BR0113994A - Otimização em um inalador de pó seco eletrostaticamente dosificado - Google Patents
Otimização em um inalador de pó seco eletrostaticamente dosificadoInfo
- Publication number
- BR0113994A BR0113994A BR0113994-0A BR0113994A BR0113994A BR 0113994 A BR0113994 A BR 0113994A BR 0113994 A BR0113994 A BR 0113994A BR 0113994 A BR0113994 A BR 0113994A
- Authority
- BR
- Brazil
- Prior art keywords
- ips
- dose
- deagglomeration
- electrostatic
- activation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0083—Timers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Abstract
"OTIMIZAçãO EM UM INALADOR DE Pó SECO ELETROSTATICAMENTE DOSIFICADO". São descritos um método e um processo para otimizar um inalador de pó seco eletrostaticamente dosificado (IPSE) para utilização de uma dose eletrostática pré-medida preparada consistindo de um pó eletrostático. Um sistema é configurado para determinar parâmetros que afetam a administração sistêmica ou administração pulmonar local de uma dose eletrostática pré-medida a partir de um IPS, incluindo análises da desaglomeração da dose, distribuição do tamanho de partícula, bem como a variação dose-a-dose em conjunto com tempos e fluxos de pressurização. Um inalador de pó seco, IPS, é ajustado para uma formatação para administração sistêmica ou local com relação à pressão de ativação e pressão de fechamento para um IPS com um fluxo de ar de inalação de 20 a 60 litros/minuto no caso da formatação de administração sistêmica, e 20 a 80 litros/minuto no caso da formatação de administração local. Além disto, a energia de desaglomeração é ajustada entre 0,1 e 6 watts para ser utilizada no IPS, pela otimização da queda de pressão e taxa de fluxo de inalação pela modificação do bocal e/ou do membro de dispositivo e suas relações entre si. A pressão de ativação do IPS é adicionalmente ajustada para um valor entre 0,5 e 4 kPa para eliminar a baixa energia no início da inalação. O método e o processo verificam então se o IPS atende ao conjunto de especificações relativas à energia de desaglomeração e pressões de ativação e fechamento em conjunto com a regulação do tempo dentro do tempo de ativação do IPS. Além disto, é verificado se a diferença de desaglomeração, expressa em percentagem, utilizando a expressão 100[1 - desaglomeração(Q~ 1kpa~)/desaglomeração (Q)], não é maior que 50%. Finalmente, se o IPS não é aprovado como um IPSE, o IPS testado e/ou a dose eletrostática são posteriormente ajustados para checar se o IPS pode atender às especificações para um IPSE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0003364A SE517225C2 (sv) | 2000-09-21 | 2000-09-21 | Optimering av en elektrostatiskt doserad inhalator för torrt pulver |
PCT/SE2001/001942 WO2002024264A1 (en) | 2000-09-21 | 2001-09-12 | Optimization of an electrostatically dosed dry powder inhaler |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0113994A true BR0113994A (pt) | 2003-08-12 |
Family
ID=20281098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0113994-0A BR0113994A (pt) | 2000-09-21 | 2001-09-12 | Otimização em um inalador de pó seco eletrostaticamente dosificado |
Country Status (12)
Country | Link |
---|---|
US (1) | US6571793B1 (pt) |
EP (1) | EP1322361A1 (pt) |
JP (1) | JP2004508899A (pt) |
KR (1) | KR20030033072A (pt) |
CN (1) | CN1462196A (pt) |
AU (1) | AU2001290410A1 (pt) |
BR (1) | BR0113994A (pt) |
CA (1) | CA2418189A1 (pt) |
PL (1) | PL360125A1 (pt) |
RU (1) | RU2003105888A (pt) |
SE (1) | SE517225C2 (pt) |
WO (1) | WO2002024264A1 (pt) |
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SE525027C2 (sv) | 2002-04-12 | 2004-11-16 | Microdrug Ag | Anordning utgörande en pulverlufthyvel |
SE524957C2 (sv) * | 2002-04-12 | 2004-11-02 | Microdrug Ag | Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament |
GB0308771D0 (en) * | 2003-04-16 | 2003-05-21 | Univ Loughborough | Pulmonary drug delivery |
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SE0303270L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Metod för administration av tiotropium |
SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
EP1691782A1 (en) * | 2003-12-03 | 2006-08-23 | Microdrug AG | Medical product containing tiotropium |
GB0328959D0 (en) * | 2003-12-12 | 2004-01-14 | Okpala Joseph | Crystalline and aerodynamic particles for patients with low inspiratory flow rates |
EP1696875A2 (en) * | 2003-12-12 | 2006-09-06 | Joseph Okpala | A method of engineering particles for use in the delivery of drugs via inhalation |
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KR101306384B1 (ko) | 2004-08-23 | 2013-09-09 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염 |
