CA2354599C - Binding molecules for human factor viii and factor viii-like proteins - Google Patents

Binding molecules for human factor viii and factor viii-like proteins Download PDF

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Publication number
CA2354599C
CA2354599C CA2354599A CA2354599A CA2354599C CA 2354599 C CA2354599 C CA 2354599C CA 2354599 A CA2354599 A CA 2354599A CA 2354599 A CA2354599 A CA 2354599A CA 2354599 C CA2354599 C CA 2354599C
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Canada
Prior art keywords
cys
phe
pro
trp
ser
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA2354599A
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English (en)
French (fr)
Other versions
CA2354599A1 (en
Inventor
Jinan Yu
M. Daniel Potter
Brian D. Kelley
Jeffrey S. Deetz
James E. Booth
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Dyax Corp
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Publication of CA2354599A1 publication Critical patent/CA2354599A1/en
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Publication of CA2354599C publication Critical patent/CA2354599C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Reciprocating Pumps (AREA)
CA2354599A 1999-01-04 2000-01-03 Binding molecules for human factor viii and factor viii-like proteins Expired - Lifetime CA2354599C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/224,785 US6197526B1 (en) 1999-01-04 1999-01-04 Polypeptides for binding human factor VIII and fragments of human factor VIII
US09/224,785 1999-01-04
PCT/US2000/000043 WO2000040602A1 (en) 1999-01-04 2000-01-03 Binding molecules for human factor viii and factor viii-like proteins

Publications (2)

Publication Number Publication Date
CA2354599A1 CA2354599A1 (en) 2000-07-13
CA2354599C true CA2354599C (en) 2013-03-12

Family

ID=22842198

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2354599A Expired - Lifetime CA2354599C (en) 1999-01-04 2000-01-03 Binding molecules for human factor viii and factor viii-like proteins

Country Status (12)

Country Link
US (2) US6197526B1 (enExample)
EP (5) EP1705183B1 (enExample)
JP (3) JP4733272B2 (enExample)
AT (1) ATE433992T1 (enExample)
AU (3) AU769745B2 (enExample)
CA (1) CA2354599C (enExample)
DE (1) DE60042430D1 (enExample)
DK (4) DK1705183T3 (enExample)
ES (4) ES2390360T3 (enExample)
HK (1) HK1038756A1 (enExample)
PT (3) PT1705183E (enExample)
WO (1) WO2000040602A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820796B2 (en) * 1998-03-12 2010-10-26 Genetics Institute, Llc. Methods for producing Factor VIII proteins
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) * 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
FR2830865B1 (fr) 2001-10-17 2004-10-22 Centre Nat Rech Scient Leurres peptidiques pour la preparation de medicaments destines a la prevention ou au traitement des pathologies auto-immunes, ou des troubles lies a l'apparition d'anticorps diriges contre des proteines exogenes
US20030149246A1 (en) * 2002-02-01 2003-08-07 Russell John C. Macromolecular conjugates and processes for preparing the same
WO2003093821A1 (en) * 2002-04-29 2003-11-13 Affibody Ab Sandwich assay and kit
WO2007065691A2 (en) * 2005-12-07 2007-06-14 Technische Universität München Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins
TW200745163A (en) 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
WO2008124107A1 (en) 2007-04-04 2008-10-16 The Regents Of The University Of California Compositions, devices, systems, and methods for using a nanopore
CA2694824A1 (en) 2007-08-09 2009-02-12 Syntonix Pharmaceuticals, Inc. Immunomodulatory peptides
AR071478A1 (es) 2008-04-17 2010-06-23 Baxter Healthcare Sa Peptidos de bajo peso molecular con actividad procoagulante para el tratamiento de pacientes con deficiencia de factor v (fv), fvii, fviii, fx y/o fxi
US20100048488A1 (en) * 2008-08-01 2010-02-25 Syntonix Pharmaceuticals, Inc. Immunomodulatory peptides
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
CA2838833A1 (en) * 2011-06-10 2012-12-13 Biogen Idec Ma Inc. Pro-coagulant compounds and methods of use thereof
BR112016011195A2 (pt) 2013-11-18 2017-09-19 Rubius Therapeutics Inc Células eritroides enucleadas e seus métodos de fabricação, composição farmacêutica e seu uso, uso de uma população de células eritroides, biorreator, mistura de células e dispositivo médico
CN116731197A (zh) 2016-09-19 2023-09-12 豪夫迈·罗氏有限公司 基于补体因子的亲和层析
CA3301165A1 (en) 2017-08-04 2026-03-02 Takeda Pharmaceutical Company Limited Antibody-resin coupling apparatus and methods

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
SE8501050D0 (sv) 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
MX9203440A (es) 1985-04-12 1992-07-01 Genetics Inst Proteinas procoagulantes novedosas.
DE68927933T2 (de) * 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5661008A (en) 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
SE468050C (sv) * 1991-03-15 1998-04-27 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
WO1992017192A1 (en) * 1991-03-27 1992-10-15 The Scripps Research Institute Therapeutic fragments of von willebrand factor
IL126045A0 (en) * 1996-03-20 1999-05-09 Dyax Corp Purification of tissue plasminogen activator (tpa)
US5817752A (en) 1996-06-06 1998-10-06 La Jolla Pharmaceutical Company Cyclic polypeptides comprising a thioether linkage and methods for their preparation
EP0954531A1 (en) 1996-06-06 1999-11-10 Lajolla Pharmaceutical Company aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES
AU760678B2 (en) * 1998-05-08 2003-05-22 Stichting Sanquin Bloedvoorziening Method for diagnosis and treatment of haemophilia a patients with an inhibitor
US5994310A (en) 1998-09-03 1999-11-30 Bayer Corporation Peptide ligands for affinity purification of human Factor VIII
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII

Also Published As

Publication number Publication date
DK2301953T3 (da) 2014-09-22
WO2000040602A1 (en) 2000-07-13
ES2499040T3 (es) 2014-09-26
EP1705183A1 (en) 2006-09-27
AU769745B2 (en) 2004-02-05
EP2090582A2 (en) 2009-08-19
AU2004201830B2 (en) 2007-04-05
HK1155756A1 (en) 2012-05-25
PT2301953E (pt) 2014-09-15
DK2298791T3 (en) 2014-12-08
JP5368371B2 (ja) 2013-12-18
ES2524965T3 (es) 2014-12-16
PT1705183E (pt) 2009-07-31
CA2354599A1 (en) 2000-07-13
JP5572207B2 (ja) 2014-08-13
US20010014456A1 (en) 2001-08-16
DK2090582T3 (da) 2012-10-15
EP2301953A1 (en) 2011-03-30
AU2598200A (en) 2000-07-24
HK1131398A1 (en) 2010-01-22
JP2013079272A (ja) 2013-05-02
JP2002536297A (ja) 2002-10-29
US6492105B2 (en) 2002-12-10
HK1155182A1 (en) 2012-05-11
JP4733272B2 (ja) 2011-07-27
US6197526B1 (en) 2001-03-06
EP2298791B1 (en) 2014-11-12
PT2298791E (pt) 2014-12-16
AU2004201810A1 (en) 2004-05-27
EP2301953B1 (en) 2014-07-30
HK1038756A1 (zh) 2002-03-28
EP2298791A1 (en) 2011-03-23
EP1147128A4 (en) 2004-10-13
EP2298791B8 (en) 2014-12-24
DK1705183T3 (da) 2009-10-19
DE60042430D1 (de) 2009-07-30
ES2390360T3 (es) 2012-11-12
JP2010254694A (ja) 2010-11-11
ATE433992T1 (de) 2009-07-15
EP2090582B1 (en) 2012-09-19
EP2090582A3 (en) 2009-11-11
EP1147128A1 (en) 2001-10-24
ES2328722T3 (es) 2009-11-17
AU2004201830A1 (en) 2004-05-27
EP1705183B1 (en) 2009-06-17

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Effective date: 20200103