ATE357457T1 - Verfahren zum screenen eines plättchenhemmers - Google Patents

Verfahren zum screenen eines plättchenhemmers

Info

Publication number
ATE357457T1
ATE357457T1 AT01978964T AT01978964T ATE357457T1 AT E357457 T1 ATE357457 T1 AT E357457T1 AT 01978964 T AT01978964 T AT 01978964T AT 01978964 T AT01978964 T AT 01978964T AT E357457 T1 ATE357457 T1 AT E357457T1
Authority
AT
Austria
Prior art keywords
screening
sub
tool
antiplatelet agent
protein
Prior art date
Application number
AT01978964T
Other languages
English (en)
Inventor
Jun Takasaki
Mitsuyuki Matsumoto
Masazumi Kamohara
Tetsu Saito
Takahide Ohishi
Takatoshi Soga
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of ATE357457T1 publication Critical patent/ATE357457T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT01978964T 2000-11-01 2001-10-31 Verfahren zum screenen eines plättchenhemmers ATE357457T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000334721 2000-11-01
JP2001003577 2001-01-11

Publications (1)

Publication Number Publication Date
ATE357457T1 true ATE357457T1 (de) 2007-04-15

Family

ID=26603288

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01978964T ATE357457T1 (de) 2000-11-01 2001-10-31 Verfahren zum screenen eines plättchenhemmers

Country Status (8)

Country Link
US (1) US7405051B2 (de)
EP (1) EP1331228B1 (de)
JP (1) JP3519078B2 (de)
AT (1) ATE357457T1 (de)
AU (1) AU2002210982A1 (de)
DE (1) DE60127435T2 (de)
ES (1) ES2282304T3 (de)
WO (1) WO2002036631A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046454A1 (en) 1999-12-23 2001-06-28 Cor Therapeutics, Inc. P2y12 receptor
EP1411130A1 (de) * 2002-10-15 2004-04-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Zusammenhang zwischen dem H2 Haplotyp des P2Y12 Rezeptors und einem erhöten Risiko auf Thrombose und peripheren arteriellen Erkrankungen
EP1411134A1 (de) * 2002-10-15 2004-04-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Zusammenhang zwischen dem H2 Haplotyp des P2Y12 Rezeptors und einem erhöten Risiko auf Thrombose und peripheren arteriellen Erkrankungen
WO2005007868A2 (en) 2003-07-08 2005-01-27 Accumetrics, Inc. Controlled platelet activation to monitor therapy of adp antagonists
US20070243632A1 (en) 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
WO2005076007A2 (en) * 2004-02-03 2005-08-18 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y12 (p2y12)
WO2006039212A2 (en) * 2004-09-29 2006-04-13 Portola Pharmaceuticals, Inc. Substituted 2h-1,3-benzoxazin-4(3h)-ones
TWI391378B (zh) 2006-03-16 2013-04-01 Astellas Pharma Inc 喹啉酮衍生物或其製藥學上可被容許之鹽
DE102006020385A1 (de) * 2006-04-28 2007-10-31 Dade Behring Marburg Gmbh Verfahren und Vorrichtung zur Bestimmung der Thrombozytenfunktion unter Flussbedingungen
DE102006020386A1 (de) * 2006-04-28 2007-10-31 Dade Behring Marburg Gmbh Verfahren zur Bestimmung der Thrombozytenfunktion unter Flussbedingungen
EP2138482A4 (de) 2007-04-19 2011-06-15 Astellas Pharma Inc Bicyclische heterocyclische verbindung
JP5514101B2 (ja) * 2007-05-03 2014-06-04 アキュメトリックス インコーポレイテッド トロンビンレセプターアンタゴニストによる血小板凝集阻害を測定する方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060272A (en) 1997-05-07 2000-05-09 Human Genome Sciences, Inc. Human G-protein coupled receptors
WO2000012704A2 (en) * 1998-09-01 2000-03-09 Basf Aktiengesellschaft Enhanced functional expression of g protein-coupled receptors
IL142153A0 (en) 1998-10-13 2002-03-10 Arena Pharm Inc Non-endogenous, constitutively activated human g protein-coupled receptors
AU1712200A (en) 1998-11-06 2000-05-29 Millennium Pharmaceuticals, Inc. G-protein coupled receptors, homologous to ebv-induced gpcr 2 (ebi-2). methods to seek for ligands thereof
ES2289610T3 (es) 1998-11-20 2008-02-01 Arena Pharmaceuticals, Inc. Receptor acoplado a proteina g humano huerfano rup3.
SE9804274D0 (sv) * 1998-12-10 1998-12-10 Astra Pharma Inc Novel receptor
US6689866B1 (en) * 1999-03-09 2004-02-10 Curagen Corporation Polynucleotides and proteins encoded thereby
WO2001046454A1 (en) * 1999-12-23 2001-06-28 Cor Therapeutics, Inc. P2y12 receptor
US20010046497A1 (en) * 2000-04-21 2001-11-29 Zhang Fang Liang G-protein coupled receptor and methods
WO2001085791A1 (en) 2000-05-11 2001-11-15 Lifespan Biosciences, Inc. Nucleic acid sequences for novel gpcrs

Also Published As

Publication number Publication date
WO2002036631A1 (fr) 2002-05-10
ES2282304T3 (es) 2007-10-16
DE60127435T2 (de) 2007-11-29
JP3519078B2 (ja) 2004-04-12
US20030124626A1 (en) 2003-07-03
US7405051B2 (en) 2008-07-29
AU2002210982A1 (en) 2002-05-15
EP1331228A1 (de) 2003-07-30
DE60127435D1 (de) 2007-05-03
JPWO2002036631A1 (ja) 2004-03-11
EP1331228A4 (de) 2005-01-19
EP1331228B1 (de) 2007-03-21

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