox and air
Barry et al. Drug output from nebulizers is dependent on the method of measurement
Finlay et al. Variations in predicted regional lung deposition of salbutamol sulphate between 19 nebulizer types

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]