CA2193809A1 - Recepteurs modifies lies a des proteines g - Google Patents

Recepteurs modifies lies a des proteines g

Info

Publication number
CA2193809A1
CA2193809A1 CA 2193809 CA2193809A CA2193809A1 CA 2193809 A1 CA2193809 A1 CA 2193809A1 CA 2193809 CA2193809 CA 2193809 CA 2193809 A CA2193809 A CA 2193809A CA 2193809 A1 CA2193809 A1 CA 2193809A1
Authority
CA
Canada
Prior art keywords
receptor
modified
protein coupled
coupled receptor
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2193809
Other languages
English (en)
Inventor
Catherine D. Strader
Maria-Luisa Rios Candelore
Xiaoming Guan
Richard Dixon
George Mcallister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2193809A1 publication Critical patent/CA2193809A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

On a identifié des récepteurs modifiés couplés à des protéines G présentant des délétions dans le troisième domaine intracellulaire et développé des procédés de production de ces récepteurs modifiés. Cette invention concerne les récepteurs modifiés, des dosages employant les récepteurs modifiés, des cellules exprimant les récepteurs modifiés et des composés identifiés à l'aide desdits récepteurs modifiés, y compris des modulateurs de ces récepteurs.
CA 2193809 1994-06-29 1995-06-02 Recepteurs modifies lies a des proteines g Abandoned CA2193809A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26814794A 1994-06-29 1994-06-29
US26798794A 1994-06-29 1994-06-29
US268,147 1994-06-29
US267,987 1994-06-29

Publications (1)

Publication Number Publication Date
CA2193809A1 true CA2193809A1 (fr) 1996-01-11

Family

ID=26952801

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2193809 Abandoned CA2193809A1 (fr) 1994-06-29 1995-06-02 Recepteurs modifies lies a des proteines g

Country Status (4)

Country Link
EP (1) EP0770094A4 (fr)
JP (1) JPH10502245A (fr)
CA (1) CA2193809A1 (fr)
WO (1) WO1996000739A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606126D0 (en) * 1996-03-22 1996-05-22 British Biotech Pharm Biosensors
AU756244B2 (en) * 1998-09-01 2003-01-09 Basf Aktiengesellschaft Methods for improving the function of heterologous G protein-coupled receptors
US7094593B1 (en) 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
AU2001259743A1 (en) * 2000-05-12 2001-11-26 3-Dimensional Pharmaceuticals, Inc. Gpcr 4-helix and 5-helix bundles
JP2007502860A (ja) * 2003-04-24 2007-02-15 ヴァンダービルト ユニバースィティ 昆虫を防除するための組成物及び方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5462856A (en) * 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins

Also Published As

Publication number Publication date
JPH10502245A (ja) 1998-03-03
EP0770094A4 (fr) 1999-05-19
EP0770094A1 (fr) 1997-05-02
WO1996000739A1 (fr) 1996-01-11

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Legal Events

Date Code Title Description
FZDE Dead