CA2352459A1 - Agents de potentialisation de l'immunoactivite des cellules .gamma..delta. contenant un extrait mycelien de shiitake - Google Patents
Agents de potentialisation de l'immunoactivite des cellules .gamma..delta. contenant un extrait mycelien de shiitake Download PDFInfo
- Publication number
- CA2352459A1 CA2352459A1 CA002352459A CA2352459A CA2352459A1 CA 2352459 A1 CA2352459 A1 CA 2352459A1 CA 002352459 A CA002352459 A CA 002352459A CA 2352459 A CA2352459 A CA 2352459A CA 2352459 A1 CA2352459 A1 CA 2352459A1
- Authority
- CA
- Canada
- Prior art keywords
- delta
- cell activity
- cells
- lentinus edodes
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 240000000599 Lentinula edodes Species 0.000 title claims abstract description 56
- 235000001715 Lentinula edodes Nutrition 0.000 title claims description 53
- 239000003623 enhancer Substances 0.000 title claims description 44
- 230000000694 effects Effects 0.000 claims abstract description 60
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract description 22
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 21
- 208000035143 Bacterial infection Diseases 0.000 claims description 14
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 14
- 230000009385 viral infection Effects 0.000 claims description 13
- 208000036142 Viral infection Diseases 0.000 claims description 12
- 235000013305 food Nutrition 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 6
- 238000001727 in vivo Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000003612 virological effect Effects 0.000 abstract description 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 91
- 210000005259 peripheral blood Anatomy 0.000 description 14
- 239000011886 peripheral blood Substances 0.000 description 14
- 239000000203 mixture Substances 0.000 description 13
- 201000011510 cancer Diseases 0.000 description 11
- 239000007787 solid Substances 0.000 description 11
- 210000004881 tumor cell Anatomy 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 230000000091 immunopotentiator Effects 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 229940124597 therapeutic agent Drugs 0.000 description 7
- 108091008874 T cell receptors Proteins 0.000 description 6
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 6
- 241000609240 Ambelania acida Species 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 241000282414 Homo sapiens Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 239000010905 bagasse Substances 0.000 description 5
- 229940088598 enzyme Drugs 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 241000282412 Homo Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- 230000003013 cytotoxicity Effects 0.000 description 3
- 231100000135 cytotoxicity Toxicity 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000000684 flow cytometry Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000011275 oncology therapy Methods 0.000 description 3
- 230000000069 prophylactic effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- 108010059892 Cellulase Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241000186779 Listeria monocytogenes Species 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 241000700618 Vaccinia virus Species 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 229940106157 cellulase Drugs 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- -1 disintegrators Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 208000000419 Chronic Hepatitis B Diseases 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- FZHXIRIBWMQPQF-UHFFFAOYSA-N Glc-NH2 Natural products O=CC(N)C(O)C(O)C(O)CO FZHXIRIBWMQPQF-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000004366 Glucosidases Human genes 0.000 description 1
- 108010056771 Glucosidases Proteins 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 101150044453 Y gene Proteins 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 208000016350 chronic hepatitis B virus infection Diseases 0.000 description 1
- 235000019784 crude fat Nutrition 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 230000002434 immunopotentiative effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000002297 mitogenic effect Effects 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Alternative & Traditional Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fodder In General (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne des agents de potentialisation d'activité et des agents d'immunoactivité des cellules ~.delta.T contenant un extrait mycélien de shiitake, ces agents pouvant être utilisés pour traiter les tumeurs, ou pour traiter et/ou prévenir les maladies infectieuses bactériennes ou virales. Ces agents s'appuient notamment sur la forte capacité de l'extrait mycélien de shiitake à potentialiser l'activité desdites cellules ~.delta.T.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10337822A JP2000157203A (ja) | 1998-11-27 | 1998-11-27 | シイタケ菌糸体抽出物を含むγδＴ細胞免疫活性増強剤 |
| JP10/337822 | 1998-11-27 | ||
| PCT/JP1999/006617 WO2000032213A1 (fr) | 1998-11-27 | 1999-11-26 | Agents de potentialisation de l'immunoactivite des cellules $g(y)$g(d)t contenant un extrait mycelien de shiitake |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2352459A1 true CA2352459A1 (fr) | 2000-06-08 |
Family
ID=18312295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002352459A Abandoned CA2352459A1 (fr) | 1998-11-27 | 1999-11-26 | Agents de potentialisation de l'immunoactivite des cellules .gamma..delta. contenant un extrait mycelien de shiitake |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JP2000157203A (fr) |
| KR (1) | KR20010089497A (fr) |
| CN (1) | CN1171631C (fr) |
| CA (1) | CA2352459A1 (fr) |
| GB (1) | GB2359562B (fr) |
| HK (2) | HK1040913A1 (fr) |
| TW (1) | TWI245636B (fr) |
| WO (1) | WO2000032213A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO20014256D0 (no) | 2001-09-03 | 2001-09-03 | Bjoern Kristiansen | Fremstilling av immunstimulerende forbindelse |
| JP4681363B2 (ja) * | 2005-03-04 | 2011-05-11 | 美智士 谷 | 悪性腫瘍治療剤及びそれを含む飲食品 |
| JP2006273835A (ja) * | 2005-03-04 | 2006-10-12 | Michishi Tani | 悪性腫瘍治療剤及びそれを含む飲食品 |
| WO2006133707A2 (fr) | 2005-06-15 | 2006-12-21 | Medimush A/S | Polytherapie contre le cancer et kit de composants associe |
| JP5756270B2 (ja) * | 2010-09-29 | 2015-07-29 | 小林製薬株式会社 | がんペプチドワクチン療法効果向上剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0751511B2 (ja) * | 1982-03-15 | 1995-06-05 | 味の素株式会社 | インターロイキン２を含有してなる癌治療剤 |
| GB9405846D0 (en) * | 1994-03-24 | 1994-05-11 | Misevic Gradimir | Organic compounds |
| JP2002270532A (ja) * | 2001-03-14 | 2002-09-20 | Tokyo Electron Ltd | 加熱装置及び熱処理装置 |
-
1998
- 1998-11-27 JP JP10337822A patent/JP2000157203A/ja active Pending
-
1999
- 1999-11-26 CA CA002352459A patent/CA2352459A1/fr not_active Abandoned
- 1999-11-26 KR KR1020017006474A patent/KR20010089497A/ko not_active Application Discontinuation
- 1999-11-26 CN CNB998151882A patent/CN1171631C/zh not_active Expired - Fee Related
- 1999-11-26 GB GB0113001A patent/GB2359562B/en not_active Expired - Fee Related
- 1999-11-26 WO PCT/JP1999/006617 patent/WO2000032213A1/fr not_active Application Discontinuation
- 1999-11-26 TW TW093100696A patent/TWI245636B/zh not_active IP Right Cessation
-
2002
- 2002-02-27 HK HK02101523.2A patent/HK1040913A1/zh unknown
- 2002-06-08 HK HK02104332.7A patent/HK1042652B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000157203A (ja) | 2000-06-13 |
| HK1042652A1 (en) | 2002-08-23 |
| TWI245636B (en) | 2005-12-21 |
| WO2000032213A1 (fr) | 2000-06-08 |
| CN1171631C (zh) | 2004-10-20 |
| GB0113001D0 (en) | 2001-07-18 |
| HK1040913A1 (zh) | 2002-06-28 |
| CN1332634A (zh) | 2002-01-23 |
| HK1042652B (zh) | 2005-03-18 |
| KR20010089497A (ko) | 2001-10-06 |
| TW200412989A (en) | 2004-08-01 |
| GB2359562B (en) | 2004-04-28 |
| GB2359562A (en) | 2001-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100988072B1 (ko) | 황칠나무 발효물 및 그것을 포함하는 약학 조성물 | |
| KR102050265B1 (ko) | 락토바실러스 아시도필루스를 포함하는 관절염, 섬유증, 대장염 또는 이식거부 반응의 예방 또는 치료용 조성물 | |
| KR101219650B1 (ko) | 옻의 무독화 방법 및 무독화 옻피 추출물의 용도 | |
| KR101033671B1 (ko) | 상황버섯과 동충하초를 포함하는 항암용 건강식품 | |
| CA2352459A1 (fr) | Agents de potentialisation de l'immunoactivite des cellules .gamma..delta. contenant un extrait mycelien de shiitake | |
| KR100814351B1 (ko) | 담자균류 및 두릅나무과 추출물의 생리학적 활성 조성물 | |
| JP3502620B2 (ja) | 抗肝炎作用を有する組成物 | |
| JP4484267B2 (ja) | ガン免疫賦活剤およびアレルギー免疫抑制剤 | |
| JP4323128B2 (ja) | 生理活性組成物 | |
| JP2009024027A (ja) | 生理活性組成物 | |
| WO1999053937A1 (fr) | Agents immunostimulants et antitumoraux | |
| JP4245291B2 (ja) | 生理活性組成物及びその製造方法 | |
| US6585974B1 (en) | Preventives for hepatopathy | |
| JP3010258B2 (ja) | 抗ｈｉｖ剤 | |
| CN114540202B (zh) | 一种绣球菌干燥粉末的制备方法和生理机能活性剂及其应用 | |
| KR20010101065A (ko) | 표고버섯 균사체 추출물 유래의 ｌａｋ 활성증강물질 및이를 함유하는 ｌａｋ 활성증강용 제제 | |
| JP4269547B2 (ja) | 血糖降下剤及びその製造方法 | |
| KR20170090935A (ko) | 소나무잔나비버섯 균사체를 포함하는 당뇨병 예방 또는 치료용 조성물 | |
| KR101659889B1 (ko) | 김으로부터 분리된 당단백질을 포함하는 바이러스성 간 손상 예방 또는 치료용 조성물 | |
| KR20210052639A (ko) | 버섯 복합배양 균사체를 함유하는 혈당 조절용 조성물의 제조방법 | |
| KR100595852B1 (ko) | 건강식품 및 항종양제 | |
| KR20180063388A (ko) | 인진쑥(Artemisia capillaris Thunb.) 수용성 추출물을 유효성분으로 함유하는 급성 간부전 질환 예방 또는 치료용 조성물 | |
| JP2007277155A (ja) | 抗疲労作用組成物及び／又は持久力増強組成物 | |
| CN107349224A (zh) | 蜚蠊在降低体脂率方面的应用 | |
| JP2000157204A (ja) | シイタケ菌糸体抽出物の分画物及びその用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |