CA2368247A1 - Probes for a gas phase ion spectrometer - Google Patents

Probes for a gas phase ion spectrometer Download PDF

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Publication number
CA2368247A1
CA2368247A1 CA002368247A CA2368247A CA2368247A1 CA 2368247 A1 CA2368247 A1 CA 2368247A1 CA 002368247 A CA002368247 A CA 002368247A CA 2368247 A CA2368247 A CA 2368247A CA 2368247 A1 CA2368247 A1 CA 2368247A1
Authority
CA
Canada
Prior art keywords
group
probe
hydrogel material
substrate
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002368247A
Other languages
English (en)
French (fr)
Inventor
William E. Rich
Pil-Je Um
Kamen Voivodov
Tai-Tung Yip
Jody Beecher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspira Womens Health Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2368247A1 publication Critical patent/CA2368247A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/12—Ion sources; Ion guns using an arc discharge, e.g. of the duoplasmatron type
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/26—Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension
    • Y10T428/261—In terms of molecular thickness or light wave length
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CA002368247A 1999-04-27 2000-04-27 Probes for a gas phase ion spectrometer Abandoned CA2368247A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13165299P 1999-04-27 1999-04-27
US60/131,652 1999-04-29
PCT/US2000/011452 WO2000066265A2 (en) 1999-04-27 2000-04-27 Probes for a gas phase ion spectrometer
US09/560,715 2000-04-27
US09/560,715 US6897072B1 (en) 1999-04-27 2000-04-27 Probes for a gas phase ion spectrometer

Publications (1)

Publication Number Publication Date
CA2368247A1 true CA2368247A1 (en) 2000-11-09

Family

ID=26829688

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002368247A Abandoned CA2368247A1 (en) 1999-04-27 2000-04-27 Probes for a gas phase ion spectrometer

Country Status (10)

Country Link
US (3) US6897072B1 (cg-RX-API-DMAC10.html)
EP (1) EP1173878B1 (cg-RX-API-DMAC10.html)
JP (1) JP2003524772A (cg-RX-API-DMAC10.html)
KR (1) KR100713786B1 (cg-RX-API-DMAC10.html)
CN (1) CN1204592C (cg-RX-API-DMAC10.html)
AT (1) ATE504937T1 (cg-RX-API-DMAC10.html)
AU (1) AU774336B2 (cg-RX-API-DMAC10.html)
CA (1) CA2368247A1 (cg-RX-API-DMAC10.html)
DE (1) DE60045816D1 (cg-RX-API-DMAC10.html)
WO (1) WO2000066265A2 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401558A4 (en) * 2001-05-25 2007-12-12 Waters Investments Ltd DESALINATION PLATE FOR MALDI MASS SPECTROMETRY

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT700521E (pt) * 1993-05-28 2003-10-31 Baylor College Medicine Metodo e espectrometro de massa para dessorcao e ionizacao de analitos
US20020037517A1 (en) * 1993-05-28 2002-03-28 Hutchens T. William Methods for sequencing biopolymers
DE60045816D1 (de) * 1999-04-27 2011-05-19 Bio Rad Laboratories Probenhalter für ein gasphaseionenspektrometer
CA2301451A1 (en) * 2000-03-20 2001-09-21 Thang T. Pham Method for analysis of analytes by mass spectrometry
DE10027794A1 (de) * 2000-06-07 2001-12-13 Basf Ag Verfahren zur Analyse Enzym-katalysierter Umsetzungen mit MALDI-TOF-Massenspektrometrie
US20060051741A1 (en) * 2002-10-04 2006-03-09 Protosera Inc. Plate for mass spectrometry, process for preparing the same and use thereof
JP5048183B2 (ja) * 2001-01-22 2012-10-17 国立大学法人北海道大学 直鎖状高分子を有する低摩擦ハイドロゲルおよびその製造方法
US20030228639A1 (en) * 2001-03-19 2003-12-11 Wright George L Prostate cancer markers
US20020192714A1 (en) * 2001-05-22 2002-12-19 University Of Vermont And State Agricultural College Single polymer matrix unit chromatography
AU2002365110A1 (en) * 2001-07-10 2003-07-15 Massachusetts Institute Of Technology Small molecule microarrays
GB0120131D0 (en) 2001-08-17 2001-10-10 Micromass Ltd Maldi target plate
US7842498B2 (en) 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
US20040018519A1 (en) * 2001-11-16 2004-01-29 Wright ,Jr. George L Methods and devices for quantitative detection of prostate specific membrane antigen and other prostatic markers
AU2002351164A1 (en) * 2001-11-26 2003-06-10 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
US20030175170A1 (en) * 2002-02-26 2003-09-18 Ciphergen Biosystems, Inc. System for preparing and handling multiple laser desorption ionization probes
JP2005526972A (ja) * 2002-05-02 2005-09-08 シファーゲン バイオシステムズ, インコーポレイテッド 多糖系ヒドロゲルをコーティングした表面を有するバイオチップ
FR2839723B1 (fr) * 2002-05-14 2004-07-23 Rhodia Chimie Sa Polymere obtenu par polymerisation radicalaire controlee comprenant au moins une fonction boronate, association avec un compose ligand et utilisations
DE60332639D1 (de) 2002-08-06 2010-07-01 Univ Johns Hopkins Verwendung von biomarkern zum nachweis von eierstockkrebs
CN100483124C (zh) * 2002-10-04 2009-04-29 普罗托赛拉株式会社 质谱分析用板及其制备方法和用途
WO2004076511A2 (en) * 2003-02-21 2004-09-10 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel surface coatings
US6977370B1 (en) 2003-04-07 2005-12-20 Ciphergen Biosystems, Inc. Off-resonance mid-IR laser desorption ionization
CA2522709A1 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
US7785769B2 (en) * 2003-07-25 2010-08-31 The United States of America as reprsented by the Secretary of the Navy Immobilization of oligonucleotides and proteins in sugar-containing hydrogels
US7794948B2 (en) 2003-11-07 2010-09-14 Vermilllion, Inc. Biomarkers for alzheimer's disease
US8012693B2 (en) * 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US7183544B2 (en) * 2003-12-31 2007-02-27 Ciphergen Biosystems Inc. Bi-functional polymer chip
US8828203B2 (en) * 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
KR100624452B1 (ko) * 2004-12-21 2006-09-18 삼성전자주식회사 고정화된 히드로겔 또는 peg-히드로겔 공중합체를이용한 핵산의 분리 및 정제 방법
WO2006074360A2 (en) 2005-01-06 2006-07-13 Eastern Virginia Medical School Apolipoprotein a-ii isoform as a biomarker for prostate cancer
US20060183863A1 (en) * 2005-02-14 2006-08-17 Ciphergen Biosystems, Inc. Zwitterionic polymers
US7622273B2 (en) * 2005-05-11 2009-11-24 Gibbs Bernard F Method for chemical and enzymatic treatment of posttranslationally modified proteins bound to a protein chip
US20110177492A1 (en) * 2005-06-16 2011-07-21 3M Innovative Properties Company Method of classifying chemically crosslinked cellular samples using mass spectra
EP2993474B1 (en) 2005-06-24 2019-06-12 Vermillion, Inc. Biomarkers for ovarian cancer: beta-2 microglobulin
US20090215086A1 (en) * 2005-12-12 2009-08-27 Momar Ndao Biomarkers for Babesia
WO2007106466A2 (en) 2006-03-11 2007-09-20 The Board Of Trustees Of The Leland Stanford Junior University Beta-2 microglobulin as a biomarker for peripheral artery disease
JP4838639B2 (ja) * 2006-06-09 2011-12-14 キヤノン株式会社 質量分析用基板及び質量分析装置
US20080193772A1 (en) * 2006-07-07 2008-08-14 Bio-Rad Laboratories, Inc Mass spectrometry probes having hydrophobic coatiings
US8053247B2 (en) * 2006-10-11 2011-11-08 Phynexus, Inc. Method and device for preparing an analyte for analysis by mass spectrometry
EP2114396A4 (en) * 2006-12-29 2010-03-10 Salk Inst For Biological Studi METHOD FOR IMPROVING TRAINING PERFORMANCE
US20110091377A1 (en) 2007-05-11 2011-04-21 The Johns Hopkins University Biomarkers for melanoma
WO2009058331A2 (en) 2007-10-29 2009-05-07 Vermilllion, Inc. Biomarkers for the detection of early stage ovarian cancer
JP2009121997A (ja) * 2007-11-15 2009-06-04 Tokyo Metropolitan Univ 質量分析における試料の調整方法
US8673644B2 (en) 2008-05-13 2014-03-18 Battelle Memorial Institute Serum markers for type II diabetes mellitus
WO2010025190A1 (en) * 2008-08-26 2010-03-04 Liotta Lance A Hydrogel nanoparticle base immunoassay
EP2352847B1 (en) 2008-11-10 2014-01-08 The United States of America, as represented by The Secretary, Department of Health and Human Services Gene signature for predicting prognosis of patients with solid tumors
WO2010093872A2 (en) 2009-02-13 2010-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular-based method of cancer diagnosis and prognosis
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーSpotlight Technology Partners Llc 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
WO2011120691A1 (en) * 2010-04-01 2011-10-06 Roche Diagnostics Gmbh Method for isolating an analyte from a sample fluid with a protein-repellent hydrogel
WO2011149943A1 (en) 2010-05-24 2011-12-01 Ventana Midical Systems, Inc. Method for differentiation of non-small cellung carcinoma
JP6366580B2 (ja) 2012-06-22 2018-08-01 エイチティージー モレキュラー ダイアグノスティクス, インコーポレイテッド メラニン細胞性病変における分子悪性度
US9360474B2 (en) * 2012-11-29 2016-06-07 Opti Medical Systems, Inc. Multi-layer device for selectively determining magnesium ion
CA3210220A1 (en) 2013-05-10 2014-11-13 Johns Hopkins University Compositions for ovarian cancer assessment having improved specificity
KR102314014B1 (ko) * 2013-09-24 2021-10-19 엔탑시스, 엘엘씨 검출 가능한 어레이들, 진단을 위한 시스템들, 및 이를 만들고 사용하는 방법들
WO2015073709A2 (en) 2013-11-14 2015-05-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Detection of atherosclerotic cardiovascular disease risk and heart failure risk
US10398772B2 (en) 2014-01-08 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy
EP3108218A4 (en) * 2014-02-21 2017-11-15 Massachusetts Institute Of Technology Expansion microscopy
DK3256850T3 (da) 2015-02-09 2025-08-18 Slingshot Biosciences Inc Hydrogelpartikler med justerbare optiske egenskaber og fremgangsmåder til anvendelse deraf
US20160230284A1 (en) 2015-02-10 2016-08-11 Arcanum Alloy Design, Inc. Methods and systems for slurry coating
US10526649B2 (en) 2015-04-14 2020-01-07 Massachusetts Institute Of Technology Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information
US10059990B2 (en) 2015-04-14 2018-08-28 Massachusetts Institute Of Technology In situ nucleic acid sequencing of expanded biological samples
US11408890B2 (en) 2015-04-14 2022-08-09 Massachusetts Institute Of Technology Iterative expansion microscopy
EP3332029B1 (en) 2015-08-07 2021-10-06 Massachusetts Institute of Technology Nanoscale imaging of proteins and nucleic acids via expansion microscopy
WO2017027368A1 (en) 2015-08-07 2017-02-16 Massachusetts Institute Of Technology Protein retention expansion microscopy
US11988662B2 (en) 2015-12-07 2024-05-21 Nanohmics, Inc. Methods for detecting and quantifying gas species analytes using differential gas species diffusion
US10386351B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using gas species diffusion
US10386365B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using ionic species diffusion
EP3386594B1 (en) 2015-12-11 2023-05-03 The General Hospital Corporation Combination of a platelet-derived growth factor receptor alpha inhibitor and a histone lysine demethylase inhibitor for treating drug-tolerant glioblastoma
WO2017139276A1 (en) 2016-02-08 2017-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene signature predictive of hepatocellular carcinoma response to transcatheter arterial chemoembolization (tace)
WO2017201418A1 (en) 2016-05-20 2017-11-23 Arcanum Alloys, Inc. Methods and systems for coating a steel substrate
CN106323168B (zh) * 2016-08-30 2018-10-02 中航工业哈尔滨轴承有限公司 利用ogp光学测量仪测量圆弧切点的方法
US10995361B2 (en) 2017-01-23 2021-05-04 Massachusetts Institute Of Technology Multiplexed signal amplified FISH via splinted ligation amplification and sequencing
CN110234973A (zh) * 2017-01-31 2019-09-13 珀金埃尔默健康科学有限公司 盘绕线式采样器
WO2018157048A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy
WO2018157074A1 (en) 2017-02-24 2018-08-30 Massachusetts Institute Of Technology Methods for diagnosing neoplastic lesions
FR3065652B1 (fr) * 2017-04-27 2021-07-23 Biomerieux Sa Plaque d'analyse maldi-tof a support papier et son utilisation
US11180804B2 (en) 2017-07-25 2021-11-23 Massachusetts Institute Of Technology In situ ATAC sequencing
WO2019060907A1 (en) 2017-09-25 2019-03-28 Fred Hutchinson Cancer Research Center HIGH PERFORMANCE TARGETED IN SITU PANGENOMIC PROFILING
CA3082352A1 (en) * 2017-11-10 2019-05-16 Perkinelmer Health Sciences Canada, Inc. Multiple analyte ion source
WO2019156957A1 (en) 2018-02-06 2019-08-15 Massachusetts Institute Of Technology Swellable and structurally homogenous hydrogels and methods of use thereof
WO2020013833A1 (en) 2018-07-13 2020-01-16 Massachusetts Institute Of Technology Dimethylacrylamide (dmaa) hydrogel for expansion microscopy (exm)
EP3867943A1 (en) * 2018-10-18 2021-08-25 DH Technologies Development Pte. Ltd. Functionalizing a sampling element for use with a mass spectrometry system
US12405193B2 (en) 2019-02-22 2025-09-02 Massachusetts Institute Of Technology Iterative direct expansion microscopy
CN110672711B (zh) * 2019-10-22 2021-09-21 南通市第二人民医院 一种肿瘤分子的离子计数检测装置
US12265004B2 (en) 2019-11-05 2025-04-01 Massachusetts Institute Of Technology Membrane probes for expansion microscopy
US11802822B2 (en) 2019-12-05 2023-10-31 Massachusetts Institute Of Technology Multiplexed expansion (MultiExM) pathology
TW202141019A (zh) 2020-01-24 2021-11-01 美商史林夏特生化公司 類細胞校正粒子之組合物與方法
CA3177834A1 (en) 2020-05-04 2021-11-11 Jeffrey Kim Compositions and methods for passive optical barcoding for multiplexed assays
US12116637B2 (en) 2020-07-24 2024-10-15 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
US20220061705A1 (en) * 2020-08-05 2022-03-03 The Regents Of The University Of California Programmable epidermal microfluidic valving system for wearable biofluid management and contextual biomarker analysis
JP2024539956A (ja) 2021-10-29 2024-10-31 スリングショット バイオサイエンシーズ, インコーポレイテッド フィーダー細胞としておよび合成抗原提示細胞としてのヒドロゲル粒子
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
AU2023265684A1 (en) 2022-05-05 2024-11-21 Slingshot Biosciences, Inc. Engineered particles as red blood cell mimics and compositions containing same for hematology
CA3257621A1 (en) 2022-06-02 2023-12-07 Slingshot Biosciences, Inc. APOPTOTIC CELL MIMETIC
WO2024092161A2 (en) 2022-10-26 2024-05-02 Slingshot Biosciences, Inc. Size-tunable synthetic particles with tunable optical properties and methods for using the same for immune cell activation
US12461007B2 (en) 2023-08-29 2025-11-04 Slingshot Biosciences, Inc. CD34 stem cell mimics
WO2025106804A1 (en) 2023-11-16 2025-05-22 Massachusetts Institute Of Technology Compositions and methods for characterizing hepatocyte stress
WO2025217069A1 (en) 2024-04-08 2025-10-16 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating cardiotoxicity
WO2026096383A1 (en) 2024-10-28 2026-05-07 The Broad Institute, Inc. Compositions and methods for inducing phagocytosis

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070348A (en) 1973-07-25 1978-01-24 Rohm Gmbh Water-swellable, bead copolymer
US3896661A (en) 1974-01-09 1975-07-29 Stanford Research Inst Method of coupling thin layer chromatograph with mass spectrometer
US4060678A (en) * 1975-02-11 1977-11-29 Plastomedical Sciences, Inc. Cationic hydrogels based on hydroxyalkyl acrylates and methacrylates
US4154638A (en) 1977-08-04 1979-05-15 Ppg Industries, Inc. Coupling agent for bonding an organic polymer to an inorganic surface
DE3172839D1 (en) 1980-09-11 1985-12-12 Atomic Energy Authority Uk Improvements in or relating to composite materials
GB2088392B (en) 1980-12-03 1984-05-02 Sumitomo Chemical Co Production of hydrogels
JPS57158209A (en) 1981-03-25 1982-09-30 Kao Corp Production of bead-form highly water-absorbing polymer
US4438239A (en) * 1981-03-30 1984-03-20 California Institute Of Technology Microsphere coated substrate containing reactive aldehyde groups
JPS57195105A (en) * 1981-05-26 1982-11-30 Kuraray Co Ltd Preparation of modified cis-1,4-polyisoprene rubber
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
JPS61275355A (ja) 1985-05-29 1986-12-05 Kao Corp 吸収性物品
US4908512A (en) * 1985-08-21 1990-03-13 Kratos Analytical Limited Apparatus and methods of use in the mass analysis of chemical samples
US5336742A (en) 1987-03-13 1994-08-09 Minnesota Mining And Manufacturing Company Polymeric supports
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
SE462408B (sv) 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
SE8804074D0 (sv) 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
GB2226032B (en) 1988-12-16 1993-08-18 Urs Heimgartner Detection of glycoproteins
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
GB2236186B (en) 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
GB2236185B (en) 1989-08-22 1994-03-23 Finnigan Mat Gmbh Process,specimen and device for making an analyte available for an investigation
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5532279A (en) 1990-05-03 1996-07-02 Dionex Corporation Ion-exchange composition employing resin attachment to dispersant and method for forming the same
US5196302A (en) 1990-08-29 1993-03-23 The United States Of America As Represented By The Sectetary Of The Navy Enzymatic assays using superabsorbent materials
US5639620A (en) 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
JP3217171B2 (ja) * 1992-04-14 2001-10-09 住友化学工業株式会社 樹脂組成物およびそれから作られた二次加工品
US5268097A (en) 1992-06-19 1993-12-07 Sepracor Inc. Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same
US5266097A (en) * 1992-12-31 1993-11-30 The Vigoro Corporation Aminoureaformaldehyde fertilizer method and composition
US5744306A (en) * 1993-04-19 1998-04-28 Emory University Methods for nucleic acid detection, sequencing, and cloning using exonuclease
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
PT700521E (pt) 1993-05-28 2003-10-31 Baylor College Medicine Metodo e espectrometro de massa para dessorcao e ionizacao de analitos
US5438161A (en) * 1993-06-04 1995-08-01 S&C Electric Company Apparatus with interconnection arrangement
CA2131047A1 (en) 1993-09-01 1995-03-02 Takashi Sanada Thermoplastic resin composition
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
JPH10510053A (ja) 1994-11-29 1998-09-29 アナロジック コーポレーション 粒子凝集検定系
US5786439A (en) 1996-10-24 1998-07-28 Minimed Inc. Hydrophilic, swellable coatings for biosensors
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
US6013855A (en) 1996-08-06 2000-01-11 United States Surgical Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces
US5905024A (en) 1996-12-17 1999-05-18 University Of Chicago Method for performing site-specific affinity fractionation for use in DNA sequencing
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
WO1999036576A1 (en) 1998-01-20 1999-07-22 Packard Bioscience Company Gel pad arrays and methods and systems for making them
AU4025300A (en) 1999-03-24 2000-10-09 Packard Bioscience Company Continuous porous matrix arrays
DE60045816D1 (de) * 1999-04-27 2011-05-19 Bio Rad Laboratories Probenhalter für ein gasphaseionenspektrometer
JP2005526972A (ja) * 2002-05-02 2005-09-08 シファーゲン バイオシステムズ, インコーポレイテッド 多糖系ヒドロゲルをコーティングした表面を有するバイオチップ

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401558A4 (en) * 2001-05-25 2007-12-12 Waters Investments Ltd DESALINATION PLATE FOR MALDI MASS SPECTROMETRY

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WO2000066265A9 (en) 2001-09-07
US20050090016A1 (en) 2005-04-28
DE60045816D1 (de) 2011-05-19
US7205156B2 (en) 2007-04-17
EP1173878B1 (en) 2011-04-06
WO2000066265A8 (en) 2001-03-15
CN1204592C (zh) 2005-06-01
US20070158547A1 (en) 2007-07-12
KR20020026427A (ko) 2002-04-10
CN1360732A (zh) 2002-07-24
AU4675000A (en) 2000-11-17
KR100713786B1 (ko) 2007-05-07
ATE504937T1 (de) 2011-04-15
AU774336B2 (en) 2004-06-24
EP1173878A2 (en) 2002-01-23
JP2003524772A (ja) 2003-08-19
WO2000066265A3 (en) 2001-08-09
US6897072B1 (en) 2005-05-24
US7479631B2 (en) 2009-01-20
WO2000066265A2 (en) 2000-11-09

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