CA2373410C - A2a receptor agonists - Google Patents

A2a receptor agonists Download PDF

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Publication number
CA2373410C
CA2373410C CA002373410A CA2373410A CA2373410C CA 2373410 C CA2373410 C CA 2373410C CA 002373410 A CA002373410 A CA 002373410A CA 2373410 A CA2373410 A CA 2373410A CA 2373410 C CA2373410 C CA 2373410C
Authority
CA
Canada
Prior art keywords
alkyl
aryl
group
optionally substituted
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002373410A
Other languages
English (en)
French (fr)
Other versions
CA2373410A1 (en
Inventor
Jeff A. Zablocki
Elfatih O. Elzein
Venkata P. Palle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Palo Alto Inc
Original Assignee
CV Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CV Therapeutics Inc filed Critical CV Therapeutics Inc
Publication of CA2373410A1 publication Critical patent/CA2373410A1/en
Application granted granted Critical
Publication of CA2373410C publication Critical patent/CA2373410C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002373410A 1999-06-22 2000-06-20 A2a receptor agonists Expired - Fee Related CA2373410C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14047899P 1999-06-22 1999-06-22
US60/140,478 1999-06-22
PCT/US2000/016856 WO2000078776A2 (en) 1999-06-22 2000-06-20 Thiophene a2a receptor agonists

Publications (2)

Publication Number Publication Date
CA2373410A1 CA2373410A1 (en) 2000-12-28
CA2373410C true CA2373410C (en) 2006-08-29

Family

ID=22491411

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002373410A Expired - Fee Related CA2373410C (en) 1999-06-22 2000-06-20 A2a receptor agonists

Country Status (19)

Country Link
US (1) US6440948B1 (ja)
EP (1) EP1194441B1 (ja)
JP (1) JP2003502434A (ja)
KR (1) KR100463694B1 (ja)
CN (1) CN1166677C (ja)
AT (1) ATE252595T1 (ja)
AU (1) AU768530B2 (ja)
BR (1) BR0011853A (ja)
CA (1) CA2373410C (ja)
DE (1) DE60006116T2 (ja)
ES (1) ES2206259T3 (ja)
HK (1) HK1048821B (ja)
IL (2) IL147194A0 (ja)
MX (1) MXPA01013323A (ja)
NO (1) NO20016242L (ja)
NZ (1) NZ516336A (ja)
TR (1) TR200200617T2 (ja)
WO (1) WO2000078776A2 (ja)
ZA (1) ZA200200299B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE331726T1 (de) * 1998-10-16 2006-07-15 Pfizer Adenine-derivate
EP1764118B1 (en) 2002-02-15 2010-08-25 Gilead Palo Alto, Inc. Polymer coating for medical devices
TWI346109B (en) * 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
US7423144B2 (en) * 2004-05-26 2008-09-09 Inotek Pharmaceuticals Corporation Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
JP5011112B2 (ja) * 2004-09-20 2012-08-29 イノテック ファーマシューティカルズ コーポレイション プリン誘導体を含有する炎症性疾患の治療用医薬
EP1962597A4 (en) * 2005-11-30 2008-12-17 Inotek Pharmaceuticals Corp PURINE DERIVATIVES AND METHOD OF USE
ME02608B (me) 2010-01-11 2017-06-20 Inotek Pharmaceuticals Corp Kombinacija, komplet i postupak snižavanja intraokularnog pritiska
JP2013523739A (ja) 2010-03-26 2013-06-17 イノテック ファーマシューティカルズ コーポレイション Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法
RS56150B1 (sr) 2012-01-26 2017-11-30 Inotek Pharmaceuticals Corp Anhidrovani polimorfi (2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin-9-yl)-3,4-dihidroksitetrahidrofuran-2-yl)} metil-nitrata i postupak njegove pripreme
JP2016513706A (ja) 2013-03-15 2016-05-16 イノテック ファーマシューティカルズ コーポレイション 点眼用製剤
KR20190095372A (ko) 2017-01-13 2019-08-14 토비시 파마슈티칼 컴패니 리미티드 호중구 활성화 조절제

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK135130B (da) * 1970-12-28 1977-03-07 Takeda Chemical Industries Ltd Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf.
JPS4911896A (ja) * 1972-05-15 1974-02-01
JPS5518625B2 (ja) * 1973-07-26 1980-05-20
US5070877A (en) * 1988-08-11 1991-12-10 Medco Research, Inc. Novel method of myocardial imaging
ATE127808T1 (de) * 1991-04-06 1995-09-15 Fisons Plc Atp-analogen.

Also Published As

Publication number Publication date
US6440948B1 (en) 2002-08-27
DE60006116D1 (de) 2003-11-27
IL147194A (en) 2007-08-19
WO2000078776A2 (en) 2000-12-28
EP1194441A2 (en) 2002-04-10
HK1048821B (zh) 2005-02-25
DE60006116T2 (de) 2004-07-08
BR0011853A (pt) 2002-04-30
CN1166677C (zh) 2004-09-15
KR100463694B1 (ko) 2004-12-29
JP2003502434A (ja) 2003-01-21
EP1194441B1 (en) 2003-10-22
CN1364170A (zh) 2002-08-14
NO20016242D0 (no) 2001-12-19
MXPA01013323A (es) 2003-10-15
IL147194A0 (en) 2002-08-14
AU768530B2 (en) 2003-12-18
ZA200200299B (en) 2003-08-27
TR200200617T2 (tr) 2002-06-21
AU5625100A (en) 2001-01-09
NZ516336A (en) 2004-01-30
HK1048821A1 (en) 2003-04-17
KR20020028912A (ko) 2002-04-17
NO20016242L (no) 2002-02-21
ATE252595T1 (de) 2003-11-15
CA2373410A1 (en) 2000-12-28
ES2206259T3 (es) 2004-05-16
WO2000078776A3 (en) 2001-06-28

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MKLA Lapsed

Effective date: 20130620