CA2388617A1 - Molecules d'acide nucleique derivees d'un cerveau de rat et modeles de mort cellulaire programmee - Google Patents

Molecules d'acide nucleique derivees d'un cerveau de rat et modeles de mort cellulaire programmee Download PDF

Info

Publication number
CA2388617A1
CA2388617A1 CA002388617A CA2388617A CA2388617A1 CA 2388617 A1 CA2388617 A1 CA 2388617A1 CA 002388617 A CA002388617 A CA 002388617A CA 2388617 A CA2388617 A CA 2388617A CA 2388617 A1 CA2388617 A1 CA 2388617A1
Authority
CA
Canada
Prior art keywords
nucleic acid
polypeptide
expression
protein
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002388617A
Other languages
English (en)
Inventor
Lillian Wei-Ming Chiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2388617A1 publication Critical patent/CA2388617A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des homologues humains de molécules d'acide nucléique dérivées d'un cerveau de rat, et des bibliothèques d'expression de mort cellulaire programmée. Ces molécules peuvent constituer des micro-réseaux de séquences exprimées utiles pour analyser une expression génique dans différents contextes biologiques, notamment le développement, la différentiation, et la maladie, à la fois in vivo et in vitro. Les molécules d'acide nucléique sont utiles pour diagnostiquer, traiter, et mettre au point des médicaments. Elles sont également utiles pour créer des micro-réseaux de profilage transcriptionnel. L'invention concerne également des peptides codés par les molécules d'acide nucléique, utiles dans des techniques de diagnostic, de traitement, et mise au point de médicaments. L'invention utilise, de manière spécifique, les molécules d'acide nucléique impliquées dans la mort cellulaire programmée.
CA002388617A 1999-10-22 2000-10-20 Molecules d'acide nucleique derivees d'un cerveau de rat et modeles de mort cellulaire programmee Abandoned CA2388617A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16118899P 1999-10-22 1999-10-22
US60/161,188 1999-10-22
PCT/US2000/029132 WO2001031007A2 (fr) 1999-10-22 2000-10-20 Molecules d'acide nucleique derivees d'un cerveau de rat et modeles de mort cellulaire programmee

Publications (1)

Publication Number Publication Date
CA2388617A1 true CA2388617A1 (fr) 2001-05-03

Family

ID=22580209

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002388617A Abandoned CA2388617A1 (fr) 1999-10-22 2000-10-20 Molecules d'acide nucleique derivees d'un cerveau de rat et modeles de mort cellulaire programmee

Country Status (5)

Country Link
EP (1) EP1226243A2 (fr)
JP (1) JP2003512840A (fr)
AU (1) AU1099601A (fr)
CA (1) CA2388617A1 (fr)
WO (1) WO2001031007A2 (fr)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020081679A1 (en) * 1999-10-22 2002-06-27 Millennium Pharmaceuticals, Inc. NARC8 programmed cell-death-associated molecules and uses thereof
EP1257572A2 (fr) * 2000-02-07 2002-11-20 Millennium Pharmaceuticals, Inc. Nouveaux homologues de type subtilase (narc-1)
US20030165863A1 (en) * 2001-01-16 2003-09-04 Millennium Pharmaceuticals, Inc. NARC10 and NARC16, programmed cell death-associated molecules and uses thereof
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
CN101636179B (zh) 2006-11-07 2012-10-10 默沙东公司 Pcsk9拮抗剂
WO2008109871A2 (fr) * 2007-03-08 2008-09-12 Irm Llc Structure cristalline de proprotéine convertase 9 (pcsk9) et utilisations de celle-ci
WO2008118386A2 (fr) 2007-03-27 2008-10-02 Merck & Co., Inc. Procédé de détection de pcsk9 sécrétée, autogénérée
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
AR070316A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
US8748115B2 (en) 2008-12-12 2014-06-10 Merck Sharp & Dohme Corp. PCSK9 immunoassay
US8877900B2 (en) 2009-10-30 2014-11-04 Merck Sharp & Dohme Corp. AX132 PCSK9 antagonists
CA2777698A1 (fr) 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Antagonistes de la pcsk9 avec anticorps fab ax189 et ax1, et variantes afferentes
AR087715A1 (es) 2011-09-16 2014-04-09 Lilly Co Eli Anticuerpos anti pcsk9 y usos de los mismos
JP2015535464A (ja) 2012-11-21 2015-12-14 アムジエン・インコーポレーテツド 薬剤送達装置
ES2973257T3 (es) 2013-03-15 2024-06-19 Amgen Inc Casete de fármaco, autoinyector y sistema de autoinyector
JP6768501B2 (ja) 2013-03-15 2020-10-14 アムゲン・インコーポレーテッド 薬物カセット、自動注入機、および自動注入機システム
BR112015022042B1 (pt) 2013-03-15 2023-01-10 Amgen Inc Injetor para injetar um produto terapêutico
SG11201507878SA (en) 2013-03-22 2015-10-29 Amgen Inc Injector and method of assembly
JP7051293B2 (ja) 2013-10-24 2022-04-11 アムジエン・インコーポレーテツド 温度感知制御を伴う薬剤送達システム
ES2744837T3 (es) 2013-10-24 2020-02-26 Amgen Inc Inyector y procedimiento de ensamblaje
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US9023359B1 (en) 2014-07-15 2015-05-05 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US9045548B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment
US9051378B1 (en) 2014-07-15 2015-06-09 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
US9045545B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision medicine by targeting PD-L1 variants for treatment of cancer
US9034332B1 (en) 2014-07-15 2015-05-19 Kymab Limited Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment
US8945560B1 (en) 2014-07-15 2015-02-03 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
US9067998B1 (en) 2014-07-15 2015-06-30 Kymab Limited Targeting PD-1 variants for treatment of cancer
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US9914769B2 (en) 2014-07-15 2018-03-13 Kymab Limited Precision medicine for cholesterol treatment
US8883157B1 (en) 2013-12-17 2014-11-11 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
WO2015119906A1 (fr) 2014-02-05 2015-08-13 Amgen Inc. Système d'administration de médicament doté d'un générateur de champ électromagnétique
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
BR112016025852B1 (pt) 2014-05-07 2022-11-01 Amgen Inc Dispositivo de injeção para aplicação de fármaco
KR102416904B1 (ko) 2014-06-03 2022-07-04 암겐 인코포레이티드 약물 전달 디바이스에 의해 수집된 데이터를 원격으로 프로세싱하기 위한 시스템들 및 방법들
US9150660B1 (en) 2014-07-15 2015-10-06 Kymab Limited Precision Medicine by targeting human NAV1.8 variants for treatment of pain
US9139648B1 (en) 2014-07-15 2015-09-22 Kymab Limited Precision medicine by targeting human NAV1.9 variants for treatment of pain
WO2016061220A2 (fr) 2014-10-14 2016-04-21 Amgen Inc. Dispositif d'injection de médicament comportant des témoins visuels et sonores
US11357916B2 (en) 2014-12-19 2022-06-14 Amgen Inc. Drug delivery device with live button or user interface field
US10799630B2 (en) 2014-12-19 2020-10-13 Amgen Inc. Drug delivery device with proximity sensor
CA3069716C (fr) 2015-02-17 2021-11-09 Amgen Inc. Dispositif d'administration de medicament a securisation assistee par depression et/ou retour d'informations
ES2905870T3 (es) 2015-02-27 2022-04-12 Amgen Inc Dispositivo de suministro de fármacos que tiene un mecanismo de protección de aguja con un umbral de resistencia ajustable al movimiento de la protección de aguja
WO2017039786A1 (fr) 2015-09-02 2017-03-09 Amgen Inc. Adaptateur d'ensemble de seringue pour une seringue
WO2017100501A1 (fr) 2015-12-09 2017-06-15 Amgen Inc. Auto-injecteur avec capuchon de signalisation
WO2017120178A1 (fr) 2016-01-06 2017-07-13 Amgen Inc. Auto-injecteur pourvu d'une électronique de signalisation
DK3429663T3 (da) 2016-03-15 2020-09-28 Amgen Inc Reduktion af sandsynligheden for glasbrud i anordninger til indgivelse af lægemidler
WO2017189089A1 (fr) 2016-04-29 2017-11-02 Amgen Inc. Dispositif d'administration de médicament avec étiquette de messagerie
US11389588B2 (en) 2016-05-02 2022-07-19 Amgen Inc. Syringe adapter and guide for filling an on-body injector
AU2017263558B2 (en) 2016-05-13 2022-12-22 Amgen Inc. Vial sleeve assembly
WO2017200989A1 (fr) 2016-05-16 2017-11-23 Amgen Inc. Chiffrement de données dans des dispositifs médicaux à capacité de calcul limitée
EP3465124A1 (fr) 2016-06-03 2019-04-10 Amgen Inc. Appareils et procédés d'essai au choc destinés aux dispositifs d'administration de médicaments
US11285266B2 (en) 2016-07-01 2022-03-29 Amgen Inc. Drug delivery device having minimized risk of component fracture upon impact events
WO2018034784A1 (fr) 2016-08-17 2018-02-22 Amgen Inc. Dispositif d'administration de médicament avec détection de positionnement.
WO2018081234A1 (fr) 2016-10-25 2018-05-03 Amgen Inc. Injecteur porté sur le corps
EP3534947A1 (fr) 2016-11-03 2019-09-11 Kymab Limited Anticorps, combinaisons comprenant des anticorps, biomarqueurs, utilisations et procédés
CA3048479A1 (fr) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Edition genique de pcsk9
MX2019008432A (es) 2017-01-17 2019-11-18 Amgen Inc Dispositivos de inyeccion y metodos relacionados de uso y ensamblaje.
US11752258B2 (en) 2017-02-17 2023-09-12 Amgen Inc. Drug delivery device with sterile fluid flowpath and related method of assembly
AU2018221351B2 (en) 2017-02-17 2023-02-23 Amgen Inc. Insertion mechanism for drug delivery device
CA3050927A1 (fr) 2017-03-06 2018-09-13 Brian Stonecipher Dispositif d'administration de medicaments dote d'une fonction de prevention d'activation
US11571511B2 (en) 2017-03-07 2023-02-07 Amgen Inc. Insertion mechanism and method of inserting a needle of a drug delivery device
AU2018230486B2 (en) 2017-03-09 2023-05-11 Amgen Inc. Insertion mechanism for drug delivery device
HUE063805T2 (hu) 2017-03-28 2024-01-28 Amgen Inc Dugattyúrúd és fecskendõ összeállító rendszer és eljárás
EP3634539A1 (fr) 2017-06-08 2020-04-15 Amgen Inc. Ensemble de seringue d'un appareil d'administration de médicament et procédé d'assemblage
JP7200134B2 (ja) 2017-06-08 2023-01-06 アムジエン・インコーポレーテツド トルク駆動式薬物送達デバイス
MX2019015472A (es) 2017-06-22 2020-02-19 Amgen Inc Reduccion del impacto/choque de la activacion del mecanismo.
JP7475860B2 (ja) 2017-06-23 2024-04-30 アムジエン・インコーポレーテツド スイッチアセンブリにより起動されるキャップを含む電子薬物送達デバイス
JP7408398B2 (ja) 2017-07-14 2024-01-05 アムジエン・インコーポレーテツド 二重ねじりばねシステムを有する針挿入後退システム
EP3655063A1 (fr) 2017-07-21 2020-05-27 Amgen Inc. Élément d'étanchéité perméable aux gaz pour récipient à médicament et procédés d'assemblage
US11617837B2 (en) 2017-07-25 2023-04-04 Amgen Inc. Drug delivery device with gear module and related method of assembly
MA49676A (fr) 2017-07-25 2020-06-03 Amgen Inc Dispositif d'administration de médicament doté d'un système d'accès à un récipient et procédé d'assemblage associé
MA49838A (fr) 2017-08-09 2020-06-17 Amgen Inc Systèm de administration de médicaments avec pression hydraulique-pneumatique de chambre
MA49897A (fr) 2017-08-18 2020-06-24 Amgen Inc Injecteur sur-corps avec patch adhésif stérile
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
ES2939292T3 (es) 2017-10-04 2023-04-20 Amgen Inc Adaptador de flujo para dispositivo de administración de fármacos
CN111132711B (zh) 2017-10-06 2022-07-01 安进公司 带有联锁组件的药物递送装置及相关组装方法
US11464903B2 (en) 2017-10-09 2022-10-11 Amgen Inc. Drug delivery device with drive assembly and related method of assembly
WO2019090079A1 (fr) 2017-11-03 2019-05-09 Amgen Inc. Système et approches pour stériliser un dispositif d'administration de médicament
EP3707075A1 (fr) 2017-11-06 2020-09-16 Amgen Inc. Ensembles de remplissage-finition et procédés associés
CA3079197A1 (fr) 2017-11-06 2019-05-09 Amgen Inc. Dispositif d'administration de medicament avec detection de positionnement et de debit
CN111225696B (zh) 2017-11-10 2023-07-18 安进公司 用于药物递送装置的柱塞
IL273638B2 (en) 2017-11-16 2024-10-01 Amgen Inc Door lock mechanism for drug delivery device
AU2018368338B2 (en) 2017-11-16 2024-07-25 Amgen Inc. Autoinjector with stall and end point detection
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
WO2020023220A1 (fr) 2018-07-24 2020-01-30 Amgen Inc. Dispositifs d'administration de médicament hybrides dotés d'une partie de fixation collante à placer sur la peau et procédé de préparation associé
WO2020023451A1 (fr) 2018-07-24 2020-01-30 Amgen Inc. Dispositifs d'administration pour l'administration de médicaments
MA53379A (fr) 2018-07-24 2021-06-02 Amgen Inc Dispositifs d'administration pour l'administration de médicaments
WO2020023336A1 (fr) 2018-07-24 2020-01-30 Amgen Inc. Dispositifs hybrides d'administration de médicament dotés d'une partie de préhension
CA3103105A1 (fr) 2018-07-31 2020-02-06 Amgen Inc. Ensemble de trajet de fluide pour dispositif d'administration de medicament
US20210346601A1 (en) 2018-09-24 2021-11-11 Amgen Inc. Interventional dosing systems and methods
EP3856283A1 (fr) 2018-09-28 2021-08-04 Amgen Inc. Ensemble d'activation d'échappement de fil de muscle pour un dispositif d'administration de médicament
WO2020072577A1 (fr) 2018-10-02 2020-04-09 Amgen Inc. Systèmes d'injection pour administration de médicament avec transmission de force interne
TWI824026B (zh) 2018-10-05 2023-12-01 美商安進公司 具有劑量指示器之藥物遞送裝置
KR20210076935A (ko) 2018-10-15 2021-06-24 암젠 인크 댐핑 메커니즘을 갖는 약물 전달 장치
SG11202101824VA (en) 2018-10-15 2021-03-30 Amgen Inc Platform assembly process for drug delivery device
WO2020091956A1 (fr) 2018-11-01 2020-05-07 Amgen Inc. Dispositifs d'administration de médicament avec rétraction partielle de l'organe d'administration de médicament
CA3113076A1 (fr) 2018-11-01 2020-05-07 Amgen Inc. Dispositifs d'administration de medicament a retraction partielle d'element d'administration de medicament
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
WO2020219482A1 (fr) 2019-04-24 2020-10-29 Amgen Inc. Ensembles et procédés de vérification de stérilisation de seringue
EP4017560A2 (fr) 2019-08-23 2022-06-29 Amgen, Inc Dispositif d'administration de médicament doté de composants configurables de mise en prise de protection d'aiguille et méthodes associées
GB2623891B (en) 2020-04-09 2024-10-23 Verve Therapeutics Inc Base editing of ANGPTL3 and methods of using same for treatment of disease
MX2023013640A (es) 2021-05-21 2023-11-30 Amgen Inc Metodo de optimizacion de una receta de llenado para un contenedor de medicamento.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2181197T3 (es) * 1997-04-25 2003-02-16 Wyeth Corp Isoformas de mort1 neuronal.

Also Published As

Publication number Publication date
WO2001031007A9 (fr) 2002-05-10
AU1099601A (en) 2001-05-08
EP1226243A2 (fr) 2002-07-31
JP2003512840A (ja) 2003-04-08
WO2001031007A3 (fr) 2001-11-29
WO2001031007A2 (fr) 2001-05-03

Similar Documents

Publication Publication Date Title
CA2388617A1 (fr) Molecules d'acide nucleique derivees d'un cerveau de rat et modeles de mort cellulaire programmee
US20110230392A1 (en) Novel narc sc1, narc 10a, narc 1, narc 12, narc 13, narc17, narc 25, narc 3, narc 4, narc 7, narc 8, narc 11, narc 14a, narc 15, narc 16, narc 19, narc 20, narc 26, narc 27, narc 28, narc 30, narc 5, narc 6, narc 9, narc 10c, narc 8b, narc 9, narc2a, narc 16b, narc 1c, narc 1a, and narc 25 molecules and uses therefor
US20040009553A1 (en) Novel 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC1A, NARC 25, 86604 and 32222 molecules and uses therefor
US6756196B2 (en) Molecules of the card-related protein family and uses thereof
JP2010011853A (ja) Ｃｒｓｐタンパク質（システインに富む分泌性タンパク質）、それらをコードする核酸分子およびその用途
JP2002502590A (ja) Ｃａｒｄ関連蛋白質ファミリーの新規分子とその使用
JP2001512002A (ja) Ｔａｎｇｏ−７７関連蛋白質ファミリーの新規分子およびその使用
WO2001000826A2 (fr) Nouvelles molecules de la famille de proteines liee a la card et utilisations de ces dernieres
JP4495961B2 (ja) 新規なｐｇｃ−１イソフォームおよびその使用
US20100255006A1 (en) Novel molecules of the pyrin/nbs/lrr protein family and uses thereof
US20030027757A1 (en) Novel molecules of the PYRIN/NBS/LRR protein family and uses thereof
JP2002534114A (ja) 新規ｌｒｓｇタンパク質および核酸分子ならびにそのための用途
EP1228090A2 (fr) Nouvelles molecules de la famille des proteines se rapportant aux card et leurs utilisations
US6953657B2 (en) Molecules of the CARD-related protein family and uses thereof
US6869775B2 (en) Card related protein and uses thereof
US6326481B1 (en) Molecules of the AIP-related protein family and uses thereof
US20030165863A1 (en) NARC10 and NARC16, programmed cell death-associated molecules and uses thereof
WO2000000633A1 (fr) OCT1p, PROTEINE PRESENTANT UNE HOMOLOGIE AVEC LA FAMILLE DES PROTEINES ORGANIQUES ET TRANSPORTEUSES DE GLUCIDES ET UTILISATION
US20020128219A1 (en) Novel molecules of the card related protein family and uses thereof
US20020086357A1 (en) 32591, a novel human GTPase activating molecule and uses therefor
US20040209287A1 (en) OCT1p, a protein having homology to the organic and sugar transporter family of proteins, and uses thereof
US20020115185A1 (en) Neuronal cell death associated molecules and uses therefor
WO2001057185A2 (fr) Molecules de la famille des proteines de type card et leur utilisation
WO2001019410A2 (fr) La proteine flash humaine et ses utilisations
MXPA00007645A (en) Novel molecules of the card-related protein family and uses thereof

Legal Events

Date Code Title Description
FZDE Dead