CA2389773A1 - Activateurs de la guanylate cyclase soluble - Google Patents

Activateurs de la guanylate cyclase soluble Download PDF

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Publication number
CA2389773A1
CA2389773A1 CA002389773A CA2389773A CA2389773A1 CA 2389773 A1 CA2389773 A1 CA 2389773A1 CA 002389773 A CA002389773 A CA 002389773A CA 2389773 A CA2389773 A CA 2389773A CA 2389773 A1 CA2389773 A1 CA 2389773A1
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Canada
Prior art keywords
dimethylamino
propyl
phenyl
chloro
amide
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Abandoned
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CA002389773A
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English (en)
Inventor
Robert Glen
Karen Reynolds
David Selwood
Grant Wishart
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Individual
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University College London
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Priority claimed from GBGB9926286.7A external-priority patent/GB9926286D0/en
Application filed by University College London filed Critical University College London
Publication of CA2389773A1 publication Critical patent/CA2389773A1/fr
Abandoned legal-status Critical Current

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
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    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/50—Pyrenes; Hydrogenated pyrenes

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Abstract

La présente invention concerne l'utilisation d'un composé de la formule (I), ou d'un sel pharmaceutiquement acceptable de ce dernier, dans la fabrication d'un médicament utilisé pour activer la guanylate cyclase soluble, dans laquelle : R¿1? et R¿2? sont les mêmes ou différents et chacun représente un groupe alkyle en C¿1?-C¿6?, ou R¿1? et R¿2? forment ensemble un groupe alkylène en C¿3?-C¿6? ; Z est un groupe alkylène en C¿1?-C¿4? ; P est une liaison directe ou un fragment -X-, -Y-, -W-, -XY-, -YW- ou XYW, dans laquelle W est -O-, -S-, ou -NR¿3?, R¿3? étant hydrogène ou alkyle en C¿1?-C¿6? ; Y est un fragment -U-V- dans lequel V est une liaison directe ou un groupe alkylène en C¿1?-C¿6? et U est -CS-, -CO-, -S(O)¿2?- or -C(=NR)-, où R est hydrogène, hydroxy ou alkyle en C¿1?-C¿6? ; X est -O- or -NR¿6?-, où R¿6? est hydrogène, alkyle en C¿1?-C¿6?, alcényle en C¿2?-C¿6?, alkynyle, aryle ou hétéroaryle en C¿2?-C¿6? ; et R¿4? est alkyle en C¿1?-C¿6?, alcényle en C¿2?-C¿6?, alkynyle, aryle, hétéroaryle, carbocyclyle, hétérocyclyle, un groupe R-A en C¿2?-C¿6? dans lequel R est -(C¿1?-C¿6? alkyle)-, -(C¿2?-C¿6? alcényle)- ou -(C¿2?-C¿6? alkynyle)- et A est aryle, hétéroaryle, carbocyclyle, hétérocyclyle, ou R¿4? est un groupe -COR", -CO¿2?R", -S(O)¿2?R" or -CONR'R" dans lequel R' est hydrogène, alkyle en C¿1?-C¿6?, alcényle en C¿2?-C¿6?, ou alkynyle en C¿2?-C¿6?, et R'' est aryle, hétéroaryle, carbocyclyle ou hétérocyclyle.
CA002389773A 1999-11-05 2000-11-06 Activateurs de la guanylate cyclase soluble Abandoned CA2389773A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9926286.7A GB9926286D0 (en) 1999-11-05 1999-11-05 Activators of soluble guanylate cyclase
GB9926286.7 1999-11-05
US20138200P 2000-05-02 2000-05-02
US60/201,382 2000-05-02
PCT/GB2000/004249 WO2001032604A1 (fr) 1999-11-05 2000-11-06 Activateurs de la guanylate cyclase soluble

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CA2389773A1 true CA2389773A1 (fr) 2001-05-10

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