CA2344591A1 - Methodes permettant d'ameliorer la fonction des recepteurs heterologues couples a la proteine g - Google Patents

Methodes permettant d'ameliorer la fonction des recepteurs heterologues couples a la proteine g Download PDF

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Publication number
CA2344591A1
CA2344591A1 CA002344591A CA2344591A CA2344591A1 CA 2344591 A1 CA2344591 A1 CA 2344591A1 CA 002344591 A CA002344591 A CA 002344591A CA 2344591 A CA2344591 A CA 2344591A CA 2344591 A1 CA2344591 A1 CA 2344591A1
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CA
Canada
Prior art keywords
receptor
protein
yeast cell
cell according
coupled receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002344591A
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English (en)
Inventor
Mark Henry Pausch
Jurgen Wess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
US Government
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2344591A1 publication Critical patent/CA2344591A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des récepteurs mutants couplés à la protéine G, lesquels présentent un meilleur couplage à la protéine G et une meilleure réponse de réception. L'invention concerne également des cellules de levure exprimant ces récepteurs, des vecteurs convenant à la fabrication de ces cellules et des méthodes de fabrication et d'utilisation associées.
CA002344591A 1998-09-01 1999-09-01 Methodes permettant d'ameliorer la fonction des recepteurs heterologues couples a la proteine g Abandoned CA2344591A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9870498P 1998-09-01 1998-09-01
US60/098,704 1998-09-01
PCT/US1999/020013 WO2000012705A2 (fr) 1998-09-01 1999-09-01 Methodes permettant d'ameliorer la fonction des recepteurs heterologues couples a la proteine g

Publications (1)

Publication Number Publication Date
CA2344591A1 true CA2344591A1 (fr) 2000-03-09

Family

ID=22270543

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002344591A Abandoned CA2344591A1 (fr) 1998-09-01 1999-09-01 Methodes permettant d'ameliorer la fonction des recepteurs heterologues couples a la proteine g
CA002343046A Abandoned CA2343046A1 (fr) 1998-09-01 1999-09-01 Expression fonctionnelle amelioree des recepteurs couples a la proteine g

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002343046A Abandoned CA2343046A1 (fr) 1998-09-01 1999-09-01 Expression fonctionnelle amelioree des recepteurs couples a la proteine g

Country Status (5)

Country Link
EP (2) EP1112359A2 (fr)
JP (2) JP2002523090A (fr)
AU (2) AU756244B2 (fr)
CA (2) CA2344591A1 (fr)
WO (2) WO2000012705A2 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
JP2004500843A (ja) 2000-04-24 2004-01-15 ワイエス トランスジェニック動物
EP1337852A1 (fr) * 2000-10-26 2003-08-27 The University of British Columbia Essai fonctionnel a base de cellules d'insectes concernant les recepteurs coupl s aux proteines g
ATE357457T1 (de) * 2000-11-01 2007-04-15 Astellas Pharma Inc Verfahren zum screenen eines plättchenhemmers
US7018812B2 (en) 2000-11-03 2006-03-28 Duke University Modified G-protein coupled receptors
US7163800B2 (en) 2000-11-03 2007-01-16 Molecular Devices Corporation Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
DE10056899A1 (de) 2000-11-16 2002-05-29 Aventis Pharma Gmbh Promotor zur funktionellen Charakterisierung von G-Protein gekoppelten Rezeptoren in der Hefe Saccharomyces cerevisiae
AU2002228844A1 (en) * 2000-12-06 2002-06-18 Deltagen, Inc. Transgenic mice containing targeted gene disruptions
GB0030038D0 (en) * 2000-12-08 2001-01-24 Univ Warwick Yeast-based assay
US7279324B2 (en) 2001-01-23 2007-10-09 Duke University Nucleic acid encoding G-protein coupled receptor with modified DRY motif
EP1336655A1 (fr) * 2002-01-12 2003-08-20 Aventis Pharma Deutschland GmbH Méthode pour l'identification des mutants ayant une actività constitutive
DE10233516A1 (de) * 2002-07-23 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Identifizierung von Substanzen
WO2006104254A1 (fr) * 2005-03-29 2006-10-05 Bio-Energy Corporation Procede pour le criblage d'une substance de liaison des recepteurs
JP5774264B2 (ja) 2005-04-27 2015-09-09 アリーナ ファーマシューティカルズ， インコーポレイテッド 肥満および糖尿病、ならびにそれらに関連する病態の処置のため、ならびに血中ｇｌｐ−１レベルを増大させることによって緩和される病態の処置のための、併用療法
NZ564759A (en) 2005-06-30 2011-08-26 Prosidion Ltd GPCR agonists
DE602007010420D1 (de) 2006-04-11 2010-12-23 Arena Pharm Inc Verfahren zur verwendung des gpr119-rezeptors zur identifizierung von verbindungen zur erhöhung der knochenmasse bei einer person
AR064736A1 (es) 2007-01-04 2009-04-22 Prosidion Ltd Agonistas de gpcr
CL2008000018A1 (es) 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
ES2373181T3 (es) 2007-01-04 2012-02-01 Prosidion Ltd Agonistas de gpcr de piperidina.
EP3926045A1 (fr) * 2007-03-22 2021-12-22 Heptares Therapeutics Limited Protéines mutantes et leurs procédés de sélection
JP2010539152A (ja) 2007-09-10 2010-12-16 プロシディオン・リミテッド 代謝障害の治療のための化合物
GB0720389D0 (en) 2007-10-18 2008-11-12 Prosidion Ltd G-Protein Coupled Receptor Agonists
GB0720390D0 (en) 2007-10-18 2007-11-28 Prosidion Ltd G-Protein coupled receptor agonists
EP2108960A1 (fr) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Procédés d'utilisation d'un récepteur couplé à protéine G pour identifier les secrétagogues de peptide YY (PYY) et composés utiles dans le traitement des conditions modulées de secrétagogues BY (PYY) et composés utiles dans le traitement des conditions par PYY
GB0904285D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904284D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904287D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
JP7422498B2 (ja) 2019-07-25 2024-01-26 芳武 村山 ペプチド、細胞遊走抑制剤、細胞浸潤抑制剤、がん細胞転移抑制剤、及び医薬

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691188A (en) * 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
CA2193809A1 (fr) * 1994-06-29 1996-01-11 Catherine D. Strader Recepteurs modifies lies a des proteines g
WO1998038217A1 (fr) * 1997-02-27 1998-09-03 Milt Teitler Recepteurs de serotonine actives par constitution

Also Published As

Publication number Publication date
JP2002523091A (ja) 2002-07-30
WO2000012705A3 (fr) 2000-10-05
EP1112359A2 (fr) 2001-07-04
WO2000012705A9 (fr) 2000-07-13
AU5700999A (en) 2000-03-21
WO2000012705A2 (fr) 2000-03-09
WO2000012704A9 (fr) 2000-06-08
CA2343046A1 (fr) 2000-03-09
WO2000012704A3 (fr) 2000-11-30
AU756244B2 (en) 2003-01-09
EP1123391A2 (fr) 2001-08-16
WO2000012704A2 (fr) 2000-03-09
JP2002523090A (ja) 2002-07-30
AU5701199A (en) 2000-03-21

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Date Code Title Description
FZDE Discontinued