CA2361807A1 - Inhalateur a air comprime pour administration intra-pulmonaire d'aerosols a base de poudres de liposomes, et poudres pour aerosols correspondantes - Google Patents
Inhalateur a air comprime pour administration intra-pulmonaire d'aerosols a base de poudres de liposomes, et poudres pour aerosols correspondantes Download PDFInfo
- Publication number
- CA2361807A1 CA2361807A1 CA002361807A CA2361807A CA2361807A1 CA 2361807 A1 CA2361807 A1 CA 2361807A1 CA 002361807 A CA002361807 A CA 002361807A CA 2361807 A CA2361807 A CA 2361807A CA 2361807 A1 CA2361807 A1 CA 2361807A1
- Authority
- CA
- Canada
- Prior art keywords
- powder aerosol
- liposomes
- compressed air
- liposomal
- aerosol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000443 aerosol Substances 0.000 title claims abstract description 71
- 239000000843 powder Substances 0.000 title claims abstract description 54
- 230000002685 pulmonary effect Effects 0.000 title claims abstract description 10
- 239000002502 liposome Substances 0.000 claims abstract description 68
- 239000013543 active substance Substances 0.000 claims abstract description 37
- 238000001035 drying Methods 0.000 claims abstract description 25
- 239000006185 dispersion Substances 0.000 claims abstract description 23
- 239000007788 liquid Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000002105 nanoparticle Substances 0.000 claims abstract description 8
- 238000001694 spray drying Methods 0.000 claims abstract description 4
- 239000002245 particle Substances 0.000 claims description 35
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 24
- 238000000889 atomisation Methods 0.000 claims description 16
- 235000012000 cholesterol Nutrition 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 210000002345 respiratory system Anatomy 0.000 claims description 6
- 238000002525 ultrasonication Methods 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 210000003437 trachea Anatomy 0.000 claims description 4
- BZTDTCNHAFUJOG-UHFFFAOYSA-N 6-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C11OC(=O)C2=CC=C(C(=O)O)C=C21 BZTDTCNHAFUJOG-UHFFFAOYSA-N 0.000 claims description 3
- 238000000265 homogenisation Methods 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- 239000001828 Gelatine Substances 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
- 208000019693 Lung disease Diseases 0.000 claims description 2
- 102000007327 Protamines Human genes 0.000 claims description 2
- 108010007568 Protamines Proteins 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 239000000596 artificial lung surfactant Substances 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 239000002274 desiccant Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 230000003116 impacting effect Effects 0.000 claims description 2
- 150000003904 phospholipids Chemical class 0.000 claims description 2
- 229920002721 polycyanoacrylate Polymers 0.000 claims description 2
- 229920000193 polymethacrylate Polymers 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 229940048914 protamine Drugs 0.000 claims description 2
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 2
- 239000002691 unilamellar liposome Substances 0.000 claims description 2
- 210000003123 bronchiole Anatomy 0.000 claims 1
- 239000012798 spherical particle Substances 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract description 6
- 230000009471 action Effects 0.000 abstract description 2
- 210000004072 lung Anatomy 0.000 description 9
- 239000003814 drug Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000008020 evaporation Effects 0.000 description 5
- 238000001704 evaporation Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 4
- 239000003380 propellant Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 208000027775 Bronchopulmonary disease Diseases 0.000 description 2
- 240000007817 Olea europaea Species 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 208000014181 Bronchial disease Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010057362 Underdose Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 239000003580 lung surfactant Substances 0.000 description 1
- 229940066294 lung surfactant Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- -1 surfactant lipids Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/0012—Apparatus for achieving spraying before discharge from the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
- B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
- B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne un inhalateur à air comprimé qui permet d'administrer au niveau pulmonaire un aérosol constitué d'une poudre de liposomes contenant un principe actif ou non chargée. Son objectif est de proposer un inhalateur qui permette notamment d'administrer au niveau pulmonaire, sans obliger à des manoeuvres respiratoires forcées et au site d'action désiré, des liposomes porteurs d'un principe actif en une quantité suffisante et sans pertes. A cet effet, ledit inhalateur comprend un réservoir (20) pouvant contenir une dispersion aqueuse de liposomes, à l'intérieur duquel les liposomes contenant le principe actif sont dispersés dans l'eau. Le réservoir est relié, par l'intermédiaire d'un dispositif doseur (19) de liquide, à une tubulure de pulvérisation (1) et à une unité de séchage (17), telle qu'une chambre de vaporisation, qui sèche les liposomes par pulvérisation. Un dispositif de sortie (18), tel qu'un embout buccal, est raccordé à ladite unité de séchage. La tubulure de pulvérisation (1) comporte des orifices d'alimentation séparés (14, 16) pour l'air comprimé et pour la dispersion de liposomes (fig. 1). L'invention concerne également une poudre pour aérosol constituée de liposomes ou de nanoparticules.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19905285 | 1999-02-03 | ||
| DE19905285.9 | 1999-02-03 | ||
| DE19954107.8 | 1999-11-02 | ||
| DE19954107 | 1999-11-02 | ||
| PCT/DE2000/000337 WO2000045878A2 (fr) | 1999-02-03 | 2000-02-03 | Inhalateur a air comprime pour administration intra-pulmonaire d'aerosols a base de poudres de liposomes, et poudres pour aerosols correspondantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2361807A1 true CA2361807A1 (fr) | 2000-08-10 |
Family
ID=26051750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002361807A Abandoned CA2361807A1 (fr) | 1999-02-03 | 2000-02-03 | Inhalateur a air comprime pour administration intra-pulmonaire d'aerosols a base de poudres de liposomes, et poudres pour aerosols correspondantes |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1148905A2 (fr) |
| JP (1) | JP2002538855A (fr) |
| KR (1) | KR20010101991A (fr) |
| CN (1) | CN1338956A (fr) |
| AU (1) | AU3416400A (fr) |
| CA (1) | CA2361807A1 (fr) |
| DE (1) | DE10004860A1 (fr) |
| HU (1) | HUP0105445A2 (fr) |
| PL (1) | PL349885A1 (fr) |
| RU (1) | RU2001124354A (fr) |
| SK (1) | SK10942001A3 (fr) |
| WO (1) | WO2000045878A2 (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10112167C2 (de) | 2001-03-12 | 2003-02-13 | Bionorica Ag | Verfahren zur schonenden Gewinnung von Trockenextrakten |
| US6900317B2 (en) | 2002-02-19 | 2005-05-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Salts of the CGRP antagonist BIBN4096 and inhalable powdered medicaments containing them |
| GB0219815D0 (en) * | 2002-08-24 | 2002-10-02 | Accentus Plc | Preparation of small crystals |
| US6883517B2 (en) * | 2002-09-30 | 2005-04-26 | Asaf Halamish | Downdraft nebulizer |
| US7459146B2 (en) * | 2003-05-30 | 2008-12-02 | 3M Innovative Properties Company | Stabilized aerosol dispersions |
| EP1744800B1 (fr) | 2004-04-21 | 2016-06-22 | Innovata Biomed Limited | Inhalateur |
| KR100682334B1 (ko) * | 2006-07-14 | 2007-02-16 | (주)지에프씨 | 미립상 레시틴 왁스 조성물 제조장치 |
| AU2010218750A1 (en) * | 2009-02-26 | 2010-09-02 | Acp Japan Co., Ltd. | Gas mist inhaler |
