CA2402341A1 - Metabotropic glutamate receptor antagonists for treating tolerance and dependency - Google Patents
Metabotropic glutamate receptor antagonists for treating tolerance and dependency Download PDFInfo
- Publication number
- CA2402341A1 CA2402341A1 CA002402341A CA2402341A CA2402341A1 CA 2402341 A1 CA2402341 A1 CA 2402341A1 CA 002402341 A CA002402341 A CA 002402341A CA 2402341 A CA2402341 A CA 2402341A CA 2402341 A1 CA2402341 A1 CA 2402341A1
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- dependence
- tolerance
- antagonist
- treatment
- mglur
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
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| PCT/GB2001/001058 WO2001066113A1 (en) | 2000-03-09 | 2001-03-09 | Metabotropic glutamate receptor antagonists for treating tolerance and dependency |
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| CA2402341A1 true CA2402341A1 (en) | 2001-09-13 |
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| EP (1) | EP1267869B1 (enExample) |
| JP (1) | JP2003525902A (enExample) |
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| SE (1) | SE1267869T5 (enExample) |
| TR (1) | TR200401862T4 (enExample) |
| WO (1) | WO2001066113A1 (enExample) |
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| WO2004024150A2 (en) * | 2002-09-10 | 2004-03-25 | Novartis Ag | Mglu receptors antagonists for treating disorders associated with mglu receptors including addiction and depression |
| EP2201963B1 (en) | 2005-04-05 | 2016-01-27 | Yale University | Glutamate modulating agents in the treatment of mental disorders |
| US20060264381A1 (en) * | 2005-05-05 | 2006-11-23 | Bear Mark F | Methods of treating obsessive compulsive disorder |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| US7531541B2 (en) * | 2005-09-20 | 2009-05-12 | Vanderbilt University | Partial mGluR5 antagonists for treatment of anxiety and CNS disorders |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| DE102005062985A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| PL2083811T3 (pl) | 2006-11-22 | 2017-05-31 | Clinical Research Associates, Llc | Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US20130058915A1 (en) | 2010-03-02 | 2013-03-07 | Children's Medica Center Corporation | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
| US20110294879A1 (en) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
| WO2012009646A1 (en) | 2010-07-15 | 2012-01-19 | Xenoport, Inc. | Methods of treating fragile x syndrome, down's syndrome, autism and related disorders |
| WO2012054724A1 (en) | 2010-10-21 | 2012-04-26 | Massachusetts Institute Of Technology | Methods of treating seizure disorders |
| US20130123254A1 (en) * | 2011-09-30 | 2013-05-16 | Barbara Biemans | Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification |
| GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
| CA3067688A1 (en) | 2017-07-31 | 2019-02-07 | Novartis Ag | Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use |
| EP3661500B1 (en) * | 2017-07-31 | 2026-01-07 | Novartis AG | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
| EP4181918A2 (en) * | 2020-07-17 | 2023-05-24 | Novartis AG | Mavoglurant, a mglur5 antagonist, for use in the treatment in the reduction of opioid use |
| US20240082215A1 (en) * | 2020-12-14 | 2024-03-14 | Novartis Ag | Use of mglur5 antagonists for treating gambling disorder |
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| US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
| US5543698A (en) * | 1994-09-27 | 1996-08-06 | Allen-Bradley Company, Inc. | Method and apparatus used with AC motor for detecting unbalance |
| GB9609976D0 (en) * | 1996-05-13 | 1996-07-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| CA2287591A1 (en) * | 1997-03-14 | 1998-09-17 | The Johns Hopkins University School Of Medicine | Synaptic activation protein compositions and method |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| US6057368A (en) * | 1998-08-05 | 2000-05-02 | Brookhaven Science Associates Llc | Treatment of addiction and addiction-related behavior |
| NZ510743A (en) * | 1998-10-02 | 2003-10-31 | Novartis Ag | mGluR5 antagonists for the treatment of pain and anxiety |
| TW593241B (en) * | 1999-04-20 | 2004-06-21 | Hoffmann La Roche | Carbamic acid derivatives |
| EP1183238A1 (en) * | 1999-05-17 | 2002-03-06 | Eli Lilly And Company | Metabotropic glutamate receptor antagonists |
| US6666209B2 (en) * | 2001-02-20 | 2003-12-23 | 3M Innovative Properties Company | Method and system of calibrating air flow in a respirator system |
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- 2000-03-09 GB GBGB0005700.0A patent/GB0005700D0/en not_active Ceased
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- 2001-03-09 PT PT01910051T patent/PT1267869E/pt unknown
- 2001-03-09 DE DE60103384T patent/DE60103384T2/de not_active Revoked
- 2001-03-09 AT AT01910051T patent/ATE267013T1/de not_active IP Right Cessation
- 2001-03-09 SE SE01910051T patent/SE1267869T5/xx unknown
- 2001-03-09 CN CN01808891A patent/CN1427720A/zh active Pending
- 2001-03-09 TR TR2004/01862T patent/TR200401862T4/xx unknown
- 2001-03-09 US US10/221,128 patent/US20030195139A1/en not_active Abandoned
- 2001-03-09 DK DK01910051T patent/DK1267869T3/da active
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- 2001-03-09 ES ES01910051T patent/ES2220727T3/es not_active Expired - Lifetime
- 2001-03-09 AU AU37634/01A patent/AU783869B2/en not_active Ceased
- 2001-03-09 CA CA002402341A patent/CA2402341A1/en not_active Abandoned
- 2001-03-09 WO PCT/GB2001/001058 patent/WO2001066113A1/en not_active Ceased
- 2001-03-09 NZ NZ521228A patent/NZ521228A/en unknown
- 2001-03-09 EP EP01910051A patent/EP1267869B1/en not_active Revoked
Also Published As
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| SE1267869T5 (enExample) | 2004-09-07 |
| EP1267869B1 (en) | 2004-05-19 |
| ES2220727T3 (es) | 2004-12-16 |
| PT1267869E (pt) | 2004-10-29 |
| DE60103384T2 (de) | 2005-06-16 |
| NZ521228A (en) | 2004-04-30 |
| JP2003525902A (ja) | 2003-09-02 |
| AU3763401A (en) | 2001-09-17 |
| ATE267013T1 (de) | 2004-06-15 |
| SE1267869T3 (enExample) | 2004-08-31 |
| TR200401862T4 (tr) | 2004-10-21 |
| CN1427720A (zh) | 2003-07-02 |
| GB0005700D0 (en) | 2000-05-03 |
| AU783869B2 (en) | 2005-12-15 |
| EP1267869A1 (en) | 2003-01-02 |
| DK1267869T3 (da) | 2004-09-20 |
| HK1053262A1 (en) | 2003-10-17 |
| DE60103384D1 (de) | 2004-06-24 |
| US20030195139A1 (en) | 2003-10-16 |
| WO2001066113A1 (en) | 2001-09-13 |
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| EEER | Examination request | ||
| FZDE | Discontinued |