TWI274641B (en) * | 2005-08-30 | 2007-03-01 | Rexon Ind Corp Ltd | Cutting machine |
JP5465878B2 (ja) | 2005-09-14 | 2014-04-09 | マンカインド コーポレイション | 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法 |
CN104383546B (zh) | 2006-02-22 | 2021-03-02 | 曼金德公司 | 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法 |
WO2007112271A2 (en) * | 2006-03-24 | 2007-10-04 | 3M Innovative Properties Company | Method for assessing the suitability of metered dose inhaler actuators |
US8261738B2 (en) * | 2007-07-24 | 2012-09-11 | Respironics Respiratory Drug Delivery (Uk) Ltd. | Apparatus and method for maintaining consistency for aerosol drug delivery treatments |
EP2230934B8 (en) | 2007-12-14 | 2012-10-24 | AeroDesigns, Inc | Delivering aerosolizable food products |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
CN104689432B (zh) | 2008-06-13 | 2018-07-06 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
JP5479465B2 (ja) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | 吸入努力をリアルタイムにプロファイルする対話式機器および方法 |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
PL2405963T3 (pl) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Urządzenie, układ i sposób pomiaru oporu inhalatora |
EP2440184B1 (en) | 2009-06-12 | 2023-04-05 | MannKind Corporation | Diketopiperazine microparticles with defined specific surface areas |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
RU2571331C1 (ru) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
DK2694402T3 (en) | 2011-04-01 | 2017-07-03 | Mannkind Corp | BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
AU2012328885B2 (en) | 2011-10-24 | 2017-08-31 | Mannkind Corporation | Methods and compositions for treating pain |
AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
EP3587404B1 (en) | 2013-03-15 | 2022-07-13 | MannKind Corporation | Microcrystalline diketopiperazine compositions, methods for preparation and use thereof |
BR112016000937A8 (pt) | 2013-07-18 | 2021-06-22 | Mannkind Corp | formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco |
JP2016530930A (ja) | 2013-08-05 | 2016-10-06 | マンカインド コーポレイション | 通気装置及び方法 |
GB2521148B (en) * | 2013-12-10 | 2016-06-08 | Kind Consumer Ltd | Airflow testing apparatus |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10765817B2 (en) | 2014-08-13 | 2020-09-08 | Elwha, Llc | Methods, systems, and devices related to delivery of alcohol with an inhaler |
US10987048B2 (en) | 2014-08-13 | 2021-04-27 | Elwha Llc | Systems, methods, and devices to incentivize inhaler use |
TW201618825A (zh) | 2014-08-28 | 2016-06-01 | 微劑量醫療公司 | 具有小型壓力感測器啟動的浪潮式乾粉吸入器 |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
JP6480598B2 (ja) | 2015-04-02 | 2019-03-13 | ヒル−ロム サービシーズ プライヴェート リミテッド | 呼吸装置用マニホールド |
CA3225148A1 (en) | 2016-05-19 | 2017-11-23 | Mannkind Corporation | Apparatus, system and method for detecting and monitoring inhalations |
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-
2000
- 2000-09-21 SE SE0003364A patent/SE517225C2/sv not_active IP Right Cessation
- 2000-10-17 US US09/688,697 patent/US6571793B1/en not_active Expired - Fee Related
-
2001
- 2001-09-12 CN CN01816118A patent/CN1462196A/zh active Pending
- 2001-09-12 RU RU2003105888/14A patent/RU2003105888A/ru not_active Application Discontinuation
- 2001-09-12 CA CA002418189A patent/CA2418189A1/en not_active Abandoned
- 2001-09-12 WO PCT/SE2001/001942 patent/WO2002024264A1/en not_active Application Discontinuation
- 2001-09-12 KR KR10-2003-7003961A patent/KR20030033072A/ko not_active Application Discontinuation
- 2001-09-12 AU AU2001290410A patent/AU2001290410A1/en not_active Abandoned
- 2001-09-12 JP JP2002528333A patent/JP2004508899A/ja active Pending
- 2001-09-12 PL PL36012501A patent/PL360125A1/xx unknown
- 2001-09-12 BR BR0113994-0A patent/BR0113994A/pt not_active Application Discontinuation
- 2001-09-12 EP EP01970409A patent/EP1322361A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
KR20030033072A (ko) | 2003-04-26 |
SE0003364D0 (sv) | 2000-09-21 |
PL360125A1 (en) | 2004-09-06 |
US6571793B1 (en) | 2003-06-03 |
AU2001290410A1 (en) | 2002-04-02 |
CA2418189A1 (en) | 2002-03-28 |
SE0003364L (sv) | 2002-03-22 |
CN1462196A (zh) | 2003-12-17 |
RU2003105888A (ru) | 2004-09-20 |
SE517225C2 (sv) | 2002-05-14 |
WO2002024264A1 (en) | 2002-03-28 |
JP2004508899A (ja) | 2004-03-25 |
EP1322361A1 (en) | 2003-07-02 |
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Legal Events
Date | Code | Title | Description |
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B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |