ATE552251T1 - Thiophen- und furanverbindungen - Google Patents

Thiophen- und furanverbindungen

Info

Publication number
ATE552251T1
ATE552251T1 AT05704861T AT05704861T ATE552251T1 AT E552251 T1 ATE552251 T1 AT E552251T1 AT 05704861 T AT05704861 T AT 05704861T AT 05704861 T AT05704861 T AT 05704861T AT E552251 T1 ATE552251 T1 AT E552251T1
Authority
AT
Austria
Prior art keywords
thiophene
furan compounds
alzheimer
schizophrenia
relates
Prior art date
Application number
AT05704861T
Other languages
English (en)
Inventor
Mansanet Ana Castano
Esteban Dominguez-Manzanares
Ana Escribano
Maria Fernandez
William Hornback
Alma Jimenez-Aguado
Eric Tromiczak
Zhipei Wu
Hamideh Zarrinmayeh
Dennis Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE552251T1 publication Critical patent/ATE552251T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT05704861T 2004-01-09 2005-01-05 Thiophen- und furanverbindungen ATE552251T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04380005 2004-01-09
US55208004P 2004-03-10 2004-03-10
PCT/US2005/000004 WO2005070916A1 (en) 2004-01-09 2005-01-05 Thiophene and furan compounds

Publications (1)

Publication Number Publication Date
ATE552251T1 true ATE552251T1 (de) 2012-04-15

Family

ID=45935348

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05704861T ATE552251T1 (de) 2004-01-09 2005-01-05 Thiophen- und furanverbindungen

Country Status (5)

Country Link
US (1) US7642361B2 (de)
EP (1) EP1706395B1 (de)
AT (1) ATE552251T1 (de)
ES (1) ES2383115T3 (de)
WO (1) WO2005070916A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006003661D1 (de) 2005-06-06 2008-12-24 Lilly Co Eli Ampa-rezeptoren-verstärker
TW200817385A (en) * 2006-07-04 2008-04-16 Organon Nv Heterocyclic derivatives
JP2010143826A (ja) * 2007-04-12 2010-07-01 Mitsui Chemicals Inc 3−アミノチオフェン誘導体の製造方法
TW200934497A (en) 2007-11-13 2009-08-16 Organon Nv Heterocyclic derivatives
WO2009067597A1 (en) * 2007-11-21 2009-05-28 Decode Genetics Ehf 4- (or 5-) substituted catechol derivatives
TW201012803A (en) 2008-06-06 2010-04-01 Organon Nv Heterocyclic derivatives
WO2010009029A2 (en) * 2008-07-15 2010-01-21 Wyeth Methods for the preparation of azole compounds
WO2010114881A1 (en) 2009-04-01 2010-10-07 Progenra Inc. Anti-neoplastic compounds, compositions and methods
WO2010115952A1 (en) 2009-04-09 2010-10-14 N.V. Organon Indane derivatives
EP2655330B1 (de) * 2010-12-22 2016-02-10 Purdue Pharma LP Substutuierte pyridine als kaliumkanalblocker
AU2013317791B2 (en) * 2012-09-21 2018-05-10 Midwestern University Inhibitors of beta-hydrolase for treatment of cancer
EP2919788A4 (de) 2012-11-14 2016-05-25 Univ Johns Hopkins Verfahren und zusammensetzungen zur behandlung von schizophrenie
KR20150130491A (ko) 2013-03-13 2015-11-23 제넨테크, 인크. 피라졸로 화합물 및 그것의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273602A1 (de) 1986-12-05 1988-07-06 Eli Lilly And Company 3-Cyano-4-arylthiophene
PE20000942A1 (es) * 1998-07-31 2000-09-28 Lilly Co Eli Derivados de amida, carbamato y urea
JP2003513064A (ja) * 1999-11-05 2003-04-08 ユニバーシティ カレッジ ロンドン 可溶性グアニル酸シクラーゼのアクチベーター
US6835745B2 (en) * 2002-01-15 2004-12-28 Wyeth Phenyl substituted thiophenes as estrogenic agents
US20030181468A1 (en) * 2002-03-21 2003-09-25 Michaelides Michael R. Thiopyrimidine and isothiazolopyrimidine kinase inhibitors

Also Published As

Publication number Publication date
US20070105852A1 (en) 2007-05-10
EP1706395A1 (de) 2006-10-04
US7642361B2 (en) 2010-01-05
EP1706395B1 (de) 2012-04-04
ES2383115T3 (es) 2012-06-18
WO2005070916A1 (en) 2005-08-04

Similar Documents

Publication Publication Date Title
NZ595571A (en) Pyrazole compounds and uses thereof
NO20054640D0 (no) Fremgangsmater for behandling av Parkinsons sykdom
TW200736255A (en) 5-(Substituted)-pyrazolopiperidines
BRPI0413022A (pt) derivados de 3-amino cromado e 2-amino tetralina
WO2006035237A3 (en) Methods and compositions relating to alzheimer's disease
WO2007058602A3 (en) Novel 2-amino-imidazole-4-one compounds and their use in the manufacture of a medicament to be used in the treatment of cognitive impairment, alzheimer’s disease, neurodegeneration and dementia.
ATE535236T1 (de) Therapeutische strategien für die prävention und behandlung der alzheimer-krankheit
DK1594833T3 (da) 1-phenylalkancarboxylsyrederivater til behandling af neurodegenerative sygdomme
BR0314059A (pt) Compostos heterocìclicos
BRPI0515528A (pt) n-metil hidroxietilamina úteis no tratamento de condições do sistema nervoso central
PL1765388T3 (pl) Terapia skojarzona do zapobiegania chorobie Alzheimera lub leczenia tej choroby oraz zestaw do tego celu
ATE552251T1 (de) Thiophen- und furanverbindungen
ATE486597T1 (de) 3,4-substituierte pyrrolidin-derivate zur behandlung von hypertonie
EA200800880A1 (ru) Комбинация росиглитазона и донепезила, предназначенная для улучшения когнитивной функции
IL177787A0 (en) 1-aminovyclohexane derivatives for the treatment of agitation and other behavioral disorders, especially those associated with alzheimer's disease
HK1080467A1 (en) Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
EA200801302A1 (ru) Композиции и способы лечения нарушений цнс
ATE467632T1 (de) Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
TW200716152A (en) Substituted 1,2-ethylendiamines, medicaments comprising said compound, their use and their method of manufacture
WO2009009393A3 (en) Chromium complexes for improvement of memory and cognitive function
DE60304695D1 (de) 7-ARYLSULFONAMID-2,3,4,5-TETRAHYDRO-1H-BENZOiDöAZEPINE MIT 5-HT6 REZEPTOR AFFINITÄT ZUR BEHANDLUNG VON ZENTRALNERVENSYSTEMERKRANKUNGEN
WO2007017511A3 (de) Verbindungen zur behandlung der alzheimer erkrankung
DK1463735T3 (da) Imidazo-2,1-B -1,3,4-thiadiazol-sulfonamider
DE602005002776D1 (de) Verfahren zur Herstellung von 1,3-Dihydro-2H-3-Benzazepin-2-on und Anwendung zur Herstellung von Ivabradine und ihren pharmazeutischen annehmbaren Salzen
CR11447A (es) Moduladores de piperidinil y piperazinil de y secretasa