| BR112013032558B1 (pt) | 2011-09-06 | 2021-01-12 | British American Tobacco (Investments) Limited | aparelho para aquecer material fumável |
| WO2013065776A1 (fr) * | 2011-11-04 | 2013-05-10 | 日本エー・シー・ピー株式会社 | Inhalateur de brume gazeuse |
| KR101313993B1 (ko) * | 2012-07-24 | 2013-10-01 | 한국화학연구원 | 약물 흡입 장치 |
| KR101373981B1 (ko) * | 2012-07-24 | 2014-03-12 | 한국화학연구원 | 약물 흡입 장치 |
| GB201217067D0 (en) | 2012-09-25 | 2012-11-07 | British American Tobacco Co | Heating smokable material |
| GB201311620D0 (en) | 2013-06-28 | 2013-08-14 | British American Tobacco Co | Devices Comprising a Heat Source Material and Activation Chambers for the Same |
| GB201500582D0 (en) | 2015-01-14 | 2015-02-25 | British American Tobacco Co | Apparatus for heating or cooling a material contained therein |
| GB201415381D0 (en) * | 2014-08-29 | 2014-10-15 | Algipharma As | Inhalable powder formulations of alginate oligomers |
| US20170055584A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Article for use with apparatus for heating smokable material |
| US11924930B2 (en) | 2015-08-31 | 2024-03-05 | Nicoventures Trading Limited | Article for use with apparatus for heating smokable material |
| US20170055575A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Material for use with apparatus for heating smokable material |
| US20170119046A1 (en) | 2015-10-30 | 2017-05-04 | British American Tobacco (Investments) Limited | Apparatus for Heating Smokable Material |
| US20170119047A1 (en) | 2015-10-30 | 2017-05-04 | British American Tobacco (Investments) Limited | Article for Use with Apparatus for Heating Smokable Material |
| JP6743280B2 (ja) * | 2016-04-15 | 2020-08-19 | ケーエーイーアール バイオセラピューティックス コーポレーション | エアロゾル化ノズル及びエアロゾル化ノズルの操作方法 |
| GB201817868D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolised formulation |
| CN111514418B (zh) * | 2019-06-12 | 2022-01-14 | 中南大学湘雅二医院 | 一种自吸式经鼻粉末材料给送装置 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0166476B1 (fr) * | 1984-05-28 | 1989-05-03 | MALLINCKRODT, INC.(a Missouri corporation) | Inhalateur avec générateur d'aérosol |
| US5209821A (en) * | 1985-05-09 | 1993-05-11 | Purdue Research Foundation | Apparatus for removing volatiles from, or dehydrating, liquid products |
| WO1986006959A1 (fr) * | 1985-05-22 | 1986-12-04 | Liposome Technology, Inc. | Procede et systeme d'inhalation de liposomes |
| DE4438292C2 (de) * | 1994-10-26 | 1999-07-22 | Pari Gmbh | Dosisgenaue Aerosolerzeugung für die Inhalationstherapie |
| GB2321419B (en) * | 1997-01-27 | 2001-02-07 | Medic Aid Ltd | Atomizer |
-
2000
- 2000-02-03 EP EP00912355A patent/EP1148905A2/fr not_active Withdrawn
- 2000-02-03 KR KR1020017009854A patent/KR20010101991A/ko not_active Application Discontinuation
- 2000-02-03 SK SK1094-2001A patent/SK10942001A3/sk unknown
- 2000-02-03 WO PCT/DE2000/000337 patent/WO2000045878A2/fr not_active Application Discontinuation
- 2000-02-03 CA CA002361807A patent/CA2361807A1/fr not_active Abandoned
- 2000-02-03 JP JP2000596997A patent/JP2002538855A/ja active Pending
- 2000-02-03 RU RU2001124354/14A patent/RU2001124354A/ru not_active Application Discontinuation
- 2000-02-03 CN CN00803324A patent/CN1338956A/zh active Pending
- 2000-02-03 HU HU0105445A patent/HUP0105445A2/hu unknown
- 2000-02-03 AU AU34164/00A patent/AU3416400A/en not_active Abandoned
- 2000-02-03 DE DE10004860A patent/DE10004860A1/de not_active Withdrawn
- 2000-02-03 PL PL00349885A patent/PL349885A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010101991A (ko) | 2001-11-15 |
| SK10942001A3 (sk) | 2002-05-09 |
| CN1338956A (zh) | 2002-03-06 |
| DE10004860A1 (de) | 2000-10-05 |
| WO2000045878A3 (fr) | 2000-09-28 |
| HUP0105445A2 (en) | 2002-06-29 |
| WO2000045878A2 (fr) | 2000-08-10 |
| AU3416400A (en) | 2000-08-25 |
| PL349885A1 (en) | 2002-09-23 |
| JP2002538855A (ja) | 2002-11-19 |
| EP1148905A2 (fr) | 2001-10-31 |
| RU2001124354A (ru) | 2003-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |