AU783869B2 - Metabotropic glutamate receptor antagonists for treating tolerance and dependency - Google Patents
Metabotropic glutamate receptor antagonists for treating tolerance and dependency Download PDFInfo
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- AU783869B2 AU783869B2 AU37634/01A AU3763401A AU783869B2 AU 783869 B2 AU783869 B2 AU 783869B2 AU 37634/01 A AU37634/01 A AU 37634/01A AU 3763401 A AU3763401 A AU 3763401A AU 783869 B2 AU783869 B2 AU 783869B2
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- dependence
- mglur5
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- antagonist
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Classifications
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Biomedical Technology (AREA)
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- Addiction (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Organic Chemistry (AREA)
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- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fertilizers (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0005700.0A GB0005700D0 (en) | 2000-03-09 | 2000-03-09 | Therapy |
| GB0005700 | 2000-03-09 | ||
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| US8354447B2 (en) * | 2002-09-10 | 2013-01-15 | The Scripps Research Institute | mGLU receptors antagonists for treating disorders associated with mGLU receptors including addiction and depression |
| EP3753561A1 (en) | 2005-04-05 | 2020-12-23 | Yale University | Glutamate modulating agents in the treatment of mental disorders |
| US20060264381A1 (en) * | 2005-05-05 | 2006-11-23 | Bear Mark F | Methods of treating obsessive compulsive disorder |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| WO2007035823A2 (en) * | 2005-09-20 | 2007-03-29 | Molecular Neuroimaging, Llc | Partial mglur5 antagonists and methods of use thereof |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| DE102005062985A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2008030651A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| HUE032743T2 (en) | 2006-11-22 | 2017-10-30 | Clinical Res Ass Llc | A method for treating Down syndrome, fragilis X syndrome and autism |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US20130058915A1 (en) | 2010-03-02 | 2013-03-07 | Children's Medica Center Corporation | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
| WO2011150380A1 (en) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
| WO2012009646A1 (en) | 2010-07-15 | 2012-01-19 | Xenoport, Inc. | Methods of treating fragile x syndrome, down's syndrome, autism and related disorders |
| WO2012054724A1 (en) | 2010-10-21 | 2012-04-26 | Massachusetts Institute Of Technology | Methods of treating seizure disorders |
| US20130123254A1 (en) * | 2011-09-30 | 2013-05-16 | Barbara Biemans | Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification |
| GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
| CN110891564A (zh) | 2017-07-31 | 2020-03-17 | 诺华股份有限公司 | 玛沃谷兰在减少酒精使用或在预防复用酒精中的用途 |
| CN110958879A (zh) * | 2017-07-31 | 2020-04-03 | 诺华股份有限公司 | 玛沃谷兰在减少可卡因使用或预防复用可卡因中的用途 |
| CN115942979A (zh) * | 2020-07-17 | 2023-04-07 | 诺华股份有限公司 | 在减少阿片类物质使用的治疗中使用的mglur5拮抗剂玛沃谷兰 |
| WO2022130136A1 (en) * | 2020-12-14 | 2022-06-23 | Novartis Ag | Use of mglur5 antagonists for treating gambling disorder |
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| ID29095A (id) * | 1998-10-02 | 2001-07-26 | Novartis Ag Cs | Antagonis mglur5 untuk pengobatan rasa sakit dan kegelisahan |
| TW593241B (en) * | 1999-04-20 | 2004-06-21 | Hoffmann La Roche | Carbamic acid derivatives |
| WO2000069816A1 (en) * | 1999-05-17 | 2000-11-23 | Eli Lilly And Company | Metabotropic glutamate receptor antagonists |
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| DK1267869T3 (da) | 2004-09-20 |
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| WO2001066113A1 (en) | 2001-09-13 |
| JP2003525902A (ja) | 2003-09-02 |
| ATE267013T1 (de) | 2004-06-15 |
| CA2402341A1 (en) | 2001-09-13 |
| EP1267869A1 (en) | 2003-01-02 |
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