CA2367375A1 - Utilisation de vecteurs d'administration d'un gene recombinant pour le traitement ou la prevention des maladies de l'oeil - Google Patents
Utilisation de vecteurs d'administration d'un gene recombinant pour le traitement ou la prevention des maladies de l'oeil Download PDFInfo
- Publication number
- CA2367375A1 CA2367375A1 CA002367375A CA2367375A CA2367375A1 CA 2367375 A1 CA2367375 A1 CA 2367375A1 CA 002367375 A CA002367375 A CA 002367375A CA 2367375 A CA2367375 A CA 2367375A CA 2367375 A1 CA2367375 A1 CA 2367375A1
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- fgf
- eye
- gene delivery
- vector
- cells
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
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- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cell Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne des vecteurs d'administration de gènes, tels que, par exemple, des vecteurs de virus associés aux adénovirus recombinants, ainsi que des techniques d'utilisation de tels vecteurs pour le traitement ou la prévention des maladies de l'oeil.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12446099P | 1999-03-15 | 1999-03-15 | |
| US60/124,460 | 1999-03-15 | ||
| US17498400P | 2000-01-06 | 2000-01-06 | |
| US60/174,984 | 2000-01-06 | ||
| PCT/US2000/007062 WO2000054813A2 (fr) | 1999-03-15 | 2000-03-15 | Utilisation de vecteurs d'administration d'un gene recombinant pour le traitement ou la prévention des maladies de l'oeil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2367375A1 true CA2367375A1 (fr) | 2000-09-21 |
Family
ID=26822618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002367375A Abandoned CA2367375A1 (fr) | 1999-03-15 | 2000-03-15 | Utilisation de vecteurs d'administration d'un gene recombinant pour le traitement ou la prevention des maladies de l'oeil |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1183051A2 (fr) |
| JP (1) | JP2002539176A (fr) |
| AU (1) | AU3755900A (fr) |
| CA (1) | CA2367375A1 (fr) |
| WO (1) | WO2000054813A2 (fr) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6943153B1 (en) | 1999-03-15 | 2005-09-13 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| JP2002542805A (ja) | 1999-04-30 | 2002-12-17 | ユニバーシティ オブ フロリダ | アデノ随伴ウイルス送達リボザイム組成物および使用方法 |
| US7253266B2 (en) | 1999-07-27 | 2007-08-07 | Curagen Corporation | Polypeptides of FGF-CX |
| US7056885B1 (en) | 1999-07-27 | 2006-06-06 | Curagen Corporation | Fibroblast growth factor and nucleic acids encoding same |
| AU2008201780B2 (en) * | 1999-09-07 | 2012-05-17 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| US7459540B1 (en) * | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| US7408047B1 (en) | 1999-09-07 | 2008-08-05 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| CA2388637A1 (fr) * | 1999-10-22 | 2001-05-03 | Chiron Corporation | Gene fgf-20 humain et produits d'expression genique |
| US6797695B1 (en) | 1999-10-22 | 2004-09-28 | Kyoto University | Human FGF-20 gene and gene expression products |
| ES2335386T3 (es) * | 1999-11-18 | 2010-03-26 | Novartis Vaccines And Diagnostics, Inc. | Gen fgf-21 humano y productos de expresion genica. |
| US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
| WO2001058494A2 (fr) * | 2000-02-11 | 2001-08-16 | Genvec, Inc. | Matieres et procedes destines au traitement de troubles oculaires |
| US6821775B1 (en) | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
| AU2001240149A1 (en) * | 2000-03-13 | 2001-09-24 | Amgen Inc | Fibroblast growth factor-like molecules and uses thereof |
| WO2001092522A2 (fr) * | 2000-06-01 | 2001-12-06 | Eli Lilly And Company | Acides nucleiques et polypeptides humains fgf-20 |
| AU2001271811B2 (en) * | 2000-07-03 | 2006-07-20 | Curagen Corporation | Novel fibroblast growth factors and nucleic acids encoding same |
| AU2001292881A1 (en) * | 2000-09-20 | 2002-04-02 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| US7189693B2 (en) | 2000-11-06 | 2007-03-13 | Curagen Corporation | Treatment of inflammatory bowel disease using fibroblast growth factor CX polypeptides |
| EP1365793A2 (fr) * | 2000-11-06 | 2003-12-03 | Curagen Corporation | Traitement de maladies intestinales inflammatoires a l'aide de facteurs de croissance |
| US6982250B2 (en) | 2000-11-06 | 2006-01-03 | Curagen Corporation | Methods of prevention and treatment of inflammatory bowel disease |
| KR20030075152A (ko) * | 2000-12-19 | 2003-09-22 | 리서치 디벨럽먼트 파운데이션 | 렌티바이러스 벡터-매개된 유전자 전달 및 이의 용도 |
| JP2005500035A (ja) * | 2001-06-15 | 2005-01-06 | キュラジェン コーポレイション | 新規線維芽細胞成長因子およびそれをコード化する核酸 |
| US20030158112A1 (en) | 2002-02-15 | 2003-08-21 | Johns Hopkins University School Of Medicine | Selective induction of apoptosis to treat ocular disease |
| US20060193830A1 (en) * | 2002-03-20 | 2006-08-31 | Hauswirth William W | Raav vector compositions and methods for the treatment of choroidal neovascularization |
| NZ561656A (en) | 2002-05-01 | 2009-03-31 | Univ Florida | Improved rAAV expression systems for genetic modification of specific capsid proteins |
| JP2005218780A (ja) * | 2004-02-09 | 2005-08-18 | Menicon Co Ltd | 薬物放出速度を制御し得る薬物徐放可能なヒドロゲル材料の製造方法 |
| JP4944032B2 (ja) | 2004-09-13 | 2012-05-30 | ジェンザイム・コーポレーション | 多量体構築物 |
| CA2671613C (fr) * | 2006-12-05 | 2018-07-03 | The Royal Institution For The Advancement Of Learning/Mcgill University | Procedes d'utilisation de modulateurs de recepteur trk |
| CN101980668A (zh) * | 2008-02-07 | 2011-02-23 | 赛拉基因公司 | 通过玻璃体内施用编码治疗用蛋白质的表达载体救援光感器 |
| CA2762118A1 (fr) | 2008-05-20 | 2010-01-28 | Eos Neuroscience, Inc. | Vecteurs pour la delivrance de proteines photosensibles et procedes d'utilisation |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| EA201990619A1 (ru) | 2008-10-10 | 2019-07-31 | Амген Инк. | Fgf21 мутанты и их применение |
| UY32607A (es) | 2009-05-05 | 2010-12-31 | Amgen Inc | Mutantes de fgf21 y usos del mismo |
| EP2427207B1 (fr) | 2009-05-05 | 2017-08-16 | Amgen, Inc | Mutants de fgf21 et leurs utilisations |
| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| CN101947309B (zh) * | 2010-04-12 | 2012-09-19 | 南海朗肽制药有限公司 | 人碱性成纤维细胞生长因子滴眼液及其制备方法 |
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| SI2601214T1 (en) | 2010-08-06 | 2018-03-30 | Genzyme Corporation | VEGF antagonist compositions and their use |
| TWI702955B (zh) | 2012-05-15 | 2020-09-01 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒（ａａｖ）ｓｆｌｔ-１治療老年性黃斑部退化（ａｍｄ） |
| WO2015138616A1 (fr) | 2014-03-11 | 2015-09-17 | Wayne State University | Promoteur mglur6 modifié et procédés d'utilisation |
| SG10201810150UA (en) | 2014-03-17 | 2018-12-28 | Adverum Biotechnologies Inc | Compositions and methods for enhanced gene expression in cone cells |
| CN107405507B (zh) | 2015-03-02 | 2022-05-03 | 阿德夫拉姆生物技术股份有限公司 | 用于将多核苷酸玻璃体内递送到视网膜视锥的组合物和方法 |
| GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112946A (en) * | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
| FR2718150B1 (fr) * | 1994-03-29 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
| US5639725A (en) * | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
| US5641749A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product |
| EP0928203B1 (fr) * | 1996-09-24 | 2006-10-25 | Merck & Co., Inc. | Composes servant a inhiber l'angiogenese par la therapie genique |
| EP1173191A4 (fr) * | 1997-05-13 | 2004-12-01 | Univ California | Nouveaux agents peptidiques anti-angiogeniques, utilisation de ces derniers pour la therapie et le diagnostic |
| JPH11100327A (ja) * | 1997-09-26 | 1999-04-13 | Toray Ind Inc | 網膜変性症治療剤 |
| EP1705248A1 (fr) * | 1997-10-01 | 2006-09-27 | G.D. Searle LLC. | Protéines de fusion comprenant une fraction d'angiostatine et leur utilisation dans un traitement ant-tumeur |
| ATE226444T1 (de) * | 1998-03-12 | 2002-11-15 | Genentech Inc | Verwendung von fgf-5 polypetiden zur vorbeugung des absterbens retinaler neuronen und behandlung okularer krankheiten |
| US6593133B1 (en) * | 1998-07-06 | 2003-07-15 | Nsgene A/S | Neurotrophic factors |
| AU775245B2 (en) * | 1998-09-17 | 2004-07-22 | Catholic University Nijmegen | Methods for treatment of degenerative retinal diseases |
-
2000
- 2000-03-15 AU AU37559/00A patent/AU3755900A/en not_active Abandoned
- 2000-03-15 WO PCT/US2000/007062 patent/WO2000054813A2/fr not_active Application Discontinuation
- 2000-03-15 CA CA002367375A patent/CA2367375A1/fr not_active Abandoned
- 2000-03-15 JP JP2000604885A patent/JP2002539176A/ja not_active Withdrawn
- 2000-03-15 EP EP00916458A patent/EP1183051A2/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002539176A (ja) | 2002-11-19 |
| WO2000054813A2 (fr) | 2000-09-21 |
| EP1183051A2 (fr) | 2002-03-06 |
| AU3755900A (en) | 2000-10-04 |
| WO2000054813A3 (fr) | 2001-05-03 |
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