CA2343531A1 - Gaba uptake inhibitors having a pyrrolidine structure - Google Patents

Gaba uptake inhibitors having a pyrrolidine structure Download PDF

Info

Publication number
CA2343531A1
CA2343531A1 CA002343531A CA2343531A CA2343531A1 CA 2343531 A1 CA2343531 A1 CA 2343531A1 CA 002343531 A CA002343531 A CA 002343531A CA 2343531 A CA2343531 A CA 2343531A CA 2343531 A1 CA2343531 A1 CA 2343531A1
Authority
CA
Canada
Prior art keywords
mmol
alkyl
groups
optionally substituted
compounds according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002343531A
Other languages
English (en)
French (fr)
Inventor
Klaus Wanner
Gunther Fulep
Georg Hofner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BDD GROUP HOLDING AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2343531A1 publication Critical patent/CA2343531A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CA002343531A 1998-09-05 1999-09-03 Gaba uptake inhibitors having a pyrrolidine structure Abandoned CA2343531A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19840611A DE19840611A1 (de) 1998-09-05 1998-09-05 GABA-uptake-Inhibitoren mit Pyrrolidinstruktur
DE19840611.8 1998-09-05
PCT/EP1999/006486 WO2000014064A2 (de) 1998-09-05 1999-09-03 Gaba-uptake-inhibitoren mit pyrrolidinstruktur

Publications (1)

Publication Number Publication Date
CA2343531A1 true CA2343531A1 (en) 2000-03-16

Family

ID=7879962

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002343531A Abandoned CA2343531A1 (en) 1998-09-05 1999-09-03 Gaba uptake inhibitors having a pyrrolidine structure

Country Status (6)

Country Link
EP (1) EP1109783A2 (de)
JP (1) JP2002524443A (de)
AU (1) AU5972699A (de)
CA (1) CA2343531A1 (de)
DE (1) DE19840611A1 (de)
WO (1) WO2000014064A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189757B2 (en) 2001-10-16 2007-03-13 Hypnion, Inc. Treatment of sleep disorders using CNS target modulators
US7355042B2 (en) 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
JP2005529840A (ja) 2001-10-16 2005-10-06 ヒプニオン， インコーポレイテッド Ｃｎｓ標的モジュレータを使用するｃｎｓ障害の治療
KR20100038295A (ko) * 2007-06-05 2010-04-14 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383999A (en) * 1981-05-26 1983-05-17 Smithkline Beckman Corporation Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A (en) * 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
GB8320704D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agents
US4610995A (en) * 1984-07-27 1986-09-09 Coker Geoffrey G Certain 1,1-diaryl-propenyl-3-(1-pyrrolidino-2-carboxylic acids, derivatives thereof and their anti-histaminic properties
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
US4910312A (en) * 1985-11-08 1990-03-20 Warner-Lambert Company Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
EP0231996B1 (de) * 1986-01-07 1993-10-06 Novo Nordisk A/S Aminosäure-Derivate
WO1997045115A1 (en) * 1996-05-31 1997-12-04 Trophix Pharmaceuticals, Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders

Also Published As

Publication number Publication date
WO2000014064A2 (de) 2000-03-16
JP2002524443A (ja) 2002-08-06
DE19840611A1 (de) 2000-03-09
WO2000014064A3 (de) 2000-07-20
EP1109783A2 (de) 2001-06-27
AU5972699A (en) 2000-03-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead