CA2370660C - Agent for the removal of turbidity in biological samples - Google Patents
Agent for the removal of turbidity in biological samples Download PDFInfo
- Publication number
- CA2370660C CA2370660C CA2370660A CA2370660A CA2370660C CA 2370660 C CA2370660 C CA 2370660C CA 2370660 A CA2370660 A CA 2370660A CA 2370660 A CA2370660 A CA 2370660A CA 2370660 C CA2370660 C CA 2370660C
- Authority
- CA
- Canada
- Prior art keywords
- turbidity
- agent
- removal
- polyoxyethylene
- agent according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012472 biological sample Substances 0.000 title claims abstract description 5
- 150000003626 triacylglycerols Polymers 0.000 claims abstract description 16
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000003556 assay Methods 0.000 claims description 12
- -1 polyoxyethylene Polymers 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
- ITRHZTGVVSWIDC-UHFFFAOYSA-N 11-methyl-1-(11-methyldodecoxy)dodecane Chemical compound CC(C)CCCCCCCCCCOCCCCCCCCCCC(C)C ITRHZTGVVSWIDC-UHFFFAOYSA-N 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 description 18
- 238000006243 chemical reaction Methods 0.000 description 8
- 230000001000 lipidemic effect Effects 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 239000000872 buffer Substances 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000005375 photometry Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- 108010004103 Chylomicrons Proteins 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01103991A EP1233269B1 (en) | 2001-02-19 | 2001-02-19 | Agent for the removal of turbidity in biological samples |
| EP01103991.4 | 2001-02-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2370660A1 CA2370660A1 (en) | 2002-08-19 |
| CA2370660C true CA2370660C (en) | 2013-05-28 |
Family
ID=8176537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2370660A Expired - Fee Related CA2370660C (en) | 2001-02-19 | 2002-02-05 | Agent for the removal of turbidity in biological samples |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6680201B2 (enExample) |
| EP (1) | EP1233269B1 (enExample) |
| JP (1) | JP3908556B2 (enExample) |
| CN (1) | CN1206538C (enExample) |
| AT (1) | ATE254767T1 (enExample) |
| CA (1) | CA2370660C (enExample) |
| DE (1) | DE60101254T2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101223448B (zh) * | 2005-05-20 | 2012-01-18 | 健泰科生物技术公司 | 来自自身免疫病受试者的生物学样品的预处理 |
| WO2007056426A2 (en) * | 2005-11-08 | 2007-05-18 | United States Postal Service | Methods and systems for providing scanned mail delivery channel and automatic payment of reply mail |
| US8597513B2 (en) * | 2009-02-06 | 2013-12-03 | Ut-Battelle, Llc | Microbial fuel cell treatment of fuel process wastewater |
| CN101957363A (zh) * | 2010-09-13 | 2011-01-26 | 南京卡博生物科技有限公司 | 胶乳免疫比浊检测用样本处理液 |
| CN105067815A (zh) * | 2015-09-16 | 2015-11-18 | 浙江凯成生物科技有限公司 | 一种测定人血清中胃蛋白酶原i/ii含量的试剂盒 |
| CN111157712A (zh) * | 2018-11-07 | 2020-05-15 | 深圳迈瑞生物医疗电子股份有限公司 | 可抗脂血干扰的血液样本检测试剂盒及方法 |
| CN112834758B (zh) * | 2021-01-07 | 2023-06-16 | 北京九强生物技术股份有限公司 | B因子的检测试剂盒 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3853465A (en) * | 1972-06-09 | 1974-12-10 | Technicon Instr | Turbidity reduction in serum and plasma samples using polyoxyethylated lauric acid compounds |
| US4184921A (en) * | 1976-03-25 | 1980-01-22 | Boehringer Mannheim Gmbh | Process and reagent for determining cholesterol |
| DE2724757C2 (de) * | 1977-06-01 | 1979-08-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Mittel zur Beseitigung von Trübungen in Serum und Verfahren zu seiner Herstellung |
| DE2816229C2 (de) * | 1978-04-14 | 1983-11-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Beseitigung von Trübungen |
| US4503146A (en) * | 1980-10-01 | 1985-03-05 | Technicon Instruments Corporation | Method for eliminating turbidity in a biological fluid and reagent therefor |
| DE3323949A1 (de) * | 1983-07-02 | 1985-01-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und mittel zur raschen und vollstaendigen beseitigung einer truebung in einer biologischen fluessigkeit |
| DE3329952A1 (de) * | 1983-08-19 | 1985-02-28 | Behringwerke Ag, 3550 Marburg | Verfahren zur verringerung einer truebung in kontrollseren |
| US5310679A (en) * | 1985-05-13 | 1994-05-10 | Artiss Joseph D | Composition for reducing turbidity in samples of biological fluids |
| US4626511A (en) * | 1985-05-13 | 1986-12-02 | Wayne State University | Composition for reducing turbidity in samples of biological fluids |
| DE3920364A1 (de) * | 1989-06-22 | 1991-01-10 | Technicon Gmbh | Verfahren und reagenz zur verhinderung von truebungen |
| DE4018502A1 (de) * | 1990-06-09 | 1991-12-12 | Merck Patent Gmbh | Verfahren und mittel zur beseitigung von truebungen in biologischen fluessigkeiten |
| JPH10213582A (ja) * | 1997-01-30 | 1998-08-11 | Eiken Chem Co Ltd | 生体試料の濁りの除去方法 |
-
2001
- 2001-02-19 AT AT01103991T patent/ATE254767T1/de not_active IP Right Cessation
- 2001-02-19 DE DE60101254T patent/DE60101254T2/de not_active Expired - Lifetime
- 2001-02-19 EP EP01103991A patent/EP1233269B1/en not_active Expired - Lifetime
-
2002
- 2002-01-18 CN CNB021017824A patent/CN1206538C/zh not_active Expired - Fee Related
- 2002-02-04 US US10/066,902 patent/US6680201B2/en not_active Expired - Lifetime
- 2002-02-05 CA CA2370660A patent/CA2370660C/en not_active Expired - Fee Related
- 2002-02-14 JP JP2002036119A patent/JP3908556B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1372144A (zh) | 2002-10-02 |
| CN1206538C (zh) | 2005-06-15 |
| ATE254767T1 (de) | 2003-12-15 |
| CA2370660A1 (en) | 2002-08-19 |
| JP3908556B2 (ja) | 2007-04-25 |
| JP2002277470A (ja) | 2002-09-25 |
| US6680201B2 (en) | 2004-01-20 |
| DE60101254D1 (de) | 2003-12-24 |
| US20020151074A1 (en) | 2002-10-17 |
| EP1233269B1 (en) | 2003-11-19 |
| EP1233269A1 (en) | 2002-08-21 |
| DE60101254T2 (de) | 2004-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108546602B (zh) | 化学发光免疫分析用清洗液及磁微粒化学发光免疫分析检测方法 | |
| US4708939A (en) | Process and reagent for the complete and rapid removal of a turbidity in a biological fluid | |
| US9046517B2 (en) | Cystatin C adsorption inhibitor | |
| CN109633148B (zh) | Kl-6检测乳胶凝集试剂 | |
| JP4704662B2 (ja) | 免疫学的ラテックス比濁分析方法及びその試薬 | |
| CA2370660C (en) | Agent for the removal of turbidity in biological samples | |
| JPWO2001092885A1 (ja) | 免疫学的ラテックス比濁分析方法及びその試薬 | |
| AU5426300A (en) | Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same | |
| CN110865182B (zh) | 一种阻断剂及其在免疫检测中的应用 | |
| CN111157712A (zh) | 可抗脂血干扰的血液样本检测试剂盒及方法 | |
| AU751938B2 (en) | Immunoassay reagents and immunoassay method | |
| CA2557473C (en) | Measurement value lowering inhibitor for immunoassay method and immunoassay method using the same | |
| US4529708A (en) | Assay for the determination of creatinine | |
| Sims et al. | Determination of serum creatinine by reaction with methyl-3, 5-dinitrobenzoate in methyl sulfoxide | |
| WO2024190866A1 (ja) | 処理方法及びキット | |
| JPH0712807A (ja) | 体液試料中の濁りを防止する方法 | |
| CN118897075A (zh) | 一种有效克服类风湿因子干扰问题的生化试剂 | |
| JPH07181182A (ja) | リポタンパク質含有試料の処理法 | |
| AU2015202990B2 (en) | Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same | |
| JPH04363660A (ja) | 免疫比濁分析用試薬、および分析方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20210831 |
|
| MKLA | Lapsed |
Effective date: 20200205 |