CA2364146C - Method for processing a nucleic acid sample by oscillating a cartridge, a system and a cartridge for performing such a method - Google Patents

Method for processing a nucleic acid sample by oscillating a cartridge, a system and a cartridge for performing such a method Download PDF

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Publication number
CA2364146C
CA2364146C CA2364146A CA2364146A CA2364146C CA 2364146 C CA2364146 C CA 2364146C CA 2364146 A CA2364146 A CA 2364146A CA 2364146 A CA2364146 A CA 2364146A CA 2364146 C CA2364146 C CA 2364146C
Authority
CA
Canada
Prior art keywords
cartridge
active surface
channel
shaped carrier
chip shaped
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2364146A
Other languages
English (en)
French (fr)
Other versions
CA2364146A1 (en
Inventor
Peter Vischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2364146A1 publication Critical patent/CA2364146A1/en
Application granted granted Critical
Publication of CA2364146C publication Critical patent/CA2364146C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/10—Mixers with shaking, oscillating, or vibrating mechanisms with a mixing receptacle rotating alternately in opposite directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/201—Holders therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00524—Mixing by agitating sample carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Saccharide Compounds (AREA)
CA2364146A 2000-12-28 2001-11-30 Method for processing a nucleic acid sample by oscillating a cartridge, a system and a cartridge for performing such a method Expired - Fee Related CA2364146C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00811253.4 2000-12-28
EP00811253A EP1224976B1 (en) 2000-12-28 2000-12-28 Method, system and cartridge for processing a nucleic acid sample by oscillating the cartridge

Publications (2)

Publication Number Publication Date
CA2364146A1 CA2364146A1 (en) 2002-06-28
CA2364146C true CA2364146C (en) 2010-09-14

Family

ID=8175115

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2364146A Expired - Fee Related CA2364146C (en) 2000-12-28 2001-11-30 Method for processing a nucleic acid sample by oscillating a cartridge, a system and a cartridge for performing such a method

Country Status (7)

Country Link
US (2) US6921639B2 (enExample)
EP (2) EP1224976B1 (enExample)
JP (2) JP3970023B2 (enExample)
AT (1) ATE337093T1 (enExample)
CA (1) CA2364146C (enExample)
DE (1) DE60030306T2 (enExample)
ES (1) ES2269093T3 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1224976B1 (en) 2000-12-28 2006-08-23 F. Hoffmann-La Roche Ag Method, system and cartridge for processing a nucleic acid sample by oscillating the cartridge
EP1419820A1 (en) * 2002-11-14 2004-05-19 F. Hoffmann-La Roche Ag Method, system and reaction vessel for processing a biological sample contained in a liquid
EP1419821A1 (en) * 2002-11-14 2004-05-19 F. Hoffmann-La Roche Ag Method, system and reaction vessel for processing a biological sample contained in a liquid
JP3920223B2 (ja) * 2003-01-07 2007-05-30 日本碍子株式会社 反応性チップと、このチップを用いた標的物質の結合検出方法
DE602004009775T2 (de) 2004-07-02 2008-08-28 Roche Diagnostics Gmbh Vorrichtung zur zuverlässige Analyse
US20080226502A1 (en) * 2005-07-07 2008-09-18 Jacques Jonsmann Microfluidic Methods and Support Instruments
WO2008012550A2 (en) 2006-07-28 2008-01-31 Diagnostics For The Real World, Ltd. Device, system and method for processing a sample
EP2101917A1 (en) 2007-01-10 2009-09-23 Scandinavian Micro Biodevices A/S A microfluidic device and a microfluidic system and a method of performing a test
WO2008139415A1 (en) * 2007-05-14 2008-11-20 Koninklijke Philips Electronics N.V. Microfluidic device and method of operating a microfluidic device
WO2009024773A1 (en) 2007-08-17 2009-02-26 Diagnostics For The Real World, Ltd Device, system and method for processing a sample
JPWO2010001636A1 (ja) * 2008-07-01 2011-12-15 日本碍子株式会社 Ｄｎａアレイ
JP5867668B2 (ja) 2010-12-01 2016-02-24 セイコーエプソン株式会社 熱サイクル装置及び熱サイクル方法
JP5896100B2 (ja) * 2011-03-01 2016-03-30 セイコーエプソン株式会社 熱サイクル装置
JP2013208066A (ja) 2012-03-30 2013-10-10 Seiko Epson Corp 熱サイクル装置及び熱サイクル装置の制御方法
JP5971463B2 (ja) 2012-03-30 2016-08-17 セイコーエプソン株式会社 熱サイクル装置及び熱サイクル装置の制御方法
JP5967361B2 (ja) 2012-06-06 2016-08-10 セイコーエプソン株式会社 熱サイクル装置
JP2013252091A (ja) * 2012-06-06 2013-12-19 Seiko Epson Corp 熱サイクル装置
JP2015154722A (ja) 2014-02-20 2015-08-27 セイコーエプソン株式会社 核酸増幅反応容器及び核酸増幅反応装置
EP3151965B1 (en) 2014-06-04 2021-02-24 Edan Instruments, Inc. Sample collection and analysis devices
CN109794308B (zh) * 2017-11-17 2021-05-04 长春长光华大智造测序设备有限公司 一种生物芯片承载架
CN113559753B (zh) * 2021-09-23 2021-12-03 启锰生物科技(江苏)有限公司 一种佐剂疫苗用的检测组件

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5133937A (en) * 1989-06-01 1992-07-28 Iniziative Marittime, 1991 S.R.L. Analysis system having a removable reaction cartridge and temperature control
EP0695941B1 (en) * 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US5959098A (en) * 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US5922604A (en) * 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
CN1224462C (zh) 1997-07-18 2005-10-26 阿诺德有限公司 把材料粉碎成细小颗粒
JP3938982B2 (ja) * 1997-08-29 2007-06-27 オリンパス株式会社 Ｄｎａキャピラリィ
US5961930A (en) * 1997-10-15 1999-10-05 Eastman Kodak Company Integrated micro-ceramic chemical plant with insertable reaction chambers and micro-filters
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6426184B1 (en) 1998-02-11 2002-07-30 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
FR2806165B1 (fr) * 2000-03-09 2003-01-17 Genomic Sa Automate pour l'analyse biologique
JP3871846B2 (ja) * 2000-03-10 2007-01-24 日立ソフトウエアエンジニアリング株式会社 ハイブリダイゼーション反応検出方法及び検出装置
WO2002042775A2 (en) 2000-11-27 2002-05-30 Genevention L.L.C. Clinically intelligent diagnostic devices and methods
ES2232407T3 (es) * 2000-12-28 2005-06-01 F. Hoffmann-La Roche Ag Metodo para el procesado de una muestra de acido nucleico mediante la oscilacion de un segmento de una pared de un cartucho, un sistema y un cartucho para realizar dicho metodo.
EP1224976B1 (en) 2000-12-28 2006-08-23 F. Hoffmann-La Roche Ag Method, system and cartridge for processing a nucleic acid sample by oscillating the cartridge

Also Published As

Publication number Publication date
DE60030306T2 (de) 2007-08-30
DE60030306D1 (de) 2006-10-05
US20020155475A1 (en) 2002-10-24
US6921639B2 (en) 2005-07-26
JP3970023B2 (ja) 2007-09-05
EP1623762A3 (en) 2014-05-21
US20050170496A1 (en) 2005-08-04
CA2364146A1 (en) 2002-06-28
JP2007010684A (ja) 2007-01-18
EP1224976B1 (en) 2006-08-23
EP1623762A2 (en) 2006-02-08
US7435575B2 (en) 2008-10-14
JP4512573B2 (ja) 2010-07-28
ES2269093T3 (es) 2007-04-01
ATE337093T1 (de) 2006-09-15
EP1224976A1 (en) 2002-07-24
JP2002257830A (ja) 2002-09-11

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Effective date: 20141201