CA2343531A1 - Inhibiteurs d'absorption de gaba a structure pyrrolidinique - Google Patents
Inhibiteurs d'absorption de gaba a structure pyrrolidinique Download PDFInfo
- Publication number
- CA2343531A1 CA2343531A1 CA002343531A CA2343531A CA2343531A1 CA 2343531 A1 CA2343531 A1 CA 2343531A1 CA 002343531 A CA002343531 A CA 002343531A CA 2343531 A CA2343531 A CA 2343531A CA 2343531 A1 CA2343531 A1 CA 2343531A1
- Authority
- CA
- Canada
- Prior art keywords
- mmol
- alkyl
- groups
- optionally substituted
- compounds according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
L'invention concerne des composés de la formule générale (I) dans laquelle R?1¿ à R?7¿, A?1¿, A?2¿, X et Z ont la signification mentionnée dans la description. Ces composés s'utilisent comme inhibiteurs d'absorption de GABA pour traiter des affections telles que par exemple l'épilepsie.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19840611A DE19840611A1 (de) | 1998-09-05 | 1998-09-05 | GABA-uptake-Inhibitoren mit Pyrrolidinstruktur |
DE19840611.8 | 1998-09-05 | ||
PCT/EP1999/006486 WO2000014064A2 (fr) | 1998-09-05 | 1999-09-03 | Inhibiteurs d'absorption de gaba a structure pyrrolidinique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2343531A1 true CA2343531A1 (fr) | 2000-03-16 |
Family
ID=7879962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002343531A Abandoned CA2343531A1 (fr) | 1998-09-05 | 1999-09-03 | Inhibiteurs d'absorption de gaba a structure pyrrolidinique |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1109783A2 (fr) |
JP (1) | JP2002524443A (fr) |
AU (1) | AU5972699A (fr) |
CA (1) | CA2343531A1 (fr) |
DE (1) | DE19840611A1 (fr) |
WO (1) | WO2000014064A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7189757B2 (en) | 2001-10-16 | 2007-03-13 | Hypnion, Inc. | Treatment of sleep disorders using CNS target modulators |
US7355042B2 (en) | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
JP2005529840A (ja) | 2001-10-16 | 2005-10-06 | ヒプニオン, インコーポレイテッド | Cns標的モジュレータを使用するcns障害の治療 |
KR20100038295A (ko) * | 2007-06-05 | 2010-04-14 | 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 | 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4383999A (en) * | 1981-05-26 | 1983-05-17 | Smithkline Beckman Corporation | Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters |
US4514414A (en) * | 1982-10-25 | 1985-04-30 | Smithkline Beckman Corporation | N-Substituted pyrrolidineacetic acids and their esters |
GB8320704D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agents |
US4610995A (en) * | 1984-07-27 | 1986-09-09 | Coker Geoffrey G | Certain 1,1-diaryl-propenyl-3-(1-pyrrolidino-2-carboxylic acids, derivatives thereof and their anti-histaminic properties |
DK704488D0 (da) * | 1988-12-19 | 1988-12-19 | Novo Industri As | Nye n-substituerede azaheterocykliske carboxylsyrer |
DK288385D0 (da) * | 1985-06-26 | 1985-06-26 | Novo Industri As | Aminosyrederivater |
US4910312A (en) * | 1985-11-08 | 1990-03-20 | Warner-Lambert Company | Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof |
EP0231996B1 (fr) * | 1986-01-07 | 1993-10-06 | Novo Nordisk A/S | Dérivés d'amino-acides |
WO1997045115A1 (fr) * | 1996-05-31 | 1997-12-04 | Trophix Pharmaceuticals, Inc. | Produit pharmaceutique pour le traitement de troubles neurologiques et neuropsychiatriques |
-
1998
- 1998-09-05 DE DE19840611A patent/DE19840611A1/de not_active Withdrawn
-
1999
- 1999-09-03 CA CA002343531A patent/CA2343531A1/fr not_active Abandoned
- 1999-09-03 WO PCT/EP1999/006486 patent/WO2000014064A2/fr not_active Application Discontinuation
- 1999-09-03 EP EP99968664A patent/EP1109783A2/fr not_active Withdrawn
- 1999-09-03 JP JP2000568823A patent/JP2002524443A/ja active Pending
- 1999-09-03 AU AU59726/99A patent/AU5972699A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000014064A2 (fr) | 2000-03-16 |
JP2002524443A (ja) | 2002-08-06 |
DE19840611A1 (de) | 2000-03-09 |
WO2000014064A3 (fr) | 2000-07-20 |
EP1109783A2 (fr) | 2001-06-27 |
AU5972699A (en) | 2000-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |